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Nano Research 2013年第5期6卷 348-355页

作者： chan woo Lee Seung-Deok Seo Dong wook Kim Sangbaek Park Kyoungsuk Jin Dong-Wan Kim Kug Sun Hong DepartmentofMatefials Science andEngineering Seoul National University Seou1151-744 Korea WCU Hybrid Materials Program Department of Materials Science and Engineering Seoul National University Seou1151-744 Korea Department of Material Science and Engineering Ajou University Suwon 443-749 Korea Department of Chemistry Northwestern University 245 Sheridan Road Evanston IL 60208 USA

We report the direct synthesis of ZnC0204 and ZnO/ZnC0204 submicron rod arrays grown on Ni foil current collectors via an ammonia-evaporation-induced method by controlling the ratio of Zn to Co. These three-dimensional （3D） hierar- chical self-supported nanostructures are composed of one-dimensional （1D） ZnCo204 rods and two-dimensional （2D） ZnO nanosheet bands perpendicular to the axis of the each ZnCo204 rod. We carefully deal with the heteroepitaxial growth mechanisms of hexagonal ZnO nanosheets from a crystallographic point of view. Furthermore, we demonstrate the ability of these high-surface-area ZnO/ZnCo204 heterostructured rods to enable improved electrolyte permeability and Li ion transfer, thereby enhancing their Li storage capability （-900 mA.h.g-1 at a rate of 45 mA.h.g-1） for Li ion battery electrodes.

关键词： ZnCo204 submicron rods ZnO nanosheets hierarchicalheterostructure ammonia-evaporation-induced method Li ion battery

Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer

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World Journal of Gastrointestinal Oncology 2018年第11期10卷 421-430页

作者： Huapyong Kang Jung Hyun Jo Hee Seung Lee Moon Jae Chung Seungmin bang Seung woo Park Si Young Song Jeong Youp Park Division of Gastroenterology Department of Internal Medicine Yonsei University College of Medicine

AIM To directly compare the efficacy and toxicity of standarddose FOLFIRINOX(sFOLFIRINOX) and modified-dose FOLFIRINOX(mFOLFIRINOX, 75% of standard-dose) for pancreatic *** One hundred and thirty pancreatic cancer patients who received sFOLFIRINOX(n = 88) or mFOLFIRINOX(n = 42) as their first-line chemotherapy from January 2013 to July 2017 were retrospectively reviewed. For efficacy analysis, the objective response rate(ORR),disease control rate(DCR), progression-free survival(PFS), and overall survival(OS) were evaluated and compared using Pearson's chi-square test, Kaplan-Meier plot and log-rank test. The adverse events(AEs) were evaluated, and severe(≥ grade 3) AEs rates of the two groups were compared for toxicity *** The mFOLFIRINOX group included more female patients(30.7% vs 57.1%; P = 0.004) and older patients [age(median), 57 vs 63.5; P = 0.018] than the sFOLFIRINOX group. In the efficacy analysis, the ORR and DCR were not significantly different between the two groups(ORR: 39.8% vs 35.7%; P = 0.656; DCR: 80.7% vs 83.3%; P = 0.716). The median PFS and OS were also not different between the groups(PFS: 8.7 mo vs 8.1 mo, P = 0.272; OS: 13.9 mo vs 13.7 mo, P = 0.476). In the safety analysis with severe AEs, the rates of neutropenia(83.0% vs 66.7%; P = 0.044), anorexia(48.9% vs 28.6%; P = 0.029) and diarrhea(13.6% vs 0.0%; P = 0.009) were markedly lower in the mFOLFIRINOX *** m FOLFIRINOX showed comparable efficacy but better safety compared to sFOLFIRINOX. If clinically necessary, initiating FOLFIRINOX with 75% of the standard-dose can alleviate toxicity concerns without compromising efficacy.

关键词： Dose modification Adverse event Pancreatic cancer Adenocarcinoma FOLFIRINOX Chemotherapy

Proximate and mineral components of Viscum album var. coloratum grown on eight different host tree species

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Journal of Forestry Research 2019年第4期30卷 1245-1253页

作者： Chul-woo Kim chan-Hoon An Hyun-Seok Lee Jae-Seon Yi Eun Ju Cheong Sang-Hyun Lim Hee-Yeon Kim Forest Bioresources Department National Institute of Forest Science39 OnjeongroGwonseon-guSuwon 16631Republic of Korea Forest Medicinal Resources Research Center National Institute of Forest ScienceSobaek-ro 2009PunggiYoungjuGyungsangbuk-do 36040Republic of Korea Program of Forest Resources Division of Forest ScienceCollege of Forest and Environmental SciencesKangwon National UniversityChuncheon 24341Republic of Korea Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment ServicesChuncheon 24203Republic of Korea

Mistletoes are parasite plants growing on various tree species,taking nutrients from the *** compounds of mistletoe were used in medicine and these mistletoes were commonly collected from oak species that were not well *** analyzed the nutritional value by measuring proximate and mineral components of Korean mistletoe(Viscum album ***)from various host *** was the most proximate component in both leaves and twigs followed crude protein,crude fiber,crude ash and crude *** the contents of the proximate components and minerals varied among hosts and between plant parts,leaves contained higher crude protein and ash,and more minerals except for magnesium than twigs,although no significant difference was found inmistletoe grown on Prunus *** were significant differences of proximate and mineral contents depending on the host *** grown on Chaenomeles sinensis contained higher levels of carbohydrates,crude fat,crude ash,magnesium,calcium,sodium,iron,and zinc than mistletoe grown on other *** grown on *** contained high mineral levels of potassium,copper and *** nutritional value of mistletoes were greatly influenced by the host species but among the hosts,specific nutrients accumulated in leaves more than in twigs,and vice *** on the analysis,Korean mistletoe contains relatively good quality of nutrients and has high potential for dietary supplements as well as for medicinal compounds.

关键词： Mistletoe Viscum album var coloratum Proximate compositions Mineral contents Nutritional value Host species

Modeling hot deformation behavior of low-cost Ti-2Al-9.2Mo-2Fe beta titanium alloy using a deep neural network

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Journal of Materials Science & Technology 2019年第5期35卷 907-916页

作者： Cheng-Lin Li P.L.Narayana N.S.Reddy Seong-woo Choi Jong-Taek Yeom Jae-Keun Hong chan Hee Park Advanced Metals Division Korea Institute of Materials Science Changwon 51508 Republic of Korea School of Materials Science and Engineering Gyeongsang National University Jinju 52828 Republic of Korea

Ti-2 Al-9.2 Mo-2 Fe is a low-cost β titanium alloy with well-balanced strength and ductility, but hot working of this alloy is complex and unfamiliar. Understanding the nonlinear relationships among the strain,strain rate, temperature, and flow stress of this alloy is essential to optimize the hot working *** this study, a deep neural network(DNN) model was developed to correlate flow stress with a wide range of strains(0.025–0.6), strain rates(0.01–10 s^-1) and temperatures(750–1000℃). The model, which was tested with 96 unseen datasets, showed better performance than existing models, with a correlation coefficient of 0.999. The processing map constructed using the DNN model was effective in predicting the microstructural evolution of the alloy. Moreover, it led to the optimization of hot-working conditions to avoid the formation of brittle precipitates(temperatures of 820–1000℃ and strain rates of 0.01-0.1 s^-1).

关键词： Deep neural networks Back propagation Processing map Recrystallization Beta titanium

Bimodal grain structures and tensile properties of a biomedical Co-20Cr-15W-10Ni alloy with different pre-strains

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Rare Metals 2021年第1期40卷 20-30页

作者： Cheng-Lin Li Seong-woo Choi Jeong Mok Oh Jae-Keun Hong Jong-Taek Yeom Joo-Hee Kang Qing-Song Mei chan Hee Park Department of Materials Engineering School of Power and Mechanical EngineeringWuhan UniversityWuhan 430072China Advanced Metals Division.Korea Institute of Materials Science Changwon 51508Republic of Korea Materials Testing&Reliability Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

The influence of pre-strain on the formation of bimodal grain structures and tensile properties of a Co-20 Cr-15 W-10 Ni alloy was *** bimodal grain structures consist of fine grains(FGs;2-3μm in diameter)and coarse grains(CGs;8-16μm in diameter),which can be manipulated by changing the pre-strain(ε=0.3-0.7)and annealing temperatures(1000-1100℃).High pre-strain applied in the samples can intensify the plasticity heterogeneity through increasing the total dislocation density and the local volumes of high-density *** can essentially result in finer FGs,a higher FG volume fraction,and overall grain refinement in the samples after ***-temperature essentially increases both the size and volume fraction of CGs,leading to an increase in the average grain *** tensile test suggests that the bimodal grain structured samples exhibited both high strength and ductility,yield strengths of621-877 MPa and ultimate tensile strengths of1187-1367 MPa with uniform elongations of 55.0%-71.4%.The superior strength-ductility combination of the samples arises from the specific deformation mechanisms of the bimodal grain *** tensile properties strongly depend on the size ratio and volume fraction of FGs/CGs in addition to the average grain size in the bimodal grain *** grain structures can be modified via changing the pre-strain and annealing temperature.

关键词： Biomaterials Bimodal grain structure Deformation heterogeneity Pinning High strength/ductility

CFD Simulation of Reactor Internal Flow in the Scaled APR＋

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Journal of Energy and Power Engineering 2013年第8期7卷 1533-1538页

作者： Gong Hee Lee chan Yi Song Young Seok bang Sweng woong woo Do Hyeong Kim Min Gu Kang Korea Institute of Nuclear Safety Daejon 305-338 Republic of Korea 4NFLUX Inc. Seou1152-847 Republic of Korea

A series of 1/5 scale reactor flow model tests have been conducted in order to determine the hydraulic characteristics of the APR＋（advanced power reactor plus）. The objective of test was to determine the core inlet flow field of the model reactor in order to provide input information required by the open core thermal margin analysis code such as TORC. In this study, in order to examine the validity of the results of reactor flow model tests and the applicability of CFD （computational fluid dynamics） in the simulation of reactor internal flow, CFD simulation was conducted with the commercial multi-purpose CFD software, ANSYSCFX V. 14. It was found that the velocity field in the downcomer had the inhomogeneous feature. Relative high velocity region was located in the core region. This result was different from measurement and this difference may result from the fact that some internal structures were not modeled with the real geometry but treated as the porous domain.

关键词： Computational fluid dynamics flow similarity porous assumption reactor internal flow turbulent flow.

Comparison of brush and basket cytology in differential diagnosis of bile duct stricture at endoscopic retrograde cholangiopancreatography

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 622-627页

作者： Ki Bae bang Hong Joo Kim Jung Ho Park Dong Il Park Yong Kyun Cho Chong Il Sohn woo Kyu Jeon Byung Ik Kim Department of Internal Medicine Sungkyunkwan University Kangbuk Samsung Hospital 108 Pyung-Dong Jongro-Ku Seoul 110-746 Korea

BACKGROUND： A previous report has identified a significantly higher sensitivity of cancer detection for dedicated grasping basket than brushing at endoscopic retrograde cholangiopancreato- graphy （ERCP）. This study aimed to compare the diagnostic accuracy of Geenen brush and Dormia basket cytology in the differential diagnosis of bile duct stricture. METHOD： The current study enrolled one hundred and fourteen patients who underwent ERCP with both Geenen brush and Dormia basket cytology for the differential diagnosis of bile duct stricture at our institution between January 2008 and December 2012. RESULTS： We adopted sequential performances of cytologic samplings by using initial Geenen brush and subsequent Dormia basket cytology in 59 patients and initial Dormia basket and subsequent Geenen brush cytology in 55 patients. Presampling balloon dilatations and biliary stentings for the stricture were performed in 17 （14.9%） and 107 patients （93.9%）, respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of Geenen brush cytology for the diagnosis of malignant bile duct stricture were 75.0%, 100.0%, 100.0%, 66.7% and 83.3%, respectively, and those of Dormia basket cytology were 64.5%, 100.0%, 100.0%, 58.5% and 76.3%, respectively （P=0.347 and 0.827 for sensitivity and accuracy, respectively）. The good and excellent cellular yields （≥grade 2） were obtained by Geenen brush and Dormia basket cytology in 88 （77.2%） and 79 （69.3%） patients, ***： The sensitivity, specificity and accuracy of biliary sampling with a Dormia basket are comparable to those with conventional Geenen brush cytology in the detection of malignant bile duct stricture.

关键词： bile duct stricture cholangiocarcinoma brush cytology basket cytology

A comparative study of totally laparoscopic distal gastrectomy versus laparoscopic-assisted distal gastrectomy in gastric cancer patients: Short-term operative outcomes at a high-volume center

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Chinese Journal of Cancer Research 2018年第5期30卷 537-545页

作者： Won Ho Han Amir Ben Yehuda Deok-Hee Kim Seung Geun Yang bang wool Eom Hong Man Yoon Young-woo Kim Keun Won Ryu Center for Gastric Cancer National Cancer Center Department of Surgery Assaf Harofeh Medical Center

Objective： Laparoscopic gastrectomy has been established as a standard treatment for early gastric cancer, and its use is increasing recently. Compared with the conventional laparoscopy-assisted distal gastrectomy （LADG）, totally laparoscopic distal gastrectomy （TLDG） involves intracorporeal reconstruction, which can avoid the additional incision, resulting in pain reduction and early recovery. This study aimed to compare the short-term postoperative outcomes of TLDG vs. LADG in gastric cancer in a high-volume ***： A retrospective cohort study was conducted on 1,322 patients who underwent laparoscopic distal gastrectomy from June 2012 to June 2017 at the National Cancer Center, Korea. LAD G was performed in the early period before July 2015, and TLDG was applied in the later period. Postoperative short-term outcomes were compared in terms of complication and clinical course between the two groups. Pain score was measured by rating the pain intensity from 0 to 10 points on postoperative day （POD） 1 and 3. Results： A total of 667 patients underwent LADG and 655 patients underwent TLDG. Clinieopathologic characteristics were not different in both groups. Intraoperative estimated blood loss （EBL） was significantly lower in the TLDG group （P〈0.001）. Postoperative pain scores were significantly lower in the TLDG group than in the LADG group on POD 1 （5.1±1.5 vs. 4.8±1.4, P=0.015）. First flatus passage after operation was significantly earlier in the TLDG group （3.4±0.8 d vs. 3.2±0.6 d, P〈0.001）. There were no differences in postoperative complications and hospital stay between the two groups. Conclusions： Based on the reported short-term postoperative outcomes, TLDG is safe and feasible as well as LADG. Moreover, compared with LADG, TLDG can reduce intraoperative EBL and postoperative pain and enhance the bowel motility in gastric cancer surgery.

关键词： Distal gastrectomy gastric cancer intracorporeal anastomosis laparoscopic surgery

Surface-area-tuned, quantum-dot-sensitized heterostructured nanoarchitectures for highly efficient photoelectrodes

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Nano Research 2014年第1期7卷 144-153页

作者： Sangbaek Park Donghoe Kim chan woo Lee Seong-Deok Seo Hae Jin Kim Hyun Soo Han Kug Sun Hong Dong-Wan Kim Department of Materials Science and Engineering Seoul National University Seou1151-744 Republic of Korea Department of Energy Systems Research and Department of Materials Science and Engineering Ajou University Suwon 443-749 Republic of Korea

Harvesting solar energy to produce clean hydrogen from photoelectrolysis of water presents a valuable opportunity to find alternatives for fossil fuels. Three- dimensional nanoarchitecturing techniques can afford enhanced photoelectrochemical properties by improving geometrical and structural effects. Here, we report quantum-dot sensitized TiO2-Sb：SnO2 heterostructures as a model electrode to enable the optimization of the structural effects through the creation of a highly conductive pathway using a transparent conducting oxide （TCO）, coupled with a high surface area, by introducing branching and low interfacial resistance via an epitaxial relationship. An examination of various morphologies （dot, rod, and lamella shape） of TiO2 reveals that the rod-shaped TiO2-Sb：SnO2 is a more effective structure than the others. A photoelectrode fabricated using optimized CdS--TiO2-Sb：SnO2 produces a photocurrent density of 7.75 mA/cm2 at 0.4 V versus a reversible hydrogen electrode. These results demonstrate that constructing a branched heterostructure based on TCO can realize highperformance photoelectrochemical devices.

关键词： photoelectrochemical hydrogen evolution antimony-doped tinoxide TiO2 quantum dot

Peptidic defective interfering gene nanoparticles against Omicron,Delta SARS-CoV-2 variants and influenza A virus in vivo

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3484-3493页

作者： Hanjun Zhao Chuyuan Zhang Hoiyan Lam Xinjie Meng Zheng Peng Man Lung Yeung Jasper Fuk-woo chan Kelvin Kai-Wang To Kwok-Yung Yuen State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Department of Microbiology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong Special Administrative RegionChina Department of Infectious Disease and Microbiology The University of Hong Kong-Shenzhen HospitalShenzhenGuangdong ProvinceChina Carol Yu Centre for Infection The University of Hong KongPokfulamHong Kong Special Administrative RegionChina Guangzhou Laboratory GuangzhouGuangdong ProvinceChina

Defective interfering genes(DIGs)are short viral genomes and interfere with wild-type viral ***,we demonstrate that the new designed SARS-CoV-2 DIG(CD3600)can significantly inhibit the replication of SARS-CoV-2 including Alpha,Delta,Kappa and Omicron variants in human HK-2 cells and influenza DIG(PAD4)can significantly inhibit influenza virus replication in human A549 *** dose of influenza DIGs prophylactically protects 90%mice from lethal challenge of A(H1N1)pdm09 virus and CD3600 inhibits SARS-CoV-2 replication in hamster lungs when DIGs are administrated to lungs one day before viral *** further investigate the gene delivery vector in the respiratory tract,a peptidic TAT2-P1&LAH4,which can package genes to form small spherical nanoparticles with high endosomal escape ability,is demonstrated to dramatically increase gene expression in the lung ***2-P1&LAH4,with the dual-functional TAT2-P1(gene-delivery and antiviral),can deliver CD3600 to significantly inhibit the replication of Delta and Omicron SARS-CoV-2 in hamster *** peptide-based nanoparticle system can effectively transfect genes in lungs and deliver DIGs to inhibit SARS-CoV-2 variants and influenza virus in vivo,which provides the new insight into the drug delivery system for gene therapy against respiratory viruses.

关键词： influenza vivo Delta