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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第4期7卷 270-274页

作者： Keon M.Parsa caroline Rieger Dara Khati Jennifer R.White Jodi Barth chad c.zatezalo Michael J.Reilly Department of Otolaryngology MedStar Georgetown University HospitalWashingtonDCUSA The center for Facial Recovery RockvilleMDUSA The zatezalo Group RockvilleMDUSA

Determine the impact of upper eyelid weight placement at 3 months post onset of idiopathic facial paralysis(IFP)on the recovery of facial function in patients with ***:This is a retrospective review of patients with incomplete recovery of IFPddefined as a Sunnybrook Facial Grading Scale(FGS)score of less than 100,3 months after *** patients with FGS and Facial clinimetric Evaluation(FacE)scores recorded at 3 and 12 months were *** were categorized into 3 groups:Group A,lagophthalmos with eyelid weight placement;Group B,lagophthalmos without eyelid weight placement;Group c,complete eye closure(cEc)without eyelid weight *** eye comfort domain and composite score of the FacE questionnaire were *** eye closure,synkinesis with eye closure,overall synkinesis and the composite score of the FGS were also *** two-tailed t-test was used to evaluate the data comparing the 3 and 12 month FacE and FGS scores within and between the 3 ***:The change in composite FGS score significantly increased from month 3 to month 12 in Group A as compared to Group B(37 vs 4.25,P=0.01).While Group A had significantly lower eye comfort(-12.5,P=0.01),voluntary eye closure(-1.75,P=0.05)and overall FGS scores(-28.75,P=0.04)at 3 months compared to those in Group c,there were no differences between these two groups at 12 month ***:For patients with lagophthalmos at 3 months,early eyelid weight placement may lead to improved facial function at 12 months.

关键词： Facial paralysis Synkinesis Eyelid weight

Longwall automation:trends,challenges and opportunities

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International Journal of Mining Science and Technology 2017年第5期27卷 733-739页

作者： Jonathon c.Ralston chad O.Hargrave Mark T.Dunn coal Mining Research Program CSIRO EnergyBrisbaneAustralia

This paper explores the ongoing development and implementation of longwall automation technology to achieve greater levels of underground coal mining performance. The primary driver behind the research and development effort is to increase the safety, productivity and efficiency of longwall mining operations to enhance the underlying mining business. A brief review of major longwall automation challenges is given followed by a review of the insights and benefits associated with the LASc longwall shearer automation solution. Areas of technical challenge in sensing, decision support, autonomy and human interaction are then highlighted, with specific attention given to remote operating centres, proximity detection and systems-level architectures in order to motivate further automation system *** vision for a fully integrated coal mining ecosystem is discussed with the goal of delivering a highperformance, zero-exposure and environmentally coherent mining operations.

关键词： Safety Productivity Environment Mining automation Longwall mining Remote mining Sensing

Infrastructure-based localisation of automated coal mining equipment

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International Journal of coal Science & Technology 2017年第3期4卷 252-261页

作者： chad O. Hargrave craig A. James Jonathon c. Ralston Mining and Processing Technologies Research Group CoalMining Research Program CSIRO Energy BrisbaneAustralia

A novel radar-based system for longwall coal mine machine localisation is described. The system, based on a radar-ranging sensor and designed to localise mining equipment with respect to the mine tunnel gate road infrastructure, is developed and trialled in an underground coal mine. The challenges of reliable sensing in the mine environment are considered, and the use of a radar sensor for localisation is justified. The difficulties of achieving reliable positioning using only the radar sensor are examined. Several probabilistic data processing techniques are explored in order to estimate two key localisation parameters from a single radar signal, namely along-track position and across-track position, with respect to the gate road structures. For the case of across-track position, a conventional Kalman filter approach is sufficient to achieve a reliable estimate. However for along-track position estimation, specific infrastructure elements on the gate road rib-wall must be identified by a tracking algorithm. Due to complexities associated with this data processing problem, a novel visual analytics approach was explored in a 3D interactive display to facilitate identification of significant features for use in a classifier algorithm. Based on the classifier output, identified elements are used as location waypoints to provide a robust and accurate mining equipment localisation estimate.

关键词： Localisation · Waypoint navigation · Machine learning · Radar ·Underground · Longwall mining· Automation

Letting Go is Never Easy:Abscission and Receptor- Like Protein Kinases

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Journal of Integrative Plant Biology 2013年第12期55卷 1251-1263页

作者： chad E.Niederhuth Sung Ki cho Kati Seitz John c.Walker Department of Genetics University of Georgia Division of Biological Sciences University of Missouri Interdisciplinary Plant Group University of Missouri Department of Horticulture Iowa State University

Abscission is the process by which plants discard organs in response to environmental cues/stressors, or as part of their normal development. Abscission has been studied throughout the history of the plant sciences and in numerous species. Although long studied at the anatomical and physiological levels, abscission has only been elucidated at the molecular and genetic levels within the last two decades, primarily with the use of the model plant Arabidopsis thaliana. This has led to the discovery of numerous genes involved at all steps of abscission, including key pathways involving receptor-like protein kinases （RLKs）. This review covers the current knowledge of abscission research, highlighting the role of RLKs.

关键词： Abscission abscission zone cell separation cell wall remodeling receptor-like protein kinase.

changing the paradigm：the potential for targeted therapy in laryngeal squamous cell carcinoma

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cancer Biology & Medicine 2016年第1期13卷 87-100页

作者： Megan L.Ludwig Andrew c.Birkeland Rebecca Hoesli Paul Swiecicki Matthew E.Spector J.chad Brenner Department of Otolaryngology Head and Neck SurgeryUniversity of Michigan Medical SchoolAnn ArborMI 48109USA cellular and Molecular Biology Program University of MichiqanAnn ArborMI 48109USA Department of Hematology Oncology University of Michigan Medical SchoolAnn ArborMI 48109USA comprehensive cancer center University of Michigan Medical SchoolAnn ArborMI 48109USA

Laryngeal squamous cell carcinoma(LScc) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LScc has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LScc may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LScc as a model system for organ preservation, unique and potentially targetable genetic signatures of LScc, and methods for bringing stratified, personalized treatment strategies to the 21^(st) century.

关键词： Head and neck cancer laryngeal squamous cell carcinoma genetics targeted therapy personalized medicine

Approximate solutions of Klein-Gordon equation with improved Manning-Rosen potential in D-dimensions using SUSYQM

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chinese Physics B 2014年第12期23卷 38-43页

作者： A.N.Ikot H.Hassanabadi H.P.Obong Y.E.chad Umoren c.N.Isonguyo B.H.Yazarloo Department of Physics University of Port HarcourtChoba P M B5323 Port Harcourt Nigeria Department of Basic Sciences Shahrood Branch Islamic Azad UniversityShahrood Iran Theoretical Physics Group Department of Physics University of Uyo-NigeriaNigeria

In this paper, we present solutions of the Klein–Gordon equation for the improved Manning–Rosen potential for arbitrary l state in d-dimensions using the supersymmetric shape invariance method. We obtained the energy levels and the corresponding wave functions expressed in terms of Jacobi polynomial in a closed form for arbitrary l state. We also calculate the oscillator strength for the potential.

关键词： Klein–Gordon equation improved Manning–Rosen potential supersymmetric quantum mechanics(SUSYQM)

Simulation study on the emittance compensation of off-axis emitted beam in RF photoinjector

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chinese Physics c 2016年第11期40卷 184-190页

作者：黄瑞萱 chad Mitchell 贾启卡 christos Papadopoulos Fernando Sannibale [1NSRL University of Science and Technology of ChinaHefei 230029China ATAP Lawrence Berkeley National LaboratoryOne Cyclotron RoadBerkeleyCalifornia94720USA

To make full use of the photocathode material and improve its quantum efficiency lifetime, it can be necessary to operate the laser away from the cathode center in photoinjectors. In RF guns, the off-axis emitted beam will see a time-dependent RF effect, which would generate a significant growth in transverse emittance. It has been demonstrated that such an emittance growth can be almost completely compensated by orienting the beam on a proper orbit in the downstream RF cavities along the injector [1]. In this paper we analyze in detail the simulation techniques used in reference [1] and the issues associated with them. The optimization of photoinjector systems involving off-axis beams is a challenging problem. To solve this problem, one needs advanced simulation tools including both genetic algorithms and an efficient algorithm for 3D space charge. In this paper, we report on simulation studies where the two codes ASTRA and IMPAcT-T are used jointly to overcome these challenges, in order to optimize a system designed to compensate for the emittance growth in a beam emitted off axis.

关键词： photoinjector off-axis emission genetic algorithm ASTRA IMPAcT-T RF effect emittance compen-sation

Material transport in dip-pen nanolithography

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Frontiers of physics 2014年第3期9卷 385-397页

作者： Keith A. Brown Daniel J. Eichelsdoerfer Xing Liao Shu He chad A. Mirkin Department of chemistry Northwestern University 2145 Sheridan Road Evanston IL 60208 USA International Institute for Nanotechnology Northwestern University 2145 Sheridan Road Evanston IL 60208 USA Department of Materials Science and Engineering Northwestern University 2145 Sheridan Road Evanston IL 60208 USA

Dip-pen *** （DPN） is a useful method for directly printing materials on surfaces with sub-50nm resolution. Because it, involves the physical transport of materials from a scanning probe tip to a surface and the subsequent chemical interaction of that material with the surface, there are many factors to consider when attempting to understand DPN. In this review, we overview the physical and chemical processes that are known to play a role in DPN, Through a detailed review of the literature, we classify inks into three general categories based on their transport properties, and highlight the myriad ways that. DPN can be used to perform chemistry at the tip of a scanning probe.

关键词： dip-pen nanolithography scanning probe lithography materials transport

Informatic analysis reveals Legionella as a source of novel natural products

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Synthetic and Systems Biotechnology 2016年第2期1卷 130-136页

作者： chad W.Johnston Jonathan Plumb Xiang Li Sergio Grinstein Nathan A.Magarvey The Michael G.DeGroote Institute for Infectious Disease Research Department of Biochemistry and Biomedical SciencesMcMaster UniversityHamiltonONCanada L8N 3Z5 Department of chemistry and chemical Biology McMaster UniversityHamiltonONCanada L8N 3Z5 cell Biology Program Hospital for Sick ChildrenTorontoOntarioCanada M5G 1X8

Microbial natural products are a crucial source of bioactive molecules and unique chemical *** their importance,rediscovery of known natural products from established productive microbes has led to declining interest,even while emergent genomic data suggest that the majority of microbial natural products remain to be ***,new sources of microbial natural products must be defined in order to provide chemical scaffolds for the next generation of small molecules for therapeutic,agricultural,and industrial *** this work,we use specialized bioinformatic programs,genetic knockouts,and comparative metabolomics to define the genus Legionella as a new source of novel natural *** show that Legionella *** a diverse collection of biosynthetic gene clusters for the production of polyketide and nonribosomal peptide natural *** confirm this bioinformatic survey,we create targeted mutants of *** and use comparative metabolomics to identify a novel polyketide *** spectroscopic techniques,we show that this polyketide possesses a new chemical scaffold,and firmly demonstrate that this unexplored genus is a source for novel natural products.

关键词： Natural products Legionella Polyketides PRISM

Decomposition of dynamic transcriptomic responses during effector-triggered immunity reveals conserved responses in two distinct plant cell populations

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Plant communications 2024年第8期5卷 1-17页

作者： Xiaotong Liu Daisuke Igarashi Rachel A.Hillmer Thomas Stoddard You Lu Kenichi Tsuda chad L.Myers Fumiaki Katagiri Department of Plant and Microbial Biology University of Minnesota-Twin CitiesSt PaulMN 55108USA Department of computer Science and Engineering University of Minnesota-Twin CitiesMinneapolisMN 55455USA Bioinformatics and computational Biology Graduate Program University of Minnesota-Twin CitiesMinneapolisMN 55455USA Institute for Innovation Ajinomoto Co.Inc.KawasakiJapan State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryHubei Key Lab of Plant PathologyCollege of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Present address:225 S 6th St MinneapolisMN 55402USA Present address:Biotalys Inc.2520 Meridian Parkway Suite 480DurhamNC 27713USA Present address:Life Sciences Institute and Department of cell and Developmental Biology University of Michigan Medical SchoolAnn ArborMI 48109USA

Rapid plant immune responses in the appropriate cells are needed for effective defense against *** transcriptome analysis is often used to describe overall immune responses,collection of transcriptome data with sufficient resolution in both space and time is *** reanalyzed public Arabidopsis time-course transcriptome data obtained after low-dose inoculation with a Pseudomonas syringae strain expressing the effector AvrRpt2,which induces effector-triggered immunity in ***-peak time-course patterns are prevalent among thousands of upregulated *** implemented a multicompartment modeling approach to decompose the double-peak pattern into two single-peak patterns for each *** decomposed peaks reveal an“echoing”pattern:the peak times of the first and second peaks correlate well across most upregulated *** demonstrated that the two peaks likely represent responses of two distinct cell populations that respond either cell autonomously or indirectly to ***,the peak decomposition has extracted spatial information from the time-course *** echoing pattern also indicates a conserved transcriptome response with different initiation times between the two cell populations despite different elicitor types.A gene set highly overlapping with the conserved gene set is also upregulated with similar kinetics during pattern-triggered *** of a WRKY network via different entry-point WRKYs can explain the similar but not identical transcriptome responses elicited by different elicitor *** discuss potential benefits of the properties of the WRKY activation network as an immune signaling network in light of pressure from rapidly evolving pathogens.

关键词： Arabidopsis Pseudomonas syringae plant immune response multi-compartment model WRKY transcription factors resilient immune signaling network