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STING and TLR9 agonists synergistically enhance the immunogenicity of SARS-CoV-2 subunit vaccine

Nano Research 2023年第12期16卷 13322-13334页

作者： Yang Li Ziwei chen Xinyi Lu Jiufeng Sun mengyu Guo Huige Zhou Ru Bai Yuliang Zhao Chunying chen Yaling Wang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China The GBA National Institute for Nanotechnology Innovation Guangzhou 510700China Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhou 511430China Research Unit of Nanoscience and Technology Chinese Academy of Medical SciencesBeijing 100049China

Vaccines that are reliable and efficacious are essential in the fight against the COVID-19 *** this study,we designed a dual-adjuvant system with two pathogen-associated molecular patterns(PAmPs),mnOx and *** system can improve the retention of antigens at the injection site,facilitate pro-inflammatory cytokines secretion,further recruit and activate dendritic cells(DCs).As a result,antigens can be delivered to lymph nodes specifically,and adaptive immunity was *** immunized group showed an enhanced and broadened humoral and cellular immune response in systemic immunity and lung protection when combined with a tandem repeat-linked dimeric antigen version of the SARS-CoV-2 receptor binding domain(RBDdimer).Remarkably,even with a significant reduction in antigen dosage(three times lower)and a decrease in injection frequencies,our nanovaccine was able to produce the highest neutralizing antibody titers against various *** titers were four-fold higher for the wild-type strain and two-fold higher for both the Beta and Omicron variants in comparison with those elicited by the Alum adjuvant *** conclusion,our dual-adjuvant formulation presents a promising protein subunit-based candidate vaccine against SARS-CoV-2.

关键词： dual-adjuvant system synergistic immune activation antigen dosage reducing variants neutralizing

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一种亚微米阵列激光器混合集成倒装焊技术

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现代传输 2022年第6期 69-73页

作者：李量朱宇 chen ben 甘飞苏州卓昱光子科技有限公司江苏苏州215200

应用于光通信行业的硅光技术,因其高集成、规模化、低成本等优势,近年来发展十分迅速。然而,由于硅材料本身不能发光,如何将光导入硅芯片始终是一大难题。目前较为高效且可行的方案是Ⅲ-Ⅴ族器件与硅光芯片的混合集成技术。本文介绍一... 详细信息

应用于光通信行业的硅光技术,因其高集成、规模化、低成本等优势,近年来发展十分迅速。然而,由于硅材料本身不能发光,如何将光导入硅芯片始终是一大难题。目前较为高效且可行的方案是Ⅲ-Ⅴ族器件与硅光芯片的混合集成技术。本文介绍一种将Ⅲ-Ⅴ族激光器与硅芯片混合集成的倒装焊技术,除了解决光芯片之间光的低损耗耦合之外,通过高精度倒装焊实现了Ⅲ-Ⅴ族激光器与硅芯片的亚微米无源邦定。该技术具有工艺简单、精度优良、适合量产的特点,为混合集成技术的商业化打下坚实基础。

关键词：硅光混合集成倒装焊耦合

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基于流导法的G-m制冷机低温泵抽速测试与分析

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真空 2024年第3期61卷 20-25页

作者：余彦飞李晓刚胡湘娥陈进文陈洁心中山凯旋真空科技股份有限公司广东中山528478

抽气速率是衡量低温泵产品抽真空性能优劣的重要指标之一。除国内企业常用的流量法外,流导法亦是测量低温泵抽速的重要方法。本文依据现行标准中所规定的基于流导法原理测试真空泵气体抽速的方法,对ZD-200口径G-m制冷机低温泵对不同气... 详细信息

抽气速率是衡量低温泵产品抽真空性能优劣的重要指标之一。除国内企业常用的流量法外,流导法亦是测量低温泵抽速的重要方法。本文依据现行标准中所规定的基于流导法原理测试真空泵气体抽速的方法,对ZD-200口径G-m制冷机低温泵对不同气体抽速测试进行了详细介绍。结果表明:流导法测得低温泵对N^(2)和Ar的抽速分别为2410 L/s、1884 L/s,明显优于国内外同类产品指标;低温泵对H^(2)抽速为2577 L/s,与国内外产品公开技术指标处于相同水平。依照流导法获得的测试结果具有较高的准确度和可信度。

关键词： G-m制冷机低温泵流导法抽速测试性能分析

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An oxygen reservoir-irrigated photoimmunotherapy of malignant melanoma

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Nano Research 2023年第2期16卷 2875-2884页

作者： Yao Huang Tingting Peng Yangyan chen Fapeng Zhang Wanshan Hu XinYi Gao Hongyu chen Ping Tang Chuanbin Wu Xin Pan School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China International Cooperative Laboratory of Traditional Chinese medicine modernization and Innovative Drug Development of ministry of Education(mOE)of China Jinan UniversityGuangzhou 511436China College of Pharmacy Jinan UniversityGuangzhou 511436China Department of Biliary-Pancreatic Surgery Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China Shenzhen University General Hospital Shenzhen 518055China

Tumor hypoxia is the pivotal factor limiting the therapeutic efficacy of photodynamic therapy(PDT),and can be partly improved by either the oxygen economizing or the oxygen supplementation ***,the current studies scarcely integrated the merits of both strategies and neglected the bottleneck of poor oxygen infiltration in deep tumors,resulting in PDT ***,we developed an oxygen reservoir-irrigated PDT which integrates oxygen supply,oxygen economizing,and oxygen infiltration ***,mitochondria-targeted mesoporous prussian blue nanoparticles(Ce6@TPB)were fabricated to bridge the gap between oxygen economizing and oxygen supplementation by reducing oxygen output while increasing oxygen ***-loaded microneedles were further developed to pave the way for deep PDT with increased infusion of oxygen and photosensitizer by degrading dense extracellular *** modulation of tumor oxygenation and permeability during PDT leads to the complete eradication of primary melanoma and strong immunogenic cell *** further combination with checkpoint-blockade inhibitor greatly suppressed the proliferation of distal tumors by reprogramming immune microenvironments,as evidenced by the depletion of m2 macrophage,increased infiltration of anti-tumor immune cells,and elevated excretion of immune ***,such an oxygen reservoir-irrigated PDT potentiates powerful photoimmunotherapy and provides a favorable prospect for tumor treatment.

关键词： oxygen reservoir prussian blue nanoparticle hyaluronidase microneedle photodynamic therapy tumor microenvironment

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Fracture behavior of hybrid epoxy nanocomposites based on multi-walled carbon nanotube and core-shell rubber

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Nano materials Science 2022年第3期4卷 251-258页

作者： Zewen Zhu Hengxi chen Qihui chen Cong Liu Kwanghae Noh Haiqing Yao masaya Kotaki Hung-Jue Sue Department of materials Science and Engineering Texas A&M UniversityCollege StationTX77843-3003USA School of materials Science and Engineering North University of ChinaTaiyuan030051PR China Kaneka US materials Research Center FremontCA94555USA

The dispersion of nanoparticles plays a key role in enhancing the mechanical performance of polymer *** this work,one hybrid epoxy nanocomposite reinforced by a well dispersed,zinc oxide functionalized,multi-wall carbon nanotube (Zn O-mWCNT) and core-shell rubber (CSR) was prepared,which possesses both high modulus and fracture toughness while maintaining relatively high glass transition temperature (Tg).The improved fracture toughness from 0.82 mPa mfor neat epoxy to 1.46 mPa mfor the ternary epoxy nanocomposites is resulted from a series of synergistic toughening mechanisms,including cavitation of CSR-induced matrix shear banding,along with the fracture of mWCNTs and crack *** implication of the present study for the preparation of high-performance polymer nanocomposites is discussed.

关键词： Carbon nanotube Core-shell rubber Epoxy nanocomposites Fracture toughness Synergistic toughening effect

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栀子苷及其苷元京尼平的抗抑郁作用及其潜在分子机制

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中国病理生理杂志 2022年第10期38卷 1877-1882页

作者：陈光辉陈强张玲莉周本宏武汉大学人民医院药学部湖北武汉430060 华中科技大学同济医学院附属梨园医院药剂科湖北武汉430071

抑郁症是一种基因与环境交互影响的重大精神疾病,以显著而持久心境障碍为主要临床特征,主要累及青壮年人群(20~45岁)。随着现代社会生活节奏的加快和竞争压力的增加,其发病率越来越高。2018年世界卫生组织资料显示,抑郁症是世界范围内... 详细信息

抑郁症是一种基因与环境交互影响的重大精神疾病,以显著而持久心境障碍为主要临床特征,主要累及青壮年人群(20~45岁)。随着现代社会生活节奏的加快和竞争压力的增加,其发病率越来越高。2018年世界卫生组织资料显示,抑郁症是世界范围内最常见的致残原因,目前有超过3亿人患有抑郁症;2019年,Huang等的研究显示,我国抑郁症的终生患病率为6.8%。

关键词：栀子苷京尼平抑郁症

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Toxicity assessment and long-term three-photon fluorescence imaging of bright aggregation-induced emission nanodots in zebrafish

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Nano Research 2016年第7期9卷 1921-1933页

作者： Dongyu Li Xinyuan Zhao Wei Qin Hequn Zhang Yue Fei Liwei Liu Ken-Tye Yong Guangdi chen ben Zhong Tang Jun Qian State Key Laboratory of modern Optical Instrumentation Centre for Optical and Electromagnetic Research Zhejiang Provincial Key Laboratory for Sensing Technologies Zhejiang University Hangzhou 310058 China Bioelectromagnetics Laboratory Institute of Environmental Health Zhejiang University School of Medicine Hangzhou 310058 China Department of Chemistry The Hang Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong China Changchun University of Science and Technology (CUST) Changchun 130022 China School of Electrical and Electronic Engineering Nanyang Technological University Singapore 639798 Singapore

Aggregation-induced emission （AIE） luminogen displays bright fluorescence and has photobleaching resistance in its aggregation state. It is an ideal fluorescent contrast agent for bioimaging. multiphoton microscopy is an important tool for bioimaging since it possesses the ability to penetrate deep into biological tissues. Herein, we used AIE luminogen together with multiphoton microscopy for long-term imaging of zebrafish. A typical AIE luminogen, 2,3-bis（4-（phenyl（4- （1,Z2-triphenylvinyl） phenyl）amino）phenyl） fumaronitrile （TPE-TPA-FN or TTF）, was encapsulated with 1,2-distearoyl-sn-glycero-3-phosphoethanola-mine-N- [methoxy（polyethylene glycol）-2000] （DSPE-mPEG2000） to form nanodots that exhibited bright three-photon fluorescence under 1,560 nm-femtosecond （fs） laser excitation. The TTF-nanodots were chemically stable in a wide range of pH values and showed no in vivo toxicity in zebrafish according to a series of biological tests. The TTF-nanodots were microinjected into zebrafish embryos, and the different growth stages of the labeled embryos were monitored with a three-photon fluorescence microscope. TTF-nanodots could be traced inside the zebrafish body for as long as 120 hours. In addition, the TTF-nanodots were utilized to target the blood vessel of zebrafish, and three-photon fluorescence angiogram was performed. more importantly, these nanodots were highly resistant to photobleaching under 1,560 nm-fs excitation, allowing long-term imaging of zebrafish.

关键词： biocompatible organicnanodots aggregation-inducedemission three-photon fluorescence bioimaging zebrafish

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参黄排毒灌肠剂质量控制研究

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北方药学 2024年第3期21卷 1-4页

作者：陈晓铤钟昶国熊艳丽陈健明柯颖标刘舒雅陈洪毅茂名市中医院广东茂名525100 广东省实验动物监测所广东广州510663

目的:采用薄层色谱和高效液相色谱对参黄排毒灌肠剂中的大黄和丹参分别进行定性和定量的鉴别,用于医院中灌肠剂的质量保障,更有效的治疗患者。方法:薄层色谱采用硅胶G薄层板,以大黄、丹参对照药材和大黄酚、丹参素钠为对照,对薄层色谱... 详细信息

目的:采用薄层色谱和高效液相色谱对参黄排毒灌肠剂中的大黄和丹参分别进行定性和定量的鉴别,用于医院中灌肠剂的质量保障,更有效的治疗患者。方法:薄层色谱采用硅胶G薄层板,以大黄、丹参对照药材和大黄酚、丹参素钠为对照,对薄层色谱特征点进行对比;高效液相色谱采用Kromasi lC18色谱柱(4.6 mm×250 mm,5μm)进行分析,其中,大黄酸、大黄酚的流动相为甲醇-0.1%磷酸溶液(85:15),检测波长为254 nm,丹参酮I、丹参酮IIA、隐丹参酮的流动相为乙腈-0.02%磷酸溶液(61:39),梯度洗脱,检测波长为270 nm,流速为1.0mL/min,柱温为30℃。结果:参黄排毒灌肠剂的色谱斑点分离度好,大黄、丹参的特征斑点清晰,与对照品特征点一致;大黄酸、大黄酚、丹参酮I、丹参酮IIA、隐丹参酮在各自范围内与峰面积线性关系良好(r≥0.99),加样回收率为96.88%~108.28%,RSD为0.79%~2.76%,大黄酸、丹参酮I的平均含量分别为(22.15±0.42)μg/mL、(40.20±1.26)μg/mL。结论:此次方法可以多次应用,结果具有准确和一致性,我们拟定了参黄排毒灌肠剂中大黄酸和丹参酮I的含量分别不能低于15μg/mL、30μg/mL的标准,用于参黄排毒灌肠剂的质量控制。

关键词：参黄排毒灌肠剂薄层色谱高效液相色谱大黄丹参质量控制

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Controlled-Release of Plant Volatiles:New Composite materials of Porous Carbon-Citral and Their Fungicidal Activity against Exobasidium vexans

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Journal of Renewable materials 2023年第2期11卷 811-823页

作者： Yaoguo Liu Yao chen Huifang Liu Wei chen Zhiwei Lei Chiyu ma Jie Yin Wen Yang College of Tea Science Guizhou UniversityGuiyang550025China Guizhou Tea Research Institute Guizhou Academy of Agricultural SciencesGuiyang550006China

Citral(Eo)exhibits excellent fungicidal ***,it is difficult to maintain long-term fungicidal activity due to its strong ***,a controlled-release strategy by using biomass-derived porous carbon(BC)was developed to overcome the drawback of *** composite materials were prepared by loading Eo on tea stem porous carbon(BC@Eo),and their controlled-release fungicidal activity against Exobasidium vexans was *** with a large specific surface area of 1001.6 m2/g and mesoporous structure was fabricated through carbonization tempera-ture of 700℃.The BC@Eo materials were characterized using Fourier-transform infrared spectroscopy and X-ray powder *** results suggested that chemical and physical interactions occurred in BC@*** Eo release profile suggested a biphasic pattern with an initial fast release on days 1–14 and a subsequent controlled phase on days 14–*** in vitro cumulative release percentage of Eo from BC@Eo was 51%during one month,and this result was significantly lower than that from free Eo(cumulative release percentage of Eo of 82%in one week).The anti-fungal activities of Eo and BC@Eo against *** were determined using the inhibition zone *** results indicated that Eo and BC@Eo formed large inhibition zones of 19.66±0.79 and 21.92±0.77 mm,*** influence on the hyphal structure of *** was observed by scanning electron microscopy on day *** hyphal structure of *** treated with BC@Eo was more shrunken than that treated with Eo at 30 days,suggesting that BC@Eo prolongs the fungicidal activity against *** study demonstrated that the encapsulation of Eo in BC for developing the BC@Eo materials could be a promising strategy to inhibit volatility and maintain the fungicidal activity of Eo and provide a potential alternative for the reuse of abundant tea biomass waste resources.

关键词： Exobasidium vexans porous carbon citral controlled release fungicidal activity

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Iron-bound organic carbon dynamics in peatland profiles:The preservation equivalence of deep and surface soil

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Fundamental Research 2023年第6期3卷 852-860页

作者： Xinya Huang Xinwei Liu Liangshuai chen Yanfen Wang Huai chen Key Laboratory of mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China Zoige Peatland and Global Change Research Station Chinese Academy of SciencesHongyuan 624400China CAS Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences(CAS)Beijing 100101China. University of Chinese Academy of Sciences Beijing 100049China

more than half of the carbon pools in peatlands are stored in the soil layers below 30 cm,yet little is known about the carbon stabilizing factors at these *** iron oxide minerals are considered to be important for stabilizing organic carbon(OC),their role in the preservation of OC in peatlands,especially in the deep layers,is poorly ***,we collected 1 m soil profiles from six peatlands in Central and West China to quantitatively study the vertical distribution characteristics of iron-bound OC(Fe-bound OC),and the influencing physicochemical properties of the *** results showed that the content of reactive iron(FeR)was enriched in the top layer and decreased gradually with *** Fe-bound OC was positively correlated with FeR,its concentration did not decrease with depth in the peat *** were no obvious trends in the distributions of FeR and Fe-bound OC with water level fluctuations in the peat *** addition,the proportion of Fe-bound OC to soil organic carbon in the deep peat(31 to 100 cm)was equivalent to that in the surface peat(0 to 30 cm),indicating that iron oxide mineral provides comparable protection of OC in both *** to upper estimates of global peatland carbon storage(612 Pg),it could be predicted that 23.81±11.75 Pg of OC is protected by association with *** results indicated that iron oxide minerals are the effective"rusty sink"of OC sequestration in peatland,and a key factor for its long-term *** results from this study make a valuable contribution to the carbon dynamics knowledgebase for peatlands,and provide a basis for improved predictive simulations.

关键词： Iron-bound organic carbon Peatland Soil profile Reactive Fe Carbon preservation

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