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Expression and role of aryl hydrocarbon receptor in Aspergillus fumigatus keratitis

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International Journal of Ophthalmology(English edition) 2020年第2期13卷 199-205页

作者： Li Zhang Nan jiang Gui-Qiu Zhao Xu-Dong Peng Guo-Qiang Zhu Wei jiang Jing-Jing Ma Department of Ophthalmology the Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

●AIM:To observe the expression and role of aryl hydrocarbon receptor(Ah R)in the immune response of mouse cornea infected with Aspergillus fumigatus(***).●METHODS:Murine models of *** keratitis were established by scraping the central epithelium of mouse cornea,daubing *** on the cornea and covering with a contact *** mice were randomly divided into the control group and the ***-infected(A.F.)group for 1,3 and 5 d respectively,which corneas were daily monitored by a slit lamp microscope and the clinical scores were also recorded timely after *** this study,immunofluorescence staining was used to detect the expression and localization of Ah R in mouse corneas,and the m RNA and protein of Ah R were detected by reverse transcription-polymerase chain reaction(RT-PCR)and Western *** addition,mouse peritoneal macrophages were stimulated by *** with or without the pretreatment of Ah R antagonist ch223191 and Ah R agonist FICZ,and the tumor necrosis factor alpha(TNF-α),inducible nitric oxide synthase(i NOS),interleukin-10(IL-10)and Arg-1 m RNA were detected by RT-PCR.●RESULTS:According to the results of the slit light photography,it was clearly indicated that the corneal inflammation were the most severe and the clinical score became the highest as well on the 3 rd day after the infection of *** with the control group,the expression of Ah R in the corneal epithelial cells infected with *** was significantly increased detected by immunofluorescence *** R mainly expressed in the nucleus and cytoplasm of corneal epithelial *** with the transcriptional level of Ah R m RNA,the expression level of Ah R protein reached the peak on the 3 rd day after infection which was detected by Western ***,RT-PCR showed that ch223191 up-regulated the expression of TNF-αand i NOS and down-regulated the expression of IL-10 and Arg-1 in peritoneal macrophages;inversely,FICZ reduce

关键词： aryl hydrocarbon receptor keratitis Aspergillus fumigatus innate immune response

A novel thermoregulated phosphine ligand used for the Rh-catalyzed hydroformylation of mixed C_(11-12) olefins in aqueous/organic biphasic system

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chinese chemical Letters 2010年第5期21卷 515-518页

作者： Zhi jiang Ji,Jing Yang jiang,Yan Hua Wang State Key Laboratory of Fine chemicals,Dalian University of Technology,Dalian 116012,china State Key Laboratory of Fine chemicals Dalian University of Technology Dalian 116012 China

A novel thermoregulated phosphine ligand PhP(chchO)ch(n=22) was synthesized and used for the Rh-catalyzed hydroformylation of mixed Colefins in aqueous/organic biphasic *** the optimized conditions,pressure =5 MPa (H:CO=1:1),phosphine/Rh =13(molar ratio),reaction time =6 h and temperature =130℃,the conversion of Colefins and the yield of aldehyde are 99%and 94%,*** catalyst retained in aqueous phase can be easily separated from the product-containing organic phase by simple phase separation and the catalytic activity remains almost constant after four consecutive cycles.

关键词： Thermoregulated phosphine ligand Mixed C11-12 olefins Hydroformylation Rhodium

Synthesis and Bioactivity of a Novel Bismuthoxide Schiff-base Complex Derived from Salen-like Ligand and Bismuth（III） Nitrate

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chemical Research in chinese Universities 2016年第2期32卷 207-211页

作者： LI chuanhua jiang Jianhong LI Xu XIAO Shengxiong WEI Deliang jiang chao XIE Jinqi PENG Mengna GU Huiwen LI Qiangguo Hunan Provincial Key Laboratory of Xiangnan Rare-precious Metals Compounds and Applications Department of Chemistry and Life Science Xiangnan University Chenzhou 423000 P. R. China State Key Laboratory of chemo/Biosensing and chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. China

In this paper, a novel bismuthoxide Schiff-base complex [Bi9O8（vanen）3（NO3）2（ch3OH）2（H2O）·3NO3· 5.5H2O]（abbreviated as Bivanen） was synthesized with Salen-like ligand Hzvanen[Hzvanen=N,N＇-ethylene bis（3-methoxysalicylideneimine）] and bismuth（III） nitrate. Its structure was characterized by IR spectra, NMR spectra and X-ray diffraction. In particular, the biology activities of the ligand and the complex against Schizosaecharomyees pombe（S, pombe） were studied using biological mierocalorimetry. The metabolic thermogenic curves of S. pombe were measured at 32.00 ℃. Then, some quantitative thermokinetic parameters of growth metabolism of S. pombe including the rate constant（k）, inhibition ratio（I） and half inhibition concentration（IC50） were calculated. Experimental results showed that the k values of S. pombe decreased while I values of S. pombe increased with the increase of concentrations of the ligand and the complex. The IC50 of the ligand and the complex were found to be 0.067 and 0.037 mmol/L, respectively.

关键词： Bismuthoxide Schiff-base complex Mieroealorimetriy Thermokinetie property Schizosaecharomyces pombe(S, pombe)

Methane emissions from terrestrial plants over china and their effects on methane concentrations in lower troposphere

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chinese Science Bulletin 2009年第2期54卷 304-310页

作者： XIE Min LI Shu jiang Fei WANG TiJian Department of Atmospheric Sciences Nanjing University Nanjing 210093 China

Methane (ch4) is the most important greenhouse gas and reactive trace gas in the atmosphere. Recently, it has been reported that terrestrial plants can emit ch4 under aerobic conditions, which may call for reevaluation of the inventory of ch4 emissions in china. In this paper, those emissions over china and their effects on ch4 concentrations in lower troposphere were investigated. Firstly, based on the work of Keppler et al., the aerobic plant ch4 emission model (PLANTch4) for china was established. And by using the database of normalized difference vegetation index (NDVI) derived from NOAA/ AVHRR, the distribution of net primary productivity (NPP) over china was simulated, and thereby, for the first time, the amount and distribution of the newly identified source in china were estimated. Secondly, with the aid of the three-dimensional atmospheric chemistry model system (MM5-CALGRID), the effects of the emissions were studied. The results show that the annual aerobic plant ch4 emissions over china amount to 11.83 Tg, i.e. nearly 24% of chinese total ch4 emissions. And the major fraction (about 43%) comes from forests. When those emissions are considered in modeling, computed countrywide mean surface concentration of ch4 is 29.9% higher than without them, with a maximum increase of 69.61 μg·m-3 in the south of Yunnan Province. In conclusion, to study ch4 emissions from terrestrial plants over china may have important implications for correctly estimating the contribution of china to global ch4 budget, and may call for a reconsideration of the role of ch4 in global and regional environment and climate change.

关键词：环境污染大气污染甲烷治理技术

Parameters Sensitivity Analysis and Correction for Concrete Damage Plastic Model

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Journal of Beijing Institute of Technology 2018年第1期27卷 103-108页

作者： Yaqin jiang Pengfei Xu chengzhi Wang Dianshu Liu School of Mechanics and Civil Engineering China University of Mining and Technology College of Civil Engineering and Architecture Henan University of Technology School of Materials Science and Engineering Beijing Institute of Technology

In order to understand the effect of hardening ductility parameters and softening ductility parameters of the concrete damage plastic model in LS-DYNA,a sensitivity and reliability analysis of these parameters through a convenient cube unit test was conducted. The results showed that the peak strength strain was independent of the hardening ductility parameter DH,but affected by AH,BH,and ch. The softening ductility was mainly related to the softening ductility parameter AS,but not affected by the damage ductility exponent BS. In case that the model with default parameters failed to match the AS-controlled damage softening phase,an optimized model with an AS correction was developed. The corrected model with the AS value of 2 matched well with the code model,and exhibited good feasibility in predicting the stress-strain curve of different grades of concrete. Moreover,the practicability of the corrected model was further validated by the conventional triaxial test. The simulated curve exhibited favorable consistence with the trial curve. Therefore,the model with parameter correction could provide a prospective reference for predicting the mechanical properties of concrete.

关键词： damage-plastic model concrete sensitivity analysis parameter correction

The electrochemical stability of ionic liquids and deep eutectic solvents

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Science china chemistry 2016年第5期59卷 571-577页

作者： Qingbo Li Jingyun jiang Guofeng Li Wancheng Zhao Xinhui Zhao Tiancheng Mu Department of chemistry Renmin University of China

Room temperature ionic liquids （ILs） composed of cations and anions, as well as deep eutectic solvents （DESs） composed of hydrogen bond donors （HBDs） and hydrogen bond acceptors （HBAs）, are regarded as green solvents due to their low volatility. They have been used widely for electrochemically driven reactions because they exhibit high conductivity and excellent elec- trochemical stability. However, no systematic investigations on the electrochemical potential windows （EPWs）, which could be used to characterize the electrochemical stability, have been reported. In this regard, the EPWs of 33 ILs and 23 DESs have been studied utilizing cyclic voltammetry （CV） method and the effects of structural factors （cations and anions of ILs, and HBDs and HBAs of DESs） and external factors （electrode, water content） on the EPWs have been comprehensively investi- gated. The electrochemical stability of selected 1Ls comprising five traditional cations, namely imidazolium, pyridinium, pyr- rolidinium, piperidinium and ammonium and 13 kinds of versatile anions was studied. The results show that for ILs, both cati- on and anion play an important role on the reductive and oxidative potential limit. For a same IL at different working electrode, for example, glassy carbon （GC）, gold （Au） and platinum （Pt） electrode, the largest potential window is almost observed on the GC working electrode. The investigations on the EPWs of choline chloride （chCl）, choline bromide （chBr）, choline iodide （chI）, and methyl urea based DESs show that the DES composed of chCl and methyl urea has the largest potential window. This work may aid the selection of ILs or DESs for use as a direct electrolyte or a solvent in electrochemical applications.

关键词： electrochemical potential window cyclic voltammetry ionic liquids deep eutectic solvents glassy carbon water effect

Influence of the angle between two crown ether moieties on supramolecular copolymerization of bis(crown ether)s and bisparaquat homoditopic monomers

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Science china chemistry 2010年第5期53卷 1080-1087页

作者： Zhou, QiZhong jiang, Huajiang Ding, Liang Wang, Feng Wu, Tao Department of chemistry Taizhou University Taizhou 317000 China Department of chemistry Zhejiang University Hangzhou 310027 China

Bis(crown ether) homoditopic monomers containing two bis(p-phenylene)-34-crown-10 moieties with different angles(180° for monomer 3,120°for monomer 4,and 60°for monomer 5) and a complementary bisparaquat homoditopic monomer(7) were designed and *** three bis(crown ether) monomers could organize into linear supramolecular polymers in concentrated solutions in chCl3/ch3CN with the bisparaquat monomer 7,as demonstrated by 1 H NMR and viscosity studies. The pseudorotaxanes or supramolecular polymers formed from 3+7 and 4+7 had larger values of Ka,p,n,slope 1,and slope 2 than those of 5+*** result was attributed to the greater steric hindrance of compound 5 than that of 3 and 4,which resulted in less effective formation of linear supramolecular polymers from 5 with compound 7 than those from compounds 3 and 4 with compound 7,as also demonstrated by UV-vis method.

关键词： bis(crown ether) bisparaquat homoditopic monomers angle supramolecular copolymerization

Transition Metal Catalyzed Direct Oxidative Borylation of C--H Bonds

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chinese Journal of chemistry 2018年第10期36卷 950-954页

作者： Zhong-Tao jiang Bi-qin Wang Zhang-Jie Shi College of chemistry and Materials Science Sichuan Normal University Chengdu Sichuan 610068 China Department of chemistry Fudan University Shanghai 200433 China

Organoboron is well-developed and broadly utilized organometallic reagents in organic synthesis due to its extraordinary performances in transition-metal catalyzed C-C and C-X bonds construction. Catalytic C--H borylation and further transformations catalyzed by transition metal catalysts in the absence of oxidants were well studied in decades. However, as known, transition metal catalyzed oxidative C-H borylations were not reviewed up to date. In this article the oxidative borylation of C（sp2）-H and C（sp3）-H bonds were summarized and their mechanisms were also accounted.

关键词： C-H borylation oxidation organoboron transition metal catalysis

Design, synthesis and evaluation of genistein-polyamine conjugates as multi-functional anti-Alzheimer agents

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Acta Pharmaceutica Sinica B 2015年第1期5卷 67-73页

作者： Xin Zhang jiang Wang chen Hong Wen Luo chaojie Wang Key Laboratory of Natural Medicine and Immuno-Engineering Henan University

A series of genistein-polyamine conjugates(4a–4h) were designed, synthesized and evaluated as multi-functional anti-Alzheimer agents. The results showed that these compounds had significant cholinesterases(ch Es) inhibitory activity. Compound 4b exhibited the strongest inhibition to acetylcholinesterase(Ach E) with an IC_(50) value of 2.75 μmol/L, which was better than that of rivastigmine(5.60 μmol/L). Lineweaver–Burk plot and molecular modeling study showed that compound 4b targeted both the catalytic active site(CAS) and the peripheral anionic site(PAS) of Ach E. Besides, compound 4b showed potent metal-chelating ability. In addition, it was found that 4a–4h did not affect Hep G-2 cell viability at the concentration of 10 μmol/L.

关键词： Genistein Polyamine Alzheimer’s disease Acetylcholinesterase Molecular modeling Metal-chelating Inhibition Rivastigmine