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Role of neutrophil-to-lymphocyte and platelet-tolymphocyte ratios in Peyronie’s disease: a new diagnostic approach to predict the stage of the disease?

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Asian Journal of Andrology 2021年第3期23卷 325-329页

作者： Esther Garda Rojo Borja Garda Gomez Rocio Santos-Perez de la Blanca celeste Manfredi Manuel Alonso Isa Jose Medina Polo Alfredo Rodriguez Antolin Javier Romero Otero Department of Urology Research Institute Hospital 12 de Octubre(Imasl2)Madrid 29041Spain Department of Urology University Hospital HM MonteprfncipeMadrid 28668Spain.

Neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)have been associated with multiple entities and several types of *** can be assumed as markers of inflammatory *** objective of this study is to evaluate the NLR and PLR in Peyronie’s disease(PD)and to establish a comparison of its values in the acute and chronic *** recruited patients with PD from March 2018 to March *** patients enrolled underwent medical and sexual history as well as a physical *** values of blood count of each patient were collected both in the acute and chronic *** test was used to compare the acute and chronic stage ***-Wallis test was carried out to evaluate the impact of treatments on the *** identify cutoff values,we used sensibility and specificity tables and receiver operating characteristic(ROC)curves.A total of 120 patients were *** mean age was 55.85(range:18-77)years and the mean penile curvature was 48.43°(range:10°-100°).In the acute stage,the mean NLR was 2.35 and the mean PLR was *** ratios,in the chronic stage,were 1.57 and 100.00,*** significant differences between acute and stable stages for both indices were found(NLR:P<0.0001;PLR:P=0.0202).The optimal cutoff for classification in acute or stable stage was 2 for NLR and 102 for *** to our results,with an ordinary blood count,we could have important indications regarding the disease stage of the patient,and consequently on the most appropriate type of therapy to choose.

关键词： diagnosis inflammation neutrophil-to-lymphocyte ratio Peyronie^disease platelet-to-lymphocyte ratio

Corrigendum to“Silent circulation of poliovirus in small populations”[Infectious Disease Modeling 2(2017)431e440]

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Infectious Disease Modelling 2018年第1期3卷 136-138页

作者： celeste Vallejo James Keesling James Koopman Burton Singer Department of Mathematics 1400 Stadium RdUniversity of FloridaGainesvilleFL 32611United States School of Public Health 1415 Washington HeightsAnn ArborMI 48109-2029United States Emerging Pathogens Institute University of FloridaP.O.Box 1000092055 Mowry RoadGainesvilleFL 32610United States

An error in a previous publication in the calculation of the average age at first infection for the model is corrected *** average age at first infection for the effective contact rates used to generate the data ranges from 1.2 to 3.3 years of age instead of 3e5 years of age as advertised in the previous version of the *** change has an effect on the force of infection generated by this *** this corrigendum,we demonstrate the correct method to calculate the average age at first infection for the *** compare the forces of infection that correspond to these ages in our model with the forces of infection in other endemic *** show that the modified age range corresponds to forces of infection which are higher than those that are known to exist in historical studies of polioendemic ***,the results in the paper have limited applicability to real-world endemic situations.

关键词： Poliovirus Silent circulation Acute flaccid paralysis surveillance Microsimulation model Gillespie algorithm

Evaluation of Cuban Bacillus thuringiensis(Berliner,1911)(Bacillales:Bacillacea)isolates with larvicidal activity against Aedes aegypti(Linnaeus,1762)(Diptera:Culicidae)

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Asian Pacific Journal of Tropical Medicine 2022年第2期15卷 79-86页

作者： Aileen Gonzalez Rizo Camilo E Castañet Martinez celeste Ramírez Cardentey Ariamys Companioni Ibañez Zulema Menéndez Díaz Lianet Monzote Fidalgo Hilda M HernandezÁlvarez Vector Control Department Institute of Tropical MedicinePedro KouríAutopistaNovia del Mediodía km 6½La Habana 11400Cuba Virology Department Institute of Tropical MedicinePedro KouríAutopista Novia del Mediodía km 6½La Habana 11400Cuba Parasitology Department Institute of Tropical MedicinePedro KouríAutopista Novia del Mediodía km 6½La Habana 11400Cuba

Objective:To evaluate 11 Cuban native Bacillus(B.)thuringiensis isolates in order to select one with the best larvicidal activity against Aedes(Ae.)aegypti and low ***:The cry and cyt genes of the isolates(A21,A51,L95,L910,M29,R84,R85,R87,R89,U81 and X48)were amplified by *** influence of organic matter and NaCl on the larvicidal activity was tested by *** was assayed on peritoneal macrophages of BALB/c ***:The cyt1(Aa,Ab,Ba),cyt2,cry4aA,cry4Ba,cry11(Aa,Ba,Bb)and cry10 genes were identified in all native Cuban *** larvicidal activity(LC_(90))of seven isolates was affected by the presence of organic matter in the water,while A21,A51,L910,R84,U81 and X48 had better LC_(50),LC_(90),LC_(95) than the 266/29-Ⅶ-98 control *** LC_(50) of two isolates was affected by the presence of NaCl and A21,A51,R85 isolate had better larvicidal activity than the 266/29-Ⅶ-98 control *** terms of toxicity against macrophages,the extracts of nine isolates were less cytotoxic than the control ***:Native isolate A21 had the main virulence factors against *** larvae,displayed a good larvicidal activity in presence of different factors related with *** breeding sites,and had low citotoxicity against *** results can contribute to the improvement of existing biological control strategies and the development of new biolarvicides.

关键词： Mosquitoes Biological control agent Bacillus thuringiensis Bioassays Aedes aegypti cry and cyt genes

Cerebral ischemia and neuroregeneration

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Neural Regeneration Research 2018年第3期13卷 373-385页

作者： Reggie H.C.Lee Michelle H.H.Lee celeste Y.C.Wu Alexandre Couto e Silva Harlee E.Possoit Tsung-Han Hsieh Alireza Minagar Hung Wen Lin Department of Neurology Louisiana State University Health Science Center Center for Brain Health Louisiana State University Health Science Center Institute of Cellular and System Medicine National Health Research Institutes Department of Cellular Biology and Anatomy Louisiana State University Health Science Center Cardiovascular and Metabolomics Research Center Hualien Tzu Chi Hospital

Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke （a form of cerebral ischemia）-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics （i.e., tissue plasminogen activator） and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism（s） underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies （i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells） as it relates to cerebral ischemia.

关键词： cerebral ischemia melatonin resveratrol protein kinase C pifithrin-α fatty acids sympathetic nervous system neuromodulation therapy traditional Chinese therapies stem cel

Hyalinizing clear cell carcinoma-a rare entity in the oral cavity: A case report

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World Journal of Clinical Cases 2020年第1期8卷 133-139页

作者： Alejandro Donohue-Cornejo Oslei Paes de Almeida celeste Sánchez-Romero León Francisco Espinosa-Cristóbal Simón Yobanny Reyes-López Juan Carlos Cuevas-González Stomatology Department Biomedical Sciences InstituteAutonomous University of Ciudad JuárezChihuahua 32310México Diagnosis Department Oral Pathology SectionDentistry Faculty of PiracicabaState University of CampinasSão Paulo 13414-903Brazil

BACKGROUND Hyalinizing clear cell carcinoma(HCCC)is an uncommon tumor that originates in the salivary *** neoplasia constitutes less than 1%of minor salivary gland *** SUMMARY A 67-year-old female visited the maxillofacial surgery department owing to a smooth,slightly yellowish protruding mass on the left side of the floor of the mouth,at the level of the molars;the tumor mass had a soft consistency on palpation and did not adhere to deep *** microscopical analysis of the excisional biopsy showed that the lesion was composed of sheets and cords of clear cells separated by thick eosinophilic bands of hyaline *** glandular tissue was absent,periodic acid-Schiff with and without diastase stains,and immunohistochemical reactions were performed to confirm the *** is the second case reported in the literature of HCCC arising in the floor of the *** HCCC is a rare salivary gland tumor that has not been studied *** diagnosis is usually challenging,because clinically,it can be confused with a benign neoplasm.

关键词： Hyalinizing clear cell carcinoma Salivary gland tumor Immunohistochemical reactions Case report

Current strategies to induce liver remnant hypertrophy before major liver resection

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World Journal of Hepatology 2021年第11期13卷 1629-1641页

作者： celeste Del Basso Martin Gaillard Panagiotis Lainas Stella Zervaki Gabriel Perlemuter Pierre Chagué Laurence Rocher Cosmin Sebastian Voican Ibrahim Dagher Hadrien Tranchart Department of Minimally Invasive Digestive Surgery Antoine Béclère HospitalClamart 92140France Department of Hepato-Gastroenterology and Nutrition Antoine Béclère HospitalClamart 92140France Department of Radiology Antoine Béclère HospitalClamart 92140France

Hepatic resection is the gold standard for patients affected by primary or metastatic liver tumors but is hampered by the risk of post-hepatectomy liver *** recent impro-vements,liver surgery still requires excellent clinical judgement in selecting patients for surgery and,above all,efficient pre-operative strategies to provide adequate future liver *** aim of this article is to review the literature on the rational,the preliminary assessment,the advantages as well as the limits of each existing technique for preparing the liver for major hepatectomy.

关键词： Liver regeneration Major hepatectomy Liver insufficiency Future liver remnant Portal vein embolization

Mixed odontogenic tumors:A review of the clinicopathological and molecular features and changes in the WHO classification

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World Journal of Clinical Oncology 2021年第12期12卷 1227-1243页

作者： celeste Sánchez-Romero Oslei Paes de Almeida Ronell Bologna-Molina Department of Oral Pathology Faculty of DentistryUniversity Juarez of the Durango StateDurango 33106Mexico Department of Diagnosis Faculty of PiracicabaState University of CampinasSão Paulo BrazilPiracicaba 13414-903Sao PauloBrazil Department of Oral and Maxillofacial Pathology Universidad de la República UDELAR(URUGUAY)Montevideo 16400Uruguay

BACKGROUND Ameloblastic fibromas and ameloblastic fibrosarcomas are rare odontogenic tumors,and controversy exists in the classification of cases presenting hard-tissue production:Ameloblastic fibrodentinoma(AFD)and ameloblastic fibro-odontoma(AFO).These cases are currently considered“developing odontomas”(hamartomatous lesions).AIM To analyze the clinicopathologic features of these lesions and discuss the changes in the 2017 World Health Organization *** An electronic literature search was performed in the PubMed/MEDLINE *** electronic search of the English language literature was performed and last updated in September 2020 in the PubMed/MEDLINE database using the following terms:“ameloblastic fibroma”,“ameloblastic fibrodentinoma”,“ameloblastic fibro-odontoma”,“ameloblastic sarcoma”,“ameloblastic fibrosarcoma”,“ameloblastic fibrodentinosarcoma”,“ameloblastic fibroodontosarcoma”and“odontogenic carcinosarcoma”.The inclusion criteria were odontogenic tumor series,case reports and systematic reviews that provided sufficient clinical,radiological and microscopic documentation to confirm the *** The database search strategy resulted in 947 *** focusing on other topics,articles that were not in English,duplicate articles,and articles without fulfilling the inclusion criteria were ***,96 publications were included in this review to describe and discuss the main features of the searched *** aspects of AFO and AFD,such as biological behavior,age of occurrence,amount of hard tissue,and potential for malignant transformation into odontogenic sarcomas,support the neoplastic nature in most of the reported *** the clinical,radiographic,histopathological and molecular characteristics of odontogenic lesions with hard tissue production,we suggest that these types of lesions should continue to be recognized as odontogenic tumors by maintaining the classically used *** This reco

关键词： Ameloblastic fibroma Ameloblastic fibrosarcoma Odontogenic carcinosarcoma Odontogenic tumors

Potential role of intermittent fasting on decreasing cardiovascular disease in human immunodeficiency virus patients receiving antiretroviral therapy

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World Journal of Experimental Medicine 2021年第5期11卷 66-78页

作者： Martin Gnoni Renato Beas Anupama Raghuram celeste Díaz-Pardavé Adrian Riva-Moscoso Fortunato S Príncipe-Meneses Raúl Vásquez-Garagatti Department of Internal Medicine Good Samaritan HospitalCincinnatiOH 45220United States Division of Infectious Diseases Department of MedicineUniversity of Louisville Health Sciences CenterLouisvilleKY 40202United States Department of Medicine Indiana University School of MedicineIndianapolisIN 46202United States US Medical Affairs Merck Research LaboratoriesKenilworthNJ 07033United States Division of Research and Academic Affairs Larkin Health SystemSouth MiamiFL 33143United States School of Medicine Universidad Científica del SurLima 15837Peru Escuela de Medicina Universidad Peruana de Ciencias Aplicadas(UPC)Lima 15067Peru Sociedad Científica de Estudiantes de Medicina Universidad Peruana de Ciencias Aplicadas(UPC)Lima 15067Peru Hospital Medicine Department and Infectious Diseases University of Tennessee Medical Center at KnoxvilleKnoxvilleTN 37920United States Department of Internal Medicine Cherokee HealthKnoxvilleTN 37921United States

Cardiovascular disease(CVD)has become one of the commonest causes of comorbidity and mortality among People living with human immunodeficiency virus(HIV)(PLWH)on antiretroviral therapy(ART).Nearly 50%of PLWH are likely to have an increased risk of developing CVD,including coronary heart disease,cerebrovascular disease,peripheral artery disease and aortic *** from the common risk factors,HIV infection itself and side effects of antiretroviral therapy contribute to the pathophysiology of this *** non-pharmacological therapies are currently being tested worldwide for this purpose,including eating patterns such as Intermittent fasting(IF).IF is a widespread practice gaining high level of interest in the scientific community due to its potential benefits such as improvement in serum lipids and lipoproteins,blood pressure(BP),platelet-derived growth factor AB,systemic inflammation,and carotid artery intima-media thickness among others cardiovascular *** review will focus on exploring the potential role of intermittent fasting as a non-pharmacological and cost-effective strategy in decreasing the burden of cardiovascular diseases among HIV patients on ART due to its intrinsic properties improving the main cardiovascular risk factors and modulating inflammatory pathways related to endothelial dysfunction,lipid peroxidation and *** fasting regimens need to be tested in clinical trials as an important,cost-effective,and revolutionary coadjutant of ART in the fight against the increased prevalence of cardiovascular disease in PLWH.

关键词： Human immunodeficiency virus Intermittent fasting Antiretroviral therapy Metabolism Cardiovascular disease Mortality and morbidity

The Effects of Build Parameters and Strain Rate on the Mechanical Properties of FDM 3D-Printed Acrylonitrile Butadiene Styrene

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Open Journal of Organic Polymer Materials 2019年第1期9卷 1-27页

作者： Kemar Hibbert Grant Warner celeste Brown Olusegun Ajide Gbadebo Owolabi Amin Azimi Department of Mechanical Engineering Howard University Washington DC USA Department of Mechanical Engineering University of Ibadan Ibadan Nigeria

In this paper, the effects of build parameters on the mechanical properties of 3D-printed acrylonitrile butadiene styrene (ABS) produced using fused deposition modeling (FDM) are investigated. Full factorial experimental design incorporating a 2-level, 3-factor design with raster angle, layer thickness and interior fill style was carried out. Tensile tests were performed at four different strain rates to determine how the build parameters influence the mechanical properties of the 3-D printed ABS and to assess its strain rate sensitivity under quasi-static loading. It was found that the modulus of toughness of ABS material is most influenced by raster angle, while the interior fill style is the most dominant build parameter that dictates the specimen’s modulus of resilience, yield strength and ultimate tensile strength. At all strain rates, it is further revealed that higher mean values of yield strength, ultimate tensile strength and modulus of resilience were obtained when the interior fill style is solid as opposed to high density. This can be attributed to the denser structure and higher effective cross-sectional area in solid interior fill style in comparison with high density interior fill style. However, the influence of the layer thickness on the investigated mechanical properties was found to be inconsistent. It was noted that specimens built with both 0.254 mm layer thickness and the cross [0°/90°] raster angle had superior mechanical properties when compared to those built with the 0.3302 mm layer thickness and cross [0°/90°] raster angle. This suggests that there is a key interaction between the layer thickness and the raster angle. At any FDM build parameter, it was found that all the mechanical properties investigated in this work exhibited modest sensitivity to strain rates. This study has provided a platform for an appropriate selection of build parameters combinations and strain rates for additive manufacturing of 3D-printed ABS with improved mechan

关键词： Build Parameters Mechanical Properties Additive Manufacturing 3D Printing Acrylonitrile Butadiene Styrene