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Biomedical applications of the powder-based 3D printed titanium alloys:A review

Journal of Materials Science & Technology 2022年第30期125卷 252-264页

作者： Amy X.Y.Guo Liangjie Cheng Shuai Zhan Shouyang Zhang Wei Xiong Zihan Wang Gang Wang Shan cecilia Cao Materials Genome Institute Shanghai UniversityShanghai 200444China

3D printing technology is a new type of precision forming technology and the core technology of the third industrial *** powder-based 3D printing technology of titanium and its alloys have received great attention in biomedical applications since its advantages of custom manufacturing,costsaving,time-saving,and resource-saving *** particular,the personalized customization of 3D printing can meet specific needs and achieve precise control of micro-organization and structural *** purpose of this review is to present the most advanced multi-material 3D printing methods for titanium-based *** first reviewed the bone tissue engineering,the application of titanium alloy as bone substitutes and the development of manufacturing technology,which emphasized the advantages of 3D printing technology over traditional manufacturing *** is more,the optimization design of the hierarchical structure was analyzed to achieve the best mechanical properties,and the biocompatibility and osseointegration ability of the porous titanium alloy after implantation in living bodies was ***,we emphasized the development of digital tools such as artificial intelligence,which provides new ideas for the rational selection of processing *** 3D printing titanium-based alloys will meet the huge market demand in the biomedical field,but there are still many challenges,such as the trade-off between high strength and low modulus,optimization of process parameters and structural *** believe that the combination of mechanical models,machine learning,and metallurgical knowledge may shape the future of metal printing.

关键词： The powder-based 3D printing technology Ti-based alloys Biomedical applications Artificial intelligence

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Endoscopic ultrasound in the papilla and the periampullary region

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World Journal of Gastrointestinal Endoscopy 2010年第8期2卷 278-287页

作者： cecilia Castillo Endoscopy Service Latin American Endoscopy Training CenterClínica Alemana de SantiagoUniversidad del Desarrollo

Endoscopic ultrasound (EUS) provides relevant information when an ampullary or periampullary tumor is *** detection, T and N staging and Fine Needle Aspiration plus cithologic confirmation, are some of the expected benefits. Exclusion of benign findings like choledocholithiasis or chronic pancreatitis is also important. A correct understanding of the complex ampullary and periampullary anatomy is needed. Knowledge of the individual clinical history and other previous diagnostic images all contribute to a successful EUS examination. Radial and lineal EUS images are uniquely detailed and, at the moment, it seems to be the best way to exclude or confirm malignant or benign findings. We propose a procedural algorithm, including EUS,for suspected ampullary or periampullary tumors. This review summarizes the vast amount of information to be found spread in the literature, and recognizes this small anatomic area as the origin for a clinical entity with proper clinical presentation, proper imaging and proper therapeutic resolutions. The benefits of performing EUS for its study are highlighted.

关键词： Endoscopic ultrasound Periampullary region Ampulla of Vater Ampuloma Pancreatic cancer

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Insights into the hydrogen evolution reaction in vanadium redox flow batteries:A synchrotron radiation based X-ray imaging study

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Journal of Energy Chemistry 2024年第4期91卷 132-144页

作者： Kerstin Köble Alexey Ershov Kangjun Duan Monja Schilling Alexander Rampf Angelica cecilia TomášFaragó Marcus Zuber Tilo Baumbach Roswitha Zeis Helmholtz Institute Ulm Karlsruhe Institute of Technology89081 UlmGermany Laboratory for Applications of Synchrotron Radiation Karlsruhe Institute of Technology76131 KarlsruheGermany Institute for Photon Science and Synchrotron Radiation Karlsruhe Institute of Technology76344 Eggenstein-LeopoldshafenGermany Department of Electrical Electronicsand Communication EngineeringFaculty of EngineeringFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)91058 ErlangenGermany Department of Mechanical and Industrial Engineering University of TorontoToronto M5S 3G8OntarioCanada

The parasitic hydrogen evolution reaction(HER)in the negative half-cell of vanadium redox flow batteries(VRFBs)causes severe efficiency ***,a deeper understanding of this process and the accompanying bubble formation is *** benchmarking study locally analyzes the bubble distribution in thick,porous electrodes for the first time using deep learning-based image segmentation of synchrotron X-ray *** large three-dimensional data set was processed precisely in less than one minute while minimizing human errors and pointing out areas of increased HER activity in *** study systematically varies the electrode potential and material,concluding that more negative electrode potentials of-200 m V *** hydrogen electrode(RHE)and lower cause more substantial bubble formation,resulting in bubble fractions of around 15%–20%in carbon felt ***,the bubble fractions stay only around 2%in an electrode combining carbon felt and carbon *** detected areas with high HER activity,such as the border subregion with more than 30%bubble fraction in carbon felt electrodes,the cutting edges,and preferential spots in the electrode bulk,are potential-independent and suggest that larger electrodes with a higher bulk-to-border ratio might reduce HER-related performance *** described combination of electrochemical measurements,local X-ray microtomography,AI-based segmentation,and 3D morphometric analysis is a powerful and novel approach for local bubble analysis in three-dimensional porous electrodes,providing an essential toolkit for a broad community working on bubble-generating electrochemical systems.

关键词： Vanadium redox flow battery Synchrotron X-ray imaging Tomography Hydrogen evolution reaction Gas bubbles Deep learning

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Unraveling molecular interactions in whey protein-kefiran composite films to understand their physicochemical and mechanical properties

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Food Bioscience 2022年第6期50卷 345-354页

作者： Nina Gagliarini cecilia B.Figoli Judith Piermaria Alejandra Bosch Analía G.Abraham Centro de Investigación y Desarrollo en Criotecnología de Alimentos- CIDCA (CCT-CONICET La Plata UNLPCIC-PBA)47 y 1161900La PlataArgentina Laboratorio de Bioespectroscopía CINDEFI (CCT-CONICET La PlataUNLPCIC-PBA)50 y 1151900La PlataArgentina Área Bioquímica y Control de Alimentos Facultad de Ciencias ExactasUNLP47 y 1151900La PlataArgentina

To enhance health promoting properties of edible whey protein films,the inclusion of kefiran to develop composite films was *** and mechanical properties of films prepared with different wpi:kefiran ratios,different percentage of plasticizer and subjected or not to a heat treatment were *** inter-and intra-molecular interactions produced by the incorporation of kefiran into whey-protein films were studied to understand the effect exerted by kefiran on the protein network that may affect the properties of the ***-scanning-calorimetry and Fourier-transform–infrared-spectroscopy studies revealed that kefiran does not affect proteins denaturation,but rather modifies protein-protein interactions in the films,exhibiting a change in wpi secondary structure and a drop in films'melting *** wpi:kefiran films had higher opacity,lower water content and lower water activity compared to single wpi *** of kefiran into the films decreases tensile strength and elastic modulus and produces an increment in the elongation at break *** was confirmed that the addition of a whey-protein denaturation step produces an improvement in the protein network that is crucial for the mechanical behavior of the *** the molecular interactions within composite films greatly aids in obtaining novel formulations with tailor-made physicochemical properties.

关键词： Edible films Kefiran Whey-proteins Interactions Biomaterials

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Value of autopsy in the modern age:Discrepancy between clinical and autopsy diagnoses

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World Journal of Experimental Medicine 2024年第4期14卷 129-135页

作者： cecilia Salzillo Roberta Basile Gerardo Cazzato Giuseppe Ingravallo Andrea Marzullo Department of Precision and Regenerative Medicine and Ionian Area Pathology UnitUniversity of Bari“Aldo Moro”Bari 70121Italy Department of Experimental Medicine PhD Course in Public HealthUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Course in Biomedical Laboratory Technique University of Bari“Aldo Moro”Bari 70121Italy

BACKGROUND Autopsy is a medical procedure that consists of the examination of the corpse to determine the cause of death and obtain information on pathological conditions or *** recent years,there has been a reduction in hospital autopsies and an increase in forensic *** To evaluate the utility of autopsy in the modern age and the discrepancy between clinical and autopsy *** A retrospective observational study was conducted on the reports of all 645 hospital autopsies performed at Polyclinic of Bari from 2006 to *** Group A,2006-2009,174 cases were studied:58%male,58%adults,55%neonatology;pulmonary disease was the cause of death in 23%of cases;and there was a discrepancy between clinical and autopsy diagnosis in 55%of *** B,2010-2013,119 cases:52%male,46%infants,48%neonatology;pulmonary disease was the cause of death in 25%of cases;and there was a discrepancy between clinical and autopsy diagnosis in 56%of *** C,2014-2017,168 cases:sex equality,37%infants,25%gynecology;pulmonary disease was the cause of death in 24%of cases;and there was a discrepancy between clinical and autopsy diagnosis in 58%of *** D,2018-2021,184 cases:56%male,38%adult,32%gynecology;pulmonary disease was the cause of death in 27%of cases;and there was a discrepancy between clinical and autopsy diagnosis in 58%of *** The study of hospital autopsies reveals a 56.75%discrepancy between clinical diagnosis and autopsy,highlighting the importance of autopsies,especially for fetal and neonatal diseases,which represent 59%of cases.

关键词： Hospital autopsy Modern age Clinical diagnosis Autopsy diagnosis Public health

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Timing of pubertal development in boys born with cryptorchidism and hypospadias:a nation wide cohort study

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Asian Journal of Andrology 2019年第6期21卷 551-556页

作者： Linn Hakonsen Arendt Andreas Ernst Lea Lykke Braskhoj Lauridsen Nis Brix Jorn Olsen cecilia Host Ramlau-Hansen Department of Public Health Section for EpidemiologyAarhus UniversityAarhus 8000Denmark Perinatal Epidemiology Research Unit Department of Paediatric and Adolesce nt Medici neAarhus Un iversity HospitalAarhus 8000Den mark Department of Clin ical Epidemiology Aarhus University HospitalAarhus 8000Denmark.

Pubertal development may be altered in boys with cryptorchidism and hypospadias,but existing kno wledge is inc on siste ***,we investigated the association between cryptorchidism and hypospadias and pubertal development in a large cohort *** in the Puberty Cohort,a cohort nested within the Danish National Birth Cohort,were in eluded in this *** on cryptorchidism and hypospadias was retrieved from the Danish National Patient *** 11 years until 18 years or full pubertal developme nt,info rmatio n on physical markers of pubertal developme nt was provided biannu ally,in eluding Tanner stages,axillary hair,acne,voice break,and first *** multivariate regression models for interval censored data,the mean(95%confidence intervals[Cis])d iff ere nces in months in obtaining the pubertal markers between boys with and without the anomalies were *** 7698 boys,196(2.5%)had cryptorchidism and 60(0.8%)had *** with hypospadias experienced first ejaculation and voice break 7.7(95%Cl:2.5-13.0)months and 4.5(95%Cl:0.3-8.7)months later than boys without hypospadias?The age at attaining the Tanner stages for gonadal and pubic hair growth was also higher,though not statistically *** development seemed unaffected in boys with mild as well as severe cryptorchidism?In conclusion,hypospadias may be associated with delayed pubertal development,but pubertal development seems unaffected by *** relation between hypospadias and later pubertal development may be due to the underlying shared in utero risk or genetic factors.

关键词： congenital abnormalities cryptorchidism hypospadias prenatal exposure delayed effects puberty Tanner stages

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A comparison of conventional and computer-assisted semen analysis.（CRISMAS software） using samples from 166 young Danish men

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Asian Journal of Andrology 2011年第3期13卷 453-458,513页

作者： Anne Vested cecilia H Ramlau-Hansen Jens P Bonde Ane M Thulstrup Susanne L Kristensen Gunnar Toft Danish Ramazzini Center Department of Occupational Medicine Aarhus University Hospital DK-8000 Aarhus C Denmark Department of Occupational and Environmental Medicine Copenhagen University Hospital Bispebjerg DK-2400 Copenhagen NV Denmark

The aim of the present study was to compare assessments of sperm concentration and sperm motility analysed by conventional semen analysis with those obtained by computer-assisted semen analysis （CASA）（Copenhagen Rigshospitalet Image House Sperm Motility Analysis System （CRISMAS） 4.6 software） using semen samples from 166 young Danish men. The CRISMAS software identifies sperm concentration and classifies spermatozoa into three motility categories. To enable comparison of the two methods, the four motility stages obtained by conventional semen analysis were, based on their velocity classifications, divided into three stages, comparable to the three CRISMAS motility categories： rapidly progressive （A）, slowly progressive （B） and non-progressive （C＋ D）. Differences between the two methods were large for all investigated parameters （P〈0.001）. CRISMAS overestimated sperm concentration and the proportion of rapidly progressive spermatozoa and, consequently, underestimated the percentages of slowly progressive and non-progressive spermatozoa, compared to the conventional method. To investigate whether results drifted according to time of semen analysis, results were pooled into quarters according to date of semen analysis. CRISMAS motility results appeared more stable over time compared to the conventional analysis; however, neither method showed any trends. Apparently, CRISMAS CASA results and results from the conventional method were not comparable with respect to sperm concentration and motility analysis. This needs to be accounted for in clinics using this software and in studies of determinants of these semen characteristics.

关键词： computer-assisted semen analysis reproduction semen analysis sperm concentration sperm motility

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Adult female of strongyloides stercoralis in respiratory secretions

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Asian Pacific Journal of Tropical Biomedicine 2013年第4期3卷 311-313页

作者： Bava Amadeo Javier Bava Domínguez cecilia Troncoso Alcides Laboratory of Parasitology.Infectious Diseases Hospital "Francisco Javier Muniz" Uspallata 2272.Buenos AiresArgentina Department of Infectious Diseases School of MedicineBuenos Aires UniversityArgentina

Objective:To communicate the presence of adult females,rabditoid larvae and eggs of Strongyloides stercoralis(***)in the respiratory secretions obtained by tracheal aspirate from a HIV-negative patient who was suffering from polymyositis,and treated with corticoids and amethopterin and assisted by ***:The respiratory secretions submitted to the Parasitology Laboratory of the Mu(?)iz Hospital were made more concentrated by centrifugation(1 500 r/min for 15 seconds).Wet mount microscopy was performed with the ***:It revealed adult females,rabditoid larvae and eggs of *** parasitological studies performed after the start of the treatment with ivermectin on fresh fecal samples,gastric lavages and tracheal aspirates showed scanty mobile filariform and rabditoid larvae of the same ***:The presence of adult female *** which has never been observed before in the clinical samples submitted to our Laboratory for investigation can be considered as an indirect marker of the severe immunosupression of the patient.

关键词： Strongyloidiasis Strongyloides stercoralis Hyperinfection Parasitological diagnosis Adult female

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Technical and technological constraints facing Tanzania leather value chain:a snapshot of intervention measures

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Journal of Leather Science and Engineering 2022年第1期4卷 287-298页

作者： cecilia Rolence China Rahel Elibariki Jamal Msami Stephen Mwombela Lugano Wilson Tanzania Industrial Research and Development Organization P.O.Box 23235Dar es SalaamTanzania REPOA 157 Mgombani Street Regent EstateP.O.Box 33223Dar es SalaamTanzania

The leather value chain starts with livestock, the key source of hides and skins, and the main raw materials for the industry. Despite having the second-largest livestock population in Africa, Tanzania is only the 11th largest exporter of leather on the continent, underlining the disproportionate contribution of the sector to the economy. This study presents the results of a recent assessment aimed at identifying performance bottlenecks in Tanzania’s leather sector. The assessment took place in October-December 2020 and involved 10 tanneries, 30 leather goods factories and 11 service providers/institutions. Findings reveal that 90% of tanneries are dissatisfied with the quality of hides and skins due to brand marks, flay cuts, skin diseases, and inadequate curing. These supply chain bottlenecks are further compounded by skill deficiencies among processors, poor waste management, and limited awareness about laws, policies and regulations governing trade in the sector. At the downstream end of the value chain, the trade in leather and related articles is facing competition from high importation of low-grade products like plastic shoes and second- hand products. This paper recommends that efforts to increase leather’s economic and trade value need to focus on upgrading Tanzania’s production, processing, branding and marketing capacities.

关键词： Leather value chain Hides and skins Constraints Interventions

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Influence of agriculture and aquaculture activities on the response of autotrophic picoplankton in Laguna Macapule, Gulf of California (Mexico)

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Ecological Processes 2017年第1期6卷 41-51页

作者： Aída Martínez-López Cristian Hakspiel-Segura Diana cecilia Escobedo-Urías Bárbara González-Acosta Centro Interdisciplinario de Ciencias Marinas-IPN(CICIMAR) Av.IPN s/nCol.Playa Palo de Santa RitaLa PazB.C.S.23096Mexico Centro de Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR–Unidad Sinaloa)Bulevar Juan de Dios Bátiz Paredes 250Col.San JoachinGuasaveSinaloa 81101Mexico

Introduction:The lagoon is a component of coastal zones,whose populations of autotrophic picoplankton(APP)remain largely *** lagoons display high-nutrient productivity and additionally may also be subjected to anthropogenic *** study selected Laguna Macapule,located on the eastern shore in the mid-region of the Gulf of California,due to the fact that a drainage network servicing the surrounding agricultural region(>230,000 hectares under cultivation)directs irrigation runoff,shrimp farm effluents,and urban wastewater containing large quantities of nutrients to be discharged into this *** propose to identify the APP’s response to various types of environmental and anthropogenic influence in this highly impacted coastal ***:Two sites(separated by 2.7 km)were monitored from December 2007 to December ***,located at the entrance to Laguna Macapule(oceanic influence)and the other a discharge canal(eutrophic conditions)inside the lagoon at El Tortugó***:APP was the numerically dominant phytoplankton fraction(15×106 to 620×106 cells L−1)with coccoidal cyanobacteria as the dominant fraction throughout the *** levels were reached in spring-early autumn and they were the second largest contributor to *** of APP cells corresponds to the lagoon’s eutrophic *** numbers and a higher average of APP were recorded at the El Tortugón channel during the warm season(months with SST higher than 24°C).The general positive relationship of the APP’s annual cycle at both sites as well as a negative relationship with heterotrophic nanoflagellates(HNF)abundance,supports the idea that natural forcing,in particular sea surface temperature(SST)is the predominant influences on APP’s seasonal ***:Distinguishable significant differences in APP abundances and nutrients were recognizable between the two *** interplay of these variables contributed to lower densities of APP in winter and high de

关键词： Aquaculture Autotrophic picoplankton Eutrophic conditions Heterotrophic ciliates Heterotrophic nanoflagellates Urea

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