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Hepatitis C Virus Infection Sensitizes Human Hepatocytes to TRAIL-Induced Apoptosis in a Caspase 9-Dependent Manner1

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Hepatitis C Virus Infection Sensitizes Human Hepatocytes to ...

Hepatitis C Virus Infection Sensitizes Human Hepatocytes to TRAIL-Induced Apoptosis in a Caspase 9-Dependent Manner1

病毒性肝炎慢性化、重症化基础与临床研究进展学术会议

作者： Sebastian Gorke Sibylle J.Rau Mirjam B.Zeisel Eberhard Hildt Kiyoshi Himmelsbach Monica Carvajal-Yepes Roman Huber Takaji Wakita Annette Schmitt-Graeff cathy royer Hubert E.Blum Richard Fischer Thomas F.Baumert Department of infectious disease Southwest hospital of Third Military Medical University Department of infectious disease Southwest hospital of Third Military Medical UniversityChongqing 400038 China

Apoptosis of infected cells represents a key host defense mechanism against viral *** impact of apoptosis on the elimination of hepatitis C virus(HCV)-infected cells is poorly *** TRAIL has been implicated in the death of liver cells in hepatitis-infected but not in normal liver *** determine the impact of TRAIL on apoptosis of virus-infected host cells,we studied TRAIL-induced apoptosis in a tissue culture model system for HCV *** demonstrated that HCV infection sensitizes primary human hepatocytes and Huh7.5 hepatoma cells to TRAIL induced apoptosis in a dose- and time-dependent *** studies identified the HCV nonstructural proteins as key mediators of sensitization to *** a panel of inhibitors targeting different apoptosis pathways,we demonstrate that sensitization to TRAIL is caspase-9 dependent and mediated in part via the mitochondrial *** of hepatocytes to TRAIL-induced apoptosis by HCV infection represents a novel antiviral host defense mechanism that may have important implications for the pathogenesis of HCV infection and may contribute to the elimination of virus-infected hepatocytes.

关键词： HCV Caspase Hepatitis C Virus Infection Sensitizes Human Hepatocytes to TRAIL-Induced Apoptosis in a Caspase 9-Dependent Manner1

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Hepatitis C Virus Infection Sensitizes Human Hepatocytes to ...

Rapid Evaluation and Response to Impacts on Critical End-Use Loads Following Natural Hazard-Driven Power Outages:A Modular and Responsive Geospatial Technology

第五届国际暨全国肝衰竭与人工肝学术会议

作者： Sebastian Gorke Sibylle J.Rau Mirjam B.Zeisel Eberhard Hildt Kiyoshi Himmelsbach Monica Carvajal-Yepes Roman Huber Takaji Wakita Annette Schmitt-Craeff cathy royer Hubert E.Blum Richard Fischer Thomas F.Baumert Department of infectious disease Southwest hospital of Third Military Medical University

＜正＞Apoptosis of infected cells represents a key host defense mechanism against viral *** impact of apoptosis on the elimination of hepatitis C virus（HCV）-infected cells is poorly *** TRAIL has been implicated in ...

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International Journal of Disaster Risk Science 2022年第3期13卷 415-434页

作者： Patrick D.royer Wei Du Kevin Schneider Energy and Environment Pacific Northwest National LaboratoryRichlandWA99352USA

The disparate nature of data for electric power utilities complicates the emergency recovery and response *** reduced efficiency of response to natural hazards and disasters can extend the time that electrical service is not available for critical end-use loads,and in extreme events,leave the public without power for extended *** article presents a methodology for the development of a semantic data model for power systems and the integration of electrical grid topology,population,and electric distribution line reliability indices into a unified,cloud-based,serverless framework that supports power system operations in response to extreme *** iterative and pragmatic approach to working with large and disparate datasets of different formats and types resulted in improved application runtime and efficiency,which is important to consider in real time decision-making processes during hurricanes and similar catastrophic *** technology was developed initially for Puerto Rico,following extreme hurricane and earthquake events in 2017 and 2020,but is applicable to utilities around the *** the highly abstract and modular design approach,this technology is equally applicable to any geographic region and similar natural hazard *** addition to a review of the requirements,development,and deployment of this framework,technical aspects related to application performance and response time are highlighted.

关键词： Electrical grid Hurricane response Puerto Rico Resilience and geospatial technology Software applications

Improvement of microwave emissivity parameterization of frozen Arctic soils using roughness measurements derived from photogrammetry

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International Journal of Digital Earth 2021年第10期14卷 1380-1396页

作者： J.Meloche A.royer A.Langlois N.Rutter V.Sasseville Département de Géomatique Appliquée Universitéde SherbrookeSherbrookeCanada Centre d’études nordiques QuébecCanada Department of Geography and Environmental Sciences Northumbria UniversityNewcastle upon TyneUK

Soil emissivity of Arctic regions is a key parameter for assessing surface properties from microwave brightness temperature(Tb)*** in winter,frozen soil permittivity and roughness are two poorly characterized unknowns that must be ***,we show that after removing snow,the 3D soil roughness can be accurately inferred from in-situ photogrammetry using Structure from Motion(SfM).We focus on using SfM techniques to provide accurate roughness measurements and improve emissivity models parametrization of frozen arctic soil for microwave *** was performed from ground-based radiometric measurements at 19 and 37 GHz using three different soil emission models:the Wegmüller and Mätzler[1999,TGRS]model(Weg99),the Wang and Choudhury[1981,JGR]model(QNH),and a geometrical optics model(Geo Optics).Measured and simulated brightness temperatures over different tundra and rock sites in the Canadian High Arctic show that Weg99,parametrized with SfM-based roughness and optimized permittivity(1),yielded an RMSE of 3.1 K(R2=0.71)for all frequencies and *** SfM based approach allowed us to measure roughness with 0.1 mm accuracy at 55 locations of different land cover type using a digital camera and metal plates of know dimensions.

关键词： Surface roughness microwave remote sensing frozen Arctic soil SfM photogrammetry

Glutathione peroxidase activity in cell cultures from different regions of human epididymis

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Asian Journal of Andrology 2005年第1期7卷 33-37,页

作者： Enrique Castellon Hernan Rioseco Juan Rojas Michel royer Eduardo Salas Hoctor Contreras Christian Huidobro Physiology and Biophysics Program Institute of Biomedical Sciences Faculty of Medicine University. of Chile Santiago 6530499 Chile Urology Department Clinic Hospital J. J. Aguirre University of Chile Santiago 6530499 Chile

Aim: To study the secretory activity and androgen regulation of glutathione peroxidase (GPx) in epithelial cell cultures from human epididymis. Methods: Tissue was obtained from patients undergoing therapeutic orchidectomy for prostatic cancer. Epithelial cell cultures were obtained from the caput, corpus and cauda epididymides. Enzymatic activity was measured in conditioned media by colorimetric methods in absence or presence of 1, 10 or 100 nrnoI.L^(-1) testosterone. The effect of 1 μmol.L^(-1) flutamide was also evaluated. Results: GPx activity was higher in cultures from corpus and cauda than caput epididymidis. The presence of different concentrations of testosterone increase enzyme activity in cell cultures from all epididymal regions. Addition of flutamide reverses the androgen dependent increase of GPx activity. Conclusion: GPx activity is secreted from human epididymal cells in a region dependent manner and is regulated by androgens.

关键词： glutathione peroxidase human epididymis cell culture androgen regulation

Alpha Decay Half-Lives of New Superheavy Elements through Quasimolecular Shapes

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Chinese Physics Letters 2006年第7期23卷 1734-1737页

作者：张鸿飞李君清左维陈宝秋马中玉 Soojae Im royer Guy Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 Research Center of Nuclear Theory of Laboratory of Heavy Ion Accelerator of Lanzhou Lanzhou 730000 Graduate School of Chinese Academy of Sciences Beijing 100030 China Institute of Atomic Energy Beijing 102413 Laboratoire Subatech UMR: IN2P3/CNRS-Uniyersité-Ecole des Mines 4 rue A. Kastler 44307 Nantes Cedex 03 France

The lifetimes of a decays of the recently produced isotopes of the elements 112, 114, 116 and the element ^294118 and of some decay products have been calculated theoretically within the Wentzel-Kramers-Brillouin approximation. The a decay barriers have been determined in the quasimolecular shape path within a generalized liquid drop model including the proximity effects between nuclei in a neck, the mass and charge asymmetry and the precise nuclear radius. These calculations provide reasonable estimates for the observed a decay lifetimes. The calculated results have been compared with the results of the density-dependent M3Y effective interaction and the experimental data. It is indicated that the theoretical foundation of the generalized liquid drop model is as good as that of the microscopic DDM3Y model, at least in the sense of predicting the T1/2 values as long as one uses a correct a decay energy. The half lives of these new nuclei are well tested from the consistence of the macroscopic, the microscopic and the experimental data.

关键词： LIQUID-DROP MODEL DEFORMED POTENTIAL-ENERGY HEAVIEST ELEMENTS CREVICEDSHAPES NUCLEI EMISSION FISSION CA-48 BARRIER COMPACT

Performance of identical rockbolts tested on four dynamic testing rigs employing the direct impact method

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 745-754页

作者： Charlie C.Li John Hadjigeorgiou Peter Mikula Greig Knox Bradley Darlington Renee royer Andrzej Pytlik Michael Hosp Norwegian University of Science and Technology(NTNU) TrondheimNorway University of Toronto TorontoCanada Mikula Geotechnics Pty.Ltd. KalgoorlieAustralia New Concept Mining JohannesburgSouth Africa Sandvik Mining&Rock Technology HeatherbraeAustralia CanmetMINING Natural Resources CanadaOttawaCanada Central Mining Institute KatowicePoland Minova Innovation and Development Ground SupportFeistritzAustria

Impact drop tests are routinely used to examine the dynamic performance of *** impact tests have been carried out in the past decades on independently designed,constructed and operated testing *** laboratory has developed testing procedures;thus,the results are often reported in different ways by various *** inconsistency in testing procedures and reporting formats presents a challenge when comparing results from different laboratories.A series of impact tests of identical rockbolts was carried out using the direct impact method(*** mass free-fall method)on the rigs in four laboratories in different *** purpose of these tests was to investigate the level of consistency in the results from the four *** rig demonstrated a high level of repeatability,but differences existed between the various *** differences would suggest that there is noticeable equipment-dependent bias when test results obtained from different laboratories are *** was also observed that the energy dissipated for the plastic displacement of the bolt was smaller than the impact energy in the *** average impact load(AIL)and the ultimate plastic displacement(D)of the bolt describe the ultimate dynamic performance of the *** the case where the bolt does not rupture,the specific plastic energy(SPE)is an appropriate parameter in describing the impact performance of the *** other relevant parameters are the first peak load(FPL)and the initial stiffness(K)of the bolt *** information from this test series will guide the formulation of standardised testing procedures for dynamic impact tests of rockbolts.

关键词： Dynamic test Drop test Impact test Rockbolt Rock reinforcement Ground support

Unveiling how vitrification affects the porcine blastocyst: clues from a transcriptomic study

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Journal of Animal Science and Biotechnology 2022年第3期13卷 735-755页

作者： C.Almiñana F.Dubuisson S.Bauersachs E.royer P.Mermillod E.Blesbois F.Guignot UMR PRC INRAE 0085CNRS 7247Universitéde ToursIFCEF–37380 NouzillyFrance Functional Genomics Group Institute of Veterinary AnatomyVetSuisse Faculty ZurichUniversity of ZurichZürichSwitzerland UEPAO INRAEF–37380 NouzillyFrance

Background:Currently,there is a high demand for efficient pig embryo cryopreservation procedures in the porcine industry as well as for genetic diversity preservation and research *** date,vitrification(VIT)is the most efficient method for pig embryo *** a high number of embryos survives in vitro after vitrification/warming procedures,the in vivo embryo survival rates after embryo transfer are variable among *** far,most studies have focused on cryoprotective agents and devices,while the VIT effects on porcine embryonic gene expression remained *** few studies performed were based on vitrified/warmed embryos that were cultured in vitro(IVC)to allow them to re–***,the specific alterations of VIT,IVC,and the cumulative effect of both remained *** unveil the VIT-specific embryonic alterations,gene expression in VIT versus(vs.)IVC embryos was ***,changes derived from both VIT and IVC *** embryos(CO)were analyzed to confirm the VIT embryonic *** groups of in vivo embryos at the blastocyst stage were analyzed by RNA–sequencing:(1)VIT embryos(vitrified/warmed and cultured in vitro),(2)IVC embryos and(3)CO ***:RNA–sequencing revealed three clearly different mRNA profiles for VIT,IVC and CO *** analysis of mRNA profiles between VIT and IVC identified 321,differentially expressed genes(DEG)(FDR<0.006).In VIT *** and IVC ***,1901 and 1519 DEG were found,respectively,with an overlap of 1045 ***-specific functional alterations were associated to response to osmotic stress,response to hormones,and developmental *** alterations in response to hypoxia and mitophagy were related to the sum of VIT and IVC ***:Our findings revealed new insights into the VIT procedure-specific alterations of embryonic gene expression by first comparing differences in VIT *** embryos and second by an integrative transcriptome analysis in

关键词： Blastocyst Embryo Gene expression In vitro culture Porcine RNA–sequencing Transcriptomics Vitrification

High speed sub-micrometric microscopy using optical polymer microlens

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Chinese Optics Letters 2009年第10期7卷 901-903页

作者：曾新华 J.Plain S.Jradi P.Renaud Goud R.Deturche P.royer R.Bachelot Laboratoire de Nanotechnologie et d'Instrumentation Optique ICD CNRS FRE 2848Universit de technologie de Troyes Department of Physics Shanghai Jiao Tong University

We report the high speed scanning submicronic microscopy （SSM） using a low cost polymer microlens integrated at the extremity of an optical fiber. These microlenses are fabricated by a free-radical photopolymerization method. Using a polymer microlens with a radius of curvature of 250 nm, a sub-micrometric gold pattern is imaged experimentally by SSM. Different distances between the tip and the sample are used with a high scanning speed of 200 cm/s. In particular, metallic absorption contrasts are described with an optical spatial resolution of 250 nm at the wavelength of 532 nm. Moreover, finite-difference time-domain （FDTD） simulations concerning the focal lengths of microlenses with different geometries and heights support the experimental data.

关键词： Finite difference time domain method Microlenses Optical fiber fabrication Optical fibers Polymers