Hepatitis C Virus Infection Sensitizes Human Hepatocytes to TRAIL-Induced Apoptosis in a Caspase 9-Dependent Manner1
作者单位：Department of infectious diseaseSouthwest hospital of Third Military Medical University Department of infectious diseaseSouthwest hospital of Third Military Medical UniversityChongqing 400038 China
会议名称：《病毒性肝炎慢性化、重症化基础与临床研究进展学术会议》
会议日期：2009年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
关 键 词：HCV Caspase Hepatitis C Virus Infection Sensitizes Human Hepatocytes to TRAIL-Induced Apoptosis in a Caspase 9-Dependent Manner1
摘 要：Apoptosis of infected cells represents a key host defense mechanism against viral *** impact of apoptosis on the elimination of hepatitis C virus(HCV)-infected cells is poorly *** TRAIL has been implicated in the death of liver cells in hepatitis-infected but not in normal liver *** determine the impact of TRAIL on apoptosis of virus-infected host cells,we studied TRAIL-induced apoptosis in a tissue culture model system for HCV *** demonstrated that HCV infection sensitizes primary human hepatocytes and Huh7.5 hepatoma cells to TRAIL induced apoptosis in a dose- and time-dependent *** studies identified the HCV nonstructural proteins as key mediators of sensitization to *** a panel of inhibitors targeting different apoptosis pathways,we demonstrate that sensitization to TRAIL is caspase-9 dependent and mediated in part via the mitochondrial *** of hepatocytes to TRAIL-induced apoptosis by HCV infection represents a novel antiviral host defense mechanism that may have important implications for the pathogenesis of HCV infection and may contribute to the elimination of virus-infected hepatocytes.