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Prevalence of historical and replacement brominated flame retardant chemicals in New York City homes

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Emerging Contaminants 2017年第1期3卷 32-39页

作者： Whitney J.Cowell Heather M.Stapleton Darrell Holmes Lehyla Calero catherine tobon Matthew Perzanowski Julie B.Herbstman Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Columbia Center for Children's Environmental Health Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Nicholas School of the Environment Duke UniversityDurhamNC 27708United States

Background:Until their phase-out between 2005 and 2013,polybrominated diphenyl ethers(PBDEs)were added to household products including furniture,rugs,and electronics to meet flammability *** brominated flame retardant(BFR)chemicals,including 2-ethylhexyl-2,3,4,5-tetrabromobenzoate(tBB)and bis(2-ethylhexyl)2,3,4,5-tetrabromophthalate(tBPH),which are components of the Firemaster 550®commercial mixture,are now being used to meet some flammability standards in *** objective of this analysis was to evaluate the extent to which mothers and their children living in New York City are exposed to PBDEs,tBB,and ***:We measured PBDEs,tBB,and tBPH using gas chromatography mass spectrometry in dust(n=25)and handwipe(n?11)samples collected between 2012 and 2013 from mothers and children living in New York *** defined dust as enriched if the proportional distribution for a given BFR exceeded two-thirds of the total BFR ***:We detected PBDEs and tBPH in 100%of dust and handwipe samples and tBB in 100%of dust samples and 95%of handwipe *** from approximately two-thirds of households was enriched for either PBDEs(n?9)or for tBB t tBPH(n=8).Overall,the median house dust concentration of tBB+tBPH(1318 ng/g dust)was higher than that of SPentaBDE(802 ng/g dust)and BDE-209(1171 ng/g dust).Children generally had higher BFR handwipe concentrations compared to mothers(SPentaBDE:73%,BDE-209:64%,tBB t tBPH:55%)and within households,BFR concentrations from paired maternalchild handwipes were highly *** mothers,we found a significant positive relation between house dust and handwipe BDE-209 and tBB t tBPH ***:PBDEs,tBB and tBPH are ubiquitous in house dust and handwipes in a sample of motherchild pairs residing in New York City.

关键词： Flame retardants PBDEs tBB tBPH Dust Handwipe Children

Mitochondria Dynamically transplant into Cells in Vitro and in Mice and Rescue Aerobic Respiration of Mitochondrial DNA-Depleted Motor Neuron NSC-34

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Journal of Biomedical Science and Engineering 2020年第9期13卷 203-221页

作者： Xian-Peng Jiang catherine C. Baucom Robert L. Elliott Sallie A. Burdine Breast Foundation Baton Rouge LA USA Elliott Mastology Center Baton Rouge LA USA

It has been reported that transplantation of pheochromocytoma P12 and hepatoma cells’ mitochondria improve the locomotive activity and prevent disease progress in experimental Parkinson’s disease rats. to prepare for mitochondrial transplantation study in human neurodegenerative diseases, we select human fibroblasts as mitochondrial donor because that fibroblasts share many characteristics with mesenchymal stromal cells (MSCs). We isolate human primary fibroblasts and develop a mitochondrial DNA (mtDNA)-depleted mouse motor neuron NSC-34 cells (NSC-34 ρ° cells). Fibroblast and NSC-34 cell’s mitochondria are co-cultured with NSC-34 ρ° cells. Mitochondrial transplantation is observed by fluorescent microscopy. Gene expression is determined by polymerase chain reaction (PCR) and real time PCR (qPCR). Also, mitochondria are injected to mice bearing mammary adenocarcinoma 4t1 cells. We find results as following: 1) there are abundant mitochondria in fibroblasts (337 ± 80 mitochondria per fibroblast). 42.4% of viable mitochondria are obtained by using differential centrifugation. the isolated mitochondria actively transplant into NSC-34 ρ° cells after co-culture. 2) Fibroblasts transfer mitochondria to human mammary adenocarcinoma MCF-7 cells. 3) there is no expression of HLA-I antigen in fibroblast’s mitochondria indicating they can be used for allogeneic mitochondrial transplantation without HLA antigen match. 4) PCR and qPCR show that NSC-34 ρ° cells lose mitochondrially encoded cytochrome c oxidase I (Mt-CO1) and mitochondrially encoded NADH dehydrogenase 1 (Mt-ND1) and upregulate expression of glycolysis-associated genes hexokinase (HK2), glucose transporter 1 (SLC2A1) and lactate dehydrogenase A (LDHA). 5) transplantation of NSC-34 mitochondria resto

关键词： Mitochondrial transplantation Motor Neuron Mitochondria Neurodegenerative Disease Mammary Adenocarcinoma Mitochondrial DNA Depletion Fibroblast HLA-I NSC-34 Cells

Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 t-cell killing

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Cellular & Molecular Immunology 2024年第4期21卷 362-373页

作者： Zeguang Wu Qiezhong Lamao Meichao Gu Xuanxuan Jin Ying Liu Feng tian Ying Yu Pengfei Yuan Shuaixin Gao thomas S.Fulford Adam P.Uldrich catherine C.L Wong Wensheng Wei Biomedical Pioneering Innovation Center Peking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking University100871BeijingChina EdiGene Inc. Life Science ParkChangping District102206BeijingChina Center for Precision Medicine Multi-Omics Research Peking University Health Science CenterPeking University100191BeijingChina Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity The University of MelbourneParkvilleVIC3010Australia Cancer Immunology Program Peter MacCallum Cancer CentreMelbourneVICAustralia State Key Laboratory for Complex Severe and Rare DiseasesClinical Research InstitutePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegePeking-Tsinghua Center for Life Sciences100871BeijingChina

Vγ9Vδ2 t cells are specialized effector cells that have gained prominence as immunotherapy agents due to their ability to target and kill cells with altered pyrophosphate *** our effort to understand how cancer cells evade the cell-killing activity of Vγ9Vδ2 t cells,we performed a comprehensive genome-scale CRISPR screening of cancer *** found that four molecules belonging to the butyrophilin(BtN)family,specifically BtN2A1,BtN3A1,BtN3A2,and BtN3A3,are critically important and play unique,nonoverlapping roles in facilitating the destruction of cancer cells by primary Vγ9Vδ2 t *** coordinated function of these BtN molecules was driven by synchronized gene expression,which was regulated by IFN-γsignaling and the RFX ***,an enzyme called QPCtL was shown to play a key role in modifying the N-terminal glutamine of these BtN proteins and was found to be a crucial factor in Vγ9Vδ2 t cell killing of cancer *** our research,we offer a detailed overview of the functional genomic mechanisms that underlie how cancer cells escape Vγ9Vδ2 t ***,our findings shed light on the importance of the harmonized expression and function of gene family members in modulating t-cell activity.

关键词： Butyrophilin Vγ9Vδ2 t-cell Cancer-specific immune evasion Glutaminyl-peptide cyclotransferase-like Pyrophosphate metabolite Immunotherapy

Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naive CD4^+ t cells

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Journal of Genetics and Genomics 2020年第3期47卷 171-174页

作者： Anne-Marie Madore Lucile Pain Anne-Marie Boucher-Lafleur Andréanne Morin Jolyane Meloche Marie-Michelle Simon Bing Ge tony Kwan Warren A.Cheung tomi Pastinen catherine Laprise Departement des sciences fondamentales Universite du Quebec a ChicoutimiSaguenayQuebecG7H 2B1Canada Department of Human Genetics McGill UniversityMontrealQuebecH3A 0C7Canada Department of Human Genetics University of ChicagoIL60637USA McGill University and Genome Quebec Innovation Centre MontrealQuebecH3A 0G1Canada Center for Pediatric Genomic Medicine Kansas CityMO64108USA Centre intersectoriel en sante durable Universite du Quebec a ChicoutimiSaguenayQuebecG7H 2B1Canada

the 17q12-21 locus harboring ORMDL sphingolipid biosynthesis regulator 3(ORMDL3)and Gasdermin B(GSDMB)genes exhibits one of the most significant and replicated associations with asthma[MIM:600807](Stein et al.,2018).Several studies explored the complex interactions between SNPs,gene expression and epigenetic modifications at this locus,primarily focusing on the levels of expressed ORMDL3 and GSDMB(Stein et al.,2018).Given that DNA methylation and gene expression signals are cell-type specific(Reinius et al.,2012),isolated materials such as lymphocytes from blood and,to a lesser extent,bronchial epithelial cells from biopsies of bronchi or bronchoalveolar lavages have been used in a number of studies to investigate such interactions(Stein et al.,2018).

关键词： FDR t cells Asthma-associated polymorphisms gene expression of GSDMA

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雨天使

英语角 2019年第5期 48-50页

作者： catherine 不详

Leona is a new rain angel in Heaven. She doesn't know how to make the clouds cry. So she goes to ask an old rain an gel."Well," says the old angel,"You should tell sad stories to the clouds to make them cry."

关键词： rain angel stories

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一只猫的愿望

英语角 2019年第11期 44-45页

作者： catherine 不详

Hello,I am ***'t get me wrong.I am not a kind of biscuit.I am a sensitive cat.I live on the street.I feel really ***,I meet *** often touches my body softly."How does it feel,daughter?""It's soft and smooth.I like Coo... 详细信息

关键词：一只猫愿望 Cookie

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七个兄弟

英语角 2019年第35期 44-45页

作者： catherine 不详

In the Week Kingdom,there live seven *** are Monday,tuesday,Wednesday,thursday,Friday,Saturday and *** of them works once a *** keep the kingdom's *** one day,Monday is *** is he?His brothers search everywhere for *** they find Monday sitting by the road *** looks sad."What's wrong?"his brothers *** cries,"I don't want to work *** don't like me.

关键词： alone brother keep

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从上下文判断动词词组的含义（英文）

疯狂英语（新悦读） 2017年第2期 14-16页

作者： catherine Neil

catherine: In this programme we’re looking at multi-word verbs like move in, move on, move out and get on, and we call these phrasal verbs. And prepositions like in, on, or out can completely change the meaning of phrasal ***: So we’ll be looking at these verbs in sentences to help us understand their ***: Let’s start by listening to Robin. He’s having problems with his housemate, *** here’s a question for you while you listen. Why is Robin unhappy with Pete?Robin: Pete moved in three months ago. We got on well at first—we were friends—but now it’s terrible. He’s so messy! And he keeps disturbing me when I’m trying to get on with my college work. It’s really time for us to move on—we can’t be friends anymore. I’m going to ask him to move out and live somewhere else, but he gets on with my family—my brother really likes him—so it’ll be difficult.

关键词：动词词组上下文 with this family while first the