Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naive CD4^+ T cells

作     者：Anne-Marie Madore Lucile Pain Anne-Marie Boucher-Lafleur Andréanne Morin Jolyane Meloche Marie-Michelle Simon Bing Ge Tony Kwan Warren A.Cheung Tomi Pastinen Catherine Laprise Anne-Marie Madore;Lucile Pain;Anne-Marie Boucher-Lafleur;Andréanne Morin;Jolyane Meloche;Marie-Michelle Simon;Bing Ge;Tony Kwan;Warren A.Cheung;Tomi Pastinen;Catherine Laprise

作者机构：Departement des sciences fondamentalesUniversite du Quebec a ChicoutimiSaguenayQuebecG7H 2B1Canada Department of Human GeneticsMcGill UniversityMontrealQuebecH3A 0C7Canada Department of Human GeneticsUniversity of ChicagoIL60637USA McGill University and Genome Quebec Innovation CentreMontrealQuebecH3A 0G1Canada Center for Pediatric Genomic MedicineKansas CityMO64108USA Centre intersectoriel en sante durableUniversite du Quebec a ChicoutimiSaguenayQuebecG7H 2B1Canada 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2020年第47卷第3期

页      面：171-174页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by operating grants from the Canadian Institute of Health Research(CIHR awards 133605 and 141900 Laprise&Pastinen) provided by the Wellcome Trust under award WT091310 

主　　题：FDR T cells Asthma-associated polymorphisms gene expression of GSDMA 

摘      要：The 17q12-21 locus harboring ORMDL sphingolipid biosynthesis regulator 3(ORMDL3)and Gasdermin B(GSDMB)genes exhibits one of the most significant and replicated associations with asthma[MIM:600807](Stein et al.,2018).Several studies explored the complex interactions between SNPs,gene expression and epigenetic modifications at this locus,primarily focusing on the levels of expressed ORMDL3 and GSDMB(Stein et al.,2018).Given that DNA methylation and gene expression signals are cell-type specific(Reinius et al.,2012),isolated materials such as lymphocytes from blood and,to a lesser extent,bronchial epithelial cells from biopsies of bronchi or bronchoalveolar lavages have been used in a number of studies to investigate such interactions(Stein et al.,2018).