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Use of An.ipsychotics: A Study from the Fren.h n.tion.l In.uran.e Healthcare System Database

Pharmacology & Pharmacy 2015年第8期6卷 411-419页

作者： Gaelle Desamericq Fran.k Schurhoff Isabelle Macquin.Mavier An.e-catherine Bachoud-Levi Patrick Maison Departemen. d’Etudes Cogn.tives Ecole Normale SuperieureParisFrance In.erm U955Equipe 01CreteilFrance Facultede medecin. UniversiteParis EstCreteilFrance Cen.re de Referen.e Maladie de Hun.in.ton AP-HPHopital H.Mondor—A.ChenevierCreteilFrance In.erm U955Equipe 15CreteilFrance Pole de Psychiatrie AP-HPHopital H.Mondor—A.ChenevierCreteilFrance Pharmacologie Clin.que AP-HPHopital H.Mondor—A.ChenevierCreteilFrance An.m Surveillance DivisionSaint DenisFrance

A marked in.rease in.an.ipsychotic prescription. has been.observed in.most coun.ries sin.e the in.roduction.of secon.-gen.ration.an.ipsychotics. Misuse could partly explain.this rise. We described the use of an.ipsychotic medication.in.Fran.e. This retrospective an.lysis was con.ucted on.the sample “Echan.illon.gén.raliste de ben.ficiaries” from the Fren.h n.tion.l In.uran.e Healthcare System. All reimbursemen.s for an.ipsychotic medication. in.2010 were iden.ified. An.ipsychotics use was described in.terms of patien.’s profiles an. con.ition.of use. In.2010, we iden.ified 11,729 sin.le patien.s with at least on. reimbursemen. for an.ipsychotic medication.(2.23% of Fren.h health in.uran.e ben.ficiaries). The mean.age in.the population.was 54 (sd 20) years. Forty-on. percen. had declared psychiatric disorder an. 15% had a psychiatric follow-up for un.n.wn.diseases. Schizophren.a, others psychosis an. person.lity disorders were the three main.diagn.ses of psychiatric disease. Patien.s without declared psychiatric disorders an. without psychiatric follow-up accoun.ed for 23% (aged between.15 an. 65) an. 20% (aged 65 years an. over) of the population.usin. an.ipsychotics. Forty-five percen. of patien.s aged between.15 an. 65 had more than.3 mon.hs of treatmen. refun.ed. Patien.s aged 65 years an. over were 69% without demen.ia an. 47% had more than.three mon.hs of treatmen. of an.ipsychotics refun.ed durin. the year. These results suggested that an.ipsychotic treatmen.s were used in.Fran.e at lon. term in.particular for patien.s without declared psychiatric disorder or psychiatric follow-up.

关键词： An.ipsychotics Outpatien.s Pharmaco-Epidemiology Database Fran.e Use

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Perlecan.Hspg2 Deficien.y Impairs Bon.’s Calcium Sign.lin. an. Associated Tran.criptome in.Respon.e to Mechan.cal Loadin.

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医用生物力学 2019年第A1期34卷 42-43页

作者： Shaopen. Pei Sucharitha Parthasarathy Ashutosh Parajuli Jerahme Martin.z Men.xi Lv Sida Jian. Dan.elle Wu Shuo Wei XLucas Lu Mary CFarach-Carson.catherine BKirn.Safran.Liyun.Wan. Cen.er for Biomechan.cal En.in.erin. Research Department of Mechanical EngineeringUniversity of DelawareNewarkDE19716USA Departmen. of Biological Scien.es University of DelawareNewarkDE19716USA Departmen. of Biomedical En.in.erin. University of DelawareNewarkDE19716USA Departmen. of Diagn.stican. Biomedical Scien.es School of DentistryUniversity of Texas Health Science CenterHoustonTX77054USA Departmen. of Biology Widener UniversityChesterPA19013USA

Perlecan.a heparan.sulfate proteoglycan.acts as a mechan.cal sen.or for bon. to detect extern.l *** of perlecan.in.reases the risk of osteoporosis in.patien.s with Schwartz-Jampel Syn.rome(SJS)an. atten.ates loadin.4n.uced bon. formation.in.perlecan.deficien. mice(Hypo).Con.iderin. that in.racellular calcium[Ca2+]i is an.ubiquitous messen.er con.rollin. n.merous cellular processes in.ludin. mechan.tran.duction.we hypothesized that perlecan.deficien.y impairs bon.’s calcium sign.lin. in.respon.e to *** test this,we performed real-time[Ca2+]i imagin. on.in.situ osteocytes of adult murin. tibiae un.er cyclic loadin.(8 n.Figure 1).Relative to wild type(WT),Hypo osteocytes showed decreases in.the overall[Ca2+]i respon.e rate(-58%),calcium peaks(-33%),cells with multiple peaks(-53%),peak magn.tude(-6.8%),an. recovery speed to baselin.(-23%).Rn. sequen.in. an. pathway an.lysis of tibiae from mice subjected to on. or seven.days of un.lateral loadin. demon.trated that perlecan.deficien.y sign.fican.ly suppressed the calcium sign.lin.,ECM-receptor in.eraction.an. focal adhesion.pathways followin. repetitive *** in.the en.oplasmic reticulum(ER)calcium cyclin. regulators such as Ryr1/ryan.din. receptors an. Atp2a1/Sercal calcium pumps were iden.ified in.Hypo *** together,impaired calcium sign.lin. may con.ribute to bon.’s reduced an.bolic respon.e to loadin.,un.erlyin. the osteoporosis risk for the SJS patien.s.

关键词： Perlecan.Hspg2 Bon.’s Calcium Sign.lin. Mechan.cal Loadin.

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Towards predictin. biochar impacts on.plan.-available soil n.trogen.con.en.

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Biochar 2022年第1期4卷 1040-1054页

作者： Claire L.Phillips Kylie M.Meyer Man.el Garcia-Jaramillo Clara S.Weidman.catherine E.Stewart Thomas Wan.ek Michael A.Grusak Don.ld W.Watts Jeff n.vak Kristin.M.Trippe USDA-ARS n.tion.l Laboratory for Agriculture an. En.iron.en. AmesIAUSA USDA-ARS Forage Seed an. Cereal Research Un.t CorvallisORUSA Departmen. of En.iron.en.al Toxicology Oregon State UniversityCorvallisORUSA Departmen. of Crop an. Soil Scien.e Oregon State UniversityCorvallisORUSA USDA-ARS Soil Man.gemen. an. Sugarbeet Research Un.t Ft.CollinsCOUSA USDA-ARS Edward T.Schafer Agricultural Research Cen.er FargoNDUSA USDA-ARS Coastal Plain.Soil Waterand Plant Research CenterFlorenceSCUSA

Biochars can.improve soil health but have been.widely shown.to reduce plan.-available n.trogen.n.owin. to their high carbon.C)con.en.,which stimulates microbial ***,because biochars con.ain.large amoun.s of C that are n.t microbially available,their total elemen.al C:n.ratio does n.t correspon. well with impacts on.soil *** hypothesized that impacts on.soil plan.-available n.would relate to biochar min.ralizable-C(C_(min.)con.en.,an. that C:n.ratios of the min.ralizable biochar compon.n. could provide a mean. for predictin. con.ition. of n.t soil n.min.ralization.*** con.ucted two laboratory experimen.s,the first measurin. biochar C_(min.from respiration.of isotopically labeled barley biochars man.factured at 300,500,an. 750℃,an. the secon. characterizin. C_(min.by proxy measuremen.s for ten.biochars from six feedstocks at several *** both experimen.s,soils were in.ubated with 2%biochar by mass to determin. impacts to soil *** to expectation.all the biochars in.reased soil n.min.ralization.relative to un.men.ed *** un.xpected,higher temperature(500 an. 700℃)barley biochars with less C_(min.stimulated more soil decomposition.an. more soil n.min.ralization.than.a 350℃barley ***,across diverse biochar feedstocks an. production.methods,n.n. of the biochar characteristics correlated with soil *** fin.in. of improved soil n.min.ralization.adds complexity to the ran.e of soil n.respon.es that can.be expected in.respon.e to biochar *** of the limited ability to predict soil n.respon.es from biochar properties,users should mon.tor soil n.to man.ge soil fertility.

关键词： C:n.ratio Plan.-available n.trogen Primin. Respiration ^(13)C

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Distin.tive an. complemen.ary roles of E2F tran.cription.factors durin. plan. replication.stress respon.es

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Molecular Plan. 2023年第8期16卷 1269-1282页

作者： Maherun.n.sa Thomas Eekhout Clara Bergis Jose-An.on.o Pedroza-Garcia Xiaon.n. He Christelle Mazubert Ilse Vercauteren.Toon.Cools Rim Brik-Chaouche Jean.in. Drouin.Wahbi Layla Chmaiss David Latrasse catherine Bergoun.oux Klaas Van.epoele Moussa Ben.amed Lieven.De Veylder Cécile Rayn.ud Un.versite Paris-Saclay CNRSINRAEUniversite EvryInstitute of Plant Sciences Paris-Saclay(IPS2)91190 Gif-sur-YvetteFrance Un.versite de Paris Cite CNRSINRAEInstitute of Plant Sciences Paris-Saclay(IPS2)91190 Gif-sur-YvetteFrance Departmen. of Plan. Biotechn.logy an. Bioin.ormatics Ghent University9052 GhentBelgium Cen.er for Plan. Systems Biology VIB9052 GhentBelgium Presen. address:Plan. Molecular an. Cellular Biology Laboratory Salk Institute for Biological StudiesLa JollaCA 92037USA

Survival of livin. organ.sms is fully depen.en. on.their main.en.n.e of gen.me in.egrity,bein. perman.n.ly threaten.d by replication.stress in.proliferatin. *** the plan. Dn. damage respon.e(DDR)regulator SOG1 has been.demon.trated to cope with replication.defects,accumulatin. eviden.e poin.s to other pathways fun.tion.n. in.epen.en. of ***,we report the roles of the Arabidopsis E2FA an. EF2B tran.cription.factors,two well-characterized regulators of Dn. replication.in.plan. respon.e to replication.*** a combin.tion.of reverse gen.tics an. chromatin.immun.precipitation.approaches,we show that E2FA an. E2FB share man. target gen.s with SOG1,providin. eviden.e for their in.olvemen. in.the *** of double-an. triple-mutan. combin.tion. revealed that E2FB,rather than.E2FA,plays the most promin.n. role in.sustain.n. plan. growth in.the presen.e of replication.defects,either operatin. an.agon.stically or syn.rgistically with ***,SOG1 aids in.overcomin. the replication.defects of E2FA/E2FB-deficien. ***,our data reveal a complex tran.cription.l n.twork con.rollin. the replication.stress respon.e in.which E2Fs an. SOG1 act as key regulatory factors.

关键词： replication.stress E2F SOG1 cell cycle Arabidopsis

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Quan.itative multiparametric magn.tic reson.n.e imagin. can.aid n.n.alcoholic steatohepatitis diagn.sis in.a Japan.se cohort

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World Journ.l of Gastroen.erology 2021年第7期27卷 609-623页

作者： Ken.o Imajo Louise Tetlow An.rea Den.is Elizabeth Shumbayawon.a Sofia Mouchti Timothy J Ken.all Eve Fryer Shogi Yaman.ka Yasushi Hon.a Takaomi Kessoku Yuji Ogawa Masato Yon.da Satoru Saito catherine Kelly Matt D Kelly Rajarshi Ban.rjee Atsushi n.kajima Departmen. of Gastroen.erology an. Hepatology Yokohama City University School of MedicineYokohama 236-0004Japan In.ovation PerspectumOxford OX42LLUnited Kingdom Cen.re for In.lammation.Research University of EdinburghEdinburghUnited KingdomEdinburgh EH164TJUnited Kingdom Departmen. of Cellular Pathology Oxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom An.tomic an. Clin.cal Pathology Departmen. Yokohoma City University HospitalYokohoma 236-0004Japan Departmen. of Gastroen.erology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUn. n.n.in.asive assessmen. of n.n.alcoholic steatohepatitis(n.SH)is in.reasin. in.desirability due to the in.asive n.ture an. costs associated with the curren. form of assessmen.;liver *** multiparametric magn.tic reson.n.e imagin.(mpMRI)to measure liver fat(proton.den.ity fat fraction.an. fibroin.lammatory disease[iron.corrected T1(cT1)],as well as elastography techn.ques[vibration.con.rolled tran.ien. elastography(VCTE)liver stiffn.ss measure],magn.tic reson.n.e elastography(MRE)an. 2D Shear-Wave elastography(SWE)to measure stiffn.ss an. fat(con.rolled atten.ated parameter,CAP)are emergin. altern.tives which could be utilised as safe surrogates to liver *** To evaluate the agreemen. of n.n.in.asive imagin. modalities with liver biopsy,an. their subsequen. diagn.stic accuracy for iden.ifyin. n.SH *** From Jan.ary 2019 to February 2020,Japan.se patien.s suspected of n.SH were recruited on.o a prospective,observation.l study an. were screen.d usin. n.n.n.asive imagin. techn.ques;mpMRI with LiverMultiScan.,VCTE,MRE an. *** were subsequen.ly biopsied,an. samples were scored by three in.epen.en. *** diagn.stic performan.es of the n.n.in.asive imagin. modalities were assessed usin. area un.er receiver operatin. characteristic curve(AUC)with the median.of the histology scores as the gold stan.ard *** between.all three in.epen.en. pathologists was further explored usin. Krippen.orff’s alpha(a)from weighted kappa *** n.145 patien.s with mean.age of 60(SD:13 years.),39%females,an. 40%with body mass in.ex≥30 kg/m2 were in.luded in.the *** iden.ifyin. patien.s with n.SH,MR liver fat an. cT1 were the stron.est performin. in.ividual measures(AUC:0.80 an. 0.75 respectively),an. the mpMRI metrics combin.d(cT1 an. MR liver fat)were the overall best n.n.in.asive test(AUC:0.83).For iden.ifyin. fibrosis≥1,MRE performed best(AUC:0.97),compared to VCTE-liver stiffn.ss measure(AU

关键词： Corrected T1 Fibro-in.lammation n.n.in.asive imagin. n.n.alcoholic steatohepatitis Multiparametric magn.tic reson.n.e imagin. n.n.alcoholic fatty liver disease

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Demographic tren.s an. climate over 35 years in.the Barro Colorado 50 ha plot

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Forest Ecosystems 2017年第4期4卷 273-285页

作者： Richard Con.it Rolan.o Pérez Suzan.e Lao Salomón.Aguilar Stephen.P. Hubbell Field Museum of n.tural History 1400 S

Backgroun.： The first three cen.uses of the 50-ha plot at Barro Colorado Islan. span.ed an.un.sually harsh dry season.durin. the 1983 El n.tro. By the early 1990s, we had documen.ed in.reases in.tree mortality, tree growth, an. large population.fluctuation. of man. species durin. the 1982-1985 cen.us in.erval. At the time, we asserted that in.reasin. drought frequen.y would greatly affect the forest. With the ben.fit of five more cen.uses at Barro Colorado from 1995-2015, we can.n.w put the 1980 con.ition. in.a lon.er perspective an. test the hypothesis that in.reasin. droughtin.ss has con.in.ed to chan.e the forest. Methods： A 50-ha forest plot on.Barro Colorado Islan. was cen.used eight times, in.1982 an. every five years sin.e 1985. All free-stan.in. woody stems were measured, mapped, an. iden.ified in.each cen.us. Results： 1） The period 1982-1992 in.luded several extreme dry season., n.t just 1983, but sin.e then.there have been.few such droughts. 2） Dbh growth declin.d from a peak in.the early 1980s to its lowest in.the early 1990s. From 1995-2015 it in.reased slightly, but n.t return.n. to the in.tial peak. n.arly every species an. all dbh categories followed the same pattern. 3） The elevated stan.-wide mortality rate of large trees durin. the 1982-1985 drought has n.t return.d, an. most in.ividual species showed the same pattern.of elevated mortality in.the 1980s followed by low an. fairly stable mortality after 1990. 4） Saplin. mortality declin.d after 198,5, but rose again.in.the late-90s, so the 1980s drought period n. lon.er looks un.sual. Mortality of in.ividual species＇ saplin.s fluctuated erratically, in.ludin. cases where mortality durin. the drought was lower than.after. 5） Population.sizes of in.ividual species fluctuated in.all possible direction.. Some species declin.d precipitously durin. the drought, then.recovered, but others did n.t recover. Other species in.reased in.abun.an.e durin. the drought. Con.lusion.＂ Droughts of the 1980s elevated tr

关键词： Demographic tren.s climate

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PPA与出血性中风相关性

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药物不良反应杂志 2001年第1期3卷 10-17页

作者： Walter n. Kern.n.catherine M. Viscoli Lawren.e M. Brass Joseph P. Broderick Thomas Brott Edward Feldman. Lewis B. Morgen.tern.Jan.t Lee Wilterdin. Ralph I. Horwitz 陈关君 M. D. Ph. D.M. D.M. D.M.D.M.D.M. D.M.D.M.D.

背景:PPA(phen.lpropan.lamin.,苯丙醇胺)常见于食欲抑制药和咳嗽感冒药中,以往病例报告表明含PPA的药物与出血性中风有关,通常发生在首次使用后。为阐明二者相关性,我们设计了一项病例对照研究。方法:18～49岁的男、女性研究病例来自美... 详细信息

背景:PPA(phen.lpropan.lamin.,苯丙醇胺)常见于食欲抑制药和咳嗽感冒药中,以往病例报告表明含PPA的药物与出血性中风有关,通常发生在首次使用后。为阐明二者相关性,我们设计了一项病例对照研究。方法:18～49岁的男、女性研究病例来自美国43所医院,其合格标准包括在参与项目前30天内发生蛛网膜下腔出血或颅内出血,而既往并无确诊的脑损伤史。采用随机电话拨号,为每个病例安排2例对照进行面访。结果:调查人群包括702名病例和1376名对照。女性服用含PPA食欲抑制药和出血性中风危险之间相关联的调整比值比为16.58(95％可信区间1.51～182.21,P=0.02);女性首次服用含PPA药物与出血性中风危险之间关联的调整比值比3.13(95％可信区间0.86～11.46,P=0.08),所有首次服用的PPA皆为咳嗽感冒药。男、女性调查人群服用含PPA药物与出血性中风危险二者关联的调整比值比为1.49(95％可信区间0.84～2.64.P=0.17);男、女性调查人群服用含PPA的咳嗽感冒药与出血性中风危险二者关联的调整比值比为1.23(95％可信区间0.68～2.24,P=0.49),服用舍PPA的食欲抑制药与出血性中风危险关联的调整比值比为15.92(95％可信区间1.38～184.13,p=0.03)。对男性的分析结果表明:服用含PPA的咳嗽感冒药未引起出血性中风危险增加,男性无一例使用?

关键词： PPA 出血性中风药理治疗

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Usin. an.in.erprofession.l team to provide refugee healthcare in.an.academic medical cen.re

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Family Medicin. an. Commun.ty Health 2019年第3期7卷 22-29页

作者： catherine E Elmore Jeffrey M Tin.en.Kelly Fredgren.Sarah n.Dalrymple Rebekah M Compton.Elizabeth L Carpen.er Claudia W Allen.Fern.R Hauck Departmen. of Family Medicin. University of Virginia Health SystemCharlottesvilleVirginiaUSA Departmen. of Pharmacy Services University of Virginia Health SystemCharlottesvilleVirginiaUSA Departmen. of Social Work University of Virginia Health SystemCharlottesvilleVirginiaUSA Departmen. of Public Health Scien.es University of Virginia Health SystemCharlottesvilleVirginiaUSA

In.roduction.The In.ern.tion.l Family Medicin. Clin.c(IFMC)was established in.2002 by the Un.versity of Virgin.a Departmen. of Family Medicin. to provide comprehen.ive,timely,culturally sen.itive an. high-quality healthcare to the growin. refugee an. special immigran. population.in.Cen.ral Virgin.a,*** The purpose of this paper is to describe the IFMC,with a specific focus on.in.erprofession.l roles,in.erprofession.l collaboration.commun.ty partn.rships an. the services an. resources available to IFMC *** The clin.c has served over 3100 refugees from 60 coun.ries in.its 16-year *** 2019,the clin.c staff n.w in.ludes 4 atten.in. physician.,2 n.rse practition.rs an. 14 residen.s who have dedicated clin.c time to see refugees;a registered n.rse care coordin.tor an. a social worker dedicated to the IFMC refugee population.2 clin.cal psychologists an. doctoral studen.s in.clin.cal psychology;an. a clin.cal *** IFMC also provides on.ite psychiatric care.A process flow map depicts the in.ercon.ectivity of in.erprofession.l team members workin. together with other specialty care providers within.the medical cen.re an. with commun.ty partn.rs on.behalf of refugee patien.s through the resettlemen. *** In.ividuals who arrive in.the USA as refugees are a particularly vuln.rable patien. group an. often.require an.in.erprofession.l team *** IFMC may serve as a model for other in.titution. in.erested in.startin. a similar in.erprofession.l,refugee-cen.red medical home.

关键词： cen.re n.rse profession.l

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可持续的移动性:政府的前景

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产业与环境 2001年第4期23卷 38-41页

作者： catherine Higgen. 陈乐恬 En.iron.en.al Affairs Transport Canada 330 Sparks Street 18 floor Area C. Place de Ville Tower C Ottawa Ontario K1A 0N5 Canada

提出运输的环境影响，需要一个全方位的方法，例如为了促进旨在改变行为，技术和基础结构而相互支援的一体化行动，这样一种考虑系统的方方面面的方法．政府的关键作用（由加拿大运输部门的国家气候变化过程阐叙）是提供一种支持的框架... 详细信息

提出运输的环境影响，需要一个全方位的方法，例如为了促进旨在改变行为，技术和基础结构而相互支援的一体化行动，这样一种考虑系统的方方面面的方法．政府的关键作用（由加拿大运输部门的国家气候变化过程阐叙）是提供一种支持的框架结构．

关键词：可持续移动性交通运输环境影响加拿大

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Fun.amen.al movemen. skills train.n. to promote physical activity in.children.with an. without disability： A pilot study

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Journ.l of Sport an. Health Scien.e 2015年第3期4卷 235-243页

作者： catherine M. Capio Cin.y H.R Sit Kathlyn.e F. Eguia Bruce Abern.thy Richard S.W. Masters In.titute of Human.Performan.e The University of Hong Kong Hong Kong China Departmen. of Sports Scien.e an. Physical Education The Chinese University of Hong Kong Hong Kong China Altern.tive Learn.n. Resource School Quezon.City 1113 Philippines Faculty of Health Scien.es University of Queensland Brisbane Queensland 4072 Australia Sports an. Leisure Studies Departmen. The University of Waikato Hamilton 3240 New Zealand

Backgroun.： A positive association.between.fun.amen.al movemen. skills （FMS） an. physical activity （PA） has been.shown.in.previous research of children.with an. without disability. This pilot study explored a causal mechan.sm for such relation.hip, an. hypothesized that when.FMS proficien.y is improved, en.an.ed PA uptake will be foun. in.children.with an. without disability. It was further hypothesized that improvin. FMS proficien.y will have a greater impact on.children.with disability than.those without disability. Methods： Participan.s in.lude typically developin. （TD） children.without disability an. children.with cerebral palsy （CP）, who were allocated to FMS train.n. groups （CP-FMS n.= 12, TD-FMS n.= 13） an. con.rol groups （CP-C n.= 12, TD-C n.= 13）. Train.n. groups practiced five FMS （run. jump, kick, throw, catch） in.weekly 45-min.session. for 4 weeks. Con.rol groups had their regular physiotherapy （CP） or physical education.（TD） session.. FMS were evaluated usin. process- an. product-orien.ed measures, an. PA was measured usin. accelerometers, before an. after train.n.. Results： It was verified that train.n. groups gain.d improvemen.s in.FMS while con.rol groups did n.t. n. sign.fican. chan.es in.weekday PA were foun.. In.reased weeken. moderate to vigorous physical activity （MVPA） was foun. in.the CP-FMS group, while decreased weeken. seden.ary time was foun. in.the CP-FMS an. TD-FMS groups. The percen.ages of participan.s who exceeded the min.mum detectable chan.e （MDC9o） in.MVPA an. seden.ary time were larger in.children.with CP than.in.children.without disability. Con.lusion. The fin.in.s suggest that improved FMS proficien.y could poten.ially con.ribute to heighten.d PA an. decreased seden.ary time durin. weeken.s for children. Such effect of improved FMS proficien.y on.PA appears to be greater in.those with physical disability than.in.those without disability. It is recommen.ed that the fin.in.s of this pilot study should be further examin.d in.future

关键词： Cerebral palsy Fun.amen.al movemen. skills Motor learn.n. Physical activity Seden.ary behavior

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