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Diagnostic delay in inflammatory bowel diseases in a German population

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World Journal of Gastroenterology 2024年第29期30卷 3465-3478页

作者： Elisabeth blüthner Annalena Dehe carsten büning britta Siegmund Matthias Prager Jochen Maul Alexander Krannich Jan Preiß bertram Wiedenmann Florian Rieder Raneem Khedraki Frank Tacke Andreas Sturm Anja Schirbel Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Vivantes Klinikum im FriedrichshainBerlin 10249Germany Department of Internal Medicine Krankenhaus WaldfriedeBerlin 14163Germany Department of Gastroenterology Infectious Diseases and RheumatologyCharité-Universitätsmedizin BerlinBerlin 12203Germany Praxis für Gastroenterologie berlin Zehlendorf Berlin 14195Germany Gastroenterologie am bayrischen Platz Berlin 10825Germany Clinical Trial Office Charité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Diabetology and HepatologyVivantes Klinikum NeuköllnBerlin 10117Germany Department of Gastroenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine DRK Kliniken Berlin WestendBerlin 14050Germany Gastroenterologie im Havelland Straße der EinheitFalkensee 14612Germany

bACKGROUND Early diagnosis is key to prevent bowel damage in inflammatory bowel disease(IbD).Risk factor analyses linked with delayed diagnosis in European IbD patients are scarce and no data in German IbD patients *** To identify risk factors leading to prolonged diagnostic time in a German IbD *** between 2012 and 2022,430 IbD patients from four berlin hospitals were enrolled in a prospective study and asked to complete a 16-item questionnaire to determine features of the path leading to IbD *** diagnostic time was defined as the time from symptom onset to consulting a physician(patient waiting time)and from first consultation to IbD diagnosis(physician diagnostic time).Univariate and multivariate analyses were performed to identify risk factors for each time *** The total diagnostic time was significantly longer in Crohn’s disease(CD)compared to ulcerative colitis(UC)patients(12.0 vs 4.0 mo;Pning the diagnostic delay for a better outcome in these patients.

关键词： Diagnostic time Diagnostic delay Crohn’s disease Ulcerative colitis Germany

Impact of pain on health-related quality of life in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2010年第25期16卷 3168-3177页

作者： Anja Schirbel Anne Reichert Stephanie Roll Daniel C baumgart carsten büning bianca Wittig bertram Wiedenmann Axel Dignass Andreas Sturm Division of Gastroenterology and Hepatology Department of Medicine Charité-Campus Virchow Clinic Universittsmedizin Berlin 13353 Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Campus Mitte Charité-Universittsmedizin Berlin 10117 Berlin Germany Division of Gastroenterology Hepatology and Endocrinology Campus Mitte Charité-Universittsmedizin Berlin 10117 Berlin Germany Division of Gastroenterology Infectiology and Rheumatology Department of Medicine Charité-Campus Benjamin Franklin Universittsmedizin Berlin 12203 Berlin Germany Department of Medicine I Markus-Hospital Wilhelm-Epstein-Str. 4. 60431 Frankfurt/Main Germany

AIM: To evaluate intensity, localization and cofactors of pain in Crohn’s disease and ulcerative colitis patients in connection with health-related quality of life (HRQOL) and disease activity. METHODS: We reviewed and analyzed the responses of 334 patients to a specifically designed questionnairebased on the short inflammatory bowel disease questionnaire (SIbDQ) and the German pain questionnaire. Pain intensity, HRQOL, Crohn’s disease activity index (CDAI) and colitis activity index (CAI) were correlated and verified on a visual analog scale (VAS). RESULTS: 87.9% of patients reported pain. Females and males reported comparable pain intensities and HRQOL. Surgery reduced pain in both genders (P = 0.023), whereas HRQOL only improved in females. Interestingly, patients on analgesics reported more pain (P = 0.003) and lower HRQOL (P = 0.039) than patients not on analgesics. A significant correlation was found in UC patients between pain intensity and HRQOL (P = 0.023) and CAI (P = 0.027), and in CD patients between HRQOL and CDAI (P = 0.0001), but not between pain intensity and CDAI (P = 0.35). No correlation was found between patients with low CDAI scores and pain intensity. CONCLUSION: Most IbD patients suffer from pain and have decreased HRQOL. Our study reinforces the need for effective individualized pain therapy in IbD patients.

关键词： Disease activity index Health-related quality of life Inflammatory bowel disease Pain

NOD2/CARD15 gene polymorphism in patients with inflammatory bowel disease: Is Hungary different?

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World Journal of Gastroenterology 2005年第3期11卷 407-411页

作者： carsten büning Tomas Molnar Ferenc Nagy Janos Lonovics Renita Weltrich bettina bochow Janine Genschel Hartmut Schmidt Herbert Lochs Department of Gastroenterology Department of Medicine

AIM: To analyse the impact of NOD2/CARD15 mutations on the clinical course of Crohn 's disease patients from an eastern European country (Hungary). METHODS: We investigated the prevalence of the three common NOD2/CARD15 mutations (Arg702Trp, Gly908Arg, 1007finsC) in 148 patients with Crohn's disease, 128 patients with ulcerative colitis and 208 controls recruited from the University of Szeged, Hungary. In patients with Crohn 's disease, the prevalence of NOD2/CARD15 mutations was correlated to the demographical and clinical parameters. RESULTS: In total, 32.4% of Crohn's disease patients carried at least one mutant allele within NOD2/CARD15 compared to 13.2% of patients with ulcerative colitis (P = 0.0002) and to 11.5% of controls (Pbehaviour (P= 0.008). Furthermore, 51.9% of patients positive for the 1007finsC mutation underwent a surgical resection within the ileum compared to only 17.4% of patients without the 1007finsC mutation (P = 0.001). With respect to the other two mutations (Arg702Trp and Gly908Arg), no associations were found with all investigated clinical parameters. CONCLUSION: NOD2/CARD15 mutations are frequently found in Crohn's disease patients from Hungary. The 1007finsC mutation is associated with stenotic disease behaviour and frequent ileal resections.

关键词： Crohn's disease NOD2/CARD15 gene Mutation

Chlorination of para-substituted phenols:Formation of α, β-unsaturated C4-dialdehydes and C4-dicarboxylic acids

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Journal of Environmental Sciences 2022年第7期34卷 197-208页

作者： Zhuoyue Zhang carsten Prasse Department of Environmental Health and Engineering Johns Hopkins UniversityBaltimoreMD 21218USA

Despite the widespread occurrence of phenols in anthropogenic and natural compounds, their fate in reactions with hypochlorous acid(HOCl), one of the most common water treatment disinfectants, remains incompletely understood. To close this knowledge gap, this study investigated the formation of disinfection by-products(DbPs) in the reaction of free chlorine with seven para-substituted phenols. based on the chemical structures of the DbPs and the reaction mechanisms leading to their formation, the DbPs were categorized into four groups: chlorophenols, coupling products, substituent reaction products, and ring cleavage products. In contrast to previous studies that investigated the formation of earlystage chlorophenols, the primary focus of this study was on the elucidation of novel ring cleavage products, in particular α, β-unsaturated C-dialdehydes, and C-dicarboxylic acids, which, for the first time, were identified and quantified in this study. The molar yields of 2-butene-1,4-dial(bDA), one of the identified α, β-unsaturated C-dialdehydes, varied among the different phenolic compounds, reaching a maximum value of 10.4% for bisphenol S. Molar yields of 2-chloromaleic acid(Cl-MA), one of the identified C-dicarboxylic acids, reached a maximum value of 30.5% for 4-hydroxy-phenylacetic acid under given conditions. 2,4,6-trichlorophenol(TCP) was shown to be an important intermediate of the parent phenols and the C-ring cleavage products. based on the temporal trends of α, β-unsaturated C-dialdehydes and C-dicarboxylic acids, their formation is likely attributable to two separate ring cleavage pathways. based on the obtained results, an overall transformation pathway for the reaction of para-substituted phenols with free chlorine leading to the formation of novel Cring cleavage products was proposed.

关键词： High-resolution mass spectrometry Ring cleavage products Quantification Transformation pathways Mass balance

Performance characteristics of the airlift pump under vertical solid-water-gas flow conditions for conveying centimetric-sized coal particles

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International Journal of Coal Science & Technology 2024年第2期11卷 53-66页

作者： Parviz Enany carsten Drebenshtedt Faculty of Mining and Special Civil Engineering Technische Universitat BergakademieGustav-Zeuner StraBe 1A09599FreibergGermany

In this study,the installation of an airlift pump with inner diameter of 102 mm and length of 5.64 m was utilized to consider the conveying process of non-spherical coal particles with density of 1340 kg/m3 and graining 25-44.5 *** test results revealed that the magnitude of increase in the solid transport rate due to the changes in the three tested parameters between compressed air velocity,submergence ratio,and feeding coal possibility was not the same,which are stand in range of 20%,75%,and 40%,***,creating the optimal airlift pump performance is highly dependent on submergence *** importantly,we measured the solid volume fraction using the method of one-way valves in order to minimize the disadvantages of conventional devices,such as fast speed camera and conductivity ring *** results confirmed that the volume fraction of the solid phase in the transfer process was always less than 12%.To validate present experimental data,the existing empirical correlations together with the theoretical equations related to the multiphase flow was *** overall agreement between the theory and experimental solid delivery results was particularly good instead of the first stage of conveying *** drawback can be corrected by omitting the role of friction and shear stress at low air income *** was also found that the model developed by Kalenik failed to predict the performance of our airlift operation in terms of the mass flow rate of the coal particles.

关键词： Vertical velocity Non-spherical particle Submergence ratio Three-phase flow Churn flow Superficial velocity

HOW TO PROVE THE DISCRETE RELIAbILITY FOR NONCONFORMING FINITE ELEMENT METHODS

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Journal of Computational Mathematics 2020年第1期38卷 142-175页

作者： carsten carstensen Sophie Puttkammer Department of Mathematics Humboldt-Universitat zu BerlinUnter den Linden 610099 BerlinGermany

Optimal convergence rates of adaptive finite element methods are well understood in terms of the axioms of *** key ingredient is the discrete reliability of a residualbased a posteriori error estimator,which controls the error of two discrete finite element solutions based on two nested *** the error analysis of nonconforming finite element methods,like the Crouzeix-Raviart or Morley finite element schemes,the difference of the piecewise derivatives of discontinuous approximations to the distributional gradients of global Sobolev functions plays a dominant role and is the object of this *** nonconforming interpolation operator,which comes natural with the definition of the aforementioned nonconforming finite element in the sense of Ciarlet,allows for stability and approximation properties that enable direct proofs of the reliability for the residual that monitors the equilibrium *** novel approach of this paper is the suggestion of a right-inverse of this interpolation operator in conforming piecewise polynomials to design a nonconforming approximation of a given coarse-grid approximation on a refined *** results of this paper allow for simple proofs of the discrete reliability in any space dimension and multiply connected domains on general shape-regular triangulations beyond newest-vertex bisection of *** attention is on optimal constants in some standard discrete estimates listed in the appendices.

关键词： Discrete reliability Nonconforming finite element method Conforming companion Morley Crouzeix-Raviart Explicit constants Axioms of adaptivity

Assessing geological uncertainty of a cement raw material deposit,southern Vietnam,based on hierarchical simulation

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International Journal of Mining Science and Technology 2020年第6期30卷 819-837页

作者： Trong Vu carsten Drebenstedt Tran bao TU bergakademie Freiberg 09599 FreibergGermany Hanoi University of Mining and Geology Hanoi 10000Viet Nam

Resource modeling plays a crucial role in raw material quality management for cement *** has shown that geological uncertainty in resource modeling is inevitable and results in risk to future extraction planning and operations of the cement *** study aims to assess the geological uncertainty and associated risk in modeling a cement raw material deposit in southern *** this deposit,soil,clay,laterite,and limestone are the four primary rock types,controlling the occurrence and spatial distribution of chemical *** this study,hierarchical simulation method was used to evaluate the *** types were first simulated,and the chemical grades conditioning to the rock types were then *** results demonstrated the capability of the hierarchical simulation approach to incorporate the uncertainty of rock types in resource modeling and to allow evaluating the risks in providing the desired raw material for the cement plant in the form of grade-tonnage curves.

关键词： Cement raw material Geological uncertainty Rock types Grades Hierarchical simulation

Preparation of hydrogels with uniform and gradient chemical structures using dialdehyde cellulose and diamine by aerating ammonia gas

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Frontiers of Chemical Science and Engineering 2018年第3期12卷 383-389页

作者： Peiwen Liu carsten Mai Kai Zhang Wood Technology and Wood Chemistry Georg-August-Universitat Gottingen 37077 Gottingen Germany Wood biology and Wood Products Georg-August-Universitat Gottingen 37077 Gottingen Germany

Hydrogels with precisely designed structures represent promising materials with a broad application spectrum, such as for sensor, tissue engineering and biomimetic technology. However, with highly reactive compounds, the preparation of hydrogels still needs an efficient approach for desired distribution of each component within hydrogels. In addition, a method for in situ preparation of gradient hydrogels is still lacking. Herein, we report the formation ofhydrogels with either uniform or gradient internal structures via a novel, simple but very efficient method by aerating ammonia gas （NH3 gas） into the solution of dialdehyde cellulose （DAC） and a diamine. As-prepared hydrogels exhibited uniform microscopic and chemical structure or gradient distribution Of functional groups. Due to lots of aldehyde groups on DAC chains, functional hydrogels can be prepared by using diverse diamines. For instance, hydrogels prepared by using 1,6-hexanediamine as a cross-linker were responsive to pH values. Moreover, this controllable process of aerating NH3 gas allows the in situ formation of gradient hydrogels; for instance, by using cyanamide as a reaction counterpart, gradient hydrogels with gradient distributions of cyanide groups were prepared.

关键词： hydrogel uniform gradient dialdehyde cellulose ammonia gas diamine

Influence of secondary phases of AlSi9Cu3 alloy on the plasma electrolytic oxidation coating formation process

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Journal of Materials Science & Technology 2020年第15期47卷 75-85页

作者： Ting Wu carsten blawert Mikhail LZheludkevich MagIC-Magnesium Innovation Centre Helmholtz-Zentrum Geesthacht21502 GeesthachtGermany Institute of Materials Science Faculty of EngineeringKiel UniversityKaiserstrasse 224143 KielGermany

To understand the formation and growth of plasma electrolytic oxidation(PEO) coatings in presence of different secondary phases in a substrate,PEO treatment was carried out on AlSi9 Cu3 alloy at different treatment times ranging from 15 s to 480 *** coating formation and evolution process was traced by surface and cross-sectional observation of the layers on the different phases of the *** results demonstrated a sequential involvement of the different phases in the plasma discharges:firstly,discharges start on the α-Al matrix,then on the intermetallic Al2 Cu and β-Al5 FeSi phases at the same time and finally on the eutectic *** presence of intermetallic Al2 Cu remarkably affects the initial dissolution,the deposition of conversion products and the ignition of discharges at the early stages of *** Si in the substrate exhibits the highest electrochemical stability at all stages and contributes in the beginning to a distinct coating morphology *** resultant PEO coating tends to be uniform if processing times are longer and a double-layer structure appears in the coating.

关键词： Plasma electrolytic oxidation Aluminum alloy Secondary phases