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Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet

World Journal of Gastroenterology 2024年第11期30卷 1545-1555页

作者： Juan Pablo Stefanolo Verónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla María Paz Temprano Sonia Isabel Niveloni Gabriel de Diego María E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verdú carolina sousa Julio César Bai Small Bowel Section Department of MedicineGastroenterology Hospital of Buenos Aires“Dr.C.Bonorino Udaondo”Buenos Aires 1264Argentina Department of Microbiology and Parasitology Faculty of PharmacyUniversity of SevilleSeville 41080Spain Department of Medicine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Basic and Applied Research Group in Immunology and Bioactives(GIBAIB) Institute of Ecology and Sustainable Development(INEDES)National University of LujanLuján 6700Buenos AiresArgentina Department of Medicine Farncombe Family Digestive Health Research InstituteMcMaster UniversityHamilton L8S 4L8OntarioCanada Facultad de Medicina Universidad del SalvadorBuenos Aires C1051ABBArgentina

BACKGROUND The gluten-free diet(GFD)has limitations,and there is intense research in the development of adjuvant *** To examine the effects of orally administered Aspergillus niger prolyl endopeptidase protease(AN-PEP)on inadvertent gluten exposure and symptom prevention in adult celiac disease(CeD)patients following their usual *** This was an exploratory,double-blind,randomized,placebo-controlled trial that enrolled CeD patients on a long-term *** a 4-wk run-in period,patients were randomized to 4 wk of two AN-PEP capsules(GliadinX;AVI Research,LLC,United States)at each of three meals per day or *** endpoints were:(1)Average weekly stool gluten immunogenic peptides(GIP)between the run-in and end of treatments and between AN-PEP and placebo;(2)celiac symptom index(CSI);(3)CeD-specific serology;and(4)quality of *** samples were collected for GIP testing by ELISA every Tuesday and Friday during run-ins and *** Forty patients were randomized for the intention-to-treat analysis,and three were excluded from the per-protocol ***,628/640(98.1%)stool samples were *** was undetectable(0.32μg/g)to potentially cause mucosal *** GIP concentration in the AN-PEP arm was 44.7%lower than in the run-in ***-third of patients exhibiting GIP>0.08μg/g during run-in had lower or undetectable GIP after AN-PEP *** with the run-in period,the proportion of symptomatic patients(CSI>38)in the AN-PEP arm was significantly lower(P<0.03).AN-PEP did not result in changes in specific *** This exploratory study conducted in a real-life setting revealed high adherence to the *** AN-PEP treatment did not significantly reduce the overall GIP stool ***,given the observation of a significantly lower prevale

关键词： Celiac disease Aspergillus niger prolyl endoprotease Gluten immunogenic peptides Trial Symptoms Real-life trial

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Determination of gluten immunogenic peptides for the management of the treatment adherence of celiac disease: A systematic review

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World Journal of Gastroenterology 2021年第37期27卷 6306-6321页

作者： Laura Coto Irati Mendia carolina sousa Julio César Bai Angel Cebolla Research and Development BiomedalCamas 41900SevilleSpain Human Nutrition and Food Science Doctoral Program University of GranadaGranada 18011Spain Molecular Biology Biomedicine and Clinical Research Doctoral ProgramUniversity of SevilleSeville 41012Spain Department of Microbiology and Parasitology University of SevilleSeville 41013Spain Department of Gastroenterology Dr.Carlos Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Research Institutes Universidad del SalvadorBuenos Aires 1050Argentina

BACKGROUND Gluten is a complex mixture of proteins with immunogenic peptide sequences triggering the autoimmune activity in patients with celiac disease(CeD).Gluten immunogenic peptides(GIP)are resistant to gastrointestinal digestion and are then excreted via the stool and *** common detection methods applied in the follow-up visits for CeD patients such as serology tests,dietetic interviews,questionnaires,and duodenal biopsy have been proved to be inefficient,invasive,or inaccurate for evaluating gluten-free diet(GFD)*** of excreted GIP in stool and urine has been developed as a non-invasive,direct,and specific test for GFD *** To summarize published literature about the clinical utility of GIP determination in comparison to the tools employed for GFD *** PubMed and Web of Science searches were performed using the keywords“gluten immunogenic peptides”or“gluten immunogenic peptide”and a combination of the previous terms with“feces”,“stools”,“urine”,“celiac disease”,“gluten-free diet”,and“adherence”to identify relevant clinical studies published in English and Spanish between 2012 to January *** lists from the articles were reviewed to identify additional pertinent *** articles and abstracts reporting the clinical use of GIP determination in stool and/or urine for the follow-up of patients with CeD in comparison with other tools in use were *** reports,commentaries,reviews,conference papers,letters,and publications that did not focus on the aims of this review were *** Total of 15 publications were found that involved the use of GIP determination in stool and/or urine to monitor the adherence to the GFD in comparison to other *** included both children and adults diagnosed with CeD and healthy ***,these preliminary studies indicated that this novel technique was highly sensitive for the detection of GFD transgressions and therefore could fac

关键词： Celiac disease Gluten-free diet Gluten immunogenic peptides Immunoassays Stool Urine

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Stereotactic body radiotherapy in pancreatic adenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 14-19页

作者： carolina de la Pinta Radiation Oncology Department Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding *** review aimed at the SBRT application in the treatment of pancreatic *** sources:We retrieved articles published in MEDLINE/PubMed from January 2017 to December *** used in the search included:“pancreatic adenocarcinoma”OR“pancreatic cancer”AND“stereotactic ablative radiotherapy(SABR)”OR“stereotactic body radiotherapy(SBRT)”OR“chemoradiotherapy(CRT)”.English language articles with information on technical characteristics,doses and fractionation,indications,recurrence patterns,local control and toxicities of SBRT in pancreatic tumors were *** articles were assessed for validity and relevant ***:Optimal doses and fractionation have not yet been ***,SBRT could be the standard treatment in patients with pancreatic adenocarcinoma in addition to ***,the combination of SBRT with chemotherapy may have additive or synergic effect on pancreatic ***:SBRT is an effective modality for patients with pancreatic cancer,supported by clinical practice guidelines as it has demonstrated good tolerance and good disease *** opens a possibility of improving outcomes for these patients,both in neoadjuvant treatment and with radical intent.

关键词： Chemoradiotherapy Pancreatic adenocarcinoma Radiotherapy Stereotactic body radiotherapy Stereotactic ablative radiotherapy

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Optimizing oncolytic virus design:a“Swiss army knife”approach to create a systemically delivered therapeutic

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1791-1792页

作者： carolina S.Ilkow John Cameron Bell Ottawa Hospital Research Institute 501 Smyth RoadOttawaONK1H 8L6Canada

In a recent paper published in Nature Biotechnology,Chen et al.1 describe a multiplex oncolytic virus platform that coupled with adoptive T cell therapy could solve the problem of repeat,systemic delivery of virus based *** is widely accepted that multi-targeted therapeutic approaches attacking several facets of cancer biology are necessary to effectively deal with the tumor heterogeneity that exists within and between patients.

关键词： therapeutic al. targeted

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Gustatory responsiveness in Vespula germanica workers:exploring the interplay between sensory perception and task specialization

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Insect Science 2024年第2期31卷 587-598页

作者： Analia Mattiacci carolina Mengoni Gonalons MaitéMasciocchi Juan C.Corley Grupo de Ecologia de Poblaciones de Insectos IFAB(CONICETINTA EEA Bariloche)BarilocheArgentina Departamento de Ecologia Centro Regional Universitario BarilocheUniversidad Nacional Del ComahueBarilocheArgentina Departamento de Biodiversidad y Biologia Experimental Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresBuenos AiresArgentina

Workers'task specialization and division of labor are critical features of social insects'ecological *** has been proposed that the division of labor relies on response threshold models:individuals varying their sensitivity(and responsiveness)to biologically relevant stimuli and performing a specific task when a stimulus exceeds an internal *** this work,we study carbohydrate and protein responsiveness and their relation to worker task specialization in Vespula germanica,an invasive social *** sucrose and peptone responsiveness of two different subcastes,preforagers and foragers,was determined by stimulating the antenna of the wasps with increasing concentrations of the solution and quantifying whether each concentration elicited a licking *** studied responsiveness in five different ways:(1)response threshold,(2)concentration 50(concentration to which at least 50%of wasps responded),(3)maximum response,(4)mean scores and(5)median *** results suggest that V germanica foragers are more sensitive to sucrose(lower thresholds)than preforager ***,we found no differences for peptone thresholds(i.e.,a protein resource).Nonetheless,this is the first study to investigate response thresholds for protein *** intercaste variation in sucrose responsiveness shown in our work contributes to the existing knowledge about response threshold theory as a mechanism for task specialization observed in V germanica.

关键词： carbohydrates responsiveness division of labor protein responsiveness response thresholds models social insect yellow jacket

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Carbon stock estimation in halophytic wooded savannas of Uruguay:An ecosystem approach

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Forest Ecosystems 2024年第4期11卷 580-589页

作者： Andres Baietto Andres Hirigoyen carolina Toranza Franco Schinato Maximiliano Gonzalez Rafael Navarro Cerrillo Forest Department Faculty of AgronomyUniversity of the RepublicMontevideoPO 12900Uruguay National Research Program of Forest Production National Agriculture Research InstituteTacuaremboPO 97000Uruguay Soil and Water Department Faculty of AgronomyUniversity of the RepublicMontevideoPO 12900Uruguay Department of Forestry Engineering University of CordobaCordobaPO 14014Spain

Savannas constitute a mixture of trees and shrub patches with a more continuous herbaceous *** contribution of this biome to the soil organic carbon(SOC)and above-ground biomass(AGB)carbon(C)stock globally is ***,they are frequently subjected to land use changes,promoting increases in CO_(2) *** Uruguay,subtropical wooded savannas cover around 100,000 ha,of which approximately 28%is circumscribed to sodic soils(i.e.,subtropical halophytic wooded savannas).Nevertheless,there is little background about the contribution of each ecosystem component to the C stock as well as site-specific allometric *** study was conducted in 5 ha of subtropical halophytic wooded savannas of the national protected area Esteros y Algarrobales del Rio *** work aimed to estimate the contribution of the main ecosystem components(e.g.,soil,trees,shrubs,and herbaceous plants)to the C ***-specific allometric equations for the most frequent tree species and shrub genus were fitted based on basal diameter(BD)and total height(H).The fitted equations accounted for between 77%and 98%of the aerial biomass variance of Netuma affinis and Vachellia *** shrubs(Baccharis sp.),the adjusted equation accounted for 86%of total aerial biomass.C stock for the entire system was 116.71±11.07 Mg·ha^(-1),of which 90.7%was allocated in the soil,8.3%in the trees,0.8%in the herbaceous plants,and 0.2%in the *** results highlight the importance of subtropical halophytic wooded savannas as C sinks and their relevance in the mitigation of global warming under a climate change scenario.

关键词： Carbon stock Climate change Biomass modeling Sodic soils

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Review of the Cretaceous avian diversity of Antarctica:a changing scenario for the evolution of early Neornithine birds

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Advances in Polar Science 2024年第1期35卷 1-13页

作者： carolina ACOSTA HOSPITALECHE Facundo IRAZOQUI Paula BONA Ariana PAULINA-CARABAJAL División Paleontología de Vertebrados Museo de La PlataFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataPaseo del Bosque s/nLa Plata B1900FWAArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Buenos Aires C1425FQBArgentina División Paleontología Vertebrados Museo de La Plata-Anexo ⅡFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataCalles 122 y 60La Plata B1900FWAArgentina Instituto de Investigaciones en Biodiversidad y Medioambiente(INIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad Nacional del ComahueSan Carlos de Bariloche R8400GAMArgentina

The worldwide record of Cretaceous Neornithes and Neornithine-like birds is both controversial and poorly ***,in recent years,the Antarctic continent has yielded a substantial number of Maastrichtian avian specimens,contributing significantly to our understanding of the early evolution of this ***,the keen interest and collaborative efforts of various paleornithologists have resulted in a wealth of knowledge,which we have thoroughly reviewed,updated,and discussed in the context of recent discoveries.

关键词： Maastrichtian Antarctic Peninsula Vega Island Seymour(Marambio)Island Neornithes birds

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Prevalence and ecological factors affecting the distribution of plant-parasitic nematodes in Prunus groves in Spain

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Journal of Integrative Agriculture 2024年第2期23卷 566-589页

作者： Ilenia Clavero-Camacho Antonio Archidona-Yuste carolina Cantalapiedra-Navarrete Pablo Castillo Juan Emilio Palomares-Rius Institute for Sustainable Agriculture(IAS) Spanish National Research Council(CSIC)Córdoba 14004Spain Andalusian Institute of Agricultural and Fisheries Research and Training(IFAPA) Centro Alameda del ObispoCórdoba 14004Spain

A wide survey was conducted to study plant-parasitic nematodes(PPNs)associated with Prunus groves in *** research aimed to determine the prevalence and distribution of PPNs in Prunus groves,as well as the influence of explanatory variables describing soil,climate and agricultural management in structuring the variation of PPNs community composition.A total of 218 sampling sites were surveyed and 84 PPN species belonging to 32 genera were identified based of an integrative taxonomic *** species considered as potential limiting factors in Prunus production,such as Meloidogyne arenaria,***,***,Pratylenchus penetrans and ***,were identified in this *** soil physico-chemical(C,Mg,N,Na,OM,P,pH and clay,loamy sand and sandy loam texture classes),four climate(Bio04,Bio05,Bio13 and Bio14)and four agricultural management variables(grove-use history less than 10 years,irrigation,apricot seedling rootstock,and Montclar rootstock)were identified as the most influential variables driving spatial patterns of PPNs *** particular,younger plantations showed higher values for species richness and diversity indices than groves cultivated for more than 20 years with Prunus *** study increases the knowledge of the distribution and prevalence of PPNs associated with Prunus rhizosphere,as well as on the influence of explanatory variables driving the spatial structure PPNs communities,which has important implications for the successful design of sustainable management strategies in the future in this agricultural system.

关键词： nematodes Meloidogyne Pratylenchus Paratylenchus rootstock distribution soil grove-use almond peach

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Ornithine aspartate effects on bacterial composition and metabolic pathways in a rat model of steatotic liver disease

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World Journal of Hepatology 2024年第5期16卷 832-842页

作者： Elisa carolina Lange Pabulo Henrique Rampelotto Larisse Longo Laura Bainy Rodrigues de Freitas carolina Uribe-Cruz Mario Reis Alvares-da-Silva Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-007Brazil Bioinformatics and Biostatistics Core Facility Universidade Federal do Rio Grande do SulPorto Alegre 91501-970Brazil Graduate Program in Biological Sciences:Pharmacology and Therapeutics Universidade Federal do Rio Grande do SulPorto Alegre 90035-007Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007RSBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)researcher Brasília 71605-001Brazil

BACKGROUND Metabolic-dysfunction associated steatotic liver disease(MASLD)is a hepatic manifestation of metabolic *** suggest ornithine aspartate(LOLA)as drug *** To analyze the influence of LOLA intake on gut microbiota using a nutritional model of *** Adult male Sprague Dawley rats were randomized into three groups:Control(10 rats fed with a standard diet),MASLD(10 rats fed with a high-fat and choline-deficient diet),and LOLA(10 rats receiving 200 mg/kg/d LOLA,after the 16th week receiving high-fat and choline-deficient diet).After 28 wk of the experiment,animals were euthanized,and feces present in the intestine were *** fecal DNA extraction,the V4 region of the 16S rRNA gene was amplified followed by sequencing in an Ion S5™*** Alpha and beta diversity metrics were comparable between MASLD and LOLA.3 OTUs were differentially abundant between MASLD and LOLA,which belong to the species Helicobacter rodentium,Parabacteroides goldsteinii,and Parabacteroides *** functional prediction provided two different metabolic profiles between MASLD and *** 9 pathways differentially abundant in MASLD are related to a change in energy source,adenosine/purine nucleotides degradation as well as guanosine and adenosine deoxyribonucleotides *** 14 pathways differentially abundant in LOLA are associated with four major metabolic functions primarily influenced by L-aspartate,including tricarboxylic acid cycle pathways,purine/guanosine nucleotides biosynthesis,pyrimidine ribonucleotides biosynthesis and salvage as well as lipid IVA *** Although LOLA had no influence on alpha and beta diversity in this nutritional model of MASLD,it was associated with changes in specific gut microbes and their related metabolic pathways.

关键词： Animal model Gut microbiota Metabolic-associated steatotic liver disease Metabolic prediction Ornithine aspartate

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Increasing dietary fiber intake for type 2 diabetes mellitus management: A systematic review

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World Journal of Diabetes 2024年第5期15卷 1001-1010页

作者： Douglas Nitzke Juliana Czermainski carolina Rosa Chaline Coghetto Sabrina Alves Fernandes Randhall B Carteri Department of Nutrition Centro Universitário CESUCACachoeirinha 94935-630Brazil Department of Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90430-080Brazil Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Postgraduate Program in Hepatology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil

BACKGROUND Type 2 diabetes is a chronic,non-communicable disease with a substantial global impact,affecting a significant number of *** etiology is closely tied to imbalanced dietary practices and sedentary ***,increasing die-tary fiber(DF)intake has consistently demonstrated health benefits in numerous studies,including improvements in glycemic control and weight *** To investigate the efficacy of DF interventions in the management of type 2 diabetes mellitus(T2DM).METHODS A systematic literature review was conducted to explore the association between DF intake and the management of *** the inclusion and exclusion criteria,a total of 26 studies were included in this *** The main strategies implied to increased DF intake were:High DF diet plus acarbose(2 studies);DF supplements(14 studies);and high DF diets(10 studies).Overall,most studies indicated that increased DF intake resulted in im-provements in glycemic control and weight management in T2DM *** DF represents a valuable strategy in the treatment of type 2 diabetes,improving health *** intake offers the potential to improve quality of life and reduce complications and mortality associated with ***,through supplements or enriched foods,DF contributes significantly to the control of several markers such as HbA1c,blood glucose,triglycerides,low-density lipoprotein,and body weight.

关键词： Type 2 diabetes mellitus Soluble fibers Insoluble fibers Probiotics Blood glucose Nutrition

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