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Matrix-assiste. lase. de.orption/ionization time.of-flight mass spe.trome.ry trace. the.ge.graphical source.of Biomphalaria pfe.ffe.i and Bulinus forskali,involve. in schistosomiasis transmission

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Infe.tious Dise.se. of Pove.ty 2024年第1期13卷 98-99页

作者： Papa Mouhamadou Gaye.e. Hadj Ibrahima Ndiaye.Soule.mane.Doucoure.Doudou Sow Mape.da Gaye.Ndiaw Goumballa carole Cassagne.Coralie.L'Ollivie. Ole. Me.ianikov Che.kh Sokhna Ste.hane.Ranque Aix-Marse.lle.Unive.sity IRD AP-HM SSA VITROME Marseille France VITROMe International IRD-UCAD Campus Dakar Senegal Hospital-Unive.sity Institut (IHU) Me.ite.ranée.Infe.tion Marseille France De.arte.e.t of Animal Biology Faculty of Sciences and Techniques UCAD Dakar Senegal De.artme.t of Parasitology-Mycology UFR Sciences de la Santé Université Gaston Berger Saint-Louis Senegal

Background Fre.hwate. snails of the.ge.e.a Bulinus spp.,Biomphalaria spp.,and Oncome.ania *** the.main inte.me.iate.hosts of human and animal *** of the.e.snails has long be.n base. on mor-phological and/or ge.omic crite.ia,which have.the.r *** limitations include.a lack of pre.ision for the.morphological tool and cost and time.for the.DNA-base. ***,Matrix-Assiste. Lase. De.orp-tion/lonization Time.Of-Flight(MALDI-TOF)mass spe.trome.ry,a ne. tool use. which is routine.y in clinical microbi-ology,has e.e.ge. in the.fie.d of malacology for the.ide.tification of fre.hwate. *** study aime. to e.aluate.the.ability of MALDI-TOF MS to ide.tify Biomphalaria pfe.ffe.i and Bulinus forskali snail populations according to the.r *** This study was conducte. on 101 *** and 81 *** snails colle.te. in thre. distinct ge.-graphical are.s of Se.e.al(the.North-e.st,South-e.st and ce.tral part of the.country),and supple.e.te. with wild and laboratory *** which had pre.iously be.n morphologically de.cribe. we.e.ide.tifie. by MALDl-TOF MS[ide.tification log score.value.(LSV)≥1.7],afte. an initial blind te.t using the.pre.e.isting *** DNA-base. ide.tification,ne. re.e.e.ce.spe.tra of ***(n=10)and ***(n=5)from the.ge.graphical are.s we.e.adde. to the.MALDI-TOF spe.tral *** final blind te.t against this update. database.was pe.-forme. to asse.s ide.tification at the.ge.graphic source.*** MALDI-TOF MS corre.tly ide.tifie. 92.1%of 101 *** snails and 98.8%of 81 *** *** the.final blind te.t,88%of 166 spe.ime.s we.e.corre.tly ide.tifie. according to both the.r spe.ie. and sampling site.with LSVs ranging from 1.74 to *** ge.graphical source.was ade.uate.y ide.tifie. in 90.1%of 91 *** and 85.3%of 75 *** *** Our findings de.onstrate.that MALDI-TOF MS can ide.tify and diffe.e

关键词： Matrix-assiste. lase. de.orption/ionization time.of-flight mass spe.trome.ry Snail Inte.me.iate.host Biomphalaria pfe.ffe.i Bulinus forskali Schistosomiasis Se.e.al

Long Te.m Administration of Lanne. acida Rich. (Anacardiace.e. Re.e.se. the.Imidacloprid-Induce. Fe.tility Impairme.ts in Adult Male.Rat through Androge.ic and Antioxidant Prope.tie.

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Journal of Bioscie.ce. and Me.icine. 2024年第3期12卷 62-76页

作者： Aimé Césaire.Momo Te.satsi Gladis Komgue. Djuidje.Pre.hmy carole Ngue.ong Nsamou Karl Gombe. Ze.gang Yannick Tchatat Pe.nga Désiré Alume.i Munyali e.the. Ngadjui Pe.in Alango Nke.g-e.foue. Pie.re.Watcho Faculty of He.lth Scie.ce. The University of Bamenda Bamenda Cameroon Animal Physiology and Phytopharmacology Laboratory Faculty of Science University of Dschang Dschang Cameroon Laboratory of Immunology and Mole.ular Biology The Evangelical University of Cameroon Bandjoun Cameroon School of Me.icine.and Community He.lth Evangelical University in Africa Bukavu DR Congo Alango Foundation Center for African Phytomedicine Dschang Cameroon

Aim: The.harmful e.fe.ts of pe.ticide. have.be.n large.y docume.te. in re.e.t time.. But e.fe.tive.the.ape.tic solutions to pe.ticide.re.ate. male.infe.tility are.ye. to be.e.tablishe.. This study inve.tigate. the.curative.e.fe.ts of Lanne. acida on imidacloprid (IMI)-induce. hypofe.tility in male.Wistar rats. Me.hods: Rats of 150 – 200 g we.e.administe.e. IMI (22.5 mg/kg) for two we.ks and partitione. into control (distille. wate., vitamin e. clomiphe.e.citrate. or te.t (aque.us (340 mg/kg), me.hanol (170 mg/kg) e.tract) groups for e.ght we.ks tre.tme.t. Animals we.e.sacrifice. at the.e.d of the.tre.tme.t and sample. we.e.colle.te. for spe.m, antioxidant and hormonal analysis. Fe.tility te.ts we.e.pe.forme. from tre.tme.t day 47 for fe.tility indice. e.timation. Re.ults we.e.e.pre.se. as me.n ± Se. and one.way ANOVA was applie. using STATISTICA Software. Re.ults: e.position to IMI re.ulte. in a significant de.re.se.in spe.m count, motility, viability and normality, te.toste.one.and LH, couple. to an incre.se.in oxidative.stre.s marke.s. More.ve., IMI impaire. male.fe.tility e.ide.ce. by a significant drop in fe.tility inde. and litte. size. Similar to clomiphe.e.citrate.and vitamin e. plant e.tracts significantly improve. the.spe.m parame.e.s, se.ual hormone. and de.re.se. the.oxidative.stre.s marke.s. More.importantly, the.fe.tility inde. and litte. size.we.e.re.tore., e.pe.ially with the.aque.us e.tract. Conclusion: Pre.e.t re.ults indicate.that L. acida posse.se. curative.pote.tials against IMI-induce. hypofe.tility through its androge.ic and antioxidant prope.tie.. Howe.e., the.e.fe.ts the.e.tract on spe.matozoa DNA structure.and the.fe.tility of offsprings from e.pose. pare.ts are.ye. to be.studie. to conclude.on total re.ove.y from IMI toxicity.

关键词： Imidacloprid Lanne. acida Hypofe.tility Male.Rat

A Contrastive.Study on Fre.ch and Urhobo Phonological Syste.s A Case.Study of Article. and De.onstrative.Structure.

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Sino-US e.glish Te.ching 2016年第5期13卷 362-372页

作者： carole e. Oke.re.tie. Ph.D. De.ta State.Unive.sity Abraka Delta State Nigeria

It is a ge.e.al knowle.ge.that Fre.ch as a language.is wide.y spoke. inte.nationally whe.e.s Urhobo is mainly spoke. in the.ge.graphical location whe.e.it be.ongs. It is also spoke., and this, sparingly so, by Urhobo pe.sons in the.Diaspora. Pre.e.tly, Urhobo has be.ome.a language.of study at the.De.ta State.Unive.sity, Abraka. It has also be.n include. in the.e.ucational curriculum for study at the.lowe. cadre.of se.ondary school e.ucation in the.De.ta State. This situation has trigge.e. the.author＇s inte.e.t in doing a contrastive.phonological study. The.significance.of this study is that it will highlight the.salie.t diffe.e.ce. in some.of the.grammatical aspe.ts in the.language. unde. conside.ation and also ide.tify the.difficultie. that le.rne.s e.pe.ie.ce.as a re.ult of the.e.difficultie.. The.author will also, as much as it is possible. proffe. solutions to the.e.le.rning difficultie..

关键词： contrastive study Fre.ch Urhobo phonology article.

De.aye. tre.tme.t of se.ondary de.e.e.ation following acute.optic ne.ve.transe.tion using a combination of ion channe. inhibitors

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Ne.ral Re.e.e.ation Re.e.rch 2017年第2期12卷 307-316页

作者： Nathanae. J.Yate. Marcus K.Giacci Ryan L. O'Hare.Doig Wissam Chiha Be.hany e. Ashworth Jade.Ke.na carole A. Bartle.t Me.inda Fitzge.ald De.artme.t of e.pe.ime.tal and Re.e.e.ative.Ne.roscie.ce. School of Animal Biology The University of Western Australia Crawley Western Australia Australia De.artme.t of e.pe.ime.tal and Re.e.e.ative.Ne.roscie.ce. School of Anatomy Physiology and Human Biology The University of Western Australia Crawley Western Australia Australia

Studie. have.shown that a combine. application of se.e.al ion channe. inhibitors imme.iate.y afte. ce.tral ne.vous syste. injury can inhibit se.ondary de.e.e.ation. Howe.e., for clinical use. it is ne.e.sary to de.e.mine.how long afte. injury the.combine. tre.tme.t of se.e.al ion channe. inhibitors can be.de.aye. and e.ficacy maintaine.. In this study, we.de.ive.e. Ca^2＋ e.try-inhibiting P2X7 re.e.tor antagonist oxidize.-ATP and AMPA re.e.tor antagonist YM872 to the.optic ne.ve.injury site.via an iPRe.IO-@ pump imme.iate.y, 6 hours, 24 hours and 7 days afte. partial optic ne.ve.transe.tion surge.y. In addition, all of the.ion channe. inhibitor tre.te. rats we.e.administe.e. with calcium channe. antagonist lome.izine.hydrochloride. It is important to note.that as a re.ult of implantation of the.particular pumps re.uire. for programmable.de.ive.y of the.ape.tics dire.tly to the.injury site. se.omas occurre. in a significant proportion of animals, indicating infe.tion around the.pumps in the.e.animals. Improve.e.ts in visual function we.e.obse.ve. only whe. tre.tme.t was de.aye. by 6 hours; phosphorylate. Tau was re.uce. whe. tre.tme.t was de.aye. by 24 hours or 7 days. Improve.e.ts in structure.of node.paranode.of Ranvie. and re.uctions in oxidative.stre.s indicators we.e.also only obse.ve. whe. tre.tme.t was de.aye. for 6 hours, 24 hours, or 7 days. Be.e.its of ion channe. inhibitors we.e.only obse.ve. with time.de.aye. tre.tme.t, sugge.ting that de.aye. the.apy of Ca^2＋ ion channe. inhibitors produce. be.te. ne.roprote.tive.e.fe.ts on se.ondary de.e.e.ation, at le.st in the.pre.e.ce.of se.omas.

关键词： ne.ve.re.e.e.ation optic ne.ve.injury ne.rotrauma se.ondary de.e.e.ation se.omas calcium channe. inhibitor node.of Ranvie. Tau phosphorylation lipid pe.oxidation oxidative.stre.s ne.ral re.e.e.ation

e.pe.ime.tal e.ide.ce.for he.itable.re.roductive.time.in 2 allochronic populations of pine.proce.sionary moth

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Inse.t Scie.ce 2017年第2期24卷 325-335页

作者： Manue.a Branco Maria-Rosa Paiva He.e.a Maria Santos Christian Burban carole Ke.de.hue Ce.tro de.e.tudos Flore.tais (Ce.) Instituto Superior de Agronomia (ISA) Universidade de Lisboa (ULisboa) 1349-017 Lisboa Portugal Ce.Se Faculty of Sciences and Technology (FCT) Universidade Nova de Lisboa (UNL) 2829-516 Caparica Portugal INRA Ce.tre.de.Borde.ux UMR1202 BIOGECO Cestas cedex France INRA Ce.tre.de.Montpe.lie. UMR CBGP F-34988 Montferrier-sur-Lez cedex France

Phe.ology allows organisms to ove.come.se.sonally variable.conditions through life.cycle.adjustme.t. Change. in phe.ology can drastically modify the.e.olutionary tra- je.tory of a population, while.a shift in the.re.roductive.time.may cause.allochronic diffe.e.tiation. The.hypothe.is of he.itable.re.roductive.time.was e.pe.ime.tally te.te., by studying a unique.population of the.pine.proce.sionary moth Thaume.opoe.pityocampa （De.. ＆ Schiff.） which has a shifte. phe.ology, and howe.e. co-occurs with the.typical population following the.classical life.cycle. Whe. populations of both type. we.e.re.re. unde. controlle. conditions, the.re.roductive.time.was maintaine. asynchronous, as ob- se.ve. in the.fie.d. The.shifte. population was manipulate. in the.laboratory to re.roduce.late. than usual, ye. the.offspring e.e.ge. in the.ne.t ye.r at the.e.pe.te. date. thus ＂com- ing back＂ to the.usual cycle. Hybrids from crosse. pe.forme. be.we.n the.2 populations showe. an inte.me.iate.phe.ology. From the.e.e.ge.ce.time. of pare.ts and offspring, a high he.itability of the.re.roductive.time.（h = 0.76） was obse.ve.. The.offspring ob- taine. from e.ch type.of cross was ge.e.ically characte.ize. using microsate.lite.marke.s. Baye.ian cluste.ing analysis confirme. that hybrids can he.succe.sfully ide.tifie. and se.arate. from the.pare.tal ge.e.ic classe. by ge.otyping. Findings support the.hypothe.is that, for this particular population, incipie.t allochronic spe.iation is due.to a he.itable.shift in the.re.roductive.time.that furthe. cause. assortative.mating and might e.e.tually cause.e.ological adaptation/maladaptation in re.ponse.to e.vironme.tal change..

关键词： allochronic spe.iation e.pe.ime.tal crossings he.itability phe.ology re.roductive.isolation Thaume.opoe.pityocampa

e.ploring the.Curre.t Practice.,Costs and Be.e.its of FAIR Imple.e.tation in Pharmace.tical Re.e.rch and De.e.opme.t:A Qualitative.Inte.vie. Study

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Data Inte.lige.ce 2021年第4期3卷 507-527页

作者： e.tisam Alharbi Rigina Ske.a Nick Juty Caroline.Jay carole Goble School of Compute. Scie.ce University of ManchesterManchesterManchester M139PLUK Colle.e.of Compute. and Information Syste.s Umm Al-Qura UniversityMeccaMakkah 21421Saudi Arabia

The.findable.acce.sible.inte.ope.able.re.sable.FAIR)principle. for scie.tific data manage.e.t and ste.ardship aim to facilitate.data re.se.at scale.by both humans and *** and de.e.opme.t(R&D)in the.pharmace.tical industry is be.oming incre.singly data drive.,but managing its data asse.s according to FAIR principle. re.ains costly and *** date.little.scie.tific e.ide.ce.e.ists about how FAIR is curre.tly imple.e.te. in practice.what its associate. costs and be.e.its are.and how de.isions are.made.about the.re.rospe.tive.FAIRification of data se.s in pharmace.tical R&*** pape. re.orts the.re.ults of se.i-structure. inte.vie.s with 14 pharmace.tical profe.sionals who participate.in various stage. of drug R&D in se.e. pharmace.tical *** the.atic analysis ide.tifie. thre. primary the.e. of the.be.e.its and costs of FAIRification,and the.e.e.e.ts that influe.ce.the.de.ision-making proce.s for FAIRifying le.acy data *** colle.tive.y acknowle.ge. the.pote.tial contribution of FAIRification to data re.sability in dive.se.re.e.rch domains and the.subse.ue.t pote.tial for *** costs,howe.e.,we.e.still conside.e. a barrie. by participants,with the.ne.d for conside.able.e.pe.diture.in te.ms of re.ource.,and cultural *** de.isions we.e.made.about FAIRification was influe.ce. by le.al and e.hical conside.ations,manage.e.t commitme.t,and data *** findings have.significant implications for those.in the.pharmace.tical R&D industry who are.e.gage. in driving FAIR imple.e.tation,and for e.te.nal partie. who se.k to be.te. unde.stand e.isting practice. and challe.ge..

关键词： FAIR FAIRification Re.rospe.tive.FAIRification Pharmace.tical R&D Cost-be.e.it De.ision-making proce.s

e.lagic acid in strawbe.ry(Fragaria spp.):Biological,te.hnological,stability,and human he.lth aspe.ts

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Food Quality and Safe.y 2017年第4期1卷 227-252页

作者： Se.va Muthukumaran carole Tranchant John Shi Xingqian Ye.Sophia Jun Xue De.artme.t of Food Scie.ce.and Post-Harve.t Te.hnology Institute of TechnologyHaramaya UniversityPost Box 138Dire DawaEthiopia School of Food Scie.ce Nutrition and Family StudiesFaculty of Health Sciences and Community ServicesUniversitéde MonctonMonctonNew Brunswick E1A 3E9Canada***Guelph Research and Development CenterAgriculture and Agri-Food Canada93 Stone Road WestGuelphOntario N1G 5C9Canada School of Biosyste.s e.gine.ring and Food Scie.ce Zhejiang UniversityHangzhouChina

e.lagic acid(e.)is one.of the.plant phe.olics associate. with human he.lth *** de.ive. from e.lagitannins found in some.nuts,se.ds,and fruits,e.pe.ially *** are.conside.e. a functional food and nutrace.tical source.mainly be.ause.of the.r high conce.tration of e. and its *** re.ie. pre.e.ts the.curre.t state.of knowle.ge.re.arding e.,focusing on its conte.t in strawbe.ry plants,stability during proce.sing and storage.of strawbe.ry-base. foods,production me.hods,and re.e.ance.to human *** alte.native. to acid-solve.t e.traction,fe.me.tation-e.zymatic bioproce.se. hold gre.t promise. for more.e.o-e.ficie.t production of e. from plant *** fruits are.ge.e.ally rich in e.,with large.variations de.e.ding on cultivar,growth conditions and maturity at *** e. conte.ts are.also re.orte. in strawbe.ry ache.e. and le.ve.,and in wild *** postharve.t storage.proce.sing and subse.ue.t storage.can influe.ce.e. *** low conce.tration in strawbe.ry juice.and wine.can be.incre.se. by incorporating pre.tre.te. *** re.ognition of strawbe.rie. as functional foods is substantiate. by e.ide.ce.of e. biological e.fe.ts,including antioxidant,antiinflammatory,antidiabe.ic,cardioprote.tive.ne.roprote.tive.and pre.iotic *** he.lth be.e.its attribute. to e.-rich foods are.thought to involve.various prote.tive.me.hanisms at the.ce.lular *** e. is conve.te. by the.inte.tinal microbiota to urolithins,which are.be.te. absorbe. than e. and may contribute.significantly to the.he.lth e.fe.ts attribute. to e.-rich *** on the.e.ide.ce.available.strawbe.ry e. shows strong promise. for functional,nutrace.tical,and pharmace.tical *** re.e.rch should be.dire.te. at quantifying e. in diffe.e.t parts of the.strawbe.ry plant and in the.r byproducts;optimizing e. production from byproducts;unde.standing the.biological actions of e.-de.ive. me.abolite. in vivo,inc

关键词： Strawbe.ry plant e.lagic acid Proce.sing Me.abolism Bioacti

Invitation to psychology carole Wade. Carol Tavris. 2nd ed.

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FLAG方案治疗高危骨髓异常增生综合征、急性髓细胞性白血病的临床研究

2002年

作者： carole Wade.Carol Tavris.

来源：畅想之星图书光盘版（南... 评论

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江苏医药 2004年第4期30卷 298-299页

作者：孙爱宁 Nathalie.F carole e.Patrice.C 苏州大学附属第一医院血液科 215006 De.artme.t of He.atology CHU Hospital Lapeyronie

目的　了解FLAG方案 (Fludarabine.Cytarabine.G CSF)诱导治疗高危骨髓异常增生综合征 (MDS)和急性髓细胞性白血病 (AML)的疗效及其耐受性。方法　对 4 3例高危MDS和AML进行FLAG诱导治疗 ,观察疗效及其不良反应。结果　 4 3例患者中... 详细信息

目的　了解FLAG方案 (Fludarabine.Cytarabine.G CSF)诱导治疗高危骨髓异常增生综合征 (MDS)和急性髓细胞性白血病 (AML)的疗效及其耐受性。方法　对 4 3例高危MDS和AML进行FLAG诱导治疗 ,观察疗效及其不良反应。结果　 4 3例患者中获得完全缓解 (CR) 2 2例 (5 1% ) ,部分缓解 (PR) 9例 (2 1% ) ,有效率达 72 %。 1个疗程CR率为 6 8%。其中年龄 0 5× 10 9/L的中位时间为 17(13～ 39)d ,血小板数恢复至 >2 0× 10 9/L的中位时间为 2 0(12～ 4 1)d。因粒缺发热的中位时间是 5 (0～ 31)d。红细胞输注支持的中位数为 7(0～ 70 )U ,血小板输注支持的中位数为 12 (3～ 2 6 )U。非血液系统不良反应非常轻。结论　FLAG方案作为高危MDS/AML的诱导治疗 ,是可耐受的。

关键词：高危骨髓异常增生综合征急性髓细胞性白血病 FLAG方案联合化疗不良反应骨髓抑制