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二甲双胍能否诱导雄激素正常的不排卵妇女排卵

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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 11-12页

作者： carmina e. Lobo R.A. 侯巍

This study was unde.take. to e.aluate.the.e.ficacy of me.formin in wome. with anovulation who do not have.e.ide.ce.for hype.androge.ism and classic polycystic ovary syndrome. A randomize. trial of me.formin (1500 mg daily) and place.o in 24 anovulatory wome. was unde.take. for 3 months. Asse.sme.ts of change. in hormone.le.e.s and insulin se.sitivity we.e.carrie. out. Abnormal hormonal value. we.e.de.ine. by le.e.s e.ce.ding the.range.in normal ovulatory controls. Anovulatory wome. had normal androge. le.e.s and lute.nizing hormone.but had highe. se.um insulin and lowe. insulin se.sitivity compare. with controls. Ove. 3 months, the.e.we.e.16 ovulatory cycle. with me.formin and only 4 with place.o (P e.s of ovulation did not corre.ate.with change. in androge., insulin, or insulin se.sitivity parame.e.s. Me.formin may be.use.ul for inducing ovulation in anovulatory wome. who do not have.hype.androge.ism. This e.fe.t may be.inde.e.de.t of a lowe.ing of androge. or insulin le.e.s.

关键词：不排卵双胍二甲多囊卵巢综合征黄体生成素激素过多症安慰剂排卵周期范围定义随机试验

The.pote.tial of natural products for targe.ing PPARα

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Acta Pharmace.tica Sinica B 2017年第4期7卷 427-438页

作者： Danie.a Rigano carmina Sirignano Orazio Taglialate.a-Scafati De.artme.t of Pharmacy University of Naples Federico IINaples I-80131Italy

Pe.oxisome.prolife.ator activate. re.e.tors(PPARs) α,-γ and-β/δ are.ligand-activate. transcription factors and me.be.s of the.supe.family of nucle.r hormone.re.e.tor. The.e.re.e.tors play ke. role. in maintaining glucose.and lipid home.stasis by modulating ge.e.e.pre.sion. PPARs constitute.a re.ognize. druggable.targe. and inde.d se.e.al classe. of drugs use. in the.tre.tme.t of me.abolic dise.se.symptoms, such as dyslipide.ia(fibrate., e.g. fe.ofibrate.and ge.fibrozil) and diabe.e.(thiazolidine.ione., e.g. rosiglitazone.and pioglitazone. are.ligands for the.various PPAR isoforms. More.pre.ise.y, antidiabe.ic thiazolidine.ione. act on PPARγ, while.PPARα is the.main mole.ular targe. of antidyslipide.ic fibrate.. Ove. the.past fe. ye.rs, our unde.standing of the.me.hanism unde.lying the.PPAR modulation of ge.e.e.pre.sion has gre.tly incre.se.. This re.ie. pre.e.ts a surve. on te.re.trial and marine.natural products modulating the.PPARα syste. with the.obje.tive.of highlighting how the.incre.ible.che.odive.sity of natural products can provide.innovative.le.ds for this "hot" targe..

关键词： PPARα Natural product Me.hanism of action Dyslipide.ia Me.abolic syndrome

Ne.roinflammation and ne.rological alte.ations in chronic live. dise.se.

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Ne.roimmunology and Ne.roinflammation 2015年第1期2卷 138-144页

作者： carmina Montoliu Marta Llansola Vice.te.Fe.ipo Re.e.rch Foundation of the.Clinic Hospital of Vale.cia Health Research Institute-INCLIVA46010 ValenciaSpain Laboratory of Ne.robiology Prince Felipe Research Center46012 ValenciaSpain

Se.e.al million pe.ple.with chronic live. dise.se.(cirrhosis,he.atitis)show ne.rological alte.ations,name. he.atic e.ce.halopathy(He.with cognitive.and motor alte.ations that impair quality of life.and re.uce. life.*** acts syne.gistically with hype.ammone.ia to induce.cognitive.and motor alte.ations in patie.ts with chronic live. dise.se.and minimal he.atic e.ce.halopathy(MHe..Pre.ious studie. in animal mode.s have.sugge.te. that ne.roinflammation is a major playe. in *** would also be.the.case.in patie.ts with live. cirrhosis or he.atitis C with *** with MHe.show microglial activation and ne.roinflammation that is associate. with cognitive.impairme.t and *** anti-inflammatory drug ibuprofe. re.uce. microglial activation and ne.roinflammation and re.tore. cognitive.and motor functions in rats with *** hype.ammone.ia pe. se.induce. *** pe.iphe.al inflammation and hype.ammone.ia would contribute.to ne.roinflammation in chronic live. ***,ne.roinflammation may be.a ke. the.ape.tic targe. to improve.the.cognitive.and motor alte.ations in MHe.and ove.t *** ne. targe.s to re.uce.ne.roinflammation in MHe.without inducing se.ondary e.fe.ts would se.ve.to de.e.op ne. the.ape.tic tools to re.e.se.the.cognitive.and motor alte.ations in patie.ts with He.associate. with chronic live. dise.se..

关键词： Cognitive.impairme.t he.atic e.ce.halopathy hype.ammone.ia inflammation motor function ne.roinflammation

The.Conidae.Family (Snails Produce.s of Poisons) Associate. with the.Rocky Inte.tidal Zone.of Acapulco, Me.ico

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Natural Re.ource. 2014年第8期5卷 343-350页

作者： Rafae. Flore.-Garza Yare.i M. Garcia-Mocte.uma Pe.ro Flore.-Rodrígue. Je.ús e. Miche.-Morfín carmina Torre.lanca-Ramíre. De.artame.to de.e.tudios para e. De.arrollo Suste.table.de.Zonas Coste.as Universidad de Guadalajara Jalisco Mexico Laboratorio de.e.ología Coste.a y Suste.tabilidad Unidad Académica de Ecología Marina Universidad Autónoma de Guerrero Acapulco Mexico Unidad de.Cie.cias de.De.arrollo Re.ional Universidad Autónoma de Guerrero Acapulco Mexico

Acapulco, Me.ico has a coastline.of 62 km whe.e.large.are.s of rocky substrate.inhabite. by organisms such as the.GASTROPODA Class can be.found. Conidae.(Fle.ing, 1822) Family is among the.me.be.s of this Class, which has be.n poorly studie. in the.Me.ican Pacific, de.pite.the.r biome.ical pote.tial. This re.e.rch was carrie. out in the.rocky inte.tidal of nine.site. in Acapulco. The.obje.tive. we.e. 1) Pre.are.an inve.tory of spe.ie. associate. with rocky inte.tidal of Conidae.family, 2) e.amine.the.composition of the.family base. on two crite.ia: a) spe.ie. richne.s and b) abundance. 3) de.e.mine.the.ge.graphical distribution and 4) analyze.the.size.composition. The.unit sample. was 1 m2 and the.sample. are. was 10 m2 pe.site. A total of 97 organisms we.e.analyze., corre.ponding to two subfamilie., five.ge.e.a and five.spe.ie.. The.Puncticuliinae.(Tucke. & Te.orio, 2009) subfamily had highe. spe.ie. richne.s, abundance.and fre.ue.cy of occurre.ce. The.most abundant and most common spe.ie. we.e.Harmoniconus nux (Brode.ip, 1833) and Gladioconus gladiator (Brode.ip, 1833) both showe. re.ular distribution. The.size.structure.found for Conidae.family is similar to what has be.n re.orte. in othe. re.e.rch. For the.first time.G. gladiator is be.ng re.orte. for the.state.of Gue.re.o.

关键词： Conidae Acapulco Poison Distribution Rocky Inte.tidal Zone

Non invasive.blood flow me.sure.e.t in ce.e.e.lum de.e.ts minimal he.atic e.ce.halopathy e.rlie. than psychome.ric te.ts

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World Journal of Gastroe.te.ology 2014年第33期20卷 11815-11825页

作者： Vice.te.Fe.ipo Amparo Urios Carla Giméne.-Garzó Omar Cauli Maria-Je.ús Andrés-Costa Olga Gonzále. Migue. A Se.ra Javie. Sánche.-Gonzále. Robe.to Aliaga Re.e.ios Gine.-Durán Vice.te.Be.loch carmina Montoliu Laboratory of Ne.robiology Centro Investigación Príncipe Felipe 46012Valencia Spain Fundación Inve.tigación Hospital Clínico de.Vale.cia. Instituto de.Inve.tigación Sanitaria INCLIVA 46010 Valencia Spain Se.vicio Dige.tivoHospital Arnau de.Vilanova 46015 Valencia Spain Grupo He.atología Servicio Aparato Digestivo Hospital Clínico de Valencia 46010 Valencia Spain Philips He.lthcare Iberia 28050 Madrid Spain e.e.A Unidad RM 46015 Valencia Spain De.artame.to de.Patología Facultad de Medicina Universidad de Valencia 46010 Valencia Spain

AIM: To asse.s whe.he. non invasive.blood flow me.sure.e.t by arte.ial spin labe.ing in se.e.al brain re.ions de.e.ts minimal he.atic e.ce.halopathy.

关键词： Arte.ial spin labe.ling Ne.rological impair-me.t Blood flow Ce.e.e.lum Minimal he.atic e.ce.h-alopathy

苗勒抑制物比抑制素B更能反映女性多囊卵巢综合征

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世界核心医学期刊文摘（妇产科学分册） 2006年第5期2卷 25-26页

作者： carmina e.Lobo R.A. 李跃萍 De.artme.t of Obste.rics and Gyne.ology Columbia University College of Physicians and Surgeons PH 16- 69 622 West 168th Street New York NY 10032 United States

To inve.tigate.Mü lle.ian-inhibiting substance.(MIS) le.e.s in wome. with polycystic ovary syndrome.(PCOS), as we.l as re.ationships to ovarian morphology, le.e.s of inhibin B, and othe. re.roductive.hormone.. De.ign: Prospe.tive.clinical study. Se.ting: Acade.ic e.docrinology ce.te.s in Pale.mo, Italy and Ne. York. Patie.t(s): Forty-six wome. with PCOS, re.ruite. on the.basis of the.classic crite.ia of chronic anovulation and hype.androge.ism, and 25 age. matche. ovulatory controls. Inte.ve.tion(s): Fasting blood was obtaine. in all subje.ts in the.e.rly follicular phase.(days 5- 6) afte. spontane.us or induce. me.se. (in PCOS), and transvaginal ultrasounds we.e.pe.forme.. Main Outcome.Me.sure.s): Asse.sme.t of value. for lute.nizing hormone.(LH), te.toste.one.(T), and roste.e.ione.(A), e.tradiol (e.), inhibin B,MIS, fasting insulin, and the.calculate. quantitative.se.sitivity che.k inde. (QUICKI), as we.l as asse.sme.ts of ovarian volume.and blood flow. Re.ult(s): Wome. with PCOS had highe. LH, T, and A; highe. insulin and lowe. QUICKI; and highe. ovarian volume.and lowe. pulsatility inde.. Inhibin B conce.trations we.e.statistically significantly highe. in PCOS patie.ts (70 ± 8.0 vs. 40 ± 3.4 pg/mL), as was MIS (6.7 ± 0.9 vs. 4.6 ± 0.5 ng/mL). Inhibin B had a statistically significant dire.t corre.ation with le.e.s of MIS (r = 0.351). Howe.e.,MIS, but not inhibin B, had a statistically significant positive.corre.ation with ovarian size.(r = 0.350); the.re.roductive.hormone. LH, T, A, and e.; and insulin (r = 0.249), inde.e.de.t of body mass inde.. Wome. with PCOS with the.highe.t le.e.s of MIS had highe. ovarian volume. and value. of LH, T, A, and insulin. Conclusion(s): Me.sure.e.ts of MIS re.le.t ovarian findings in PCOS be.te. than le.e.s of inhibin B and are.more.fre.ue.tly e.e.ate.. Howe.e., MIS lacks se.sitivity for use.as a diagnostic tool in PCOS.

关键词：多囊卵巢综合征抑制素抑制物持续无排卵空腹胰岛素卵巢形态黄体生成素卵巢体积卵泡早期生

Mollusks of the.Rocky Inte.tidal Zone.at Thre. Site. in Oaxaca,Me.ico

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Ope. Journal of Marine.Scie.ce 2014年第4期4卷 326-337页

作者： Pe.ro Flore.-Rodrígue. Rafae. Flore.-Garza Se.gio García-Ibáne. carmina Torre.lanca-Ramíre. Lize.h Gale.na-Re.olle.o e.e.ina Santiago-Corte. Laboratorio de.e.ologia Coste.a y Suste.tabilidad Unidad Academica de Ecologia MarinaUniversidad Autonoma de GuerreroAcapulcoMexico Doctorado e. Cie.cias Ambie.tale. Unidad de Ciencias de Desarrollo RegionalUniversidad Autonoma de GuerreroAcapulcoMexico

The.community of mollusks at thre. rocky inte.tidal zone.in Oaxaca, Me.ico was analyze.. Two samplings pe. site.we.e.conducte.. At e.ch sampling the.inspe.te. are. was 10 m2. The.sampling unit was 1 m2. 5862 spe.ime.s we.e.e.amine.. 68 mollusks spe.ie. we.e.ide.tifie.. The.familie. be.te. re.re.e.te. in spe.ie. richne.s we.e. FISSURe.LIDAe. MURICIDAe. LOTIIDAe. MYTILIDAe. CHAMIDAe. ISCHNOCHITONIDAe.y CHITONIDAe. The.spe.ie. that had the.gre.te.t de.sity we.e.Lottia discors, Siphonaria palmata, Lottia acutape., Chormoytilus palliopunctatus, Brachidonte. adamsianus, Chton articulatus e.Ischnochiton muscarius. The.spe.ie. with the.wide.t distribution re.re.e.t 11.76%. With irre.ular distribution was found in 58.82% of the.spe.ie.. The.gastropod Crucibulummonticulus, the.bivalve.C. palliopunctatus and the.polyplacophoran C. articulatus had the.gre.te.t size. The.value.of dive.sity inde. was H’ = 4.29 bits/ind. and J’ = 0.72. The.mollusks community in the.rocky inte.tidal zone.study site. is characte.ize. by small size. be.ause.the. rare.y e.ce.d se.e.ty millime.e.s. The.value. of H’ and J’ indicate.that the.mollusk community in the.study are. has a high dive.sity and high uniformity, corre.ponding to mature.and stable.communitie. in a tropical re.ion.

关键词： Inte.tidal Zone Oaxaca Biodive.sity Mollusks

De.dritic ce.l de.icie.cie. pe.sist se.e. months afte. SARS-CoV-2 infe.tion

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Ce.lular & Mole.ular Immunology 2021年第9期18卷 2128-2139页

作者： Albe.to Pére.-Góme. Joana Vitallé Carme. Gasca-Capote.Alicia Gutie.re.-Vale.cia María Trujillo-Rodrigue. Ana Se.na-Galle.o e.pe.anza Muñoz-Mue.a María de.los Re.e. Jiméne.-Le.n Mohame. Rafii-e.-Idrissi Be.hnia Inmaculada Rivas-Je.e.ias Ce.ar Sotomayor Cristina Roca-Oporto Nuria e.pinosa Carme. Infante.Domíngue. Juan Carlos Cre.po-Rivas Albe.to Fe.nánde.-Villar Ale.andre.Pére.-Gonzále. Luis Fe.nando Lópe.-Cortés e.a Pove.a e.e.uie. Ruiz-Mate.s JoséMigue. Cisne.os Sonsole. Salto-Ale.andre.Judith Be.aste.ui-Cabre.a Pe.ro Camacho-Martíne. Carme. Infante.Domíngue. Marta Carre.e.o-Le.e.ma Juan Carlos Cre.po-Rivas e.uardo Márque. JoséManue. Lomas Claudio Bue.o Rosario Amaya JoséAntonio Le.e.Je.ónimo Pachón e.isa Corde.o Javie. Sánche.-Céspe.e. Manue.a Aguilar-Guisado Almude.a Aguile.a Clara Aguile.a Te.e.a Aldabo-Pallas Ve.ónica Alfaro-Lara Cristina Amode. Javie. Ampue.o María Dolore. Avilés Maribe. Ase.sio Bosco Barón-Franco Lydia Barre.a-Pulido Rafae. Be.lido-Alba Máximo Be.nabe.-Witte. Cande.a Caballe.o-e.aso Macare.a Cabre.a e.rique.Calde.ón Je.ús Carbajal-Gue.re.o Manue.a Cid-Cumplido Yae. Corcia-Palomo Juan De.gado Antonio Domíngue.-Pe.it Ale.andro De.iz Re.inal Dusse.k-Brutus Ana e.core.ca-Orte.a Fátima e.pinosa Nuria e.pinosa Miche.le.e.pinoza Carme. Fe.rándiz-Millón Marta Fe.re. Te.e.a Fe.re. Ignacio Galle.o-Te.e.ra Rosa Gáme.-Mance.a e.ilio García Horacio García-De.gado Manue. García-Gutiérre. María Luisa Gascón-Castillo Aurora Gonzále.-e.trada De.e.rio Gonzále. Carme. Góme.-Gonzále. Rocío Gonzále.-Le.n Carme. Grande.Cabre.izo Sonia Gutiérre. Carlos He.nánde.-Quile. Inmaculada Conce.ción He.re.a-Me.e.o Marta He.re.o-Rome.o Luis Jara Carlos Jiméne.-Juan Silvia Jiméne.-Jorge.Me.ce.e. Jiméne.-Sánche. Julia Lanse.os-Te.llado carmina Lópe. Isabe. Lópe. Álvaro Lópe.-Barrios Luis F.Lópe.-Cortés Rafae. Luque.Márque. Danie. Macías-García Guille.mo Martín-Gutiérre. Luis Martín-Villén JoséMolina Aurora Morillo María Dolore. Navarro-Amue.o Dolore. Nie.o-Martín Francisco Orte.a María Paniagua-García Ame.ia Pe.a-Rodrígue. e Clinical Unit of Infe.tious Dise.se. Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain De.artme.t of Me.ical Bioche.istry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pne.mology Se.vice Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infe.tious Dise.se. Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathoge.e.is Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infe.tious Dise.se. Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute.of Biome.icine.of Se.ille.IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Me.ico-Surgical Unit of Re.piratory Dise.se. Virgen del Rocío University HospitalSevilleSpain Unit of e.e.ge.cie. Virgen del Rocío University HospitalSevilleSpain Inte.sive.Care.Unit Virgen del Rocío University HospitalSevilleSpain De.artme.t of Me.icine University of SevilleSevilleSpain Cardiology and Cardiovascular Surge.y Unit Virgen del Rocío University HospitalSevilleSpain Rhe.matology Unit Virgen del Rocío University HospitalSevilleSpain Inte.nal Me.icine.Unit Virgen del Rocío University HospitalSevilleSpain Dige.tive.and He.atobiliary Unit Virgen del Rocío University HospitalSevilleSpain Ne.rology and Clinical Ne.rophysiology Unit Virgen del Rocío University HospitalSevilleSpain e.docrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Ne.hrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Inve.tigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Se.e.e.Acute.Re.piratory Syndrome.Coronavirus(SARS-CoV)-2 infe.tion induce. an e.ace.bate. inflammation drive. by innate.immunity *** ce.ls(DCs)play a ke. role.in the.de.e.se.against viral infe.tions,for instance.plasmacytoid DCs(pDCs),have.the.capacity to produce.vast amounts of inte.fe.on-alpha(IFN-α).In COVID-19 the.e.is a de.icit in DC numbe.s and IFN-αproduction,which has be.n associate. with dise.se.*** this work,we.de.cribe. that in addition to the.DC de.icie.cy,se.e.al DC activation and homing marke.s we.e.alte.e. in acute.COVID-19 patie.ts,which we.e.associate. with multiple.inflammatory ***,pre.iously hospitalize. and nonhospitalize. patie.ts re.aine. with de.re.se. numbe.s of CD1c+mye.oid DCs and pDCs se.e. months afte. SARS-CoV-2 ***,the.e.pre.sion of DC marke.s such as CD86 and CD4 we.e.only re.tore. in pre.iously nonhospitalize. patie.ts,while.no re.toration of inte.rinβ7 and indole.mine.2,3-dyoxige.ase.IDO)le.e.s we.e.*** findings contribute.to a be.te. unde.standing of the.immunological se.ue.ae.of COVID-19.

关键词： SARS-CoV-2 COVID-19 De.dritic ce.l Long-COVID