采用空腹血评估多囊卵巢综合征患者胰岛素抵抗的发病率

作     者：Carmina E. LoboR.A. 石磊 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第2期

页      面：29-30页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：多囊卵巢综合征 胰岛素抵抗 胰岛素耐量试验 敏感性检测 葡萄糖利用 学术机构 评估法 QUICK 稳态模型 法时 

摘      要：To determine the prevalence of insul in resistance(IR)in women with polycystic ovary syndrom e(PCOS)using baseline fasting blood measurement s of glucose and *** clinical *** ic endocrinology unit in Palermo,*** hundred and sixty -sevenwomenwith PCOS,consecutively evaluated,and50consecutively se-lected ovulating *** blood was obtained for glucose and insulin measurements fr om all *** 60women with PCOS and 20controls an insulin tolerance test(ITT)was also *** of normal and ab-normal values for fasting insulin,g lucose /insulin ratio,and the calculated indices of the hom eostasis model as-sessment (HOMA),quantitative sensitivity check in dex(QUICKI ),as well as Kitt(kinetic disappearance of glu-cose)values after *** was performed of the ability to detect IR using these meth ods in obese and nonobese women with *** insulin sensitivity was defined by insulin levels6.4,HOMA values of*** the entire PCOS groups,IR w as diagnosed in 65.4%of women using glucose /insu lin ratios and in77%and 79.2%using HOMA and QUICKI.I n obese women(body mass index 28in 48%of group),IR was present in 76.7%as measured by gluco se /insulin ratios but was significantly higher(95.3%)using values of ei-ther HOMA or QUICKI (P.01).All indices correlated with Kitt values with QUICKI showing the best *** resistance was detected in a pproximately 80%of women with PCOS,and in 95%of obese wo *** detection of IR is superior using the calculated indices HOMA and QUICKI.