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Prevalence of celiac disease in an urban area of Brazil with predominantly European ancestry

World Journal of Gastroenterology 2006年第40期12卷 6546-6550页

作者： maria Angélica G Pereira carmen L Ortiz-Agostinho Iêda Nishitokukado maria N Sato Adérson OMC Damio Marília L Alencar Clarice P Abrantes-Lemos Eduardo LR Canado Thales de Brito Sérgio O Ioshii Sandra BM Valarini Aytan M Sipahi Department of Gastroenterology Medical Investigation Laboratories (LIM 07) University of So Paulo School of Medicine So Paulo SP Brazil Medical Investigation Laboratories (LIM 56) University of So Paulo School of Medicine So Paulo SP Brazil Institute of Tropical Medicine (LIM 06) University of So Paulo School of Medicine So Paulo SP Brazil Department of Histopathology Federal University of Paraná Brazil Department of Internal Medicine Catholic University of Paraná Brazil

AIM： To determine the prevalence of celiac disease in a group of volunteer blood donors at a blood bank in the city of Curitiba, Brazil through detection of the serum marker immunoglobulin A （IgA） antitransglutaminase antibody. METHODS： Blood samples collected from 2086 healthy subjects at the Paraná State Center for Hematology and Hemotherapy in Curitiba were submitted to ELISA testing for the IgA antitransglutaminase antibody. Positive samples received IgA antiendomysium antibody test through indirect immunofluorescence using human umbilical cord as substrate. Subsequently, patients who were positive on both tests underwent small bowel （distal duodenum） biopsy. RESULTS： Six subjects, four males and two females, tested positive for the two serum markers. Five of the six were submitted to intestinal biopsy （one declined the procedure）. Biopsy results revealed changes in the distal duodenum mucosa （three classified as Marsh mb lesions and two as Marsh Ⅱ lesions）. Most donors diagnosed having celiac disease presented multiple symptoms （gastrointestinal tract complaints）. One donor reported having a family history of celiac disease （in a niece）. CONCLUSION： Among apparently healthy blood donors,the prevalence of biopsy-confirmed celiac disease was approximately 1：417, similar to that seen in European countries.

关键词： Celiac disease Epidemiology Malabsorption Prevalence Small bowel disease

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Local Fourier Analysis for Edge-Based Discretizations on Triangular Grids

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Numerical Mathematics(Theory,Methods and Applications) 2015年第1期8卷 78-96页

作者： carmen Rodrigo Francisco Sanz Francisco J.Gaspar Francisco J.Lisbona Department of Applied Mathematics University of ZaragozaC/Maria de Luna 350018ZaragozaSpain BIFI University of Zaragoza C/Pedro Cerbuna 1250009ZaragozaSpain Department of Applied Mathematics University of ZaragozaC/Pedro Cerbuna 1250009ZaragozaSpain

In this paper,we present a local Fourier analysis framework for analyzing the different components within multigrid solvers for edge-based discretizations on triangular *** different stencils associated with edges of different orientation in a triangular mesh make this analysis *** resulting tool is demonstrated for the vector Laplace problem discretized by mimetic finite difference *** from the local Fourier analysis,as well as experimentally obtained results,are presented to validate the proposed analysis.

关键词： Multigrid local Fourier analysis edge-based discretizations mimetic finite differences

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Architectural Educational Experience in Kansei

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Journal of Civil Engineering and Architecture 2016年第2期10卷 131-138页

作者： Igor Fernandez Plazaola carmen Llinares Millan Antoni Montafiana Avino maria Pons Morera Lab Human Research Institute Management Department Universitat Politecnica de Valencia Valencia 46022 Spain Management Department Universitat Politecnica de Valencia Valencia 46022 Spain

Since the earliest Kansei works saw the light more than 30 years ago, the Kansei has boomed exponentially. Because of many and various achieved business successes by different working groups as well as the methodology geographical dispersion throughout the world. Multi-faceted Kansei has been developed for the last 20 years in a very wide and varied way. The Kansei has experienced as if talking of a tree, a branching experience still going on nowadays. Today we can speak from Kansei in theory, Kansei emotion measurement, Kansei engineering, Kansei information, Kansei education, Kansei design to Kansei in practice and many other disciplines. Three years ago, our team started the experience to introduce Kansei in the educational atmosphere, applying it to the final degree projects. In the School of Building Engineering at the Universitat Polit^cnica de Valencia and inside its final degree project proposal, a workshop on Kansei engineering was offered. During these years at the eighth semester of the building engineer degree, students have been working for almost five months under the supervision of a team of teachers on their final project till the final public oral defense was made in front of a committee. During these years, we have worked with an average of 10 students per year. Some have successfully completed their final projects, others have not achieved the minimum required. The article aims to explain the experience during the last three years the team has accumulated in Kansei education, and can be of interest for every teacher or lecturer.

关键词： Academic Kansei Kansei final project educational experience architectural teaching.

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Hydrometeorology of Anthropogenic Erosion in the Metropolitan Region of São Paulo

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Journal of Environmental Protection 2021年第12期12卷 1234-1253页

作者： maria del carmen Sanz Lopez Augusto José Pereira Filho Jorge Luiz Diaz Pinaya Departamento de Ciências Atmosférica do Instituto de Astronomia Geofísica e Ciências Atmosféricas da Universidade de S&atilde o Paulo S&atilde o Paulo Brazil

Erosive processes play an important role in environmental degradation. Rain is the main erosive agent in the Metropolitan Region of Sao Paulo. This study characterized the erosion events caused by precipitation leveraging the accumulated daily precipitation estimate generated by the Climate Prediction Center Morphing Method (CMORPH) and integrating the surface telemetric network using the Statistical Objective Analysis method (SOAS). From the Civil Defense database, 400 events were identified in the Metropolitan region of Sao Paulo (MRSP) area between 2000 and 2013 and, of these, 3 were chosen to carry out meteorological and climatological analyses. In an initial observation, 58% of them were found to occur in summer. Two regions with the highest number of erosion events were observed, in the Serra do Mar and Serra da Cantareira. In the Serra do Mar core, the municipality of São Bernardo do Campo was the one with the greatest amount of erosion. Precipitation volumes were estimated for accumulations of 30 minutes, 1 day, 1 month, and 1 year. The results, from the 3 events, indicate accumulated precipitation in 30 minutes from 10 mm to 19.8 mm, daily from 30.8 mm to 69.5 mm, and 1 month from 369.7 mm to 742.5 mm, and 1 year (2010) from 1712.9 mm to 1961.8 mm. In these events, it was noted that there were heavy rains in December 2009 and January 2010. It was also noted that the CMORPH and SOAS identify the rain events found by the São Paulo meteorological radar. The meteorological analyzes of the events based on images from the São Paulo meteorological radar and the Meteosat-9 satellite indicate that the active precipitation systems are associated with cold fronts, instability lines, and isolated convection.

关键词： Hydrometeorology Anthropogenic Erosion CMORPH SOAS

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Effective prophylaxis with rFVIIa in young haemophiliacs with inhibitors using a schedule similar to FVIII prophylaxis in non-inhibitor patients

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Health 2013年第7期5卷 1151-1157页

作者： maria Fernanda Lopez-Fernandez carmen Altisent Victor Jimenez-Yuste Faustino Garcia-Candel carmen Sedano Ana Cid Eva Mingot Ramiro Nunez maria Jose Paloma Inmaculada Soto Manuel Prieto Haematology Complejo Hospitalario Universitario A CorunaA CorunaSpain Haemophilia Unit Hospital Universitario Vall d’HebronBarcelonaSpain Haemophilia Unit Hospital UniversitarioMadridSpain Haemophilia Unit Hospital Universitario Virgen de la ArreixacaMurciaSpain Haematology Complejo Hospitalario Universitario Marques de ValdecillaSantanderSpain Congenital Coagulophaties Unit Hospital Universitario La FeValenciaSpain Haematology Hospital Universitario Carlos HayaMalagaSpain Haematology Hospital Universitario Virgen del RocíoSevillaSpain Haematology Hospital Virgen del CaminoPamplonaSpain Haematology Hospital General de AsturiasOviedoSpain Haematology Hospital General YagüeBurgosSpain

Objective: To assess the role of early prophylaxis with recombinant activated factor VII (rFVIIa) in young haemophiliacs with inhibitors and to determine whether it can reduce bleeding episodes and prevent joint damage. Patients and Methods: Ten severe haemophiliacs, less of three years old, with up to four joint bleeds and inhibitors to FVIII who started early prophylaxis with rFVIIa, were included. A number of haemorrhages/year/patient and haemarthroses/ year/patient were compared before the start of prophylaxis, which include both the time before (initial period) and after inhibitor diagnosis (inhibitor period), with those during prophylaxis (prophylaxis period). Results: The mean time of inhibitor diagnosis was 15.6 months (range: 2.3-34.1). The mean time between inhibitor diagnosis and the start of prophylaxis was 7.1 months (range: 0-23.2), shorter than the time of rFVIIa prophylaxis (mean: 10.3 months;range: 4.1-32.0). Bleeding episodes for the three time periods were 45, 36 and 17, respectively, or 0.29 and 0.51 haemorrhages/year/patient in the two periods prior to prophylaxis compared to 0.17 during prophylaxis. Total haemarthroses for the three-time periods were 7, 5 and 5, respectively. The haemarthroses/year/patient in the pre-prophylaxis period were 0.032 and 0.070, compared to0.049 inthe prophylaxis period. rFVIIa schedules were either 90 μg/kg three times weekly or 90 μg/kg daily. Conclusions: Early prophylaxis with rFVIIa may be efficacious in young haemophiliacs with inhibitors, reducing joint bleeds. After the risky period of inhibitor presence, they are able to continue rFVIII prophylaxis with success assured to prevent arthropathy.

关键词： rFVIIa Haemarthroses Haemophilia Inhibitors Prophylaxis

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Simple anthropometric measurements to predict dyslipidemias in Mexican school-age children: a cross-sectional study

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Open Journal of Preventive Medicine 2011年第3期1卷 171-181页

作者： maria del carmen Caamano Olga Patricia Garcia maria del Rocio Arellano Karina de la Torre-Carbot Jorge LRosado School of Natural Sciences Universidad Autonoma de QueretaroQueretaroMexico Disease and Development Center for Chronic Diseases QueretaroMexico.

Objective: The purpose of this study was to identify the best predictors of dyslipidemias in Mexican obese children using different anthropometric and body composition measurements. Methods: In an observational, cross-sectional study, 905 children from 5 schools were measured for weight, height, waist and hip circumference, and triceps and subscapular skinfolds. A fasting blood sample was taken from a random sub-sample of 306 children to determine lipid profile. Abnormal total cholesterol, LDL, HDL, triglycerides, total cholesterol to HDL ratio, and LDL to HDL ratio, were determined. Logistic regressions and ROC analysis were carried out to determine the best anthropometric predictors of these risk factors. Results: Prevalence of elevated total cholesterol, triglycerides and LDL cholesterol was 14%, 56% and 58%, respectively. In logistic regressions, BMI and triceps skinfold had the highest odds ratios to predict elevated total cholesterol (1.05, 95%CI: 0.97 - 1.14;1.07, 1.01 - 1.13, respectively), triglycerides (1.19, 1.11 - 1.27;1.12, 1.08 - 1.17, respectively), LDL cholesterol (1.11, 1.04 - 1.18;1.09, 1.05 - 1.14, respectively), total cholesterol to HDL ratio (1.06, 1.00-1.14;1.07,1.03-1.12, respectively) and LDL to HDL ratio risk (1.08,1.01-1.15;1.07, 1.03-1.12, respectively). After BMI and triceps skinfold, subscapular skinfold also predicted dyslipidemias, except for low HDL;both skinfolds had a narrower odds ratio confidence interval than BMI. In ROC analysis, subscapular skinfold was the best predictor of elevated triglycerides with an AUC ≥ 0.7. Conclusion: Anthropometric measurements are not strongly associated with dyslipidemias in Mexican children. However, since triceps and subscapular skinfolds were better predictors than other anthropometry measures, they may be a simple way to predict dyslipidemias in Mexican children.

关键词： Cardiovascular Risk Dyslipidemia Lipids Anthropometry and Children

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Heritage risk index:A multi-criteria decision-making tool to prioritize municipal historic preservation projects

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Frontiers of Architectural Research 2020年第2期9卷 403-418页

作者： Jonathan Ruiz-Jaramillo carmen Munoz-Gonzalez maria Dolores Joyanes-Diaz Eduardo Jimenez-Morales Jose Manuel Lopez-Osorio Roberto Barrios-Perez Carlos Rosa-Jimenez Department of Art and Architecture School of ArchitectureUniversidad de MalagaMalaga 29071Spain

The current pressure on the built historical heritage requires a global evaluation to develop strategies for its preservation.A combined vision of the state of conservation of architectural heritage is essential to highlight the vulnerabilities of the structure from which harmonized measures can be proposed for its *** study proposes a multi-criteria analysis methodology that considers a qualitative and quantitative approach to organize the global conservation state of heritage buildings hierarchically.A global index can be determined on the basis of the generation of an interoperable data matrix by defining a set of indicators to assess different components of a *** index describes the risk with respect to the stability,safety,and habitability of the *** methodology aims to achieve the state of the building in an integral way by obtaining a simple and objective index that enables efficient comparison among different *** application of this methodology to a historic area allows creating a hierarchical map of risk to stablish priorities for intervention and enable a sustainable and critical management and planning over the actions of maintenance,conservation,and *** this way,a holistic vision of the complex reality of built heritage and the urban landscape is obtained to identify critical areas of priority intervention.

关键词： Historic city State of conservation Risk index Intervention priority Architectural heritage

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Resolution of pleural effusion in a IgD multiple myeloma after chemotherapy based on liposomal doxorubicin

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The Chinese-German Journal of Clinical Oncology 2007年第5期6卷 509-510页

作者： maria José Molina-Garrido carmen Guillén-Ponce maria Guirado-Risueo maria Angeles Molina maria Jesús Molina Alfredo Carrato Department of Oncology General University Hospital from Elche Alicante Spain

IgD myelomas account for only 2% of all myelomas. This kind of hematological malignancy is severe and carries a bleak prognosis. Pleural effusion is very rare in multiple myeloma. We reported a case in which pleural e... 详细信息

关键词： multiple myeloma pleural effusion liposomal doxorubicin

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Contamination of Water for Domestic Use and Human Consumption by Heavy Metals Derived from Mining Activity in Parral, Chihuahua, Mexico

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Journal of Environmental Science and Engineering(A) 2012年第3期1卷 286-294页

作者： Luis Miguel Rodriguez Ever Torres Luis Saenz maria del carmen Avitia Guillermo Rodriguez Eduardo Herrera carmen Julia Navarro Guillermo Gonzalez Luis Lozoya Damaris Acosta Technological Institute of Parral Parral Chihuahua 33850 Mexico Research Center for Advanced Materials （CIMA V） Chihuahua 31109 Mexico

Research was done with the objective of evaluating the quality of water supplied to the potable water system in Hidalgo Del Parral, which comes from two main supply sources： wells from ＂Valle del Verano＂, which provide water to the east side of the city, and the Water Treatment Plant, which receives water from different mines and supplies the west side of the city. When this plant is overcome on its capacity of treatment, a part of the water from the mines is fed directly to the northwest part of the city. The metals lead （Pb）, chromium （Cr）, cadmium （Cd）, zinc （Zn）, and arsenic （As） were analyzed by atomic absorption （AA） technique, based on the United States Environmental Protection Agency （EPA） Method 7000B （Revision 2, February 2007）. The digestion process was done according to the guidelines established in Method NMX-AA-051-SCFI-2001, Analysis of Water-Determination of Metals by Atomic Absorption, developed by the National Standardization Technical Committee for Environmental Protection （Mexico）. The samples were collected from the following points： 13 wells and 2 re-pumping stations of ＂Valle del Verano＂, the inlet and outlet of the Water Treatment Plant, and domestic faucets. The east side of the city, supplied by the wells of ＂Valle del Verano＂, is metal-pollution free. The water that comes from the mines contains high concentrations of As, Zn, Cd and Pb, with levels that can get to 0.12, 32.6, 0.26 and 3.5 mg/L, respectively. This water pollution generated by mining can be concluded from the high levels found in the domestic samples in which, for several points, the concentrations exceed the parameters set by the current guideline. According to the results, it is vital to set a plan of remediation for the water that comes from the mines, because there is a great risk for health in the consumotion of this water.

关键词： Heavy metals mining water contamination.

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Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism:WLB-73502,an analgesic with improved efficacy and safety profile compared to strong opioids

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Acta Pharmaceutica Sinica B 2023年第1期13卷 82-99页

作者： Alba Vidal-Torres Begoña Fernández-Pastor Mónica García Eva Ayet Anna Cabot Javier Burgueño Xavier Monroy Bertrand Aubel Xavier Codony Luz Romero Rosalía Pascual maria Teresa Serafini Gregorio Encina carmen Almansa Daniel Zamanillo Manuel Merlos JoséMiguel Vela WeLab Barcelona Parc Cientific de BarcelonaBarcelona 08028Spain

Opioids are the most effective painkillers,but their benefit-risk balance often hinder their therapeutic ***-73502 is a dual,bispecific compound that binds sigma-1(S1R)and mu-opioid(MOR)***-73502 is an antagonist at the *** behaved as a partial MOR agonist at the G-protein pathway and produced no/unsignificantβ-arrestin-2 recruitment,thus demonstrating low intrinsic efficacy on MOR at both signalling *** its partial MOR agonism,WLB-73502exerted full antinociceptive efficacy,with potency superior to morphine and similar to oxycodone against nociceptive,inflammatory and osteoarthritis pain,and superior to both morphine and oxycodone against neuropathic ***-73502 crosses the blood-brain barrier and binds brain S1R and MOR to an extent consistent with its antinociceptive *** to morphine and oxycodone,tolerance to its antinociceptive effect did not develop after repeated 4-week ***,contrary to opioid comparators,WLB-73502 did not inhibit gastrointestinal transit or respiratory function in rats at doses inducing full efficacy,and it was devoid of proemetic effect(retching and vomiting)in ferrets at potentially effective ***-73502 benefits from its bivalent S1R antagonist and partial MOR agonist nature to provide an improved antinociceptive and safety profile respect to strong opioid therapy.

关键词： WLB-73502 Sigma-1 receptor Mu-opioid receptor Biased agonist Analgesic activity Chronic pain Neuropathic pain Safety

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