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Pathological response to neoadjuvant therapy with chemotherapy vs chemoradiotherapy in stage III NSCLC-contribution of IASLC recommendations

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World Journal of Clinical Oncology 2021年第11期12卷 1047-1063页

作者： Diego Muñoz-Guglielmetti David Sanchez-Lorente Roxana Reyes Daniel Martinez carmen Lucena Marc Boada Pilar Paredes Marta Parera-Roig Ivan Vollmer Joel Mases Roberto Martin-Deleon Sergi Castillo mariana Benegas Silvia Muñoz maria Mayoral Carla Cases Meritxell Mollà Francesc Casas Radiation Oncology Department Hospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Thoracic Surgery Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Medical Oncology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Pathology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Pneumology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Nuclear Medicine Department Faculty of Medicine of University of BarcelonaInstitut d'Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)Barcelona 08036CataluñaSpain Medical Oncology Department Hospital Comarcal de VicVic 08500CataluñaSpain Radiology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Pneumology Department Hospital Universitario Reina SofiaCórdoba 14004AndalucíaSpain Medical Oncology Department Hospital de MolletMollet 08100CataluñaSpain Medical Oncology Department Hospital General de GranollersGranollers 08402CataluñaSpain Nuclear Medicine Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain Radiation Oncology Department Thoracic UnitHospital Clínic de BarcelonaBarcelona 08036CataluñaSpain

BACKGROUND Neoadjuvant treatment(NT)with chemotherapy(Ch)is a standard option for resectable stage III(N2)*** studies have suggested benefits with the addition of radiotherapy(RT)to NT *** International Association for the Study of Lung Cancer(IASLC)published recommendations for the pathological response(PHR)of NSCLC resection specimens after *** To contribute to the IASLC recommendations showing our results of PHR to NT Ch vs NT chemoradiotherapy(ChRT).METHODS We analyzed 67 consecutive patients with resectable stage III NSCLC with positive mediastinal nodes treated with surgery after NT Ch or NT ChRT between 2013 and *** NT,all patients were evaluated for radiological response(RR)according to Response Evaluation Criteria in Solid Tumours criteria and evaluated for surgery by a specialized group of thoracic *** histological samples were examined by the same two *** was evaluated by the percentage of viable cells in the tumor and the resected lymph *** Forty patients underwent NT ChRT and 27 NT ***-six(83.6%)patients underwent surgery(35 ChRT and 21 Ch).The median time from ChRT to surgery was 6 wk(3-19)and 8 wk(3-21)for Ch *** observed significant differences in RR,with disease progression in 2.5%and 14.8%of patients with ChRT and Ch,respectively,and partial response in 62.5%ChRT vs 29.6%Ch(P=0.025).In PHR we observed≤10%viable cells in the tumor in 19(54.4%)and 2 cases(9.5%),and in the resected lymph nodes(RLN)30(85.7%)and 7(33.3%)in ChRT and Ch,respectively(P=0.001).Downstaging was greater in the ChRT compared to the Ch group(80%vs 33.3%;P=0.002).In the univariate analysis,NT ChRT had a significant impact on partial RR[odds ratio(OR)12.5;95%confidence interval(CI):1.21-128.61;P=0.034],a decreased risk of persistence of cancer cells in the tumor and RLN and an 87.5%increased probability for achieving downstaging(OR 8;95%CI:2.34-27.32;P=0.001).CONCLUSION We found significant benefits in RR and PHR

关键词： Non-small cell lung cancer Chemotherapy Chemoradiotherapy Neoadjuvant treatment Resectable stage III Pathological response

SAFETY IN SCHOOL LABORATORIES CHLASTS-AN EUROPEAN PROJECT

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SAFETY IN SCHOOL LABORATORIES CHLASTS-AN EUROPEAN PROJECT

Efficacy of a Strategy for Implementing Guidelines for the Control of Cardiovascular Risk in Primary Healthcare

40th IUPAC Congress

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World Journal of Cardiovascular Diseases 2020年第3期10卷 117-130页

作者： maria Jesús Fernández-Luque Luis María Sánchez-Gómez Vicente Pastor y Aldeguer carmen Suárez-Fernández Belén Sierra-García Soledad Mayayo-Vicente Marta Ruiz-López ángela Gallego-Arenas Rosa Sánchez Alcalde Pilar Loeches-Belinchón Javier López-González Francisco Rodríguez-Salvanés Blanca Novella-Arribas Dirección General de Investigación Docencia y Documentación Consejería de Sanidad Comunidad de Madrid Madrid Spain Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa (IP) Madrid Spain Universidad Autónoma de Madrid Facultad de Medicina Madrid Spain Hospital Universitario de la Princesa SERMAS Consejería de Sanidad Comunidad de Madrid Madrid Spain Gerencia Asistencial de Atención Primaria D.G. de Coordinación de Asistencia Sanitaria SERMAS Consejería de Sanidad Comunidad de Madrid Madrid Spain Unidad de Evaluación de Tecnologías Sanitarias de Madrid Procesos Integrados de Salud Consejería de Sanidad Madrid Spain

Background: A number of strategies exist for the implementation of clinical practice guides (CPGs). Aim: To assess the efficacy of implementing a cardiovascular risk CPG based on an educational method involving opinion leaders, and the habitual method of dissemination among primary healthcare teams. Design and Setting: Controlled, blinded, community intervention trial randomised by clusters. Methods: 21 primary healthcare centres were randomly assigned to either the intervention arm (n = 11) or the control arm (n = 10). The study subjects were patients aged ≥45 years assigned to the centres. The overall impact of the intervention was measured as the difference between the increase in the proportion of patients whose medical records showed the recording of all the variables necessary to calculate cardiovascular risk in both arms. Analyses were performed with Generalized Lineal Model on an intention-to-treat basis. Results: 917 subjects were included at the beginning of the trial (437 in the intervention arm and 480 in the control arm). 826 subjects were included in the final evaluation (436 in the intervention group and 390 in the control arm). At the end of the trial, the recording of the variables necessary for the calculation of the cardiovascular risk in the intervention group had increased more than in the control group (difference between increases 7.49% (95% CI 4.62 - 10.35)) after adjusting for confounding variables. Conclusions: Compared to the habitual method of dissemination, the implementation of this CPG using an educational method involving opinion leaders, improved the recording of the variables needed to calculate patients’ cardiovascular risk.

关键词： Randomized Controlled Trial Cluster Analysis Clinical Practice Guidelines Primary Healthcare Risk Factors Cardiovascular Diseases

Oxidative stress and labile plasmatic iron in anemic patients following blood therapy

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World Journal of Experimental Medicine 2014年第3期4卷 38-45页

作者： Marília Sabo Fernandes Tatiana Tamborena Rissi Luisa Zuravski Juliana Mezzomo carmen Regla Vargas Vanderlei Folmer Félix Alexandre Antunes Soares Vanusa Manfredini Mushtaq Ahmed Robson Luiz Puntel Universidade Federal do Pampa Campus Uruguaiana Uruguaiana RS 97500-970 Brazil Servi?o de Genética Médica Laboratório de Análise de MetabólitosHospital de Clínicas de Porto Alegre Porto Alegre RS CEP 90035-003 Brazil Departamento de Química Centro de Ciências Naturais e Exatas Universidade Federal de Santa Maria Santa Maria RS CEP 97105-900 Brazil Department of Biotechnology University of Science and Technology Bannu 28100Pakistan

AIM: To determine the plasmatic iron content and evaluate the oxidative stress(OS) markers in subjects receiving blood ***: Thirty-nine individuals with unspecified anemia receiving blood transfusions and 15 healthy subjects were included in the study. Anemic subjects were divided into three subgrou P:(1) those that received up to five blood transfusions(n = 14);(2) those that received from five to ten transfusions(n = 11); and(3) those that received more than ten transfusions(n = 14). Blood samples were collected by venous arm puncture and stored in tubes containing heparin. The plasma and cells were separated by centrifugation and subsequently used for analyses. Statistical analyses were performed using Kruskal-Wallis analysis of variance followed by Dunn's multiple comparison tests when ***: The eletrophoretic hemoglobin profiles of the subjects included in this study indicated that no patients presented with hemoglobinopathy. Labile plasmatic iron, ferritin, protein carbonyl, thiobarbituric acidreactive substances(TBARS) and dichlorofluorescein diacetate oxidation were significantly higher(P < 0.05), whereas total thiol levels were significantly lower(P < 0.05) in transfused subjects compared to controls. Additionally, the activity of catalase, superoxide dismutase and glutathione peroxidase were significantly lower in the transfused subjects(P < 0.05). Antioxidant enzyme activities and total thiol levels were positively correlated(P < 0.05), and negatively correlated with the levels of protein carbonyl and TBARS(P < 0.05). In contrast, protein carbonyl and TBARS were positively correlated(P < 0.05). Altogether, these data confirm the involvement of OS in patients following therapy with repeated blood ***: Our data reveal that changes in OS markers are correlated with levels of labile plasmatic iron and ferritin and the number of transfusions.

关键词： Antioxidant enzymes Labile iron content Oxidative stress Polytransfused subjects

Effectiveness and safety of first-generation protease inhibitors in clinical practice:Hepatitis C virus patients with advanced fibrosis

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World Journal of Gastroenterology 2015年第30期21卷 9163-9174页

作者： Javier Salmeron carmen Vinaixa Ruben Berenguer Juan Manuel Pascasio Juan Jose Sanchez Ruano Miguel angel Serra Ana Gila Moises Diago Manuel Romero-Gomez Jose maria Navarro Milagros Testillano Conrado Fernandez Dolores Espinosa Isabel Carmona Jose Antonio Pons Francisco Jorquera Francisco Javier Rodriguez Ramon Perez Jose Luis Montero Rafael Granados Miguel Fernandez Ana Belen Martin Paloma Munoz de Rueda Rosa Quiles CIBERehd Instituto de Salud Carlos Ⅲ28029 MadridSpain Unit for Clinical Management of Digestive Diseases Complejo Hospitalario Universitario de Granada Instituto de Investigacion Biosanitaria de Granada University Hospital Politecnico La Fe Unit for Clinical Management of Digestive Diseases University Hospital Virgen Del Rocio Hospital Toledo University Clinic Hospital of Valencia University General Hospital of Valencia Unit for Clinical Management of Digestive Diseases University Hospital Nuestra Senora de Valme Department of Gastroenterology and Hepatology Agencia Sanitaria Costa del Sol University Hospital Cruces Gastroenterology Unit University Hospital Fundacion Alcorcon University Hospital Virgen Macarena University Hospital Virgen de la Arrixaca Hospital of Leon University General Hospital Reina Sofia Department Gastroenterology and Hepatology University Hospital Central de Asturias University Hospital Reina Sofia University Hospital De Gran Canaria Dr. Negrin Hospital San Pedro de Alcantara

AIM:To evaluates the effectiveness and safety of the first generation,NS3/4A protease inhibitors(PIs) in clinical practice against chronic C virus,especially in patients with advanced fibrosis. METHODS:Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1,treatment-na?ve(TN) or treatment-experienced(TE),who underwent triple therapy with the first generation NS3/4A protease inhibitors,boceprevir(BOC) and telaprevir(TVR),in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow ***:One thousand and fifty seven patients were included,405(38%) were treated with BOC and 652(62%) with TVR. Of this total,30%(n = 319) were TN and the remaining were TE:28%(n = 298) relapsers,12%(n = 123) partial responders(PR),25%(n = 260) null-responders(NR) and for 5%(n = 57) with prior response unknown. The rate of sustained virologic response(SVR) by intention-to-treatment(ITT) was greater in those treated with TVR(65%) than in those treated with BOC(52%)(P < 0.0001),whereas by modified intention-to-treatment(m ITT) no were found significant differences. By degree of fibrosis,56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients,both TN and TE. In the analysis by groups,the TN patients treated with TVR by ITT showed a higher SVR(P = 0.005). However,by m ITT there were no significant differences between BOC and TVR. In the multivariate analysis by m ITT,the significant SVR factors were relapsers,IL28 B CC and non-F4; the type of treatment(BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients,treated with BOC(46%) or with TVR(45%). 28% of the patients interrupted the treatment,mainly by non-viral response(51%):this outcome was

关键词： Hepatitis C Boceprevir Telaprevir First-generation protease inhibitors Advanced fibrosis

Post-Mortem Study of Refractory Concretes Exposed to Corrosive Effect of Synthetic Slag of Petroleum Coke

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材料科学与工程（中英文版） 2010年第10期4卷 24-33页

作者： Rodrigo Puente Ornelas Ana maria Guzman Hernandez Tushar Kanty Das Roy Guadalupe Alan Castillo Rodriguez Carlos Javier Lizcano Zulaica Patricia del carmen Zambrano Robledo Doctoral Program of Materials Engineering Faculty of Mechanical and Electrical Engineering Autonoma University of Nuevo Leon Av. Universidad S/N Cd. Universitaria San Nicolas de los Garza C.P. 66450 Nuevo Le6n Mexico

Fluctuating temperature modifies heat-mortality association around the globe

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The Innovation 2022年第2期3卷 65-72页

作者： Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana maria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahmad Ben Armstrong Bertil Forsberg carmenÍñiguez Caroline Ameling César De la Cruz Valencia ChristoferÅström Danny Houthuijs Do Van Dung Dominic Royé Ene Indermitte Eric Lavigne Fatemeh Mayvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim Iulian-Horia Holobaca Jan Kyselý Joana Madureira Joel Schwartz Klea Katsouyanni Magali Hurtado-Diaz Martina SRagettli Masahiro Hashizume Mathilde Pascal Micheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola Michelozzi Patrick Goodman Paulo Hilario Nascimento Saldiva Rosana Abrutzky Samuel Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda Michelle L.Bell Yuming Guo Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Department of Public Health Environments and SocietyLondon School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre for Statistical Methodology London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre on Climate Change&Planetary Health London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Shanghai Children’s Medical Centre Shanghai Jiao Tong UniversityShanghai 200025China School of Public Health Institute of Environment and Human HealthAnhui Medical UniversityHefei 230032China Center for Global Health Nanjing Medical UniversityNanjing 211166China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4000Australia National Agency for Public Health of the Ministry of Health Labour and Social Protection of the Republic of MoldovaChisinau MD-2009Republic of Moldova Institute of Atmospheric Physics Czech Academy of SciencesPrague 14100Czech Republic Faculty of Environmental Sciences Czech University of Life SciencesPrague 16500Czech Republic Institute of Epidemiology Helmholtz Zentrum M€unchen-German Research Center for Environmental HealthNeuherberg 85747Germany Faculty of Geography and Environmental Sciences Hakim Sabzevari UniversitySabzevar ***Iran Institute of Social and Preventive Medicine University of BernBern 3012Switzerland Oeschger Center for Climate Change Research University of BernBern 3012Switzerland Department of Environmental Health Harvard T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115USA Department of Hygiene Epidemiology and Medical StatisticsNational and Kapodistrian University of AthensAthens 11527Greece Institute for Environment Healthand SocietiesBrunel University LondonLondon UB83PNUK Institute of Environmental Assessment and

Studies have investigated the effects of heat and temperature variability(TV)on ***,few assessed whether TV modifies the heat-mortality *** on daily temperature and mortality in the warm season were collected from 717 locations across 36 *** was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures.

关键词： deviation modif heat

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新西兰酒庄中，为什么获奖最多的是它？

Nuclear imaging in detection and monitoring of cardiotoxicity

葡萄酒 2019年第12期

作者： carmen

在新玛利庄园(Villa maria Estate)的历史上,获得的各类奖项不胜枚举,成为了新西兰获奖最多的酒庄,可以说是来新西兰酒庄游必打卡的。酒庄位于奥克兰西南,距离国际机场只有几分钟车程,常有国内外旅行者造访这里。这次三年级便带大家认...

在新玛利庄园(Villa maria Estate)的历史上,获得的各类奖项不胜枚举,成为了新西兰获奖最多的酒庄,可以说是来新西兰酒庄游必打卡的。酒庄位于奥克兰西南,距离国际机场只有几分钟车程,常有国内外旅行者造访这里。这次三年级便带大家认识一下这个酒庄有哪些特别之处!（共2页)

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World Journal of Radiology 2014年第7期6卷 486-492页

作者： carmen D’Amore Paola Gargiulo Stefania Paolillo Angela maria Pellegrino Tiziana Formisano Antonio Mariniello Giuseppe DellaRatta Elisabetta Iardino marianna D’Amato Lucia La Mura Irma Fabiani Flavia Fusco Pasquale Perrone Filardi Department of Advanced Biomedical Sciences Federico II University SDN Foundation Institute of Diagnostic and Nuclear Development

Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient’s management and *** coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor *** ventricular dysfunction is the most typical manifestation and can lead to heart *** ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage,but it identifies a late manifestation of myocardial *** non-invasive imaging techniques are needed for the diagnosis and monitoringof cardiotoxic *** echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment,greater attention is focused on new nuclear cardiologic techniques,which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical *** aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage,focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity.

关键词： Cardiotoxicity Cardiac nuclear imaging Early diagnosis Scintigraphy Positron emission tomography