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Concentric Centrifugal Figurate Erythema as an Unusual COVID-19 Evanescent Skin Manifestation in a Patient With CD3^(+)/CD45^(+)Lymphocyte Infiltration:A Case Report

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International Journal of Dermatology and Venereology 2024年第2期7卷 115-118页

作者： Lucía Achell Achell-Nava José Luis zaldivar-Fujigaki Rebeca Pérez-Cabeza de Vaca Ana Maria Espinosa García Luis Montiel López Dermatology Department National Medical Center 20 de NoviembreISSSTEMexico City 03229Mexico Biomedical Research Department National Medical Center 20 de NoviembreISSSTEMexico City 03100Mexico Clinical Pharmacology Division General Hospital of MexicoMexico City 06720Mexico Internal Medicine Department National Medical Center 20 de NoviembreISSSTEMexico City 03100Mexico

Introduction:Coronavirus disease 2019(COVID-19)may be associated with various skin *** them,figurate erythema(FE)is rare;only a few clinical reports have been ***,we reported an unusual concentric FE lesions and their immunohistochemical profile in a patient with *** presentation:A 52-year-old woman was diagnosed with *** month later,she developed asymptomatic annular erythematous concentric ring lesions on her inner right *** margin of every ring increased in coloration,and the lesions then completely resolved in 2 weeks.A biopsy revealed vasculitis of small vessels,an increase in the fluorescence intensity of CD3 and CD45,and negativity for COVID-19 ***:The results showed an unusual FE that has a clinical mixed type between erythema annulare centrifugum and erythema gyratum repens;the physiopathological mechanism in the FE due to COVID-19 is unknown;one theory involves rapid viral passage into the cutaneous vascular system that triggers an immune and inflammatory *** the results exhibited a negative COVID-19 RNA in the tissue,the CD3^(+)/CD45^(+)lymphocyte infiltration could explain the clinical pattern as a direct inflammatory response in the small vessel or as a delayed immune ***:Our findings suggest an immunohistochemical small vessel vasculitis pattern with an unusual clinical FE that differs from other types of COVID-19-associated FE or erythema reported previously.

关键词： erythema COVID-19 leukocytoclastic vasculitis skin manifestation CD3 complex CD45 antigen

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Environmental analysis of innovative sustainable composites with potential use in aviation sector -A life cycle assessment review

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Science China(Technological Sciences) 2017年第9期60卷 1301-1317页

作者： BACHMANN Jens HIDALGO carme RICOUT Stephanie Deutsches Zentrum fiir Lufi- und Raumfahrt e. V. (German Aerospace Centre) Institute of Composite Structures and Adaptive Systems-Department of Multifunctional Materials Lilienthalplatz 7 38108 Braunsehweig Germany Leitat Technological Center C/Innovacio 2 08225 Terrassa Spain Airbus Group Innovations Fuels and Environment 12 rue Pasteur 92152 Suresnes France

The forecast of growing air transport in the upcoming decades faces the challenge of an increasing environmental *** industry is working on promising technologies to mitigate this environmental *** design is a strong lever to lower the fuel consumption and,consequently,with it the emissions of *** performance composites are a key technology to help achieve these aims thanks to their favourable combination of mechanical properties and low weight in primary ***,mainly synthetic materials such as petrol based carbon fibres and epoxy resins are used nowadays to produce composite in *** materials like bio-based fibres and resin systems offer potential environmental ***,they have not found their way into aviation,*** reasons are reduced mechanical properties and,especially for the use of natural fibres,their *** of these shortcomings are under *** the application of bio-based and recycled materials in certain areas of the aircraft could be possible in the *** examples for applications are furnishings and secondary *** motivation for this paper is to give an overview of potential environmental properties by using such eco-materials in *** cycle assessment(LCA) is a tool to calculate environmental impacts during all life stages of a *** main focus is laid on the bio-fibres flax and ramie,recycled carbon fibres and bio-based thermoset resin *** an overview of environmental aspects of existing composite materials used in aviation is ***,a lack of LCA results for the substitution of synthetic materials by bio-based/recycled composite materials in aviation applications has been ***,available information from other transport areas,such as automotive,has been *** detailed LCA data for eco-composite materials and technologies to improve their properties is import

关键词： aviation composite natural fibre recycled carbon fibre bio-resin cabin interior secondary structure,fife cycle assessment (LCA)

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Male genitourinary schistosomiasis-related symptoms among long-term Western African migrants in Spain: a prospective population-based screening study

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贫困所致传染病(英文) 2024年第2期13卷 29-38页

作者： Roure Sílvia Vallès Xavier Pérez-Quílez Olga López-Mu?oz Israel Chamorro Anna Abad Elena Valerio Lluís Soldevila Laura Espa?a Sergio Hegazy Alaa H. A. Fernández-Rivas Gema Gorriz Ester Herena Dolores Oliveira Mário Miralles Maria carme Conde carmen Montero-Alia Juan José Fernández-Pedregal Elia Miranda-Sánchez Jose Llibre Josep M. Isnard Mar Bonet Josep Maria Estrada Oriol Prat Núria Clotet Bonaventura The Schisto-Stop study group International Health Program (PROSICS) Barcelona North Metropolitan Territorial Directorate for Infectious Diseases Catalan Institute for Health CAP La Salut Passatge dels Encants S/N Badalona Spain Fundació Lluita contra les Infeccions c/Can Ruti s/n Badalona Spain Infectious Diseases Department Hospital Universitari Germans Trias i Pujol c/Can Ruti s/n Badalona Spain Germans Trias i Pujol Research Institute c/Can Ruti s/n Badalona Spain Microbiology Department Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Department of Genetics and Microbiology Universitat Autònoma de Barcelona c/Can Ruti s/n Badalona Spain Faculty of Medicine University of Asyut El Fateh Assiut Governorate Egypt Department of Urology Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Canovelles Primary Health Care Unit Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Indústria Canovelles Spain Primary Health Care Unit Mataró-(Rocafonda-Palau) Barcelona North Metropolitan Health Directorate Catalan Institute for Health Camí Ral el Ravalet Mataró Barcelona Spain Barcelona North Metropolitan Primary Care Directorate Catalan Institute for Health Ctra. de Barcelona Sabadell Barcelona Spain Directorate for Innovation and Interdisciplinary Cooperation Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain IrsiCaixa-AIDS Research Institute Hospital Universitari Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Infectious Diseases Directorate Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain

Background Schistosomiasis is highly endemic in sub-Saharan Africa and frequently imported to Europe. Male urogenital manifestations are often neglected. We aimed to ascertain the prevalence of genitourinary clinical signs and symptoms among long-term African migrants in a non-endemic European country using a serology *** We carried out a prospective, community-based cross-sectional study of adult male migrants from sub-Saharan Africa living in *** serology tests and microscopic urine examinations were carried out, and clinical data were obtained from an electronic medical record search and a structured *** We included 388 adult males, mean age 43.5 years [Standard Deviation (SD) = 12.0, range: 18–76]. The median time since migration to the European Union was 17 [Interquartile range (IQR): 11–21] years. The most frequent country of origin was Senegal (N = 179, 46.1%). Of the 338, 147 (37.6%) tested positive forSchistosoma. Parasite eggs were present in the urine of only 1.3%. Nine genitourinary clinical items were significantly associated with positiveSchistosoma serology results: pelvic pain (45.2%;OR = 1.57, 95%CI: 1.0–2.4), pain on ejaculation (14.5%;OR = 1.85, 95%CI: 1.0–3.5), dyspareunia (12.4%;OR = 2.45, 95%CI: 1.2–5.2), erectile dysfunction (9.5%;OR = 3.10, 95%CI: 1.3–7.6), self-reported episodes of infertility (32.1%;OR = 1.69, 95%CI: 1.0–2.8), haematuria (55.2%;OR = 2.37, 95%CI: 1.5–3.6), dysuria (52.1%;OR = 2.01, 95%CI: 1.3–3.1), undiagnosed syndromic STIs (5.4%), and orchitis (20.7%;OR = 1.81, 95%CI: 1.0–3.1). Clinical signs tended to *** Urogenital clinical signs and symptoms are prevalent among male African long-term migrants with a positiveSchistosoma serology results. Genital involvement can be frequent even among those with long periods of non-residence in their sub-Saharan African countries of origin. Further research is needed to develop diagnostic tools and validate therapeutic approaches to

关键词： Schistosomiasis Chronic schistosomiasis Urogenital schistosomiasis Male genital schistosomiasis Longterm migrant

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Short-Stay Surgery: Impact of Opening a New Unit in a Tertiary Urban Hospital

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International Journal of Clinical Medicine 2016年第11期7卷 723-725页

作者： Albert Salazar carme Bello Rosa Muñoz Ferran Caballero carme Rullo carme.zaldivar Xavier Martin Margarita Esteve Gemma Craywinckel Hospital de la Santa Creu i Sant Pau Universitat Autònoma Barcelona Barcelona Spain

Objective: The number of procedures considered suitable for short-stay surgery has experienced a remarkable increase. The objective of the study was to determine whether a new short-stay surgical unit (SSSU) was an effective alternative to conventional Hospital Units (HU) for selected elective and urgent surgical conditions. Methods: A comparative analysis (Mann-Whitney test) was used to identify differences between patients admitted to HU (n = 2873) and those admitted to the SSSU (n = 544) during the following months (January 1, 2014 to August 31, 2014, and January 1, 2015 to August 31, 2015, respectively). Results: Statistically significant differences were found in terms of mean length of stay (HU: 4.8 days versus SSSU: 2.2 days;P P = 0.02). There were no statistically significant differences regarding age and sex. Conclusions: We conclude that selected surgical patients with elective or acute conditions can be effectively treated in the SSSU.

关键词： Surgery Short-Stay Hospital Management

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Inflammatory bowel disease in travelers:Choosing the right vaccines and check-ups

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World Journal of Gastroenterology 2011年第22期17卷 2708-2714页

作者： Maria Esteve carme Loras Ester García-Planella Department of Gastroenterology Hospital Universitari Mútua de Terrassa Fundació per la Recerca Mútua de Terrassa University of Barcelona Terrassa Catalonia 08221 Spain Department of Gastroenterology Hospital de la Santa Creu i Sant Pau Barcelona Catalonia 08193 Spain

The majority of patients with inflammatory bowel disease (IBD) achieve good control of the inflammatory activity using available therapies. When remission is achieved and quality of life recovered, a considerable proportion of IBD patients express their desire to travel abroad, be it for business, academic or leisure purposes. Their physicians should help and encourage them whenever possible. However, preventive measures are warranted to minimize the risk, since IBD patients are exposed to the same infections affecting the general population, plus opportunistic infections (OI) related to the immunosuppression. There are a large number of potential OI that might affect patients with IBD. The true prevalence of these infections is unknown, and can vary from country to country. Therefore, reactivation or de novo acquisition of infections such as tuberculosis, malaria, and viral hepatitis will be much more frequent in endemic areas. Therefore, physicians should beaware of these aspects when planning specific preventive measures for patients traveling to a particular country. This includes good control of environmental exposure, chemoprophylaxis when indicated, and the use of a specific vaccination program to prevent endemic infections. In addition, it should be noted that, though the risk of acquiring an infectious disease is probably greater for IBD patients traveling from a developed to a developing country, the inverse situation can also occur; it depends on the previous acquired immunity of the host against infections in any particular environment.

关键词： Inflammatory bowel disease Vaccination Opportunistic infections

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Impact of mass screening for gluten-sensitive enteropathy in working population

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World Journal of Gastroenterology 2009年第11期15卷 1331-1338页

作者： Meritxell Mariné Fernando Fernández-Baares Montserrat Alsina carme Farré Montserrat Cortijo Rebeca Santaolalla Antonio Salas Margarita Tomàs Elias Abugattas carme Loras Ingrid Ordás Josep M Viver Maria Esteve Department of Gastroenterology University Hospital of Mútua de TerrassaResearch Foundation Mútua de TerrassaUniversity of Barcelona08221 TerrassaCataloniaSpain Department of Immunology(Catlab) University Hospital of Mútua de TerrassaResearch Foundation Mútua de TerrassaUniversity of Barcelona08221 TerrassaCataloniaSpain Department of Biochemistry Sant Joan de DéuHospitalEsplugues08950 CataloniaSpain Occupational Health Department Egarsat(Prevention Society)Sant Cugat del Vallès08173 CataloniaSpain Department of Pathology University Hospital of Mútua de TerrassaResearch Foundation Mútua de TerrassaUniversity of Barcelona08221 TerrassaCataloniaSpain

AIM:To assess:(1)frequency and clinical relevanceof gluten sensitive enteropathy(GSE)detected by serology in a mass screening program;(2)sensitivity of antitransglutaminase(tTGA)and antiendomysium antibodies(EmA);and(3)adherence to gluten-free diet(GFD)and follow-up. METHODS:One thousand,eight hundred and sixtyeight subjects recruited from an occupational health department underwent analysis for tTGA and EmA and, if positive,duodenal biopsy,DQ2/DQ8 genotyping, clinical feature recording,blood tests,and densitometry were ***>98%of individuals had tTGA <2 U/mL,this value was established as the cut-off limit of normality and was considered positive when confirmed twice in the same *** to a GFD and follow up were registered. RESULTS:Twenty-six(1.39%)subjects had positive tTGA and/or EmA,and 21 underwent biopsy:six Marsh Ⅲ(oneⅢa,fourⅢb,oneⅢc),nine MarshⅠand six Marsh 0(frequency of GSE 1:125).The sensitivity of EmA for GSE was 46.6%(11.1%for MarshⅠ,100% for MarshⅢ),while for tTGA,it was 93.3%(88.8% for MarshⅠ,100%for MarshⅢ).All 15 patients with abnormal histology had clinical features related to ***ⅠandⅢsubjects had more abdominal pain than Marsh 0(P=0.029),and a similar trend was observed for distension and *** differences in the percentage of osteopenia were found between MarshⅠandⅢ(P=0.608).Adherence to follow-up was 69.2%.Of 15 GSE patients,66.7%followed a GFD with 80%responding to it. CONCLUSION:GSE in the general population is frequent and clinically relevant,irrespective of histological *** is the marker of *** screening programs are useful in identifying patients who can benefit from GFD and follow-up.

关键词： Antitransglutaminase and antiendomysiumantibodies Celiac disease Lymphocytic enteritis Massscreening

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Neuroimaging studies of cognitive remediation in schizophrenia:A systematic and critical review

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World Journal of Psychiatry 2017年第1期7卷 34-43页

作者： Rafael Penadés Alexandre González-Rodríguez Rosa Catalán Bàrbara Segura Miquel Bernardo carme Junqué Department of Psychiatry and Psychology Clinical Institute of NeurosciencesHospital Clínic Neuropsychology Lab University of Barcelona Institut d’Investigacions Biomèdiques August Pi i Sunyer

AIM To examine the effects of cognitive remediation therapies on brain functioning through neuroimaging procedures in patients with *** A systematic, computerised literature search was conducted in the PubM ed/Medline and PsychI nfo databases. The search was performed through February 2016 without any restrictions on language or publication date. The search was performed using the following search terms: [("cogniti*" and "remediation" or "training" or "enhancement") and("fMRI" or "MRI" or "PET" or "SPECT") and(schizophrenia or schiz*)]. The search was accompanied by a manual online search and a review of the references from each of the papers selected, and those papers fulfilling our inclusion criteria were also *** A total of 101 studies were found, but only 18 of them fulfilled the inclusion criteria. These studies indicated that cognitive remediation improves brain activation in neuroimaging studies. The most commonly reported changes were those that involved the prefrontal and thalamic regions. Those findings are in agreement with the hypofrontality hypothesis, which proposes that frontal hypoactivation is the underlying mechanism of cognitive impairments in schizophrenia. Nonetheless,great heterogeneity among the studies was found. They presented different hypotheses, different results and different findings. The results of more recent studies interpreted cognitive recovery within broader frameworks, namely, as amelioration of the efficiency of different networks. Furthermore, advances in neuroimaging methodologies, such as the use of wholebrain analysis, tractography, graph analysis, and other sophisticated methodologies of data processing, might be conditioning the interpretation of results and generating new theoretical frameworks. Additionally, structural changes were described in both the grey and white matter, suggesting a neuroprotective effect of cognitive remediation. Cognitive, functional and structural improvements tend

关键词： Cognitive remediation Cognitive training Neuroimaging Cognition Prefrontal cortex Thalamus Plasticity Schizophrenia

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Radiation and concomitant chemotherapy for patients with glioblastoma multiforme

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Chinese Journal of Cancer 2014年第1期33卷 25-31页

作者： Salvador Villà carme Balaà Sílvia Comas Radiation Oncology Catalan Institute of Oncology HU Germans TriasBadalona 08916 Catalonia Spain Medical Oncology Catalan Institute of Oncology HU Germans TriasBadalona 08916 Catalonia Spain

Postoperative external beam radiotherapy was considered the standard adjuvant treatment for patients with glioblastoma multiforme until the advent of using the drug temozolomide(TMZ) in addition to radiotherapy. High-dose volume should be focal, minimizing whole brain irradiation. Modern imaging, using several magnetic resonance sequences, has improved the planning target volume definition. The total dose delivered should be in the range of 60 Gy in fraction sizes of 1.8-2.0 Gy. Currently, TMZ concomitant and adjuvant to radiotherapy has become the standard of care for glioblastoma multiforme patients. Radiotherapy dose-intensification and radiosensitizer approaches have not improved the outcome. In spite of the lack of high quality evidence, stereotactic radiotherapy can be considered for a selected group of patients. For elderly patients, data suggest that the same survival benefit can be achieved with similar morbidity using a shorter course of radiotherapy(hypofractionation). Elderly patients with tumors that exhibit methylation of the O-6-methylguanine-DNA methyltransferase promoter can benefit from TMZ alone.

关键词：母细胞患者放疗胶质多形性 DNA甲基转移酶化疗放射治疗

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Implementation and Follow-Up of Medical Abortion in Catalonia (2010-2014)

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Open Journal of Obstetrics and Gynecology 2017年第2期7卷 208-219页

作者： carme Ollé Roser Bosser Rosa Gispert Neus Prat Pilar Magrinyà carme Coll Ramón Escuriet Ricard Tresserras Joaquim Calaf Subdirectorate-General for the Service Porfofolio and Health Map Directorate-General for Health Planning Ministry of Health Barcelona Spain Studies Service Directorate-General for Health Planning Ministry of Health Barcelona Spain Sexual and Reproductive Health Services Directorate-General for Health Planning (ASSIR) Costa Ponent Barcelona Spain Directorate-General for Health Planning Ministry of Health Barcelona Spain Sexual and Reproductive Health Services Directorate-General for Health Planning (ASSIR) Barcelonès Nord i Maresme Barcelona Spain Chair of Obstetrics and Gynaecology Autonomous University of Barcelona Barcelona Spain

In 2011 a protocol for medical abortions (MA) up to 49 days of pregnancy was approved by the Ministry of Health of Catalonia’s autonomous government and it was progressively introduced through the public network of the Sexual and Reproductive Health Units (SRHU). In 2014, a new protocol extended to 63 days of pregnancy was set up. Data come from the official abortion registry held by the Ministry of Health, which collects statistical data from all abortions performed in Catalonia. Since 2011, the number and rate of abortions in Catalonia have decreased while the number of health centers providing abortions has increased, especially the SRHU. The proportion of MA abortions went from 0.4% (2010) to 36.9% (2014), while the percentage of early abortions (up to 7 weeks) surged by 14.7%. SRHU reported 73.4% of all MA and hospitals performed 18.7% of the total, while outpatient centers accounted for the remaining 7.9%. Compared to surgical abortions, women having had MA have higher levels of education and lower rates of unemployment. Furthermore, they have more living offspring and fewer previous terminations as well as more frequent attendance to a public family planning center.

关键词： Medical Abortion Catalonia Early Abortions Sexual and Reproductive Health Units (SRHU)

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Predictors of bowel damage in the long-term progression of Crohn’s disease

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World Journal of Clinical Cases 2022年第33期10卷 12208-12220页

作者： Agnes Fernández-Clotet Julian Panés Elena Ricart Jesús Castro-Poceiro Maria carme Masamunt Sonia Rodríguez Berta Caballol Ingrid Ordás Jordi Rimola Department of Gastroenterology Hospital ClinicBarcelona 08036Spain Universitat de Barcelona Institut d'Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)Barcelona 08036Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHDMadrid 28029Spain Department of Radiology Hospital ClinicBarcelona 08036Spain

BACKGROUND Crohn’s disease(CD)is a chronic inflammatory bowel disorder that progresses to bowel damage(BD)over *** image-based index,the Lémann index(LI),has been developed to measure cumulative *** To characterize the long-term progression of BD in CD based on changes in the LI and to determine risk factors for long-term *** This was a single-center longitudinal cohort *** who had participated in prospective studies on the accuracy of magnetic resonance imaging using endoscopy as a gold standard and who had a follow-up of at least 5 years were reevaluated after 5-12 *** Seventy-two patients were *** increased in 38 patients(52.8%),remained unchanged in 9 patients(12.5%),and decreased in 25 patients(34.7%).The small bowel score and surgery subscale significantly increased(P=0.002 and P=0.001,respectively),whereas the fistulizing subscale significantly decreased(P=0.001).Baseline parameters associated with BD progression were ileal location(P=0.026),CD phenotype[stricturing,fistulizing,or both(P=0.007,P=0.006,and P=0.035,respectively)],disease duration>10 years(P=0.019),and baseline LI stricturing score(P=0.049).No correlation was observed between BD progression and baseline clinical activity,biological markers,or severity of endoscopic *** BD,as assessed by the LI,progressed in half of the patients with CD over a period of 5-12 *** main determinants of BD progression were ileal location,stricturing/fistulizing phenotype,and disease duration.

关键词： Crohn’s disease Lémann index Bowel damage Inflammatory bowel disease Magnetic resonance imaging

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