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Advances in Pure Mathematics 2011年第3期1卷 67-72页

作者： carlos j. G. Machado juan de Dios Pérez Young jin Suh 不详

We prove the non-existence of Hopf real hypersurfaces in complex two-plane Grassmannians whose jacobi operators or the jacobi corresponding to the directions in the distribution are of Codazzi type if they satisfy a further condition. We obtain that that they must be either of type (A) or of type (B) (see [2]), but no one of these satisfies our condition. As a consequence, we obtain the non-existence of Hopf real hypersurfaces in such ambient spaces whose jacobi operators corresponding to -directions are parallel with the same further condition.

关键词： Real Hypersurfaces Complex Two-Plane Grassmannians jacobi Operators Codazzi Type

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Open journal of Psychiatry 2018年第3期8卷 212-232页

作者： carlos A. Soria Carolina Remedi Luciana D’Alessio Emilio j. A. Roldán Institute of Biosciences Henri Laborit Córdoba Argentina Buenos Aires University ENyS-CONICET Buenos Aires Argentina Scientific Direction Department Gador SA Buenos Aires Argentina

Introduction: Allostatic load (AL) index proposes indicators for the functioning of the main potentially stress-affected systems. Sex differences in stress response and stress-related diseases susceptibility have been described for the general population. In this observational study we describe the effects of sex and age on AL variables, in a cohort of patients with general anxiety disorders and neuroticism treated with alprazolam during 12 weeks, before and after treatment. Methods: Patients with general (DSM IV) anxiety disorders with >6 in Hamilton scale, AL (>1 Crimmins and Seeman AL modified criteria) and neuroticism >18 (NEO-FFI inventory), were included. All patients completed psychiatric assessment, AL index determination before (−1 week) and after 12 weeks of treatment with alprazolam (0.25 - 1 mg/t.i.d). Allostatic load parameters comprised cardiovascular, metabolic and inflammatory variables. Univariate analysis (two-way ANOVA), Student’s t-test (related variables) and Pearson correlations were determined. Results: Fifty-four patients, 35 females (48.6 ± 11.7 years) and 19 males (44.2 ± 12.8 years) with general anxiety disorder were included;28 patients with Conclusions: In this preliminary analysis we described sex and age differences in psychiatry aspects and AL indexes in patients with general anxiety disorders in the short-term treatment with alprazolam. These considerations remark the need of pondering sex and age differences during the use of drugs for protracted periods.

关键词： Chronic Stress Neuroticism Alprazolam Anxiety Allostatic Load

LIV-4:A novel model for predicting transplant-free survival in critically ill cirrhotics

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World journal of Hepatology 2020年第6期12卷 298-311页

作者： Christina C Lindenmeyer Gianina Flocco Vedha Sanghi Rocio Lopez Ahyoung j Kim Fadi Niyazi Neal A Mehta Aanchal Kapoor William D Carey Eduardo Mireles-Cabodevila carlos Romero-Marrero Department of Gastroenterology Hepatology and NutritionCleveland ClinicClevelandOH 44195United States Department of Internal Medicine Cleveland ClinicClevelandOH 44195United States Department of Quantitative Health Sciences Cleveland ClinicClevelandOH 44106United States Department of Critical Care Medicine Cleveland ClinicClevelandOH 44195United States

BACKGROUND Critically ill patients with cirrhosis,particularly those with acute decompensation,have higher mortality rates in the intensive care unit(ICU)than patients without chronic liver *** of short-term mortality is important in order to identify patients at highest risk of *** of the currently available prognostic models have been widely accepted for use in cirrhotic patients in the ICU,perhaps due to complexity of calculation,or lack of universal variables readily available for these *** believe a survival model meeting these requirements can be developed,to guide therapeutic decision-making and contribute to cost-effective healthcare resource *** To identify markers that best identify likelihood of survival and to determine the performance of existing survival *** Consecutive cirrhotic patients admitted to a United States quaternary care center ICU between 2008-2014 were included and comprised the training *** data and clinical laboratory test collected on admission to ICU were *** under the curve receiver operator characteristics(AUROC)analysis was performed to assess the value of various scores in predicting inhospital mortality.A new predictive model,the LIV-4 score,was developed using logistic regression analysis and validated in a cohort of patients admitted to the same institution between *** Of 436 patients,119(27.3%)died in the *** multivariate analysis,a combination of the natural logarithm of the bilirubin,prothrombin time,white blood cell count,and mean arterial pressure was found to most accurately predict in-hospital *** from the regression coefficients of the independent variables,a novel model to predict inpatient mortality was developed(the LIV-4 score)and performed with an AUROC of 0.86,compared to the Model for End-Stage Liver Disease,Chronic Liver Failure-Sequential Organ Failure Assessment,and Royal Free Hospital Score,wh

关键词： Risk stratification Resource allocation Intensive care unit Acute-on-chronic liver failure Modeling Mortality

Fuzzy Voice Coding with Significant Impulses Modeling and Redundant Waveform Recycling

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Communications and Network 2013年第1期5卷 50-56页

作者： Ismael Rosas Arriaga juan C. García Infante j. carlos Sánchez García Microelectronics Department Escuela Superior de Ingeniería Mecánica y Eléctrica Culhuacán Ciudad de México México

This paper proposes a voice codification based on two algorithms that make the wave form codification in time domain. The first uses the significant impulse model (SIM), which has as a goal to operate as an endpoint detector and as a dawn sampling, through the detection and selection of the significant valleys and crests;the second algorithm, is a redundant wave-form recycler (RWR) that uses an architecture based on fuzzy logic with an accumulative memory. The fuzzy algorithm obtains the similitude grade between the redundant wave forms, this with the objective of save into an knowledge base the patterns, based on the no supervised learning and when there are into memory, automatically there will be used to identified their arrive respect to the input signal, substituting the input block by the correspondent pattern into memory. This decoding process is using the SIM interpolation with a memory in accordance to the RWR.

关键词： Coding Signal Processing Fuzzy Logic Algorithms Pattern Recognition

The role of hypoxia-induced factor 1α in breast cancer

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journal of Cancer Metastasis and Treatment 2019年第6期4卷 44-54页

作者： carlos Henrique F.Peiró jéssica A.Encina Matheus M.Perez Glauco S.A.Aquino Glaucia L.Veiga Fernando Fonseca Beatriz C.A.Alves Laboratório de Análises Clínicas da Faculdade e Medicina do ABC Santo AndréSP CEP 09060-650Brazil Instituto de Ciências Farmacêuticas Universidade Federal de São PauloDiademaSP CEP 09972-270Brazil

Breast cancer usually grows very quickly,becoming insensitive to blood flow in nearby veins;because of that,inside solid tumors it's possible to find a hypoxic environment,in other words,an environment where oxygen is less *** feature of cancer is its angiogenesis rate,because of the high energy demand,new blood vessels must be produced to take nutrients inside the solid tumor *** with normal blood flow bringing the cancer oxygen and nutrients,its cells favor hypoxia,in an event known as Warburg *** to the Warburg Effect,cells,even with normal oxygen rates,prefer to use fermentation instead of the citric acid cycle to produce *** the cancer to operate normally in hypoxia,a transcription factor family is activated,known as hypoxia-induced factors(HIF),composed of a HIF-1βand a HIF-1α*** HIF-1αis expressed during hypoxia,it is a great target for treatments and a breast cancer *** of the role of HIF-1αin cancer and the high incidence of breast cancer worlwide,this review was performed in order to bring the most recent results concerning the role HIF-1αcan exert in breast cancer development and progression.

关键词： Breast neoplasms hypoxia-induced factor 1 HIF-1α

Polarization-independent multimode interference coupler with anisotropy-engineered bricked metamaterial

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Photonics Research 2022年第4期10卷 I0001-I0009页

作者： carlos Perez-Armenta Alejandro Ortega-Monux jose Manuel Luque-Gonzalez Robert Halir Pedro j.Reyes-Iglesias jens Schmid Pavel Cheben Inigo Molina-Fernandez j.Gonzalo Wanguemert-Perez Telecommunication Research Institute(TELMA) Universidad de MalagaCEI Andalucia TECHE.T.S.I.Telecomunicacion29010 MalagaSpain Bionand Center for Nanomedicine and Biotechnology Parque Tecnologico de AndaluciaMalaga 29590Spain National Research Council Canada OttawaOntario K1A 0R6Canada

Many applications, including optical multiplexing, switching, and detection, call for low-cost and broadband photonic devices with polarization-independent operation. While the silicon-on-insulator platform is well positioned to fulfill most of these requirements, its strong birefringence hinders the development of polarizationagnostic devices. Here we leverage the recently proposed bricked metamaterial topology to design, for the first time, to our knowledge, a polarization-independent 2 × 2 multimode interference coupler using standard 220 nm silicon thickness. Our device can be fabricated with a single etch step and is optimized for the O-band,covering a wavelength range of 160 nm with excess loss, polarization-dependent loss, and imbalance below 1 dB and phase errors of less than 5°, as demonstrated with full three-dimensional finite-difference time-domain simulations.

关键词： polarization multimode multiplexing

Collagen secretion screening in Drosophila supports a common secretory machinery and multiple Rab requirements

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journal of Genetics and Genomics 2018年第6期45卷 299-313页

作者： Hongmei Ke Zhi Feng Min Liu Tianhui Sun jianli Dai Mengqi Ma Lu-Ping Liu jian-Quan Ni jos carlos Pastor-Pareja School of Life Sciences Tsinghua University School of Medicine Tsinghua University

Collagens are large secreted trimeric proteins making up most of the animal extracellular *** of collagen has been a focus of interest for cell biologists in recent years because collagen trimers are too large and rigid to fit into the COPII vesicles mediating transport from the endoplasmic reticulum（ER） to the Golgi. Collagen-specific mechanisms to create enlarged ER-to-Golgi transport carriers have been postulated, including cargo loading by conserved ER exit site（ERES） protein ***, we report an RNAi screening for genes involved in collagen secretion in Drosophila. In this screening, we examined distribution of GFP-tagged Collagen IV in live animals and found 88 gene hits for which the knockdown produced intracellular accumulation of Collagen IV in the fat body, the main source of matrix proteins in the larva. Among these hits, only two affected collagen secretion specifically：PH4 a EFB and Plod, encoding enzymes known to mediate posttranslational modification of collagen in the ER. Every other intracellular accumulation hit affected general secretion, consistent with the notion that secretion of collagen does not use a specific mode of vesicular transport, but the general secretory pathway. Included in our hits are many known players in the eukaryotic secretory machinery, like COPII and COPI components, SNAREs and Rab-GTPase regulators. Our further analysis of the involvement of Rab-GTPases in secretion shows that Rab1, Rab2 and Rab X3, are all required at ERES, each of them differentially affecting ERES morphology. Abolishing activity of all three by Rep knockdown, in contrast,led to uncoupling of ERES and Golgi. We additionally present a characterization of a screening hit we named trabuco（tbc）, encoding an ERES-localized TBC domain-containing Rab-GAP. Finally, we discuss the success of our screening in identifying secretory pathway genes in comparison to two previous secretion screenings in Drosophila S2 cells.

关键词： Collagen Ⅳ COPⅡ vesicles RNAi screening Secretory pathway Rab-GTPases ER exit site

Levels of Norovirus and E. coliin Untreated, Biologically Treated and UV-Disinfected Sewage Effluent Discharged to a Shellfish Water

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journal of Water Resource and Protection 2013年第10期5卷 978-982页

作者： carlos j. A. Campos justin Avant james Lowther Dale Till David Lees Aquatic Health & Hygiene Division Centre for Environment Fisheries & Aquaculture Science (CEFAS) Weymouth Laboratory Weymouth UK Southern Water Chichester UK

The efficacy of an activated sludge (modified Ludzack-Ettinger (MLE)) UV disinfection processes in removing human noroviruses and E. coli from sewage were compared with the prevalence of these microorganisms in a settled storm discharge from the same sewage treatment works. Both discharges impacted a designated oyster production area. The treatment process delivered average NoV and E. coli reductions of 2.9log10 and 5.2log10, respectively. Most E. coli reductions occurred during the UV disinfection process whereas the MLE process was comparatively more important in reducing NoV levels. A positive relationship was found between NoV removal and measured applied UV dose. The average levels of total NoV in the settled storm tank were of the same order of magnitude of those in screened raw influent at the works. These results highlight the importance of measures to reduce the impact of stormwater discharges to minimise the risk of NoV gastroenteritis associated with the consumption of oysters.

关键词： Activated Sludge E. coli Norovirus Sewage Stormwater UV Disinfection

Gastrointestinal Kaposi's sarcoma: Case report and review of the literature

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World journal of Gastrointestinal Pharmacology and Therapeutics 2015年第3期6卷 89-95页

作者： Ann joo Lee Lacie Brenner Bashar Mourad Carmela Monteiro Kenneth j Vega juan carlos Munoz Division of Gastroenterology Department of Medicine University of Florida College of Medicine Jacksonville Department of Medicine University of Florida College of Medicine Jacksonville Department of Pathology University of Florida College of Medicine Jacksonville Division of Digestive Diseases and Nutrition University of Oklahoma Health Sciences Center

Kaposi's sarcoma(KS) of the gastrointestinal tract is not an uncommon disease among individuals with acquired immunodeficiency syndrome(AIDS). The majority is asymptomatic, and for this reason, gastrointestinal KS(GI-KS) remains undiagnosed. With continued tumor growth, considerable variation in clinical presentation occurs including abdominal pain, nausea, vomiting, iron deficiency anemia(either chronic or frank gastrointestinal bleeding), and rarely mechanical obstruction alone or combined with bowel perforation. Endoscopy with biopsy allows for histological and immunohistochemical testing to confirm the diagnosis of GI-KS among those with clinical symptoms. In previous studies, dual treatment with highly active antiretroviral therapy and systemic chemotherapy have been associated with improved morbidity and mortality in individuals with visceral KS. Therefore, investigators have suggested performing screening endoscopies in select patients for early detection and treatment to improve outcome. In this review, we describe a 44 years old man with AIDS and cutaneous KS who presented for evaluation of postprandial abdominal pain, vomiting, and weight loss. On upper endoscopy, an extensive, infiltrative,circumferential, reddish mass involving the entire body and antrum of the stomach was seen. Histologic examination later revealed spindle cell proliferation, and confirmatory immunohistochemical testing revealed human herpes virus 8 latent nuclear antigen expression consistent with a diagnosis of gastric KS. Following this, we present a comprehensive review of literature on KS with emphasis on gastrointestinal tract involvement and management.

关键词： Kaposi sarcoma Acquired immunodeficiency syndrome Gastrointestinal endoscopy Epidemiology Gastrointestinal tumor symptoms

Presence of Multidrug-Resistant E. coli, Enterococcusspp. and Salmonellaspp. in Lakes and Fountains of Porto, Portugal

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journal of Water Resource and Protection 2013年第11期5卷 1117-1126页

作者： carlos E. Flores Luís Loureiro Lucinda j. Bessa Paulo Martins da Costa 1ICBAS-Abel Salazar Biomedical Sciences Institute University of Porto Porto Portugal 2CIIMAR-Interdisciplinary Center for Marine and Environmental Research University of Porto Porto Portugal 1ICBAS-Abel Salazar Biomedical Sciences Institute University of Porto Porto Portugal 2Faculty of Sciences (FCUP) University of Porto Porto Portugal CIIMAR-Interdisciplinary Center for Marine and Environmental Research University of Porto Porto Portugal Tulane University School of Public Health and Tropical Medicine New Orleans USA

Urban lakes and fountains provide recreational activities that could facilitate the contact between humans, animals and biological agents. The objective of this work was to assess the water quality and safety of 17 lakes and 13 fountains in the city of Porto (Portugal), by detecting the presence of Escherichia coli, enterococci and Salmonella spp., and analyzing their antimicrobial resistance. (For more information,please refer to the pdf.)

关键词： Antimicrobial Resistance Enterococcus spp. Escherichia coli Salmonella spp. Fountains Lakes