The role of hypoxia-induced factor 1α in breast cancer
作者机构：Laboratório de Análises Clínicas da Faculdade e Medicina do ABCSanto AndréSP CEP 09060-650Brazil Instituto de Ciências FarmacêuticasUniversidade Federal de São PauloDiademaSP CEP 09972-270Brazil
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2019年第4卷第6期
页 面：44-54页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：FAPESP Grant(2017/03558-3) Fellowship grant CNPq(133505/2018-9)to Carlos HFP
主 题：Breast neoplasms hypoxia-induced factor 1 HIF-1α
摘 要：Breast cancer usually grows very quickly,becoming insensitive to blood flow in nearby veins;because of that,inside solid tumors it s possible to find a hypoxic environment,in other words,an environment where oxygen is less *** feature of cancer is its angiogenesis rate,because of the high energy demand,new blood vessels must be produced to take nutrients inside the solid tumor *** with normal blood flow bringing the cancer oxygen and nutrients,its cells favor hypoxia,in an event known as Warburg *** to the Warburg Effect,cells,even with normal oxygen rates,prefer to use fermentation instead of the citric acid cycle to produce *** the cancer to operate normally in hypoxia,a transcription factor family is activated,known as hypoxia-induced factors(HIF),composed of a HIF-1βand a HIF-1α*** HIF-1αis expressed during hypoxia,it is a great target for treatments and a breast cancer *** of the role of HIF-1αin cancer and the high incidence of breast cancer worlwide,this review was performed in order to bring the most recent results concerning the role HIF-1αcan exert in breast cancer development and progression.
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