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Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease

World journal of Gastroenterology 2009年第10期15卷 1209-1218页

作者： Courtney S Schaffert Michael j Duryee carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele Department of Internal Medicine University of Nebraska Medical Center 986350 Nebraska Medical Center Omaha NE 68198-6350 United States Veterans Administration Alcohol Research Center Omaha Veterans Administration Medical Center 4101 Woolworth Avenue Omaha NE 68105 United States Department of Pathology and Microbiology University of Nebraska Medical Center 986495 Nebraska Medical Center Omaha NE 68198-6495 United States

The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD.

关键词： Alcoholic liver disease Inflammation Fibrosis Sinusoidal liver endothelial cells Kupffer cells Hepatocyte Stellate cells Precision cut liver slices

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Sex and season explain spleen weight variation in the Egyptian mongoose

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Current Zoology 2019年第1期65卷 11-20页

作者： Victor BANDEIRA Emilio Virgos Alexandre AZEVEDO joao Carvalho Monica V. CUNHA carlos Fonseca Dartment of Biology Centro de Estudos do Ambiente e do Mar (CESAM) University of Aveiro Campus Universitario de Santiago Aveiro 3810-193 Portugal Departamento de Biologia Geologia Fisica y Qufmica Inorganica Area Biodiversidad y Conservacion Escuela Superior de Ciencias Experimentales y Tecnologia (ESCET) Universidad Rey Juan Carlos c/Tulipan s/n Mostoles Madrid E-28933 Spain Leibniz Institute for Zoo and Wildlife Research Alfred-Kowalke-Straβe 17 Berlin 10315 Germany Instituto de Ciencias Biomedicas Abel Salazar R. Jorge de Viterbo Ferreira 228 Porto 4050-313 Portugal Instituto Nacional de Investigaqao Agraria e Veterinaria (INIAV) IP-National Institute for Agrarian and Veterinary Research Rua dos Lagidos Lugar da Madalena Vairao 4485-655 Portugal cE3c-Centre for Ecology Evolution and Environmental Changes Faculdade de Ciencias Universidade de Lisboa Lisboa 1749-016 Portugal BiolSI-Biosystems & Integrative Sciences Institute Faculdade de Ciencias Universidade de Lisboa Lisboa 1749-016 Portugal Wildlife Ecology & Health group (WE&H) and Servei d'Ecopatologia de Fauna Salvatge (SEFaS) Departament de Medicina i Cirurgia Animals Universitat Autonoma de Barcelona 08193-Bellaterra Barcelona Spain

The Egyptia n mon goose (Herpestes ichneumon Linn aeus, 1758) is a medium-sized car nivore that experienced remarkable geographic expansion over the last 3 decades in the Iberian Peninsula. In this study, we investigated the association of species-related and abiotic factors with spleen weight (as a proxy for immunocompete nee) in the species. We assessed the relationship of body con dition, sex, age, seas on, and envir onmental conditi ons with splee n weight established for 508 hunted specimens. Our results indicate that the effects of sex and season outweigh those of all other variables, including body condition. Spleen weight is higher in males than in females, and heavier spleens are more likely to be found in spring, coinciding with the highest period of investment in reproduction due to mating, gestation, birth, and lactation. Coupled with the absence of an effect of body condition, our findi ngs suggest that splee n weight variation in this species is mostly influe need by lifehistory traits linked to reproduction, rather than overall energy availability, winter immunoenhancement, or energy partitioning effects, and prompt further research focusing on this topic.

关键词： body condition carnivore Herpestes ichneumon Iberian Peninsula mongoose spleen weight

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High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease

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World journal of Gastroenterology 2010年第36期16卷 4558-4563页

作者： juan L Mendoza Amparo San-Pedro Esther Culebras Raquel Cíes carlos Taxonera Raquel Lana Elena Urcelay Fernando de la Torre juan j Picazo Manuel Díaz-Rubio Department of Gastroenterology Hospital Clinico San Carlos28040 MadridSpain Department of Clinical Microbiology Hospital Clinico San Carlos28040 MadridSpain Department of Internal Medicine Hospital Clinico San Carlos28040 MadridSpain Department of Immunology Hospital Clinico San Carlos28040 MadridSpain

AIM:To examine the detection rate of viable Mycobacterium avium subspecies paratuberculosis(MAP) in patients with inflammatory bowel disease [Crohn's disease(CD) and ulcerative colitis(UC)].METHODS:Thirty patients with CD(15 with at least one NOD2/CARD15 mutation),29 with UC,and 10 with no inflammatory bowel disease(IBD).were tested for MAP by polymerase chain reaction(specific IS900 fragment) and blood ***:MAP DNA was detected in all original blood samples and 8-wk blood cultures(CD,UC and non-IBD).Positive MAP DNA status was confirmed by dot blot *** 69 cultures were negative by acid-fast Ziehl-Neelsen *** MAP,in spheroplast form,was isolated from the 18-mo blood cultures of all 30 CD patients,one UC patient,and none of the non-IBD *** association was found between positive MAP cultures and use of immunosuppressive drugs or CDassociated single nucleotide ***:MAP is widely present in our area and MAP DNA can be recovered from the blood of CD,UC and non-IBD ***,MAP spheroplasts were only found in CD patients.

关键词： Mycobacterium avium subspecies paratuberculosis Crohn’s disease Ulcerative colitis Inflammatory bowel disease Polymerase chain reaction Genetic susceptibility

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Preclinical models of idiosyncratic drug-induced liver injury(iDILI):Moving towards prediction

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3685-3726页

作者： Antonio Segovia-Zafra Daniel E.Di Zeo-Sanchez carlos Lopez-Gomez Zeus Perez-Valdes Eduardo Garcıa-Fuentes Raul j.Andrade M.Isabel Lucena Marina Villanueva-Paz Unidad de Gestio´n Clı´nica de Gastroenterologı´a Servicio de Farmacologıa ClınicaInstituto de Investigacio´n Biomedica de Malaga-IBIMAHospital Universitario Virgen de la VictoriaUniversidad de MalagaMalaga 29071Spain Centro de Investigacion Biomedica en Red en el Area Tematica de Enfermedades Hepaticas y Digestivas(CIBERehd) Madrid 28029Spain Platform ISCIII de Ensayos Clınicos UICEC-IBIMAMalaga 29071Spain Unidad de Gestion Clınica de Aparato Digestivo Instituto de Investigacion Biomedica de Malaga(IBIMA)Hospital Universitario Virgen de la VictoriaMalaga 29010Spai

Idiosyncratic drug-induced liver injury(iDILI) encompasses the unexpected harms that prescription and non-prescription drugs,herbal and dietary supplements can cause to the *** remains a major public health problem and a major cause of drug *** the lack of biomarkers for iDILI prediction,diagnosis and prognosis,searching new models to predict and study mechanisms of iDILI is *** of the major limitations of iDILI preclinical assessment has been the lack of correlation between the markers of hepatotoxicity in animal toxicological studies and clinically significant ***,major advances in the understanding of iDILI susceptibility and pathogenesis have come from the study of well-phenotyped iDILI ***,there are many gaps for explaining all the complexity of iDILI susceptibility and ***,there is a need to optimize preclinical human in vitro models to reduce the risk of iDILI during drug ***,the current experimental models and the future directions in iDILI modelling are thoroughly discussed,focusing on the human cellular models available to study the pathophysiological mechanisms of the disease and the most used in vivo animal iDILI *** also comment about in silico approaches and the increasing relevance of patient-derived cellular models.

关键词： Drug-induced liver injury Preclinical models Mechanisms Oxidative stress Mitochondrial damage Immune response Personalized medicine

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Mercury removal using ground and calcined mussel shell

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journal of Environmental Sciences 2013年第12期25卷 2476-2486页

作者： Susana Pea-Rodríguez Alipio Bermúdez-Couso juan carlos Nóvoa-Muoz Manuel Arias-Estvez María j.Fernndez-Sanjurjo Esperanza lvarez-Rodríguez Avelino Núez-Delgado rea de Edafoloxía e Qu' mica Agr' cola. Departamento de Bioloxía Vexetal e Ciencia do Solo. Univ. Vigo. Facultade de Ciencias Ourense Departamento de Edafoloxía e Química Agrícola. Univ. Santiago de Compostela. Escola Politcnica Superior campus univ. s/n

We determined mercury retention on calcined and ground mussel shell, in presence and absence of phosphate, using batch and stirred flow chamber experiments. In batch experiments the calcined shell exhibited higher Hg adsorption, with good fitting to Freundlich equation （R^2： 0.925-0.978）; the presence of phosphate increased Hg adsorption; mercury desorption was 13% or lower, diminishing up to 2% under the presence of phosphates. In stirred flow chamber experiments calcined shell retained more Hg than ground shells （6300 vs. 4000-5200 μmol/kg）; Hg retention increased an additional 40% on calcined shell and up to an additional 70% on ground shells when phosphates were present; mercury desorption was quite similar in all shell types （20%-34%）, increasing up to 49%-60% in ground shells when phosphates were present. The higher Hg adsorption on calcined shell would be related to its calcite and dolomite concentrations; mercury-phosphate interactions would cause the increase in Hg retention when phosphates are present. Data on Hg desorption suggest that Hg retention was not easily reversible after batch experiments, increasing in the stirred flow chamber due to convective flow. Calcined and ground mussel shells could be recycled removing Hg from water, with the presence of phosphates in solution improving efficacy.

关键词： adsorption desorption heavy metals pollution mercury mollusc shell

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An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

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Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha jeong jarno Hiemstra Patrick V.Blokzijl Rebeca Damian-Ferrara Danilo Martins dos Santos jéssica H.L.da Fonseca Min-Ho Kang jihyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez jeroen Leijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

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Test of the Rosetta Pedotransfer Function for Saturated Hydraulic Conductivity

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Open journal of Soil Science 2012年第3期2卷 203-212页

作者： carlos Alvarez-Acosta Robert j. Lascano Leo Stroosnijder Cropping System Research Laboratory Wind Erosion and Water Conservation Research Unit 3810 4th St Lubbock TX 79415 USA Wageningen University Land Degradation and Development Group Soil Science Centre P. O. Box 47 6700 AA Wageningen The Netherlands

Simulation models are tools that can be used to explore, for example, effects of cultural practices on soil erosion and irrigation on crop yield. However, often these models require many soil related input data of which the saturated hydraulic conductivity (Ks) is one of the most important ones. These data are usually not available and experimental determination is both expensive and time consuming. Therefore, pedotransfer functions are often used, which make use of simple and often readily available soil information to calculate required input values for models, such as soil hydraulic values. Our objective was to test the Rosetta pedotransfer function to calculate Ks. Research was conducted in a 64-ha field near Lamesa, Texas, USA. Field measurements of soil texture and bulk density, and laboratory measurements of soil water retention at field capacity (–33 kPa) and permanent wilting point (–1500 kPa), were taken to implement Rosetta. Calculated values of Ks were then compared to measured Ks on undisturbed soil samples. Results showed that Rosetta could be used to obtain values of Ks for a field with different textures. The Root Mean Square Difference (RMSD) of Ks at 0.15 m soil depth was 7.81 × 10–7 m·s–1. Further, for a given soil texture the variability, from 2.30 × 10–7 to 2.66 × 10–6 m·s-1, of measured Ks was larger than the corresponding RMSD. We conclude that Rosetta is a tool that can be used to calculate Ks in the absence of measured values, for this particular soil. Level H5 of Rosetta yielded the best results when using the measured input data and thus calculated values of Ks can be used as input in simulation models.

关键词： Rosetta Saturated Hydraulic Conductivity Ks Pedotransfer Function

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Water,electrolytes,and acid-base alterations in human immunodeficiency virus infected patients

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World journal of Nephrology 2016年第1期5卷 33-42页

作者： carlos G Musso waldo H Belloso Richard j Glassock Division of Nephrology Department of MedicineHospital Italiano de Buenos AiresBuenos Aires C1199ABBArgentina Infectology Section Division of Internal MedicineDepartment of MedineHospital Italiano de Buenos AiresBuenos Aires C1199ABBArgentina Department of Medicine Geffen School of MedicineUCLALos AngelesCA 90095United States

The clinical spectrum of human immunodeficiency virus （HIV） infection associated disease has changed significantly over the past decade, mainly due to the wide availability and improvement of combination antiretroviral therapy regiments. Serious complications associated with profound immunodeficiency are nowa-days fortunately rare in patients with adequate access to care and treatment. However, HIV infected patients, and particularly those with acquired immune defciency syndrome, are predisposed to a host of different water, electrolyte, and acid-base disorders （sometimes with opposite characteristics）, since they have a modified renal physiology （reduced free water clearance, and relatively increased fractional excretion of calcium and magnesium） and they are also exposed to infectious, inflammatory, endocrinological, oncological variables which promote clinical conditions （such as fever,tachypnea, vomiting, diarrhea, polyuria, and delirium）, and may require a variety of medical interventions （antiviral medication, antibiotics, antineoplastic agents）, whose combination predispose them to undermine their homeostatic capability. As many of these disturbances may remain clinically silent until reaching an advanced condition, high awareness is advisable, particularly in patients with late diagnosis, concomitant inflammatory conditions and opportunistic diseases. These disorders contribute to both morbidity and mortality in HIV infected patients.

关键词： Human immunodeficiency virus Acquired immune defciency syndrome Salt water potassium Acid-base

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Nonparametric estimation for stationary and strongly mixing processes on Riemannian manifolds

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Communications in Mathematics and Statistics 2022年第4期10卷 599-621页

作者： Amour T.Gbaguidi Amoussou Freedath Djibril Moussa carlos Ogouyandjou Mamadou Abdoul Diop IMSP Universitéd’Abomey-Calavi(UAC)DangboBenin FAST Universitéd’Abomey-CalaviAbomey-CalaviBenin UniversitéGaston Berger DakarSenegal

In this paper,nonparametric estimation for a stationary strongly mixing and manifoldvalued process(X_(j))is *** this non-Euclidean and not necessarily i.i.d setting,we propose kernel density estimators of the joint probability density function,of the conditional probability density functions and of the conditional expectations of functionals of X_(j)given the past behavior of the *** prove the strong consistency of these estimators under sufficient conditions,and we illustrate their performance through simulation studies and real data analysis.

关键词： Riemannian manifolds Nonparametric estimation Kernel density estimation Stationary and strongly mixing processes Strong consistency

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The descriptive epidemiology of sitting in Chilean adults: Results from the National Health Survey 2009-2010

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journal of Sport and Health Science 2019年第1期8卷 32-38页

作者： Nicolas Aguilar-Farias Pia Martino-Fuentealba ANDrea Cortinez-O'Ryan Damian Chandia-Poblete carlos A.Celis-Morales Paz Bahamondes jaime Leppe Zamora Wendy j.Brown Department of Physical Education Sports and Recreation Universidad de La Frontera BHF Glasgow Cardiovascular Research Centre Institute of Cardiovascular and Medical Science University of Glasgow School of Physiotherapy Universidad del Desarrollo School of Human Movement and Nutrition Sciences The University of Queensland

Background: Although evidence on the health effects of sedentary behavior(SB) has grown systematically in recent years, few developing countries have reported population levels of SB, especially in South America. Our objective was to describe time spent sitting in a representative sample from Chile categorized by age, gender, educational level, and body mass index(BMI).Methods: A national health survey was conducted in Chile in a nationally representative sample(n = 5411) in 2009-2010. Sitting time(ST) was measured with the Global Physical Activity Questionnaire Version ***: Data were from 5031 participants(43.26±0.41 years, mean±SE; 40.3% male). Overall, there were no gender differences in mean ST(men: 158.10±5.80 min/day, women 143.45±4.77 min/day; p = 0.05). ST was lower in those who lived in rural areas compared with urban areas(99.4 min/day vs. 160.0 min/day; p = 0.001). ST increased significantly with increasing BMI, but only in men(p = 0.009), and was positively related to years of education in both men and women(p < 0.0001).Conclusion: The findings were different from those reported in other countries and contexts, reinforcing the need for international surveillance and monitoring over time to inform policy makers. Differences in ST across different groups emphasize the need to develop tailored messages and interventions for reducing ST in different population subgroups.

关键词： Ageing Health behavior Health inequalities Lying Preventive medicine Reclining Screen time Surveillance

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