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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： j.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan carlos Cruchaga Ashley Kleinman jangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor julian C.Schmidt Michael A.Schmidt Kelly Blease juan Moreno Andrew Boddicker junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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Determination of mRNA Expression of Typical Proteins of Tight junctions in the Intestinal Mucosa of Broilers (<i>Gallus gallus domesticus</i>)

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Open journal of Veterinary Medicine 2021年第6期11卷 212-225页

作者： Elizabeth Aguirre García carlos Ignacio Soto Zárate Francisco Rodolfo González Díaz josé Luis Nieto Bordes Germán Isauro garrido Fariña carlos Gerardo García Tovar Laboratorio 4 de Morfología Veterinaria y Biología Celular Unidad de Investigación Multidisciplinaria Facultad de Estudios Superiores Cuautitlán Universidad Nacional Autónoma de México Cuautitlán Izcalli México Laboratorio de Apoyo a Histología y Biología. Facultad de Estudios Superiores Cuautitlán Universidad Nacional Autónoma de México Cuautitlán Izcalli México

Tight junctions are mainly formed by two types of proteins;claudins and occludin, both of which are fundamental to maintain the integrity and barrier function of the intestinal epithelium. This barrier function allows for the absorption of nutrients, mainly by transcytosis;however, in birds, 90% of the substances are absorbed by paracellular mechanisms. Despite this, claudins present in the different parts of the intestinal tract of adult chickens are not known, much less their functional role. This study aimed to determine the presence of mRNA of claudins 1, 2, 3, 5, 10, 12, 16 and occludin, in the different regions of the intestine (duodenum, jejunum, ileum, cecum, and rectum) in chickens (Gallus gallus domesticus) through RT-PCR. To meet this goal, 7 weeks old roosters destined for slaughter and chicken embryos of 16 days of incubation (positive control) were used. For all the processed samples, amplicons of the expected size were obtained;claudin 1 (662 pb), claudin 2 (162 pb), claudin 3 (185 pb), claudin 5 (224 pb), claudin 10 (687 pb), claudin 12 (738 pb), claudin 16 (191 pb) and occludin (430 pb). To corroborate these findings, obtained amplicons were sequenced and, subsequently, a basic alignment was performed on the NCBI, obtaining a correlation of 100% with the original sequences in all analyzed samples. To our knowledge, the present work represents the first written report regarding the presence of mRNA of the main proteins involved in tight junction formation throughout the intestinal tract of domestic chickens of 7 weeks of age. These findings will allow elucidating the specific function of each of the reported proteins in the process of paracellular absorption in chickens.

关键词： Chicken mRNA Claudins Ocludin Tight junctions and RT-PCR

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Biotransformation and degradation of 2,4,6-trinitrotoluene by microbial metabolism and their interaction

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Defence Technology（防务技术） 2018年第2期14卷 151-164页

作者： mónica y. serrano-gonzález rashmi chandra carlos castillo-zacarias felipe robledo-padilla magdalena de j. rostro-alanis roberto parra-saldivar Tecnologico de Monterrey School of Engineering and ScienceCampus MonterreyAve.Eugenio Garza Sada 2501MonterreyN.L.CP 64849Mexico

2,4,6-trinitrotoluene(TNT) and its derivatives are nitrogen-containing aromatic compounds having chemical and thermal stability at ambient temperature and pressure. TNT has high toxicity and mutagenic activity to humans, plants and animals, thus decontamination processes are necessary. Many microorganisms are capable to bioremediate TNT such as bacteria from the genera Pseudomonas,Enterobacter, Rhodococcus, Mycobacterium, Clostridium and Desulfovibrio: fungus such as Phanerochate and Stropharia species are able to perform TNT biotransformation under aerobic and anaerobic conditions. In this work we review the state of TNT biodegradation by various routes: aerobic, anaerobic,combined, fungal, enzymatic, and bio-electrochemical.

关键词： Laccases Aerobic degradation Anaerobic degradation Fungal TNT degradation

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Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America?

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Asian Pacific journal of Tropical Medicine 2015年第12期8卷 1045-1046页

作者： Fernando Mazulis Claudia Weilg carlos Alva-Urcia Maria j.Pons juana del Valle Mendoza School of Medicine Research Center of the Health Sciences FacultyUniversidad Peruana de Ciencias Aplicadas(UPC)

Glucose-6-phosphate dehydrogenase(G6PD) is a cytoplasmic enzyme with an important function in cell oxidative damage *** have a predisposition towards oxidized environments due to their lack of mitochondria,giving G6 PD a major role in its stability.G6 PD deficiency(G6PDd) is the most common enzyme deficiency in humans:it affects approximately 400 million individuals *** overall G6 PDd allele frequency across malaria endemic countries is estimated to be 8%.corresponding to approximately 220 million males and 133 million ***,there are no reports on the prevalence of G6 PDd in Andean communities where bartonellosis is prevalent.

关键词： Glucose-6-phosphate dehydrogenase G6PD Bartonella

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Hidden diversity of marine borderline lichens and a new order of fungi:Collemopsidiales(Dothideomyceta)

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Fungal Diversity 2016年第5期80卷 285-300页

作者： Sergio Pérez-Ortega Isaac garrido-Benavent Martin Grube Rocío Olmo Asunción de los Ríos Museo Nacional de Ciencias Naturales(CSIC) Serrano 115 dpdoE-28006 MadridSpain Real jardín Botánico de Madrid(CSIC) Plaza Murillo 2E-28014 MadridSpain Institute of Plant Sciences University of GrazHolteigasse 6A-8010 GrazAustria Facultad de Ciencias Ambientales y Bioquímica Universidad de Castilla-La ManchaAvenida de Carlos III s/n45071 ToledoSpain

The fungal genus Collemopsidium comprises species that develop so-called borderline lichen symbioses with algae or *** with morphologically similar pyrenocarpous fungi it has been assigned to the family *** adscription of this family to higher taxonomic ranks remain *** sequence data of five nuclear genomic regions(nuLSU,nuSSU,tef1-α,rpb1 and rpb2)and onemitochondrial locus(mtSSU)we found that the studied representatives of this family are placed in the Dothideomyceta,yet relationships with the classes Dothideomycetes and Arthoniomycetes remain *** describe the new order Collemopsidiales to accommodate the genus Collemopsidium(paraphyletic as currently understood)and the lichenicolous genus *** five fungal fossils as calibrations points,we infer an age of c.230 Mya for the crown of *** on two molecular markers,we also provide insight into the global diversity of marine species of the genus *** to the species delimitation algorithm GMYC,c.26 putative species exist,far more than the six species recognized *** have confirmed this result by comparing the two alternative species models by means of Bayes factors,using path sampling and stepping-stone sampling algorithms to estimate the marginal likelihood of each ***,our observations suggest rock-boring ability evolved in parallel in the different lineages within this group of fungi.

关键词： Borderline lichens Dothideomycetes Endolithics.Lichen-forming fungi Lichenicolous fungi Boring ability Marine fungi Model comparison

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PM Diagram of the Transfer Function and Its Use in the Design of Controllers

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journal of Mathematics and System Science 2015年第4期5卷 138-149页

作者： Santiago garrido Luis Moreno carlos Ⅲ University of Madrid Spain

This paper presents an enhanced Root Locus diagram that consists of the representation of the phase and the magnitude of the transfer function G（s） of a system. The magnitude is represented in decibels and the phase is represented by colors. It also presents how to use it to calculate different kinds of controllers. An important characteristic of this diagram is that permits to read the phase and the gain margins directly and the imaginary axis cut represents the Bode diagram. It is also possible to put the grid with damping ratio ξ and frequency ωn.

关键词： Root Locus PID controller Lead network Bode plot Phase margin Gain margin.

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Sound Modulation in Singing Katydids Using Ionic Polymer-Metal Composites （IPMCs）

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journal of Bionic Engineering 2013年第4期10卷 464-468页

作者： Yan Zhou Cheng-Wei Chiu carlos j. Sanchez jorge M. Gonzalez Benjamin Epstein David Rhodes S. Bradleigh Vinson Hong Liang Materials Science and Engineering Texas A&M University College Station TX 77843 USA Department of Mechanical Engineering Texas' A&M University College Station TX 77843 USA Department of Entomology Texas A&M University College Station TX77843 USA Department of Plant Science California State University Fresno CA 93740 USA OpCoast LLC Brick NJ08723 USA

Many insect families have evolved to produce and detect complex singing patterns for the purposes of mating, display of dominance, predator escape, and other needs. While the mechanisms of sound production by insects have been thoroughly studied, man-machine exploitation of such mechanisms has remained unreported. We therefore describe a method to modulate the frequency spectrum in the chirp call of a singing insect, Gampsocleis gratiosa （Orthoptera： Tettigoniidae）, a large katydid indigenous to China and commonly known as Guo Guo or Chinese Bush Cricket. The chirp modulation was achieved through the contact of a ribbon of lonic Polymer-Metal Composite （IPMC） against wing of the insect. The IPMC effectively served as an actuator when a small DC voltage was applied to the ribbon＇s faces. By applying a sequential on/off voltage waveform to the IPMC ribbon, the katydid＇s chirp was modulated in a corresponding manner. This configuration can be used as part of a broader application of using singing insects to harness their acoustic power to produce and propagate machine-induced messages into the acoustic environment.

关键词： chirp modulation katydid IPMC

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Assessing cotton defoliation, regrowth control and root rot infection using remote sensing technology

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International journal of Agricultural and Biological Engineering 2011年第4期4卷 1-11页

作者： Chenghai Yang Shoil M.Greenberg james H.Everitt carlos j.Fernandez USDA-ARS Kika de la Garza Subtropical Agricultural Research CenterWeslacoTexas 78596USA Texas AgriLife Research and Extension Center Corpus ChristiTexas 78406USA

Cotton defoliation and post-harvest destruction are important cultural practices for cotton *** root rot is a serious and destructive disease that affects cotton yield and lint *** paper presents an overview and summary of the methodologies and results on the use of remote sensing technology for evaluating cotton defoliation and regrowth control methods and for assessing cotton root rot infection based on published *** reflectance spectra and airborne multispectral and hyperspectral imagery were used in these *** reflectance spectra effectively separated different levels of defoliation and airborne multispectral imagery permitted both visual and quantitative differentiations among defoliation *** ground reflectance and airborne imagery were able to differentiate cotton regrowth among different herbicide treatments for cotton stalk *** multispectral and hyperspectral imagery accurately identified root rot-infected areas within cotton *** from these studies indicate that remote sensing can be a useful tool for evaluating the effectiveness of cotton defoliation and regrowth control strategies and for detecting and mapping root rot damage in cotton *** with traditional visual observations and ground measurements,remote sensing techniques have the potential for effective and accurate assessments of various cotton production operations and pest conditions.

关键词： remote sensing cotton defoliation regrowth control root rot reflectance spectrum airborne multispectral imagery airborne hyperspectral imagery

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Do non-target species visit feeders and water troughs targeting small game?A study from farmland Spain using camera-trapping

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Integrative Zoology 2021年第2期16卷 226-239页

作者： joséA.ARMENTEROS jesús CARO carlos SÁNCHEZ-GARCÍA Beatriz ARROYO joséA.PÉREZ Vicente RGAUDIOSO Emilio j.TIZADO Department of Animal Production Research Group on Game Species Breeding and ManagementUniversity of LeónLeónSpain Instituto de Investigación en Recursos Cinegéticos(IREC CSIC-UCLM-JCCM)Ciudad RealSpain Fundación Artemisan Ciudad RealSpain Department of Biodiversity and Environmental Management University of LeónPonferradaSpain

Provision of food and water is a widespread tool implemented around the world for the benefit of game and other wildlife,but factors affecting the use of food and water by non-target species are poorly *** evaluated visits to feeders and water troughs by non-game species using camera-traps in two separate areas of *** and water troughs were either“protected”(when surrounded by more than 50%of shrubs/forest)or“open”(in the opposite case).A total of 18948 photos from 5344 camera-trapping days depicted animals,and 75 species were *** and water troughs were visited by target species(partridges and lagomorphs,55.3%of visits)and non-target species(44.7%of visits).Among the latter,corvids were themost common(46.1%of visits),followed by rodents(26.8%),other birds(23.6%,mainly passerines),columbids(1.9%),and other species at minor *** highest proportion of visiting days to feeders and water troughs was from corvids(0.173)followed by otherbirds(0.109)and rodents(0.083);the lowest proportion was recorded for columbids(0.016).Use intensity and visit frequency of water troughs tripled that recorded in feeders,and visits to open feeders/troughs were approximately twice those to protected *** summary:feeders and water troughs targeting small game species are also used regularly by non-target ones;they should be set close to cover to optimize their use by non-target species that are not competitors of target species(though corvids may visit them);water availability should be prioritized where drought periods are expected.

关键词： camera-trapping feeding game species management watering wildlife

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Accumulation of mutations in genes associated with sexual reproduction contributed to the domestication of a vegetatively propagated staple crop,enset

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Horticulture Research 2020年第1期7卷 449-458页

作者： Kiflu Gebramicael Tesfamicael Endale Gebre Timothy j.March Beata Sznajder Diane E.Mather carlos Marcelino Rodríguez López Environmental Epigenetics and Genetics Group Department of HorticultureCollege of AgricultureFood and EnvironmentUniversity of KentuckyLexingtonKY 40546USA Policy Study Institute P.O.Box:2479Addis AbabaEthiopia School of Agriculture Food&WineThe University of AdelaideWaite CampusGlen OsmondSAAustralia

Enset(Ensete ventricosum(Welw.)Cheesman)is a drought tolerant,vegetatively propagated crop that was domesticated in *** is a staple food for more than 20 million people in *** its current importance and immense potential,enset is among the most genetically understudied and underexploited food *** collected 230 enset wild and cultivated accessions across the main enset producing regions in Ethiopia and applied amplified fragment length polymorphism(AFLP)and genotype by sequencing(GBS)analyses to these *** and cultivated accessions were clearly separated from each other,with 89 genes found to harbour SNPs that separated wild from cultivated *** these,17 genes are thought to be involved in flower initiation and seed *** cultivated accessions,differentiation was mostly associated with geographical location and with proximity to wild *** results indicate that vegetative propagation of elite clones has favoured capacity for vegetative growth at the expense of capacity for sexual *** is consistent with previous reports that cultivated enset tends to produce non-viable seeds and flowers less frequently than wild enset.

关键词： cultivated elite flowers

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