检索结果-南通市图书馆

The Immune System and the Role of Inflammation in Perinatal Depression

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2016年第4期32卷 398-420页

作者： Philippe Leff-Gelman Ismael Mancilla-Herrera Monica Flores-Ramos carlos cruz-fuentes Juan Pablo Reyes-Grajeda maría del pilar garcía-cuétara Marielle Danitza Bugnot-Perez David Ellioth Pulido-Ascencio National Institute of Perinatology Mexico City Mexico National Institute of Psychiatry Mexico City Mexico National Institute of Genomic Medicine Mexico CityMexico Faculty of Psychology Anahuac University HuixquilucanMexico National Council of Science and Technology Mexico CityMexico

Major depression during pregnancy is a common psychiatric disorder that arises from a complex and mul- tifactorial etiology. Psychosocial stress, sex, hormones, and genetic vulnerability increase the risk for triggering mood disorders. Microglia and toll-like receptor 4 play a crucial role in triggering wide and varied stress-induced responses mediated through activation of the inflammasome; this leads to the secretion of inflammatory cytokines, increased serotonin metabolism, and reduction of neurotransmitter availability along with hypothalamic-pituitary-adrenal axis hyperactivity. Dysregulation of this intricate neu- roimmune communication network during pregnancy modifies the maternal milieu, enhancing the emergence of depressive symptoms and negative obstetric and neu- ropsychiatric outcomes. Although several studies have clearly demonstrated the role of the innate immune system in major depression, it is still unclear how the placenta, the brain, and the monoaminergic and neuroendocrine systems interact during perinatal depression. Thus, in the present review we describe the cellular and molecular interactions between these systems in major depression during preg- nancy, proposing that the same stress-related mechanisms involved in the activation of the NLRP3 inflammasome in microglia and peripheral myeloid cells in depressed patients operate in a similar fashion in the neuroimmune placenta during perinatal depression. Thus, activation of Toll-like receptor 2 and 4 signaling and the NLRP3 inflammasome in placental immune cells may promote a shift of the Thl/Th2 bias towards a predominant Thl/Thl7 inflammatory response, associated with increased secretion of pro-inflammatory cytokines, among other secreted autocrine and paracrine mediators, which play a crucial role in triggering and/or exacerbating depressive symptoms during pregnancy.

关键词： Depression Pregnancy Immune systemInflammation Cytokine Serotonin Indoleamine dioxygenase Glucocorticoid Brain Placenta

Serum levels of chemokines in adolescents with major depression treated with fluoxetine

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2020年第8期10卷 175-186页

作者： Francisco Rafael de la Peña carlos cruz-fuentes Lino Palacios Manuel Iván Girón-Pérez Emilio Medina-Rivero Maria Dolores Ponce-Regalado Samantha Alvarez-Herrera Gilberto Pérez-Sánchez Enrique Becerril-Villanueva JoséLuis Maldonado-García María C Jiménez-Martínez Lenin Pavón Adolescent Clinic Clinical ServicesNational Institute of Psychiatry“Ramón de la Fuente”Mexico City 14370Mexico Department of Psychiatric Genetics Clinical Research BranchNational Institute of Psychiatry“Ramón de la Fuente”Mexico City 14370Mexico Universidad Autónoma de Nayarit Laboratorio de InmunotoxicologíaBoulevard Tepic-Xalisco s/nCd de la Cultura Amado NervoTepic 63000Mexico Centro Nayarita de Innovación y Transferencia de Tecnología A.C.Laboratorio Nacional para la Investigación en Inocuidad Alimentaria-Unidad Nayarit Calle Tres s/n.Cd IndustrialTepic 63000NayaritMexico Unidad de Desarrollo e Investigación en Bioprocesos Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalUnidad Profesional Lázaro CárdenasMexico City 11340Mexico Departamento de Ciencias de Salud Centro Universitario de los AltosUniversidad de Guadalajara Av Rafael Casillas Aceves No.1200Tepatitlán de MorelosJalisco47610Mexico Laboratory of Psychoimmunology National Institute of Psychiatry“Ramón de la Fuente”Mexico City 14370Mexico Department of Immunology and Research Unit Institute of Ophthalmology“Conde de Valenciana Foundation”Mexico City 06800Mexico Department of Biochemistry Faculty of MedicineNational Autonomous University of MexicoMexico City 04510Mexico

BACKGROUND Major depressive disorder(MDD)is a global health issue that affects 350 million people of all *** between 2%and 5.6%of affected individuals are adolescents,research on young patients is *** inflammatory response contributes to the onset of depression,and in adult MDD patients,symptom severity has been linked to chemokine *** To determine the differences in circulatory levels of chemokines in healthy volunteers(HVs)and adolescents with MDD,and assess the changes induced by fluoxetine *** The 22 adolescents with MDD were monitored during the first 8 wk of clinical follow-up and clinical psychiatric evaluation was done using the Hamilton depresión rating scale(HDRS).The serum levels of monocyte chemoattractant protein-1(MCP-1),macrophage inflammatory protein(MIP)-1α,MIP-1β,interleukin(IL)-8,interferon gamma-induced protein(IP)-10,and eotaxin were measured in patients and *** In all cases,significant differences were detected in circulating chemokine levels between patients before treatment and HVs(P<0.0001).All chemokines decreased at 4 wk,but only MCP-1 and IL-8 significantly differed(P<0.05)between 0 wk and 4 *** the patients,all chemokines rose to their initial concentrations by 8 wk vs 0 wk,but only IP-10 did so significantly(P<0.05).All patients experienced a significant decrease in HDRS scores at 4 wk(P<0.0001)and 8 wk(P<0.0001)compared with 0 *** Despite the consumption of fluoxetine,patients had significantly higher chemokine levels,even after considering the improvement in HDRS *** high levels of eotaxin,IP-10,and IL-8 partially explain certain aspects that are affected in MDD such as cognition,memory,and learning.

关键词： Adolescents Major depression Chemokine Fluoxetine Interferon gammainduced protein-10

Potential seed germination-enhancing plant growth-promoting rhizobacteria for restoration of Pinus chiapensis ecosystems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2021年第5期32卷 2143-2153页

作者： Cristina Domínguez-Castillo Julia María Alatorre-cruz Dolores Castañeda-Antonio Jose Antonio Munive Xianwu Guo Jesús Francisco López-Olguín Luis Ernesto fuentes-Ramírez Ricardo Carreño-López Centro de Investigaciones en Ciencias Microbiológicas Instituto de CienciasBenemérita Universidad Autónoma de PueblaPueblaMéxico Universidad Autónoma de Querétaro QuerétaroMéxico Centro de Biotecnología Genómica Instituto Politécnico NacionalReynosaTamaulipasMéxico

Rhizosphere soil samples of three Pinus chiapensis sites were analyzed for their physicochemical properties,soil bacteria isolated and screened in vitro for growthpromoting *** isolates that showed promise were identified to five genera Dyella,Luteimonas,Euterobacter,Paraburkholderia and Bacillus based on the sequences of16 S rRNA *** the strains were isolated from nondisturbed *** bacteria significantly decreased germination time and increased sprout *** acetic acid and gibberellin production and phosphate solubilisation were *** indicate that these biochemicals could be essential for *** distribution and suggest the possibility that PGPR inoculation on *** seeds prior to planting could improve germination and possibly seedling development.

关键词： Pinus chiapensis Plant growth-promoting rhizobacteria Dyella Luteimonas Enterobacter

Stereological Evaluation of Precipitates within Ferrite Grains in Heat-Treated 1.25Cr0.5Mo Steel Previously Exposed to Service

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Metallic Material Research 2019年第2期2卷 1-8页

作者： Rafael Fernandez-fuentes Americo Scotti Amado cruz-Crespo Roberto Silva Gonzalez Rafael Ariza Nelson Guedes de Alcantara Universidad Central Marta Abreu de Las Villas–UCLV Cuba Universidade Federal de Uberlandia–UFU Brazil Universidade Federal de Sao carlos-UFSCar Brazil University of West Department of Engineering ScienceTrollhattanSweden

The objective of this work was to study the effect of the heat treatment and further operation aging on the stereological parameters(size,quantity and volume fraction)of precipitates within ferrite grains of a creep-resistant 1.25Cr0.5Mo steel after long-term *** heat treatment was similar to the treatment that is carried out in industrial steam pipelines after welding(post weld heat treatment-PWHT)during installation and/or *** operation aging corresponds to a subsequent long in-service operation after *** determine the stereological parameters,SEM digital images were taken from samples of this material after conditions of in-service-aged(after long-term operation),in-service-aged and heat-treated(simulating repairing)and in-service-aged,heat-treated and in-laboratory aged(simulating subsequent long-term operation after repairing).The results indicate that the changes in the stereological parameters of the precipitates within ferrite grains after PWHT is associated with the coarsening process of the within-ferrite-grain precipitates as well as stabilizing the microstructure,since the material aging after PWHT of an in-serviced aged material would not change the stereological parameters.

关键词： Creep-resistant 1.25Cr0.5Mo Steel Repairing PWHT Precipitation coarsening

A biomarker study in Peruvian males with breast cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2021年第10期12卷 926-934页

作者： carlos A Castaneda Miluska Castillo Luis A Bernabe Joselyn Sanchez Ebert Torres Nancy Suarez Katherine Tello Hugo fuentes Jorge Dunstan Miguel De La cruz Jose Manuel Cotrina Julio Abugattas Henry Guerra Henry L Gomez Faculty of Health Sciences Universidad Cientifica del SurLima 15067Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Breast Cancer Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru

BACKGROUND Breast cancer(BC)frequency in males is extremely low and tumor features vary from its female *** cancer clinical and pathological features differ by race in *** infiltrating lymphocyte(TIL)levels,mismatch repair(MMR)protein loss,androgen receptor(AR)expression,and PIK3CA gene mutations are predictive biomarkers of response to biological therapy in female *** is limited information about clinical and pathological features as well as predictive biomarkers in males of non-Caucasian races with *** To investigate clinicopathological features and biomarkers of BC tumors in males and their prognostic value in Peruvian *** This study looked at a single-institution series of 54 Peruvian males with invasive BC who were diagnosed from Jan 2004 to June *** pathological features,TIL levels,MMR proteins,AR immunohistochemistry staining,and PIK3CA gene mutations were prospectively evaluated in cases with available paraffin *** of AR and estrogen receptor(ER)positive cells was additionally calculated by software after slide *** analyses included association tests,intraclass correlation test and Kaplan Meier overall survival *** The median age was 63 years and most cases were ER-positive(85.7%),HER2 negative(87.2%),Luminal-A phenotype(60%)and clinical stage II(41.5%)among our male breast *** TIL was 10%and higher levels tended to be associated with Luminal-B phenotype and higher ***-positive was found in 85.3%and was correlated with ER(intraclass index of 0.835,P<0.001).Loss of MMR proteins was found in 15.4%and PIK3CA mutation(H1047R)in 14.3%(belonged to the Luminal-A phenotype).Loss of MMR proteins was associated with AR-negative(P=0.018)but not with ER(P=0.43)or TIL(P=0.84).Early stages(P<0.001)and lower grade(P=0.006)were associated with longer overall *** status,phenotype,AR status,TIL level,MMR protein loss nor PIK3CA mutation was not associated

关键词： Male breast neoplasm Androgen receptor Tumor-infiltrating lymphocyte Mismatch repair protein PIK3CA mutation

Nonlinear Coefficient Determination of Au/Pd Bimetallic Nanoparticles Using Z-Scan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Nanoparticles 2013年第3期2卷 223-228页

作者： José Luis Jiménez Pérez Rubén Gutiérrez-fuentes José Francisco Sánchez Ramírez Omar Uriel García Vidal Daniel Erick Téllez-Sánchez Zormy Nacary Correa Pacheco Alfredo cruz Orea Jesús Antonio fuentes García Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada México D.F. México Departamento de Física Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional México D.F. México Unidad Profesional Interdisciplinaria en Ingeniería y Tecnologías Avanzadas del IPN México D.F. México

In this paper we present the nonlinear optical characterization of Au/Pd nanoparticles in order to obtain the nonlinear refractive indices using the Z-scan technique. The experiments were performed using a 514 nm laser beam Ar+, with 14 Hz of modulation frequency, as excitation source. By using a lens the excitation beam was focused to a small spot and the sample was moved across the focal region along the z-axis by a motorized translation stage. Seven samples with different concentration ratio of Au/Pd nanoparticles were prepared by simultaneous reduction of gold and palladium ions in presence of poly (N-vinyl-2-pirrolidone) (PVP) using ethanol as a reducing agent. In this work, we report the application of the Z-scan technique, to generate optical transmission of laser light as a function of the z position for solutions containing bimetallic nanoparticles of Au (core)/Pd (shell) with average sizes ranging from 3 to 5 nm. The magnitude of the obtained nonlinear refractive index was in the order of 10?8 cm2/W. Our results show that the nonlinear refractive index has a nonlinear behavior when the (Au/Pd) ratio was increased.

关键词： Nanofluids Nanoparticles Nonlinear Refractive Indices Z-Scan

Mobility Habitus in the Literature From 2020 to 2024

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journalism and Mass Communication 2024年第2期14卷 53-62页

作者： María del Rosario Molina González cruz García Lirios Julio E Crespo Isabel Cristina Rincón Rodríguez Jorge Enrique Chaparro Medina Francisco Rubén Sandoval Vázquez Enrique Martínez Muñoz JoséAlfonso Aguilar fuentes Alfredo Barrera Escobar Universidad de Sonora NavojoaMéxico Universidad de la Salud Ciudad de MexicoMéxico Universidad de Los Lagos OsornoChile Universidad de Santander UDES BucaramangaColombia Universidad de Investigación y Desarrollo UDI BucaramangaColombia Universidad Autónoma del Estado de Morelos CuernavacaMéxico Universidad Autónoma del Estado de Hidalgo PachucaMéxico Universidad Autónoma del Estado de México HuehuetocaMéxico Universidad Fidel Velazquez EdomexMéxico

The objective of the present work is modeling the mobility habitus in the public transport system with low Co2 emission mechanics in the center of *** this sense,a documentary work was carried out with a review of sources indexed to national repositories,using the Delphi technique for the content analysis and the specification of the model.A study was conducted with a selection of 100 students to establish the reliability,linearity,sphericity,adequacy,and validity of an instrument from which a relationship of dependence between income and mobility habitus was *** limits of the search,selection,and processing of information are recognized,and it is recommended to extend the research to international repositories,as well as to employ a more sophisticated technique.

关键词： spatiality habitus capacities model complexity

Implications of Klotho in vascular health and disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2014年第12期6卷 1262-1269页

作者： Ernesto Martín-Núez Javier Donate-Correa Mercedes Muros-de-fuentes Carmen Mora-Fernández Juan F Navarro-González Research Unit University Hospital Nuestra Se?ora de Candelaria 38010 Santa Cruz de Tenerife Spain Clinical Analysis Service and Research Unit University Hospital Nuestra Se ora de Candelaria 38010 Santa Cruz de Tenerife Spain Nephrology Service and Research Unit University Hospital Nuestra Se ora de Candelaria 38010 Santa Cruz de Tenerife Spain

Cardiovascular disease(CVD) is a prevalent condition in general population and the first cause of death overall. Klotho, a pleiotropic protein related to longevity that acts as a co-receptor of the fibroblast growth factor 23, has been proposed as a key regulator of the development of CVD. In the few clinical studies made, it has been observed a relationship between low levels of soluble Klotho and the occurrence and severity of CVD, as well as a reduction of cardiovascular risk when they are high. Also, different polymorphisms of human Klotho gene have been related to the incidence of cardiovascular events. Moreover, several experimental studies indicate that this protein acts in the maintenance of vascular homeostasis. Klotho improves endothelial dysfunction through promotion of NO production and mediates antiinflammatory and anti-aging effects such as suppression of adhesion molecules expression, attenuation of nuclear factor-kappa B or inhibition of Wnt signaling. Furthermore,this protein is related to the attenuation of vascular calcification as well as prevention of cardiac hypertrophy. The expression of this protein in the vascular wall implies a new scenario for the treatment of vascular disorders. The purpose of this review is to provide an overview of the relationship between the Klotho protein and CVD, in addition to its role in the maintenance of functional vascular integrity.

关键词： Klotho Cardiovascular disease Vascular health Aging Endothelial dysfunction Vascular calcification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

阿尔特米奥·克罗斯之死第1版

阿尔特米奥·克罗斯之死