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Neuroscience Bulletin 2015年第1期31卷 75-86页

作者： Jing Wang Liang Jing Juan-carlos Toledo-salas Lin Xu Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of Sciences Kunming College of Life Science University of the Chinese Academy of Sciences

Depression is a devastating psychiatric disorder widely attributed to defi cient monoaminergic signaling in the central nervous system. However,most clinical antidepressants enhance monoaminergic neurotransmission with little delay but require 4-8 weeks to reach therapeutic efficacy,a paradox suggesting that the monoaminergic hypothesis of depression is an oversimplifi cation. In contrast to the antidepressants targeting the monoaminergic system,a single dose of the N-methyl-D-aspartate receptor（NMDAR） antagonist ketamine produces rapid（within 2 h） and sustained（over 7 days） antidepressant effi cacy in treatment-resistant patients. Glutamatergic transmission mediated by NMDARs is critical for experience-dependent synaptic plasticity and learning,processes that can be modifi ed indirectly by the monoaminergic system. To better understand the mechanisms of action of the new antidepressants like ketamine,we review and compare the monoaminergic and glutamatergic antidepressants,with emphasis on neural plasticity. The pathogenesis of depression may involve maladaptive neural plasticity in glutamatergic circuits that may serve as a new class of targets to produce rapid antidepressant effects.

关键词： depression stress neural plasticity glutamatergic transmission monoamine-based antidepressant ketamine

Site Characterization Index for Continuous Power Quality Monitoring Based on Higher-order Statistics

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 222-231页

作者： Olivia Florencias-Oliveros Juan-José González-de-la-Rosa Jose-María Sierra-Fernández Agustín Agüera-Pérez Manuel-Jesús Espinosa-Gavira José-carlos Palomares-salas Department of Automation Engineering ElectronicsArchitecture and Computers NetworksResearch Group TIC168Higher Polytechnic SchoolUniversity of CádizAlgeciras 11202Spain

The high penetration of distributed generation(DG)has set up a challenge for energy management and consequently for the monitoring and assessment of power quality(PQ).Besides,there are new types of disturbances owing to the uncontrolled connections of non-linear *** stochastic behaviour triggers the need for new holistic indicators which also deal with big data of PQ in terms of compression and scalability so as to extract the useful information regarding different network states and the prevailing PQ disturbances for future risk assessment and energy management *** and continuous monitoring would guarantee the report to claim for damages and to assess the risk of PQ *** this context,we propose a measurement method that postulates the use of two-dimensional(2D)diagrams based on higher-order statistics(HOSs)and a previous voltage quality index that assesses the voltage supply waveform in a continous monitoring *** suitable for both PQ and reliability applications,the results conclude that the inclusion of HOS measurements in the industrial metrological reports helps characterize the deviations of the voltage supply waveform,extracting the individual customers’pattern fingerprint,and compressing the data from both time and spatial *** method allows a continuous and robust performance needed in the SG ***,the method can be used by an average consumer as a probabilistic method to assess the risk of PQ deviations in site characterization.

关键词： Continuous statistical monitoring big data data compression higher-order statistics(HOSs) power quality(PQ)

Low Voltage Daily Energy Demand Temperature Dependent Representation by Using Circular Statistics

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Applied Mathematics 2019年第3期10卷 61-74页

作者： Pucheta Julián salas carlos Piumetto Miguel Herrera Martín Rodriguez Rivero Cristian Departamento de Electrónica-FCEFyN-Universidad Nacional de Córdoba Córdoba Argentina FTyCA-Universidad Nacional de Catamarca San Fernando del Valle de Catamarca Argentina Center for Neuroscience University of California at Davis-EEUU Davis Argentina

In this work, a tool that allows visualizing the probability of the power demand according to the temperature and the hours of the day is presented. This aim contributes to the decision making support for the transformer and its service administration. The objective is to represent the demand accurately as a color statistical map based on two variables: the time of day and the ambient temperature. Since the daily energy consumption is periodic regarding the hours of the day in terms of several days, its representation with Gaussian models becomes difficult, but it is simplified when working with circular statistics. The circular statistics used here is the Von Mises distribution, which has the parameters mean address and kappa concentration. Results obtained from measurements made over a year in a medium-voltage transformer with intervals of 60 minutes are shown.

关键词： Distribution Transformers Charge Estimation Time Series Dynamic Process Circular Statistics

Short and Long-Term Time Series Forecasting Stochastic Analysis for Slow Dynamic Processes

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Applied Mathematics 2019年第8期10卷 704-717页

作者： Julián Pucheta carlos salas Martín Herrera Cristian Rodriguez Rivero Gustavo Alasino FCEFyN-Universidad Nacional de Córdoba Córdoba Argentina FTyCA-Universidad Nacional de Catamarca Catamarca Argentina Cristian University of California Los Angeles USA Universidad Torcuato Di Tella Buenos Aires Argentina

This paper intends to develop suitable methods to provide likely scenarios in order to support decision making for slow dynamic processes such as the underlying of agribusiness. A new method to analyze the short- and long-term time series forecast and to model the behavior of the underlying process using nonlinear artificial neural networks (ANN) is presented. The algorithm can effectively forecast the time-series data by stochastic analysis (Monte Carlo) of its future behavior using fractional Gaussian noise (fGn). The algorithm was used to forecast country risk time series for several countries, both for short term that is 30 days ahead and long term 350 days ahead scenarios.

关键词： Stochastic Analysis Time Series Forecasting Decision Making Dynamic Process Process Modelling

HVOF-sprayed HAp/S53P4 BG composite coatings on an AZ31 alloy for potential applications in temporary implants

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Journal of Magnesium and Alloys 2024年第1期12卷 345-360页

作者： carlos A.Poblano-salas John Henao Astrid L.Giraldo-Betancur Paola Forero-Sossa Diego German Espinosa-Arbelaez Jorge A.González-Sánchez Luis R.Dzib-Pérez Susana T.Estrada-Moo Idelfonso E.Pech-Pech CIATEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-CIATEQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-Cinvestav Libramiento Norponiente#2000.Fraccionamiento Real de JuriquillaQuerétaro 76230Mexico Universidad Tecnológica de Querétaro Av.Pie de la Cuesta N°2501Querétaro 76148Mexico CIDESI Av.Playa Pie de la Cuesta No 702Col.San PabloQuerétaro 76125Mexico Center for Corrosion Research Autonomous University of CampecheAv.Héroe de Nacozari No.480P.C.24070San Francisco de CampecheCam.Mexico

Bioactive thermal spray coatings produced via high-velocity oxygen fuel spray(HVOF)from hydroxyapatite(HAp)and bioactive glasses(BG)have the potential to be employed on temporary implants due to the ability of both HAp and BG to dissolve and promote osseointegration,considering that both phases have different reaction and dissolution rates under in-vitro *** the present work,75%***-25%wt.S53P4 bioactive glass powders were HVOF-sprayed to obtain HAp/S53P4 BG composite coatings on a bioresorbable AZ31 *** study is focused on exploring the effect of the stand-off distance and fuel/oxygen ratio variation as HVOF parameters to obtain stable structural coatings and to establish their effect on the phases and microstructure produced in those *** characterization techniques,such as scanning electron microscopy,X-ray diffraction,and Fourier transform infrared spectroscopy,were employed to characterize relevant structural and microstructural properties of the composite *** results showed that thermal gradients during coating deposition must be managed to avoid delamination due to the high temperature achieved(max 550℃)and the differences in coefficients of thermal *** was also found that both spraying distance and oxygen/fuel ratio allowed to keep the hydroxyapatite as the main phase in the *** addition,in-vitro electrochemical studies were performed on the obtained HAp/S53P4 BG composite coatings and compared against the uncoated AZ31 *** results showed a significant decrease in hydrogen evolution(at least 98%)when the bioactive coating was applied on the Mg alloy during evaluation in simulated body fluid(SBF).

关键词： Coatings Composites Thermal spray Temporary implants Hydrogen evolution

Stability Analysis of a Neurocontroller with Kalman Estimator for the Inverted Pendulum Case

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Applied Mathematics 2017年第11期8卷 1602-1618页

作者： Julián Antonio Pucheta Cristian Rodríguez Rivero carlos Alberto salas Martín Herrera Sergio Oscar Laboret Departamentos de Electrotecnia y de Electrónica Laboratorio de Investigación Matemática Aplicada a Control (LIMAC) Facultad de Ciencias Exactas Físicas y Naturales-Universidad Nacional de Córdoba Córdoba Argentina Departamento de Ingeniería Electrónica Facultad de Tecnología y Ciencias Aplicadas Universidad Nacional de Catamarca Catamarca Argentina

In this paper, a practical analysis of stability by simulation for the effect of incorporating a Kalman estimator in the control loop of the inverted pendulum with a neurocontroller is presented. The neurocontroller is calculated by approximate optimal control, without considering the Kalman estimator in the loop following the Theorem of the separation. The results are compared with a time-varying linear controller, which in noiseless conditions in the state or in the measurement has an acceptable performance, but when it is under noise conditions its operation closes into a state space range more limited than the one proposed here.

关键词： Optimal Control Neurocontroller Inverted Pendulum State Estimation Stability

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G6PD缺陷症对恶性疟疾感染风险的影响

实用医学杂志 2014年第21期30卷 3418-3421页

作者：陈江涛林敏刘配芬钟德善谢东德 Santiago-m Monte-Nguba Juan carlos salas Ehapo Urbano Monsuy Eyi 杨立业杨辉詹小芬杨惠钿广东省惠州市中心医院检验中心 516001 南方医科大学附属潮州市中心医院中心实验室广东省潮州市521000 广东省惠州市中医医院 516001 广东省江门市人民医院检验科 529020 赤道几内亚马拉博马拉博地区医院检验科

目的:观察葡萄糖-6-磷酸脱氢酶(G6PD)缺陷症不同表型对恶性疟原虫感染的影响。方法:采用横断面研究的方式,将2012年雨季到马拉博地区医院就诊的2 690名比奥克岛当地居民纳入研究。用显微镜镜检、荧光定量PCR结合熔解曲线法检测疟原虫。... 详细信息

目的:观察葡萄糖-6-磷酸脱氢酶(G6PD)缺陷症不同表型对恶性疟原虫感染的影响。方法:采用横断面研究的方式,将2012年雨季到马拉博地区医院就诊的2 690名比奥克岛当地居民纳入研究。用显微镜镜检、荧光定量PCR结合熔解曲线法检测疟原虫。用荧光斑点法及PCR-DNA测序鉴定G6PD缺陷症。采用Logistic回归进行关联性分析。结果:该人群的G6PD缺陷症的总发生率为9.22%,基因型均为G6PD*A-(c.202 G>A/c.376 A>G)。G6PD缺陷症体现出强烈的疟疾保护作用(P0.05)。结论:G6PD缺陷症的男性半合子表型能够减低恶性疟疾感染的风险,但是其机制尚未明确,有待更深入的研究。

关键词：疟疾,恶性 G6PD缺乏症横断面研究

赤道几内亚比奥科岛G6PD缺乏症分子流行病学研究

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分子诊断与治疗杂志 2014年第5期6卷 296-301页

作者：詹小芬陈江涛谢东德杨辉杨惠钿杨立业陆志为 Santiago-m Monte-Nguba Juan carlos salas Ehapo Urbano Monsuy Eyi 林敏南方医科大学附属潮州市中心医院检验实验中心广东潮州521000 中国第25批援赤道几内亚医疗队广东广州510000 广东省惠州市中心医院检验中心广东惠州516001 中国第26批援赤道几内亚医疗队广东广州510000 潮州市公安局法医鉴定中心广东潮州521000 Malabo Regional Hospital Malabothe Republic of Equatorial Guinea

目的探讨非州西部赤道几内亚比奥科岛(Bioko Island)人群的葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症的发生率及基因型。方法在2012年1月至5月期间,用荧光斑点法对2 187名比奥科岛当地居民进行G6PD缺乏症筛查。采用高分辨熔解曲线(High-resoluti... 详细信息

目的探讨非州西部赤道几内亚比奥科岛(Bioko Island)人群的葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症的发生率及基因型。方法在2012年1月至5月期间,用荧光斑点法对2 187名比奥科岛当地居民进行G6PD缺乏症筛查。采用高分辨熔解曲线(High-resolution melting,HRM)分析G6PD缺乏的标本的c.202 G>A与c.376 A>G。对HRM筛选不出突变的G6PD酶学缺乏的样本,针对非洲的其他突变类型:c.542 A>T(rs5030872)、c.680 G>A(rs137852328)、c.968 T>C(rs76723693)进行PCR-DNA测序。结果赤道几内亚比奥科岛人群的G6PD缺乏症总发生率为8.54%(189/2 187),其中男性84例(9.04%,84/929),女性105例(8.34%,105/1 258),男女检出率比为1.08:1。在189例G6PD缺乏标本中共检出两种基因类型,其中包括G6PD A-变异体(c.376 A>G/c.202 G>A)186例(98.41%,186/189G6PD Betica(c.376 A>G/c.968T>C)3例(1.59%3/189)。结论赤道几内亚比奥科岛是G6PD缺乏症高发区,基因型比较单一。HRM技术可用于非洲地区G6PD缺乏症的临床诊断和流行病学研究。

关键词： G6PD缺乏症比奥科岛高分辨熔解曲线基因型 PCR-DNA测序

SYBR GreenⅠ染料法定量PCR检测疟原虫感染及

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分子诊断与治疗杂志 2013年第4期5卷 227-231页

作者：陈江涛刘配芬钟德善潘雪峰杨辉杨立业陆志为杨惠钿林敏 Santiago-m Monte-Nguba Juan carlos salas Ehapo Urbano Monsuy Eyi 广东省惠州市中心人民医院检验中心广东惠州516001 中国第25批援赤道几内亚医疗队广东广州510000 广东省惠州市中医医院广东惠州516001 南方医科大学附属潮州市中心医院中心实验室广东潮州521000 潮州市公安局法医鉴定中心广东潮州521000 Hospital Regional De Malabo

目的评价一种可以快速定量检测疟原虫及虫种鉴别的荧光定量PCR法。方法将SYBR Green Ⅰ法与TaqMan探针法检测疟原虫进行比对,评价定量的准确性及方法的敏感度。以PCR-DNA测序法为金标准,评价SYBR Green Ⅰ法分型的准确性。结果两个方法... 详细信息

目的评价一种可以快速定量检测疟原虫及虫种鉴别的荧光定量PCR法。方法将SYBR Green Ⅰ法与TaqMan探针法检测疟原虫进行比对,评价定量的准确性及方法的敏感度。以PCR-DNA测序法为金标准,评价SYBR Green Ⅰ法分型的准确性。结果两个方法的定量拷贝检测数无显著性差异(P>0.05)。SYBR Green Ⅰ法检测疟原虫的最低检测下限为1×102copy/mL至5×102copy/mL之间。与PCR-DNA测序法比较,SYBR Green Ⅰ法能准确的对感染的疟原虫虫种做准确的鉴定。结论 SYBR Green I染料法定量可同时进行人体疟原虫的定量检测和虫种鉴别,且成本低廉,操作简便快速,可以在疟疾的高发地区推广使用。

关键词：疟疾荧光定量PCR SYBR Green Ⅰ 虫种鉴别

赤道几内亚Bioko岛的恶性疟原虫多药抗性基因(pfMDR-1)的研究

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分子诊断与治疗杂志 2014年第3期6卷 152-156页

作者：卢丹洁陈江涛谢东德杨辉詹小芬杨惠钿杨立业陆志为 Santiago-m Monte-Nguba Juan carlos salas Ehapo Urbano Monsuy Eyi 林敏南方医科大学附属潮州市中心医院检验实验中心广东潮州521000 中国第25批援赤道几内亚医疗队广东广州510000 广东省惠州市中心医院检验中心广东惠州516001 中国第26批援赤道几内亚医疗队广东广州510000 潮州市公安局法医鉴定中心广东潮州521000 Malabo Regional Hospital Malabothe Republic of Equatorial Guinea

目的对赤道几内亚Bioko岛上恶性疟原虫多药抗性基因(pfMDR-1)进行分析,为Bioko岛的疟疾防控和治疗提供依据。方法2012年雨季期间采集的恶性疟原虫感染患者样本151份,用巢式PCR技术特异性扩增N86Y、E130K、Y184F、S1034C、N1042D、V1109I... 详细信息

目的对赤道几内亚Bioko岛上恶性疟原虫多药抗性基因(pfMDR-1)进行分析,为Bioko岛的疟疾防控和治疗提供依据。方法2012年雨季期间采集的恶性疟原虫感染患者样本151份,用巢式PCR技术特异性扩增N86Y、E130K、Y184F、S1034C、N1042D、V1109I、D1246Y耐药分子标记的pfMDR-1基因片段,然后进行测序分析。结果虫株中共发现了4种不同的单倍型:YEY/SNVD、NEF/SNVD、YEF/SNVD和NEY/SNVD。91.39%(138/151)的样本发现了耐药性位点突变,包括3.31%(5/151)的86Y,29.80%的184F,和58.29%(88/151)的双重突变86Y/184F。结论结果表明赤道几内亚Bioko岛上的恶性疟原虫株存在较高比例耐药基因突变和耐药复合基因突变,为当地的抗疟疾选用药物提供指导。

关键词：恶性疟原虫多药抗性基因(pfMDR-1) 耐药突变 Bioko岛