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Complex derivatives valuation: applying the Least-Squares Monte Carlo Simulation Method with several polynomial basis

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Financial Innovation 2016年第1期2卷 1-14页

作者： Ursula Silveira Monteiro de Lima carlos patricio samanez Department of Industrial Engineering Pontifical Catholic University of Rio de JaneiroMarquês de São Vicente Street225/22453-900 GáveaRio de JaneiroBrazil

Background:This article investigates the Least-Squares Monte Carlo Method by using different polynomial basis in American Asian Options *** standard approach in the option pricing literature is to choose the basis *** comparing four different polynomial basis we show that the choice of basis interferes in the option's ***:We assess Least-Squares Method performance in pricing four different American Asian Options by using four polynomial basis:Power,Laguerre,Legendre and Hermite *** every American Asian Option priced,three sets of parameters are used in order to evaluate it ***:We show that the choice of the basis interferes in the option's price by showing that one of them converges to the option's value faster than any other by using fewer simulated *** the case of an Amerasian call option,for example,we find that the preferable polynomial basis is Hermite *** an Amerasian put option,the Power polynomial basis is *** empirical outcome is theoretically unpredictable,since in principle all basis can be indistinctly used when pricing the ***:In this article The Least-Squares Monte Carlo Method performance is assessed in pricing four different types of American Asian Options by using four different polynomial basis through three different sets of *** results suggest that one polynomial basis is best suited to perform the method when pricing an American Asian *** all basis can be indistinctly used when pricing the ***,our results does not confirm *** find that when pricing an American Asian put option,Power A is better than the other basis we have studied here whereas when pricing an American Asian call,Hermite A is better.

关键词： Complex derivatives valuation Least-Squares Monte Carlo Method Amerasian options Polynomial basis

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Physical activity and amyloid beta in middle-aged and older adults:A systematic review and meta-analysis

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Journal of Sport and Health Science 2024年第2期13卷 133-144页

作者： María Rodriguez-Ayllon patricio Solis-Urra Cristina Arroyo-ávila Miriam álvarez-Ortega Pablo Molina-García Cristina Molina-Hidalgo Manuel Gómez-Río Belinda Brown Kirk I.Erickson Irene Esteban-Cornejo Department of Epidemiology Erasmus University Medical Center RotterdamRotterdamGD 3015the Netherlands Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18071Spain Faculty of Education and Social Sciences Universidad Andres BelloVina del Mar 2531015Chile Department of Nuclear Medicine Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Physical Medicine and Rehabilitation Service Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Department of Psychology University of PittsburghPittsburghPA 15260USA Centre for Healthy Ageing Health Futures InstituteMurdoch UniversityMurdochWA 6150Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia Advent Health Research Institute Neuroscience Institute OrlandoOrlandoFL 32803USA Physiopathology of Obesity and Nutrition Research Center(CIBERobn) Institute of Health Carlos Ⅲ(ISCⅢ)Madrid 28029Spain

Background:One of the pathological hallmarks distinguishing Alzheimer’s disease from other dementias is the accumulation of amyloid beta(Aβ).Higher physical activity is associated with decreased dementia risk,and one potential path could be through Aβlevels *** aimed to explore the relationship between physical activity and Aβin middle-aged and older ***:A systematic search of PubMed,Web of Science,PsycINFO,Cochrane Central Register of Controlled Trials,and SPORTDiscus was performed from inception to April 28,*** were eligible if they included physical activity and Aβdata in adults aged 45 years or ***-level metaanalyses of intervention and observational studies were performed to examine the role of physical activity in modulating Aβ***:In total,37 articles were included(8 randomized controlled trials,3 non-randomized controlled trials,4 prospective longitudinal studies,and 22 cross-sectional studies).The overall effect size of physical activity interventions on changes in blood Aβwas medium(pooled standardized mean difference=-0.69,95%confidence interval(95%CI):-1.41 to 0.03;I^(2)=74.6%).However,these results were not statistically significant,and there were not enough studies to explore the effects of physical activity on cerebrospinal fluid(CSF)and brain Aβ.Data from observational studies were examined based on measurements of Aβin the brain using positron emission tomography scans,CSF,and *** physical activity was positively associated with Aβonly in the CSF(Estimate r=0.12;95%CI:0.05-0.18;I^(2)=38.00%).Conclusion:Physical activity might moderately reduce blood Aβin middle-aged and older ***,results were only near statistical significance and might be interpreted with caution given the methodological limitations observed in some of the included *** observational studies,higher levels of physical activity were positively associated with Aβonly in ***,further research is needed t

关键词： Aging Cognitive impairment Dementia Exercise PET

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Gamification in innovation teams

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International Journal of Innovation Studies 2022年第3期6卷 156-168页

作者： Rui patricio Antonio Carrizo Moreira Francesco Zurlo UNIDCOM/IADE Unidade de Investigacao em Design e ComunicacaoAv.D.Carlos I41200-649LisboaPortugal GovcoPP and DEGEIT Department of EconomicsManagementIndustrial Engineering and TourismUniversity of AveiroAveiroPortugal INESCTEC-Institute for Systems and Computer Engineering Technology and SciencePorto4099-002Portugal Department of Design Politecnico di MilanoMilano20133Italy

The paper examines the relationship between gamification-the use of game elements in non-gaming contexts-and innovation teams *** builds on psychological and teamwork theories,arguing that gamification overcomes collaboration issues and generates multiple positive outcomes,particularly in coordination,alignment,engagement,and teams'*** research follows a qualitative theory-driven using a case study of an innovation *** conceptual model built through the findings offers valuable insights about applying gamification in innovation teams,namely:i)surprising teams with such a new and playful approach reduces stress among team members;i)rules and time constraints play a crucial role in teams'coordination by avoiding dispersion and enhancing focused *** paper provides a set of testable theoretical propositions derived from the conceptualization of gamification in the context of innovation *** supports innovation managers interested in measuring gamification outcomes in teams.

关键词： Gamification Innovation teams Outcomes Innovation management

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Understanding Chemical Reactivity in Extended Systems：Exploring Models of Chemical Softness in Carbon Nanotubes

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物理化学学报 2018年第6期34卷 631-638页

作者： CáRDENAS carlos MUNOZ Macarena CONTRERAS Julia AYERS Paul W. GóMEZ Tatiana FUENTEALBA patricio Departamento de Flsica Facultad de Ciencias Universidad de Chile Casilla 653 Santiago Chile Centro para el Desarrollo de la Nanociencias y Nanotecnologia CEDENNA Avenida Ecuador 3493 Santiago Chile Nucleo de Matematicas Fisica y Estad

Chemical reactivity towards electron transfer is captured by the Fukui ***,this is not well defined when the system or its ions have degenerate or pseudo-degenerate ground *** such a case,the first-order chemical response is not independent of the perturbation and the correct response has to be computed using the mathematical formalism of perturbation theory for degenerate ***-degeneracy is ubiquitous in nanostructures with high symmetry and totally extended *** the size of these systems,using degenerate-state perturbation theory is impractical because it requires the calculation of many excited *** we present an alternative to compute the chemical response of extended systems using models of local softness in terms of the local density of *** local softness is approximately equal to the density of states at the Fermi ***,such approximation leaves out the contribution of inner *** order to include and weight the contribution of the states around the Fermi level,a model inspired by the long-range behavior of the local softness is *** wall capped carbon nanotubes(SWCCNT) illustrate the limitation of the frontier orbital theory in extended ***,we have used a C360 SWCCNT to test the proposed model and how it compares with available models based on the local density of ***,a simple Hü ckel approximation captures the main features of chemical response of these *** results suggest that density-of-states models of the softness along simple tight binding Hamiltonians could be used to explore the chemical reactivity of more complex system,such a surfaces and nanoparticles.

关键词： Local softness Fukui function Reactivity Carbon nanotubes Density of states

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Latitudinal pattern of the thermal sensitivity of running speed in the endemic lizard Liolaemus multimaculatus

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Integrative Zoology 2022年第4期17卷 619-637页

作者： Oscar Aníbal STELLATELLI Laura EVEGA Carolina BLOCK Camila ROCCA patricio BELLAGAMBA Juan Esteban DAJIL Félix Benjamín CRUZ Instituto de Investigaciones Marinas y Costeras(IIMyC) Universidad Nacional de Mar del Plata-CONICETFacultad de Ciencias Exactas y NaturalesMar del PlataArgentina Municipalidad de General Pueyrredón Mar del PlataArgentina Instituto de Investigaciones en Biodiversidad y Medioambiente(INIBIOMA) Universidad Nacional del Comahue-CONICETSan Carlos de BarilocheArgentina

Physiological performance in lizards may be affected by climate across latitudinal or altitudinal *** the coastal dune barriers in central-eastern Argentina,the annual maximum environmental temperature decreases up to 2℃ from low to high latitudes,while the mean relative humidity of the air decreases from 50%to 25%.Liolaemus multimaculatus,a lizard in the family Liolaemidae,is restricted to these coastal *** investigated the locomotor performance of the species at 6 different sites distributed throughout its range in these dune *** inquired whether locomotor performance metrics were sensitive to the thermal regime attributable to *** thermal performance breadth increased from 7%to 82%with latitude,due to a decrease in its critical thermal minimum of up to 5℃ at higher *** from high latitude sites showed a thermal optimum,that is,the body temperature at which maximum speed is achieved,up to 4℃lower than that of lizards from the low *** relatively low temperatures,the maximum running speed of high-latitude individuals was faster than that of low-latitude *** parameters of locomotor performance were labile,decreasing as a function of *** results show populations of *** adjust thermal physiology to cope with local climatic *** suggests that thermal sensitivity responds to the magnitude of latitudinal fluctuations in environmental temperature.

关键词： latitude Liolaemus reptile running speed temperature thermal sensitivity

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Analysis of Growth and Productivity of Green Chickpea Using Nitrogen and Phosphorus Fertilization

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Phyton-International Journal of Experimental Botany 2021年第4期90卷 1193-1203页

作者： Maricela Apáez-Barrios JoséAlberto Salvador Escalante-Estrada patricio Apáez-Barrios Yurixhi Atenea Raya-Montaño Juan carlosÁlvarez-Hernández Facultad de Ciencias Agropecuarias-Universidad Michoacana de San Nicolás de Hidalgo Apatzingán60670México Colegio de Postgraduados-Campus Montecillo Texcoco56230México Facultad de Agrobiología“Presidente Juárez” Universidad Michoacana de San Nicolás de HidalgoUruapan60190México

Chickpea contains high levels of protein,vitamins and *** chickpea yield is the result of meeting nitrogen and phosphorus *** effect of appropriately meeting such requirements reflects on growth and can easily be evaluated using growth *** research determined:(a)The effect of nitrogen and phosphorus fertilization on phenology,net assimilation rate,number of green leaves,leaf area,leaf area index and leaf area duration;(b)Green chickpea yield and number of pods due to fertilization;and(c)The combination of nitrogen and phosphorus fertilization that yields the most net *** and phosphorus fertilization was evaluated;each at the doses of 0,75 and 150 kg ha–1(N0,N75,N150;P0,P75 and P150,respectively).The combination of the levels of both nutrients generated nine combinations of treatments which were distributed in the field in a randomized complete block design in an arrangement of divided plots with four *** of phenological phases were similar among *** and phosphorus fertilization increased number of leaves,leaf area index,and leaf area duration that translated into increased green chickpea yield(GCY).Combinations N150-P75 and N150-P150 produced the highest *** highest net revenue and revenue per peso invested was obtained with N150-P75.

关键词： Cicer arietinum economic analysis leaf area number of leaves yield

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Endoscopic submucosal dissection in dogs in a World Gastroenterology Organisation training center

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World Journal of Gastroenterology 2010年第14期16卷 1759-1764页

作者： Miguel A Tanimoto Gonzalo Torres-Villalobos Rikiya Fujita patricio Santillan-Doherty Jorge Albores-Saavedra German Gutierrez Luis A Martin-del-Campo carlos Bravo-Reyna Octavio Villanueva Jose J Villalobos Misael Uribe Miguel A Valdovinos Department of Gastroenterology and World Gastroenterology Organisation Training Center National Institute of Medical Sciences and Nutrition Salvador Zubiran Mexico City 14000 Mexico Department of Surgery and Experimental Surgery National Institute of Medical Sciences and Nutrition Salvador Zubiran Mexico City 14000 Mexico The Cancer Institute Hospital of JFCR Tokyo Tokyo 135-8550 Japan Department of Pathology National Institute of Medical Sciences and Nutrition Salvador Zubiran Mexico City 14000 Mexico Department of Experimental Surgery National Institute of Medical Sciences and Nutrition Salvador Zu- biran Mexico City 14000 Mexico Animal lab and Department of Experimental Research National Institute of Medical Sciences and Nutrition Salvador Zubiran Mexico City 14000 Mexico

AIM: To evaluate if canine models are appropriate for teaching endoscopy fellows the techniques of endoscopic submucosal dissection (ESD). METHODS: ESD was performed in 10 canine models under general anesthesia, on artificial lesions of the esophagus or stomach marked with coagulation points. After ESD, each canine model was euthanized and surgical resection of the esophagus or stomach was carried out according to "The Principles of Humane Experimental Technique, Russel and Burch". The ESD specimens were fixed with needles on cork submerged in a formol solution with the esophagus or stomach, and delivered to the pathology department to be analyzed. RESULTS: ESD was completed without complications using the Hook-knife in five esophageal areas, with a procedural duration of 124 ± 19 min, a length of 27.4 ± 2.6 mm and a width of 21 ± 2.4 mm. ESD was also completed without complications using the IT-knife2 in five gastric areas, with a procedural duration of 92.6 ± 19 min, a length of 32 ± 2.5 mm and a width of 18 ± 3.7 mm. CONCLUSION: ESD is feasible in the normal esopha- gus and stomach of canine models, which are appropriate for teaching this technique.

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Stomach neoplasms Training

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Role of Salmonella enterica exposure in Chilean Crohn's disease patients

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World Journal of Gastroenterology 2013年第35期19卷 5855-5862页

作者： Manuel Alvarez-Lobos Daniela P Pizarro Christian E Palavecino Abner Espinoza Valentina P Sebastián Juan C Alvarado patricio Ibaez carlos Quintana Orlando Díaz Alexis M Kalergis Susan M Bueno CAREI Group (Active Cohort Registry of Inflammatory Bowel Disease) Department of Gastroenterology Facultad de MedicinaPontificia Universidad Católica de Chile Departamento de Genética Molecular y Microbiología Facultad de Ciencias Biológicas Pontificia Universidad Católica de Chile School of Medicine Facultad de MedicinaPontificia Universidad Católica de Chile Department of Respiratory Diseases Facultad de Medicina Pontificia Universidad Católica de Chile

AIM:To study the association between exposure toSalmonella enterica(SE)and Crohn’s disease(CD)and its clinical implications in Chilean ***:Ninety-four unrelated Chilean CD patients from CAREI(Active Cohort Registry of Inflammatory Bowel Disease)presenting to a single inflammatory bowel disease(IBD)unit of a University Hospital were prospectively included in this study.A complete clinical evaluation,including smoking history,was performed at the initial visit,and all the important data of clinical evolution of CD were *** samples from these CD patients and 88 healthy sex-and agematched control subjects were analyzed for exposure to SE and for their NOD2/CARD15 gene status using the presence of anti-Salmonella lipopolysaccharide antibodies[immunoglobulin-G type(IgG)]and polymerase chain reaction(PCR),*** also evaluated exposure to SE in 90 sex-and age-matched patients without CD,but with known smoking status(30 smokers,30 non-smokers,and 30 former smokers).RESULTS:CD patients comprised 54 females and 40males,aged 35.5±15.2 years at diagnosis with a mean follow-up of 9.0±6.8 *** was inflammatory in 59 patients(62.7%),stricturing in 24(25.5%)and penetrating in 15(15.5%).Thirty cases(31.9%)had lesions in the ileum,29(30.8%)had ileocolonic lesions,32(34.0%)had colonic lesions and 23(24.4%)had perianal *** CD patients(17%)were exposed to SE compared to 15(17%)of 88 healthy control subjects(P=0.8).Thirty-one CD patients(32.9%)were smokers,and 7(7.4%)were former smokers at *** the group exposed to SE,10 of 16 patients(62.5%)were active smokers compared to 21 of 78 patients(26.9%)in the unexposed group(P=0.01).On the other hand,10 of 31 smoking patients(32%)were exposed to SE compared to 5 of 56 nonsmoking patients(9%),and one of the seven former smokers(14%)(P=0.01).In the group of 90 patients without CD,but whose smoking status was known,there was no differ-ence in exposure to SE[3 of 30 smokers(10%),5 of30 non-s

关键词： Crohn’s disease Salmonella Infection Tobacco Smoking Environmental factors

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Is the present cut-point to define type 2 diabetes appropriate in Latin-Americans?

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World Journal of Diabetes 2014年第6期5卷 747-755页

作者： patricio López-Jaramillo carlos Velandia-Carrillo Diego Gómez-Arbeláez Martin Aldana-Campos Dirección de Investigaciones Clínica de Síndrome MetabólicoPrediabetes y DiabetesFundación Oftalmo-lógica de Santander-FOSCAL Instituto de Investigaciones MASIRA Facultad de MedicinaUniversidad de Santander-UDES Departamento de Medicina Interna Universidad Autónoma de Bucaramanga División de Endocrinología Escuela de MedicinaUniversidad de Santiago de Compostela

The diagnosis of diabetes mellitus type 2(DM2) is based either on increased plasma glucose or Glycated hemoglobin levels. Since these measures are the only means for diagnosis of DM2, they must be well adapted to each population according to their metabolic characteristics, given that these may vary in each population. The World Health Organization(WHO) determined the cut-points of plasma glucose levels for the diagnosis of DM2 by associating hyperglycemia with the risk of a specific microvascular complication-retinopathy. Cardiovascular diseases are however the principal causes of mortality in patients with DM2 and we reported that in the Colombo-Ecuadorian population impaired fasting glucose and impaired glucose tolerance are both riskmarkers for myocardial infarction. We propose that the current cut-points accepted by the WHO need to be revaluated in populations such as Latin America and that there should be lower cut points for glycaemia in this population, to reduce the prevalence of cardiovascular complications associated with DM2.

关键词： impaired fasting hemoglobin microvascular cardiovascular Americans prevalence mortality populations streptozotocin

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Thyroid Nodule: Alpha Score 2.0 Classification for FNAB Selection, Multicentric Study in Latin America

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Open Journal of Radiology 2021年第4期11卷 160-174页

作者： Glenn Mena Maria Cristina Chammas carlos Mario Gonzalez Vasquez Lylian Rocío Villagómez Marco Alfredo Muñoz Pico patricio Alejandro Montalvo Santiago Mena-Bucheli Julio Olmedo Elizabeth Quintero Pedro Henrique de Marqui Moraes Osmar Cassio Saito Hubertino Diaz Denise Romero Gabriela Velalcazar Angel Ramón Sosa Fleitas Yamil Oliver Quevedo Ontaneda Victor Ricardo Chara Alpha Imagen Radiología e Intervencionismo Quito Ecuador Hospital das Clínicas Faculdade de Medicina da Universidade de Sã o Paulo S&#227 o Paulo Brasil Hospital Pablo Tobón Uribe Medellin Colombia Hospital del Instituto Ecuatoriano de Seguridad Social Quito Sur Quito Ecuador Hospital San Francisco de Quito Quito Ecuador Hospital Edgardo Rebagliati Martins Lima Perú Hospital carlos Andrade Marín Quito Ecuador Hospital de Clínicas San José de San Martín Buenos Aires Argentina Hospital Universitario de Los Andes Mérida Venezuela Hospital de la Policía Quito Ecuador Hospital Sisol Tacna Perú

Introduction: To perform a Latin-American multicentric study for the prediction of benign and malignant thyroid nodules using Alpha Score, and to compare it with ACR TIRADS® and Bethesda®. Materials and Methods: A prospective multicentric study in 10 radiological hospitals and institutions of Latin America was performed and 818 thyroid nodules were analyzed by ultrasound and classified by using both ACR TIRADS® and Alpha Score;fine-needle aspiration biopsy was performed when needed and classified with Bethesda. The relationships between predictors were analyzed by using binary logistic regression, statistical significance was defined by a p-value of 0.05, with an error margin of 4% and 95% confidence intervals. Results: Alpha Score 2.0 establishes five types of malignant predictors: microcalcifications, irregular borders, taller-than-wide shape, predominant solid texture and hypoechogenicity;a diameter equal to or greater than 1.5 cm adds an extra point to the final score. Resulting classification divides TNs into 4 categories: benign (1.9%), low suspicion (8.7%), mild suspicion (13.6%) and high suspicion (75.7%) of malignancy probability;sensitivity of 82%, specificity of 74%, the positive predictive value of 94%, the negative predictive value of 51%, the statistical accuracy of 81%, odds ratio of 108.89 and correlation with ACR TIRADS of 0.77 and Bethesda of 0.91. Conclusions: Alpha Score 2.0 has superior diagnostic accuracy and performance compared to the previously published Alpha Score and is able to classify a benign TN in a precise, safe and accurate way, avoiding unnecessary FNABs or determining the necessity of FNAB in cases of moderate to high suspicion of malignancy.

关键词： Thyroid Cancer-Clinical Radiology-Imaging Thyroid Nodule Alpha Score TIRADS® Thyroid Ultrasonography

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