Is the present cut-point to define type 2 diabetes appropriate in Latin-Americans?

作     者：Patricio López-Jaramillo Carlos Velandia-Carrillo Diego Gómez-Arbeláez Martin Aldana-Campos 

作者机构：Dirección de InvestigacionesClínica de Síndrome MetabólicoPrediabetes y DiabetesFundación Oftalmo-lógica de Santander-FOSCAL Instituto de Investigaciones MASIRAFacultad de MedicinaUniversidad de Santander-UDES Departamento de Medicina InternaUniversidad Autónoma de Bucaramanga División de EndocrinologíaEscuela de MedicinaUniversidad de Santiago de Compostela 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2014年第5卷第6期

页      面：747-755页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Type 2 diabetes Cut-off points Cardiovascular diseases Plasma glucose Coronary disease 

摘      要：The diagnosis of diabetes mellitus type 2(DM2) is based either on increased plasma glucose or Glycated hemoglobin levels. Since these measures are the only means for diagnosis of DM2, they must be well adapted to each population according to their metabolic characteristics, given that these may vary in each population. The World Health Organization(WHO) determined the cut-points of plasma glucose levels for the diagnosis of DM2 by associating hyperglycemia with the risk of a specific microvascular complication-retinopathy. Cardiovascular diseases are however the principal causes of mortality in patients with DM2 and we reported that in the Colombo-Ecuadorian population impaired fasting glucose and impaired glucose tolerance are both riskmarkers for myocardial infarction. We propose that the current cut-points accepted by the WHO need to be revaluated in populations such as Latin America and that there should be lower cut points for glycaemia in this population, to reduce the prevalence of cardiovascular complications associated with DM2.