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Global longitudinal strain is superior to ejection fraction for detecting myocardial dysfunction in end-stage renal disease with hyperparathyroidism

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World Journal of Cardiology 2022年第4期14卷 239-249页

作者： Maria Fernanda Carrasco-Ruiz Antonio Ruiz-Rivera Marvin A Soriano-Ursúa carlos martinez-hernandez Leticia Manuel-Apolinar Carmen Castillo-hernandez Gustavo Guevara-Balcazar Eunice D Farfán-García Ana Mejia-Ruiz Ivan Rubio-Gayosso Teresa Perez-Capistran Department of Physiology Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico Department of Cardiology Instituto Mexicano del Seguro SocialCiudad de México 06720Mexico Endocrine Research Unit Instituto Mexicano del Seguro SocialCiudad de México 06720Mexico Department of Cardiovascular Pharmacology Instituto Politécnico NacionalCiudad de México 11340Mexico Department of Biochemistry Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico Education Research Comisión Nacional Para la Mejora Continua de la EducaciónCiudad de México 03900Mexico Postgraduate Studies and Research Section Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico Department of Physiology Instituto Politécnico NacionalMexico City 11340Ciudad de MéxicoMexico

BACKGROUND The estimation of left ventricular ejection fraction(LVEF)by 2D echocardiography(2D-ECHO)is the most used tool to assess LV systolic function(LVSF).Global longitudinal strain(GLS)has recently been suggested as a superior method for several *** study explored the association and prevalence of LV systolic dysfunction(LVSD)by using these methods in patients with end-stage renal disease(ESRD)and severe hyperparathyroidism(SHPTH);both associated with cardiovascular events(CEs).AIM To evaluate the myocardial function in patients with ESRD and SHPTH by using the GLS and LVEF measured through conventional *** In 62 patients with ESRD and SHPTH,asymptomatic,and without a history of CEs,LVSF was evaluated by 2D-ECHO,obtaining the EF,by the Simpson biplane method,and GLS by speckle *** The total patients with ESRD had a preserved LVEF(>50%)but abnormal GLS(<13.55%).Additionally,multivariate analysis showed an independent association of GLS and serum parathyroid hormone(PTH),LV mass index,and ***,PTH was independently associated with lateral e'wave and tricuspid regurgitation *** In patients with SHPTH linked to ESRD,the use of GLS by 2D-ECHO is a more sensitive tool than LVEF for detecting LVSD.

关键词： Left ventricular hypertrophy Systolic dysfunction Global longitudinal strain End-stage renal disease Parathormone

Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

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Eye and Vision 2024年第2期10卷 12-21页

作者： Jose Maria martinez‑de‑la‑Casa carlos Oribio‑Quinto Almudena Milans‑del‑Bosch Pilar Perez‑Garcia Laura Morales‑Fernandez Javier Garcia‑Bella Jose Manuel Benitez‑del‑Castillo Julian Garcia‑Feijoo David P.Pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after ***:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez Jose J.Gil-Cosano Esther Ubago-Guisado Francisco J.Llorente-Cantarero Juan Francisco Pascual-Gázquez Kirsten K.Ness Vicente martinez-Vizcaino Jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

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Military Medical Research 2024年第2期11卷 228-267页

作者： Miguel A.Ortega Oscar Fraile-martinez Cielo García-Montero Sergio Haro Miguel Ángel Álvarez-Mon Diego De Leon-Oliva Ana M.Gomez-Lahoz Jorge Monserrat Mar Atienza-Pérez David Díaz Elisa Lopez-Dolado Melchor Álvarez-Mon Department of Medicine and Medical Specialities University of Alcala28801 Alcala de HenaresSpain Ramón y Cajal Institute of Sanitary Research(IRYCIS) 28034 MadridSpain Department of Psychiatry and Mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System Diseases‑Rheumatology Service and Internal Medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this ***(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a *** initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and *** the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are ***,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

关键词： Spinal cord injury(SCI) Psychoneuroimmunoendocrinology(PNIE) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

Surgical treatment of acute cholecystitis in patients with confirmed COVID-19:Ten case reports and review of literature

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World Journal of Clinical Cases 2022年第4期10卷 1296-1310页

作者： Katya Bozada-Gutierrez Mario Trejo-Avila Fatima Chavez-hernandez Sara Parraguirre-martinez carlos Valenzuela-Salazar Jesus Herrera-Esquivel Mucio Moreno-Portillo Department of General and Endoscopic Surgery Hospital General Dr.Manuel Gea GonzalezMexico City 14090Mexico Department of Pathology Hospital General Dr.Manuel Gea GonzalezMexico City 14090Mexico

BACKGROUND Research concerning postoperative outcomes of confirmed coronavirus disease 2019(COVID-19)patients revealed unfavorable postoperative results with increased morbidity,pulmonary complications and *** reports have suggested that COVID-19 is associated with more aggressive presentation of acute *** aim of the present study is to describe the perioperative assessment and postoperative outcomes of ten patients with confirmed severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection with concomitant acute cholecystitis who underwent *** SUMMARY We report a total of 10 SARS-CoV-2 positive patients with concomitant acute cholecystitis that underwent *** patients were males,the mean age was 47.1 *** patients had moderate acute cholecystitis,and one patient had severe acute *** patients were treated with urgent/early laparoscopic *** the Parkland grading scale,two patients received a Parkland grade of 3,two patients received a Parkland grade of 4,and six patients received a Parkland grade of *** patients required a bail-out *** patients developed biliary leakage and required endoscopic retrograde cholangiopancreatography with biliary *** surgery,five patients developed acute respiratory distress syndrome(ARDS)and required intensive care unit(ICU)*** patient died after cholecystectomy due to ARDS *** mean total length of stay(LOS)was 18.2 *** histopathology demonstrated transmural necrosis(n=5),vessel obliteration with ischemia(n=3),perforation(n=3),and acute peritonitis(n=10).CONCLUSION COVID-19 patients with acute cholecystitis had difficult cholecystectomies,high rates of ICU admission,and a prolonged LOS.

关键词： COVID-19 SARS-CoV-2 Cholecystectomy in COVID-19 Acute cholecystitis in COVID-19 Case report

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论点摘编

马克思主义文化研究

马克思主义文化研究 2024年第1期013卷 299-305页

作者：陈金龙黄建军陈远章阎树群顾海良项久雨张志强梁燕晓 Yun Gong carlos martinez 不详

一中华民族现代文明的生成、特质与价值陈金龙文明生成是长期积累的历史过程,也是多种因素综合作用的结果,中华文明历经五千多年的创造与积累才完善其体系、成就其辉煌。中华民族现代文明是相对于中华民族传统文明而言的,是处于成长和... 详细信息

一中华民族现代文明的生成、特质与价值陈金龙文明生成是长期积累的历史过程,也是多种因素综合作用的结果,中华文明历经五千多年的创造与积累才完善其体系、成就其辉煌。中华民族现代文明是相对于中华民族传统文明而言的,是处于成长和发展过程中的文明,是基于中华民族传统文明而生成的文明,中华民族传统文明和中华民族现代文明构成中华文明的整体。中华民族现代文明是在“两个结合”、推进中国式现代化、巩固中华民族共同体、构建人类命运共同体过程中生成的。中华民族现代文明既蕴含中华民族传统文明的突出特性,又具有新时代的文明特质。从中国共产党团结带领人民建设中华民族现代文明的理念、实践和中华民族现代文明的样态来看,其特质可概括为五个方面:第一,中华民族现代文明是坚持人民至上的文明;第二,中华民族现代文明是协调发展的文明;第三,中华民族现代文明是创新发展的文明;第四,中华民族现代文明是兼收并蓄的文明;第五,中华民族现代文明是和平发展的文明。中华民族现代文明的生成及其特质,具有独特的文明价值,对促进中华文明现代性转型、推进中华民族伟大复兴、推动人类文明发展、塑造国家民族政党现代形象将产生深远影响。

关键词：中国式现代化现代文明人类命运共同体现代性转型中华文明中华民族共同体论点摘编人民至上

Overview of the anterolateral complex of the knee

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World Journal of Clinical Cases 2022年第24期10卷 8474-8481页

作者： Ignacio Garcia-Mansilla Juan Pablo Zicaro Ezequiel Fernando martinez Juan Astoul carlos Yacuzzi MatiasCosta-Paz Knee Surgery Hospital Italiano de Buenos AiresBuenos Aires 1199Argentina

In the last few years,much more information on the anterolateral complex of the knee has become *** has now been demonstrated how it works in conjunction with the anterior cruciate ligament(ACL)controlling anterolateral rotatory *** studies have shown that the anterolateral complex(ALC)has a role as a secondary stabilizer to the ACL in opposing anterior tibial translation and internal tibial *** is of utmost importance that surgeons comprehend the intricate anatomy of the entire anterolateral aspect of the *** most studies have only focused on the anterolateral ligament(ALL),the ALC of the knee consists of a functional unit formed by the layers of the iliotibial band combined with the anterolateral joint *** interest has also been given to imaging evaluation using magnetic resonance and several studies have targeted the evaluation of the ALC in the setting of ACL *** are inconsistent with a lack of association between magnetic resonance imaging evidence of injury and clinical *** ACL reconstruction may not always reestablish knee rotatory stability in patients with associated ALC *** such cases,additional procedures,such as anterolateral reconstruction or lateral tenodesis,may be *** are several techniques available for ALL *** options include the iliotibial band,gracilis or semitendinosus tendon autograft,or allograft.

关键词： Anterolateral complex Knee instability Anterolateral ligament Anterior cruciate ligament reconstruction

Ammonia borane-based reactive mixture for trapping and converting carbon dioxide

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Frontiers of Materials Science 2022年第2期16卷 71-81页

作者： carlos A.CASTILLA-martinez Bilge COŞKUNER FİLİZ Eddy PETIT Aysel KANTÜRK FİGEN Umit B.DEMIRCI Institut Europeen des Membranes(IEM) UMR 5635Univ MontpellierENSCMCNRSMontpellierFrance Department of Metallurgy and Materials Engineering Yildiz Technical UniversityİstanbulTurkey Department of Chemical Engineering Yildiz Technical UniversityİstanbulTurkey

Ammonia borane(NH_(3)BH_(3))is a reducing agent,able to trap and convert carbon *** the present work,we used a reactive solid consisting of a mixture of 90 wt.%of NH_(3)BH_(3)and 10 wt.%of palladium chloride,because the mixture reacts in a fast and exothermic way while releasing H2 and generating catalytic *** took advantage of such reactivity to trap and convert CO_(2)(7 bar),knowing besides that Pd0 is a CO_(2)hydrogenation *** operation(*** 1)was effective:BNH polymers,and B−O,C=O,C−O,and C−H bonds(like in BOCH_(3)and BOOCH groups)were *** then(in stage 2)pyrolyzed the as-obtained solid at 1250℃ and washed it with *** doing so,we isolated cyclotriboric acid H_(3)B3O6(stemming from B2O3 formed at 1250℃),hexagonal boron nitride,and graphitic *** conclusion,the stage 1 showed that CO_(2)can be‘trapped’and converted,resulting in the formation of BOCH_(3)and BOOCH groups(possible sources of methanol and formic acid),and the stage 2 showed that CO_(2)transforms into graphitic carbon.

关键词： ammonia borane boron nitride boron oxide carbon dioxide graphitic carbon

Nanotechnology in aquaculture: Applications, perspectives and regulatory challenges

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Aquaculture and Fisheries 2022年第2期7卷 185-200页

作者： carlos Fajardo Gonzalo martinez-Rodriguez Julian Blasco Juan Miguel Mancera Bolaji Thomas Marcos De Donato School of Tourism and Maritime Technology Polytechnic of Leiria(MARE-IPLeiria)Santuario de Nossa Senhora dos RemediosCampus 4Peniche2520-641Portugal Department of Biology Faculty of Marine and Environmental SciencesInstituto Universitario de Investi-gaci´on Marina(INMAR)Campus de Excelencia Internacional del Mar(CEI⋅MAR)University of Cadiz(UCA)Puerto Real11519Spain Institute of Marine Sciences of Andalusia(ICMAN) Department of Marine Biology and AquacultureSpanish National Research Council(CSIC)Puerto Real11519Spain Department of Biomedical Sciences Rochester Institute of TechnologyRochester14623USA Tecnologico de Monterrey Escuela de Ingenieria y CienciasQueretaro76130Mexico

Aquaculture is considered one of the most important food production systems both in terms of economic impact and food security,and the ongoing development of this industry is a key factor in the strategy to guarantee global nutritional ***,different types of nanotechnology-based systems have been employed to increase its production,efficiency and *** efforts have been made in the fields of health management,enhancement of fish and shellfish development by dietary supplementation with nutraceuticals,but also in the processing and preservation of seafood and water treatment,among ***,nanotechnology has a significant role to play in the improvement of the efficiency and the environmental impact of this *** this perspective,we propose to review the current situation of nanotechnology in the field of aquaculture and fisheries,emphasizing not only in current applications,and future prospects,but also in the ethical and governance aspects associated with this topic.

关键词： Health management Nano-regulation Nutraceuticals Preservation of seafood Risk assessment