检索结果-南通市图书馆

Diabetes mellitus and Parkinson's disease:dangerous liaisons between insulin and dopamine

Neural Regeneration Research 2022年第3期17卷 523-533页

作者： Angela De Iuliis Ennio Montinaro Giuseppe Fatati Mario Plebani carlo colosimo Department of Medicine-DiMED University of PadovaItaly Department of Neurology Santa Maria University HospitalTerniItaly Italian Obesity Network TerniItaly Department of Medicine-DiMED University of PadovaPadovaItaly/Department of Laboratory Medicine-Hospital of PadovaPadovaItaly

The relationship between diabetes mellitus and Parkinson's disease has been described in several epidemiological studies over the 1960 s to *** studies have shown the possible functional link between insulin and dopamine,as there is strong evidence demonstrating the action of dopamine in pancreatic islets,as well as the insulin effects on feeding and cognition through central nervous system mechanism,largely independent of glucose *** used for the treatment of type 2 diabetes mellitus appear to be promising candidates for symptomatic and/or disease-modifying action in neurodegenerative diseases including Parkinson's disease,while an old dopamine agonist,bromocriptine,has been repositioned for the type 2 diabetes mellitus *** review will aim at reappraising the different studies that have highlighted the dangerous liaisons between diabetes mellitus and Parkinson's disease.

关键词： dopamine GLP-1 insulin Parkinson's disease type 2 diabetes mellitus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hypofractionated and Low Dose Radiotherapy Combined with Temozolomide in Naive Unresectable Glioblastoma:A Pilot Study

引用

肿瘤预防与治疗 2017年第1期30卷 9-15页

作者： Silvia Chiesa Milena Ferro Stefano Luzi Barbara Diletto Francesco Beghella Bartoli Nicola Dinapoli Gian carlo Mattiucci Vincenzo Frascino Francesco Miccichè Cesare colosimo Carmelo Anile Alessandro Olivi Vincenzo Valentini Mario Balducci Department of Radiation Oncology Catholic University of the Sacred HeartL.go A.Gemelli8 00168-RomeItaly Department of Radiology Catholic University of the SacredHeartL.go A.Gemelli8 00168-RomeItaly Department of Neurosurgery Catholic Uni-versity of the Sacred HeartL.go A.Gemelli8 00168-RomeItaly

Background/Aim: To assess safety of hypo-fractionated radiotherapy( HyRT) followed by low dose radiation therapy( LD-FRT) plus Temozolomide( TMZ) in naive unresectable Glioblastoma. Methods: Patients( ECOG 18) undergone to biopsy or with gross residual tumor after surgery were enrolled. HyRT( 30 Gy in ten fraction) plus TMZ was administered. From the second adjuvant cycle of TMZ,patients received LD-FRT( 0. 40 Gy twice daily over 5 days,every 28 days) for two cycles. The primary endpoints were safety and toxicity. Moreover we analyzed response,overall survival( OS) and progression-free survival( PFS). Results: Twenty patients were enrolled. Median dose of LD-FRT was 12 Gy. All toxicities were reversible. Four out of 20 patients had Partial Response( PR)and 6 experienced a stable disease( SD). Median OS and PFS were 14 and 11 months,***: HyRT followed by LD-FRT plus TMZ is safe and shows good clinical outcomes. A new study is ongoing.

关键词：胶质瘤恶性肿瘤临床治疗患者

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：