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Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso

药物非临床安全性研究学术研讨会

作者： Michelle M．He lisa A．Shipley carl l.mcmillian 礼来公司礼来研究实验室礼来公司礼来研究实验室礼来公司礼来研究实验室病理及毒理学研究室

ADME 在安全性评价中的作用·描述候选药物在动物和人体内的吸收、分布、代谢和扫泄(ADME) ·在毒理学研究中测定暴露量以确定安全范围(MOS)

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Food Science and Human Wellness 2024年

作者： Giles T.Hanley-Cook Yuri Bastos-Moreira Dries S.Martens Trenton Dailey-Chwalibóg laeticia Celine Toe Brenda de Kok lionel Ouédraogo Alemayehu Argaw Kokeb Tesfamariam Patrick Kolsteren lieven Huybregts Tim S.Nawrot Sarah De Saeger Marthe De Boevre carl lachat Department of Food Technology Safety and Health Faculty of Bioscience Engineering Ghent University Center of Excellence in Mycotoxicology and Public Health MYTOXSOUTH~(?) Coordination Unit Faculty of Pharmaceutical Sciences Ghent University Centre for Environmental Sciences Hasselt University Unité Nutrition et Maladies Métaboliques Institut de Recherche en Sciences de la Santé (IRSS) Centre Muraz Center of Excellence in Mycotoxicology and Public Health MYTOXSOUTH? Coordination Unit Faculty of Pharmaceutical Sciences Ghent University Nutrition Diets and Health Unit Department of Food and Nutrition Policy International Food Policy Research Institute (IFPRI) Department of Public Health & Primary Care University of leuven Department of Biotechnology and Food Technology Faculty of Science University of Johannesburg Doornfontein Campus

Background: Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes. The effect on markers of health and disease， such as offspring telomere length (Tl) and mitochondrial DNA content (mtDNAc) is unknown. Objectives: We assessed the efficacy of maternal multiple micronutrient (MMN)-fortified balanced-energy protein (BEP) and iron-folic acid (IFA) supplementation on newborn Tl as a secondary outcome and mtDNAc as a non-declared outcome. Design: We conducted a randomized controlled trial in rural Burkina Faso， among pregnant females (15-40 years old) enrolled at ly (control) throughout pregnancy. Whole arterial blood samples were collected from the umbilical cord of 104 control and 90 intervention group infants， respectively. Average relative Tl and mtDNAc were measured using quantitative polymerase chain reaction. linear regression models were fitted to assess Tl and mtDNAc differences across trial arms. Results: We found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn Tl [β = -0.010 (95% CI: -0.057， 0.036); P = 0.662] or mtDNAc [β = 0.065 (95% CI: -0.203， 0.073); P = 0.354]， as compared to an IFA tablet alone. These findings were confirmed (P > 0.05) by adjusting the regression models for potential prognostic factors of study outcomes at enrollment. Exploratory analyses indicated higher， but non-significantly different mtDNAc among children born either small-for-gestational age， low birthweight， or preterm. Conclusions: Newborns from mothers who received daily nutritional supplements across gestation did not have different relative Tl or mtDNAc.

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Using a modified PAP/RAC model and GIS-for mapping water erosion and causal risk factors:Case study of the Asfalou watershed,Morocco

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International Soil and Water Conservation Research 2022年第2期10卷 254-272页

作者： Jad Tahouri Abdelhamid Sadiki l'houcine Karrat Verner carl Johnson Ngai weng Chan Zhang Fei Hsiang Te Kung Departement des Sciences de la Terre Université Sidi Mohammed Ben AbdellahFaculté des Sciences Dhar MahrazLaboratoire de GeosciencesEnvironnement et Ressources Associées(LGERA)B.P.1796FèsAtlasMorocco International Association of Seismology and Physics of the Earth’s Interior(IASPEI) Japan Department of Physical and Environmental Sciences Colorado Mesa UniversityGrand JunctionCO81501USA School of Humanities University Sains Malaysia11800PenangMalaysia Resources and Environment Department Xinjiang UniversityUrumqi830046People's Republic of China Key laboratory of Oasis Ecology Ministry of EducationXinjiang UniversityUrumqi830046People's Republic of China Key laboratory of Xinjiang Wisdom City and Environment Modeling Urumqi830046People's Republic of China Departments of Earth Sciences The University of MemphisMemphisTN38152USA

Our work focuses on the assessment of trends,erosion states and causal risk factors for soil erosion of the Asfalou watershed through the use of the Priority Actions Program/Regional Activity Center(PAP/RAC).This qualitative study model for water erosion makes it possible to assess susceptibility and determine potential fragile areas in order to diagnose the state of soil *** adopted the PAP/RAC crossed matrices,the geographic information system(GIS)and remote sensing(RS)to develop the classical *** method is based on three main approaches:predictive,descriptive and *** soil types,slope length(lS)and climatic factors into our model,including rainfall erosivity(R),slope exposure,soil moisture index(SMI)and land surface temperature(lST),improved the reli-ability of our *** correlation analysis identified these factors that explain erosion states and the risk of soil *** coefficients of determination(R2)of the various erosive states resulting from the modified PAP/RAC approach explain respectively 98.30%,77%and 49.3%of the observed variability of the erosive *** factors provide information on the current state of soil degradation depending on the degree of influence of the different factors that control *** descriptive approach has shown that soil loss manifests itself in different forms,whether for sheet erosion(l)and ravines(C1)succes-sively affecting 79.95%and 17.84%of the *** integration approach identifies factors and areas requiring intervention to counter the effects of soil erosion in the Asfalou watershed effectively and sustainably.

关键词： Modified PAP/RAC Model GIS Water erosion Causative factors Soil erosion

Hierarchically Structured Nanocomposites via a“Systems Materials Science”Approach

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Accounts of Materials Research 2022年第12期3卷 1248-1259页

作者： Rebecca l.li carl J.Thrasher Theodore Hueckel Robert J.Macfarlane Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139United States Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusetts 02139United States

CONSPECTUS:Nanocomposite materials can achieve desirable characteristics otherwise unavailable to single component systems,making them attractive platforms to precisely modulate a material’s mechanical,electromagnetic,thermal,and optical *** these properties are often dependent on the organization of constituent materials just as much as their relative composition,intentionally programming composite properties requires hierarchical structural control across many length ***,the fundamental forces governing the atomic,molecular,nanoscale,microscale,and macroscale composition and structure of a material are all interlinked,and thus must be manipulated simultaneously to properly create ideal designer materials.

关键词： properties composite composites

NUMERICAl SIMUlATION OF THE XZ TAURI SUPERSONIC ASTROPHYSICAl JET

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Acta Mathematica Scientia 2009年第6期29卷 1677-1683页

作者： carl l. Gardner Steven J. Dwyer School of Mathematical and Statistical Sciences Arizona State University Tempe AZ 85287 USA

Computational gas dynamical simulations using the WENO-lF method are applied to modeling the high Mach number astrophysical jet XZ Tauri, including the effects of radiative cooling. Mach 55 simulations of the pulsed proto-jet are presented and analyzed in terms of interacting nonlinear waves： terminal Mach disks, bow shocks, and Meshkov-Richtmyer instabilities of the leading jet contact boundary.

关键词： astrophysical jets ENO. method gas dynamics

Observation of a single protein by ultrafast X-ray diffraction

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light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer lutz A.Eichacker linda E.Franken Davide E.Galli luca Gelisio lars Gumprecht laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang lugmayr Jannik lübke Adrian P.Mancuso Tommaso Mazza carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber lena Worbs Paul lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.C.Maia laboratory of Molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches Electronen-Synchrotron DESY Notkestrasse 8522607 HamburgGermany European XFEl Holzkoppel 422869 SchenefeldGermany Diamond light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway leibniz Institute for Experimental Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Center for Free-Electron laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor GmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden ElI Beamlines/IoP Institute of Physics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic Multi-User CryoEM Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University Medical Center Hamburg-Eppendorf(UKE) Martinistrasse 5220246 HamburgGermany The Hamburg Center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific Computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden European Molecular Biology laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEl which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast

A Hunter-Gatherer Exercise Prescription to Optimize Health and Well-Being in the Modern World

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Journal of Science in Sport and Exercise 2021年第2期3卷 147-157页

作者： Evan l.O’Keefe carl J.lavie Ochsner Clinical School The University of Queensland School of MedicineNew OrleansLAUSA Department of Cardiovascular Diseases John Ochsner Heart and Vascular Institute1514 Jefferson HighwayNew OrleansLA 70121-2483USA

There has been considerable innovation and advancement in the field of exercise and physical activity (PA).In regards to the battle against chronic non-communicable disease,however,we believe the model of PA that would prove most salu-tary is one closely mimicking that of our hunter-gatherer *** the purpose of longevity,the human body and our genetic makeup have been evolutionarily adapted to respond best to moderate amounts of high-intensity interval training,in conjunction with high amounts of low intensity ***,to optimize resiliency and cardiorespiratory fitness,a hunter-gatherer fitness regimen must include cross training targeted at flexibility,balance and *** not com-monly understood,the health benefits from exercise comprise a reverse *** endurance athletes residing on the furthest reaches of the PA spectrum appear to lose a substantial portion of the exercise-related longevity and cardiovascular benefits due to cardiac overuse ***,there is an emerging body of evidence suggesting leisure time exercise done with peers in a natural environment is significantly superior to that training done in *** idea of the "power of play" lends support to the ancestral model of PA whereby humans are evolutionary adapted to be highly social,outdoor creatures capable of a diverse range of PA at varying intensities.

关键词： Hunter-gatherer Cardiovascular disease Physical activity Exercise