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主动脉瓣环扩大联合环上瓣置换术治疗成人小瓣环主动脉瓣狭窄近中期疗效分析

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中国胸心血管外科临床杂志 2014年第4期21卷 452-456页

作者：曹向戎张健群伯平张富恩李继勇李温斌陈宝田首都医科大学附属北京安贞医院心外科北京市心肺血管疾病研究所北京100029

目的评价主动脉瓣环扩大联合环上瓣置换术治疗成人小瓣环主动脉瓣狭窄的近中期结果。方法对2007年1月至2011年7月北京安贞医院心外科38例成人小瓣环主动脉瓣狭窄患者行主动脉瓣环扩大后植入环上型人工瓣膜,男12例、女26例,年龄16~58（3... 详细信息

目的评价主动脉瓣环扩大联合环上瓣置换术治疗成人小瓣环主动脉瓣狭窄的近中期结果。方法对2007年1月至2011年7月北京安贞医院心外科38例成人小瓣环主动脉瓣狭窄患者行主动脉瓣环扩大后植入环上型人工瓣膜,男12例、女26例,年龄16~58（38.6±21.0）岁,体重48~78（58.5±12.0）kg,身高153~176（162.8±12.0）cm,体表面积（1.67±0.32）m2。风湿性主动脉瓣狭窄19例,先天性主动脉瓣二叶瓣畸形合并狭窄11例,主动脉瓣退行性钙化伴狭窄5例,主动脉瓣狭窄合并感染性心内膜炎3例。入院时心功能分级（NYHA）Ⅱ级8例,Ⅲ级29例,Ⅳ级1例。主动脉瓣环内径15~20（17.6±2.8）mm,平均跨瓣压差53~75（62.8±10.5）mm Hg。结果体外循环时间83~145（112±29）min,升主动脉阻断时间58~116（87±28）min,手术中测瓣器测得主动脉瓣环径15~20（17.3±2.6）mm,扩大瓣环后测瓣器测得瓣环径20~25（22.6±2.3）mm,主动脉瓣环周径增加12~17（14.0±2.6）mm,植入瓣膜增加2~3个标号。无围手术期死亡,无出血等严重并发症。住ICU时间12~41（26±14）h,总住院时间9~15（12.5±3.2）d。37例（97.4%）门诊随访2年以上,所有患者心功能分级（NYHA）Ⅰ级,3例主动脉瓣听诊区存在2/6级收缩期杂音。35例心电图显示左心室肥厚心电图表现显著改善或消失,2例表现为左心室轻度肥厚劳损,无明显心肌缺血表现,无室性心律失常及严重房室传导阻滞。结论主动脉瓣环扩大联合环上瓣置换术治疗成人小瓣环主动脉瓣狭窄近中期效果满意,远期结果有待进一步随访。

关键词：小主动脉瓣环主动脉瓣置换术主动脉瓣环扩大随访

Smooth Solution of Multi-dimensional Nonhomogeneous Conservation Law: Its Formula, and Necessary and Sufficient Blowup Criterion

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Acta Mathematicae Applicatae Sinica 2023年第1期39卷 17-27页

作者： Gao-wei cao Hui KAN Wei xiang Xiao-zhou YANG Wuhan Institute of Physics and Mathematics Chinese Academy of SciencesInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China City University of Hong Kong Hong KongChina

In this paper, we are concerned with the necessary and sufficient condition of the global existence of smooth solutions of the Cauchy problem of the multi-dimensional scalar conservation law with source-term,where the initial data lies in W1,∞(Rn) ∩ C1(Rn). We obtain the solution formula for smooth solution, and then apply it to establish and prove the necessary and sufficient condition for the global existence of smooth solution. Moreover, if the smooth solution blows up at a finite time, the exact lifespan of the smooth solution can be obtained. In particular, when the source term vanishes, the corresponding theorem for the homogeneous case is obtained too. Finally, we give two examples as its applications, one for the global existence of the smooth solution and the other one for the blowup of the smooth solutions at any given positive time.

关键词： global smooth solution blowup multi-dimensional conservation law solution formula

Effect of Strong Basic Oxide（ Li2O,Na2O,K2O and BaO）on Property of cao-Based Flux

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Journal of Iron and Steel Research International 2003年第3期10卷 6-9页

作者： LI Gui-rong Jiangsu University

It is found that strong basic oxides including Li2O,Na2O,K2O and BaO,which are used to replace a part of cao in cao-based fluxes,can lower the melting point and the viscosity and enhance the dephosphorizing ability. T... 详细信息

关键词： strong basic oxide cao-based flux melting point viscosity dephosphorizing ability

FY-4A/GIIRS Temperature Validation in Winter and Application to Cold Wave Monitoring

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Journal of Meteorological Research 2022年第4期36卷 658-676页

作者： Suling REN Jianying JIANG xiang FANG Hui LIU Zhiqiang cao Key Laboratory of Radiometric Calibration and Validation for Environmental Satellites Innovation Center for Fengyun Meteorological Satellite(FYSIC)National Satellite Meteorological CenterChina Meteorological AdministrationBeijing 100081 National Meteorological Center China Meteorological AdministrationBeijing 100081

In order to improve the operational application ability of the Fengyun-4A(FY-4A)new sounding dataset,in this paper,validation of the FY-4A Geosynchronous Interferometric Infrared Sounder(FY-4A/GIIRS)temperature was carried out using the balloon sounding temperature from meteorological sounding *** than 350,000 samples were obtained through time–space matching,and the results show that the FY-4A/GIIRS temperature mean bias(MB)is 0.07°C,the mean absolute error(MAE)is 1.80°C,the root-mean-square error(RMSE)is 2.546°C,and the correlation coefficient(RR)is *** FY-4A/GIIRS temperature error is relatively larger in the upper and lower troposphere,and relatively smaller in the middle troposphere;that is,the temperature at 500 hPa is better than that at 850 *** temporal variation is smaller in the upper and middle troposphere than in the lower *** reconstruction of missing data of FY-4A/GIIRS temperature in cloudy areas is also carried out and the results are *** spatial distribution of reconstructed FY-4A/GIIRS temperature and the fifth generation ECMWF reanalysis(ERA5)data is consistent and completely retains the minimum temperature center with high precision of FY-4A/*** are more detailed characteristics of intensity and position at the cold center than that of the reanalysis ***,an operational satellite retrieval temperature product with time–space continuity and high accuracy is *** reconstructed FY-4A/GIIRS temperature is used to monitor a strong cold wave event in November *** results show that the product effectively monitors the movement and intensity of cold air activities,and it also has good indication for the phase transition of rain and snow triggered by cold wave.

关键词： Fengyun-4A Geosynchronous Interferometric Infrared Sounder(FY-4A/GIIRS) temperature profile,cold wave Cressman interpolation algorithm

Failure of Placebo Analgesia Model in Rats with Inflammatory Pain

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Neuroscience Bulletin 2020年第2期36卷 121-133页

作者： xiang-Sha Yin Jin-Yu Yang Shuai cao Yun Wang Department of Neurobiology School of Basic Medical Sciences and Neuroscience Research InstituteKey Laboratory for NeuroscienceMinistry of Education of Chinaand National Health CommissionState key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing 100083China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China

With the shifting role of placebos,there is a need to develop animal models of placebo analgesia and elucidate the mechanisms underlying the *** the present study,male Sprague-Dawley rats with chronic inflammatory pain caused by complete Freund’s adjuvant(CFA)underwent a series of conditioning procedures,in which morphine was associated with different cues,but they failed to induce placebo ***,conditioning with the conditioned place preference apparatus successfully induced analgesic expectancy and placebo analgesia in naive rats but only induced analgesic expectancy and no analgesic effect in CFA ***,we found enhanced c-fos expression in the nucleus accumbens and reduced expression in the anterior cingulate cortex in naive rats while c-fos expression in the anterior cingulate cortex in CFA rats was not *** summary,the behavioral conditioning model demonstrated the difficulty of establishing a placebo analgesia model in rats with a pathological condition.

关键词： Placebo analgesia Morphine Conditioning Inflammatory pain Rat

Combining electroacupuncture and transcranial direct current stimulation as an adjuvant therapy enhances spontaneous conversation and naming in subacute vascular aphasia:A retrospective analysis

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Journal of Integrative Medicine 2022年第3期20卷 244-251页

作者： Samwel Sylvester Msigwa Yan Li xiang-lin Cheng Fen cao Department of Neurology the Clinical Medicine School of Yangtze Universitythe First Affiliated Hospital of Yangtze UniversityJingzhou 424023Hubei ProvinceChina Department of Research and Training Mirembe National Mental Health HospitalP.O.Box 910DodomaTanzania Department of Rehabilitation The First Affiliated Hospital of Yangtze UniversityJingzhou 424023Hubei ProvinceChina

Objective:Emerging evidence shows the effectiveness of speech and language therapy(SLT);however,precise therapeutic parameters remain *** for the use of adjunctive transcranial direct current stimulation(t DCS)to treat post-stroke aphasia(PSA)is promising;however,the utility of combining t DCS and electroacupuncture(EA)has not yet been *** study assessed the therapeutic consequences of EA and t DCS coupled with SLT in subacute PSA patients who were also undergoing hyperbaric oxygen therapy(HBOT).Methods:A retrospective analysis was conducted on subacute(<6 months)PSA patients who were divided into three groups:patients who received EA plus t DCS(acupuncture group),patients who underwent t DCS(t DCS group),and patients who experienced conventional therapy(HBOT+SLT).All subjects underwent 21 days of treatment and also received conventional *** aphasia battery of Chinese(ABC)was used to score pre-and post-intervention ***:The analysis comprised 238 *** infarction was the most frequent stroke type(137[57.6%]),while motor(66[27.7%])and global aphasia(60[25.2%])were the most common types of *** 21 days of intervention,the ABC scores of all patients were *** acupuncture group had the highest ABC scores,but only repetition,naming,and spontaneous speech were statistically improved(P<0.01).Post-hoc tests revealed significant improvement in word retrieval in the acupuncture and t DCS groups(P<0.01,P=0.037),while the acupuncture group had additional significant improvement in spontaneous conversation(P<0.01).Conclusion:Combining acupuncture and t DCS as an adjuvant therapy for subacute PSA led to significant spontaneous speech and word retrieval *** prospective,multi-ethnic,multi-center trials are warranted.

关键词： Aphasia Stroke rehabilitation Acupuncture Electroacupuncture Transcranial direct current stimulation Speech therapy

Purification of Antimicrobial Peptide from Antarctic Krill (Euphausia superba) and its Function Mechanism

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Journal of Ocean University of China 2013年第3期12卷 484-490页

作者： ZHAO Ling YIN Bangzhong LIU Qi cao rong Department of Food Engineering and Nutrition Yellow Sea Fisheries Research InstituteChinese Academy of Fishery Sciences

The preliminary purification and antimicrobial mechanism of antimicrobial peptide from Antarctic Krill were studied in this paper. The results showed that the molecular weight range of antimicrobial polypeptide （CMCC-1） obtained by cation exchange chromatography was between 245-709D as detected by molecular sieve chromatography, and the minimum inhibition concentration （MIC） of CMCC-1 against Staphylococcus aureus was 5.0mgmL^-1. The antimicrobial mechanism of CMCC-1 was studied with S. aureus as indicator bacterium. Compared with control group, the results of the experimental group in which S. aureus was treated with CMCC-1 were as follows： l） CMCC-1 could inhibit cell division at logarithmic phase. 2） The protein and reducing sugar con- tent, and the conductivity of culture medium increased, and the activity of alkaline phosphatase and [3-galactosidase could be detected in the culture medium. 3） Observation under scanning electron microscope revealed that somatic morphology became irregular, and then somatic surface became coarse. The cell became much smaller, and most somatic ceils gathered. The boundary between cells became dim and finally fused as a whole. 4） Observation under transmission electron microscope showed that the surface of S. aureus became rough and the reproducing ability was restrained. The cell wall became thin and the cytoplasm shrunk. Substances inside cell leaked out, which caused cells death. 5） SDS-PAGE analysis showed that some bands disappeared, and the residual bands became vague. 6） The genomic DNA electrophoresis results showed that the genomic DNA bands ofS. aureus were not degraded but the brightness significantly reduced. Thus, it is supposed that CMCC-1 could destroy the cell wall and membrane of S. aureu, increase the cell membrane permeability and the leaking-out of intracellular substances, and thus cause the death ofS. aureu.

关键词： Antarctic Krill antimicrobial peptide purification antimicrobial mechanism

Chitosan Extends the Shelf-life of Filleted Tilapia (Oreochromis niloticus) During Refrigerated Storage

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Journal of Ocean University of China 2012年第3期11卷 408-412页

作者： cao rong LIU Qi YIN Bangzhong WU Biao Department of Food Engineering and Nutrition Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdao 266071P.R.China

Shelf-life extension of aquatic products is of significant economical importance. To determine the potential effect of chitosan on the shelf-life of filleted tilapia, this study analyzed the bacterial community diversity in fresh and spoiled tilapia fillets stored at (4 ± 1)℃ and examined the antimicrobial activity of chitosan against relevant bacteria isolates. Results showed that Pseudomonas (20%) and Aeromonas (16%) were abundant in fresh tilapia fillets, whereas Pseudomonas (52%), Aeromonas (32%) and Staphylococcus (12%) were dominant in the spoiled samples. Chitosan showed wide-spectrum antibacterial activity against bacteria isolated from tilapia and 5.0 g L-1 chitosan was selected for application in preservation. We further determined the shelf-life of chitosan-treated, filleted tilapia stored at (4 ± 1)℃ based on microbiological, biochemical and sensory analyses. Results showed that the shelf-life of chitosan-treated, filleted tilapia was extended to 12 d, whereas that of untreated, control samples was 6 d. These indicate that chitosan, as a natural preservative, has great application potential in the shelf-life extension of tilapia fillets.

关键词： Oreochromis niloticus bacterial flora chitosan refrigeration shelf-life

Electrostatic generator enhancements for powering IoT nodes via efficient energy management

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Microsystems & Nanoengineering 2024年第2期10卷 143-152页

作者： Zibo Wu Zeyuan cao Junchi Teng rong Ding Jiani Xu Xiongying Ye State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua University100084BeijingChina

Electrostatic generators show great potential for powering widely distributed electronic devices in Internet of Things(IoT)***,a critical issue limiting such generators is their high impedance mismatch when coupled to electronics,which results in very low energy utilization ***,we present a high-performance energy management unit(EMU)based on a spark-switch tube and a buck converter with an RF *** optimizing the elements and parameters of the EMU,a maximum direct current output power of 79.2 mW m^(-2)rps^(-1)was reached for a rotary electret generator with the EMU,achieving 1.2 times greater power output than without the ***,the maximum power of the contact-separated triboelectric nanogenerator with an EMU is 1.5 times that without the *** excellent performance is attributed to the various optimizations,including utilizing an ultralow-loss spark-switch tube with a proper breakdown voltage,adding a matched input capacitor to enhance available charge,and incorporating an RF inductor to facilitate the high-speed energy transfer *** on this extremely efficient EMU,a compact self-powered wireless temperature sensor node was demonstrated to acquire and transmit data every 3.5 s under a slight wind speed of 0.5 m/*** work greatly promotes the utilization of electrostatic nanogenerators in practical applications,particularly in IoT nodes.

关键词： IoT power generator