Failure of Placebo Analgesia Model in Rats with Inflammatory Pain

作     者：Xiang-Sha Yin Jin-Yu Yang Shuai Cao Yun Wang Xiang-Sha Yin;Jin-Yu Yang;Shuai Cao;Yun Wang

作者机构：Department of NeurobiologySchool of Basic Medical Sciences and Neuroscience Research InstituteKey Laboratory for NeuroscienceMinistry of Education of Chinaand National Health CommissionState key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing 100083China PKU-IDG/McGovern Institute for Brain ResearchPeking UniversityBeijing 100871China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2020年第36卷第2期

页      面：121-133页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(31720103908,31530028,and 81821092) the National Basic Research Development Program of the Ministry of Science and Technology of China(2017YFA0701300) 

主　　题：Placebo analgesia Morphine Conditioning Inflammatory pain Rat 

摘      要：With the shifting role of placebos,there is a need to develop animal models of placebo analgesia and elucidate the mechanisms underlying the *** the present study,male Sprague-Dawley rats with chronic inflammatory pain caused by complete Freund’s adjuvant(CFA)underwent a series of conditioning procedures,in which morphine was associated with different cues,but they failed to induce placebo ***,conditioning with the conditioned place preference apparatus successfully induced analgesic expectancy and placebo analgesia in naive rats but only induced analgesic expectancy and no analgesic effect in CFA ***,we found enhanced c-fos expression in the nucleus accumbens and reduced expression in the anterior cingulate cortex in naive rats while c-fos expression in the anterior cingulate cortex in CFA rats was not *** summary,the behavioral conditioning model demonstrated the difficulty of establishing a placebo analgesia model in rats with a pathological condition.