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Asymmetrically coordinated main group atomic In-S_(1)N_(3.interface sites for promoting electrochemical CO_(2.reduction

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Nano Research 2024年第6期17卷 5011-5021页

作者： Yan Gao Jinlong Ge Jingqiao Zhang Ting cao zhiyi Sun Wensheng Yan Yu Wang Jie Lin Wenxing Chen Zheng Liu Anhui Provincial Engineering Laboratory of Silicon-based Materials Bengbu UniversityBengbu 233030China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China SEPA Key Laboratory of Eco-Industry Chinese Research Academy of Environmental SciencesBeijing 100012China Ningbo Institute of Materials Technology and Engineering Chinese Academy of ScienceNingbo 315201China Energy&Catalysis Center School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Shanghai Synchrotron Radiation Facilities Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghai 201204China

Designing catalysts with highly active,selectivity,and stability for electrocatalytic CO_(2.to formate is currently a severe ***,we developed an electronic structure engineering on carbon nano frameworks embedded with nitrogen and sulfur asymmetrically dual-coordinated indium active sites toward the efficient electrocatalytic CO_(2.reduction *** expected,atomically dispersed In-based catalysts with In-S_(1)N_(3.atomic interface with asymmetrically coordinated exhibited high efficiency for CO_(2.reduction reaction(CO_(2.RR)to *** achieved a maximum Faradaic efficiency(FE)of 94.3.towards formate generation at−0.8 V *** hydrogen electrode(RHE),outperforming that of catalysts with In-S2.2.and In-N4 atomic *** at a potential of−1.10 V ***,In-S_(1)N_(3.achieves an impressive Faradaic efficiency of 93.7%in flow *** catalytic performance of In-S_(1)N_(3.sites was confirmed to be enhanced through in-situ X-ray absorption near-edge structure(XANES)measurements under electrochemical *** discovery provides the guidance for performance regulation of main group metal catalysts toward CO_(2.RR at atomic scale.

关键词： indium single-site catalyst main group metal asymmetrical coordination CO_(2.reduction reaction structure-activity relationship

Comparative Study of 3.-Printed Porous Titanium Alloy with Rod Designs of Three Different Geometric Structures for Orthopaedic Implantation

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 54-66页

作者： Jiaxin Li Haozhang Zhong Bojun cao Zhaoyang Ran Jia tan Liang Deng Yongqiang Hao Jinglong Yan department of Orthopedics The Second Affiliated Hospital of Harbin Medical UniversityHarbin150001China Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Institute of Materials Modification and Modeling Shanghai Jiao Tong UniversityShanghai200240China

Porous titanium alloy is currently widely used in clinical treatment of orthopaedic diseases for its lower elastic modulus and ability to integrate with bone *** the micro-level,cells can respond to different geometries,and at the macro-level,the geometric design of implants will also affect the biological function of *** this study,three kinds of porous scaffolds with square,triangular and circle rod shapes were designed and 3. *** study observed the proliferation and differentiation of MC3.3.E1 cells during surface culture of the three types of *** also evaluated the characteristics of the three scaffolds by means of compression tests and scanning electron microscopy to provide a reference for the design of porous titanium alloy implants for clinical *** trends of cell proliferation and gene expression between the three types of scaffolds were observed after treatment with two *** results show that the square rod porous scaffolds have the best proliferative and osteogenic activities,and these findings may be due to differences in piezo-type mechanosensitive ion channel component 1(Piezo1)and Yes-associated protein(YAP)expression caused by the macro-geometric topography.

关键词： Porous titanium scaffolds Geometric morphology Cell proliferation Structural design

Regulating the electronic structure of Ir single atoms by ZrO_(2.nanoparticles for enhanced catalytic oxidation of formaldehyde at room temperature

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Chinese Chemical Letters 2024年第7期35卷 200-205页

作者： Shiqi Peng Yongfang Rao tan Li Yufei Zhang Jun-ji cao Shuncheng Lee Yu Huang Key Laboratory of Aerosol Chemistry&Physics State Key Laboratory of Loess and Quaternary Geology(SKLLQG)Institute of Earth EnvironmentChinese Academy of Sciences(CAS)Xi’an 710061China School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an 710049China department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China Faculty of Chemical Engineering Kunming University of Science and TechnologyKunming 650500China School of Environment and Energy South China University of TechnologyGuangzhou 51006China School of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100190China department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina CAS Center for Excellence in Quaternary Science and Global Change Xi’an 710061China

Developing low-loading single-atom catalysts with superior catalytic activity and selectivity in formaldehyde(HCHO)oxidation at room temperature remains ***,ZrO_(2.nanoparticles coupled low-loading Ir single atoms in N-doped carbon(Ir_(1)-N-C/ZrO_(2.)was *** optimal Ir_(1)-N-C/ZrO_(2.with 0.2. wt%Ir loading delivers the high HCHO removal and conversion efficiency(>95%)at 2.℃,which is higher than that over Ir_(1)-N-C with the same Ir *** specific rate can reach 12.5.6 mmol gIr^(-1)h^(-1),surpassing the Ir based catalysts reported to *** functional theory calculation results and electron spin resonance spectra indicate that the introduction of Zr O_(2.nanoparticles modulate the electronic structure of the Ir single atoms,promoting O_(2.activation to·O_(2.^(–).Moreover,the Ir-C-Zr channel is favorable for the dissociation of·O_(2.^(–)to active oxygen atom(*O),and further accelerates the transformation of HCHO and intermediates(dioxymethylene and formates)to CO_(2.and H_(2.*** work provides a facile strategy to design low-loading single-atom catalysts with high catalytic activity toward HCHO oxidation.

关键词： ZrO_(2.nanoparticles Ir single atoms Electronic structure Formaldehyde Catalytic oxidation

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Clinical characteristics and genetic mutations of 10 Chinese children with cystic fibrosis or cystic frbrosis transmembrane conductance regulator-related disorders

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中华医学杂志(英文版) 2024年第14期137卷 1753-1755页

作者： tan Shanshan cao Ling department of Pulmonology The Children’s Hospital Affiliated to the Capital Institute of Pediatrics Beijing China

To the Editor: Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. To date, over 2.00 CFTR mutations have been identified. CF mostly occurs in the Caucasian population, and its incidence is approximately 1/2.,000 to 1/1800. However, the number of CF cases in China is small. To discover the gene mutations and clinical characteristics of Chinese children with CF, as well as their correlation, the clinical data of 10 children with CF or CFTR-related disorders (CFTR-RD) were retrospectively analyzed in this study.

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Global, regional, and national burden of early-onset gastric cancer

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Cancer Biology & Medicine 2024年第8期21卷 667-678页

作者： Nuopei tan Hongliang Wu Maomao cao Fan Yang Xinxin Yan Siyi He Mengdi cao Shaoli Zhang Yi Teng Qianru Li Jiachen Wang Changfa Xia Wanqing Chen department of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: The burden of gastric cancer(GC) across different age groups needs updating. We determined the GC global, regional, and national burden profiles and changes in incidence for 3.sequential 5-year intervals from 2.03.to ***: The latest incidence and mortality estimates of GC from 185 countries and regions were extracted from the GLOBOCAN 2.2. database. The 5-year interval age-s{3.dardised incidence rates(ASIRs) were evaluated using cancer registry data from volumes X±XII of the Cancer Incidence in Five Continents(CI5). Correlation analysis was used to evaluate the relationship between ASIR or the age-s{3.dardised mortality rate(ASMR) and the Human Development Index(HDI).Results: There was an estimated global 968,000 new GC cases and 660,000 deaths in 2.2., with male predominance. GC ASIRs and ASMRs were 9.{2. 6.1 per 100,000 persons, respectively. East Asia had the highest burden, with 53.8% of cases and 48.2. of deaths among all geographic regions. There was a significant correlation between ASIR and HDI. Over three 5-year intervals from 2.03.to 2.17, the incidence of GC notably decreased in most countries but peaked at 2.08±2.12.in New Zealand, Turkey, and South Africa. Several countries in Europe, Oceania, and America suggest an increasingly concerning trend among younger individuals, especially ***: GC is a significant health issue, especially among males and in geographic regions with an HDI, such as eastern Asia. While the incidence of GC is decreasing in many countries due to prevention efforts and improved treatments, a rising trend persists among younger individuals. Comprehensive prevention strategies tailored to different age patterns are clearly needed.

关键词： Gastric cancer cancer burden GLOBOCAN incidence mortality

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An analysis of the transcriptional landscape in hypoxia-treated primary nucleus pulposus cells

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Genes & Diseases 2024年第2期11卷 558-560页

作者： Zhicai Peng Zhuo Wang Shuaichi Guo Bing tan Ruichao cao Shengqiang Cheng Jun Chen Chunwang Xie Dehong Mao Zhenming Hu department of Orthopaedics Yongchuan Traditional Chinese Medicine Hospital of ChongqingChongqing 402160China department of Orthopaedic Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China department of Spine Surgery The Third Hospital of MianyangSichuan Mental Health CenterMianyangSichuan 621000China

Intervertebral disc degeneration(IDD)is the main cause of lower back *** back pain places a huge burden on society,and all current treatments for IDD cannot restore the original function of the intervertebral *** new treatments for IDD requires clarifying the mechanisms of *** hypoxia is an important feature of the nucleus pulposus because of its special anatomical *** RNA sequencing(RNA-seq),we obtained the whole transcriptome of nucleus pulposus cells(NPCs)under hypoxia and hypoxia-inducible factor(HIF1A)*** demonstrated possible effects of oxygen concentration and HIF1A on *** addition,our results showed that hypoxia can affect lipid metabolism in NPCs.

关键词： structure metabolism degeneration

Inhibition of the RXRA-PPARα-FABP4 signaling pathway alleviates vascular cellular aging by an SGLT2.inhibitor in an atherosclerotic mice model

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Science China Life Sciences 2024年

作者： Weiwei Zhang Linghuan Wang Yujia Wang Yan Fang Ruihua cao zhiyi Fang Dong Han Xu Huang Zhenghui Gu Yingjie Zhang Yan Zhu Yan Ma Feng cao department of Cardiology The Second Medical Centre Chinese PLA General Hospital National Clinical Research Center for Geriatric Diseases School of Medicine Nankai University department of Cardiology Beijing Friendship Hospital Capital Medical University

Atherosclerosis is the pathological cause of atherosclerotic cardiovascular disease （ASCVD）, which rapidly progresses during the cellular senescence. Sodium-glucose cotransporter 2.inhibitors （SGLT2.s） reduce major cardiovascular events in patients with ASCVD and have potential antisenescence effects. Here, we investigate the effects of the SGLT2.inhibitor dapagliflozin on cellular senescence in atherosclerotic mice. Compared with ApoE-/-control mice treated with normal saline, those in the ApoE-/-dapagliflozin group, receiving intragastric dapagliflozin （0.1 mg kg-1d-1） for 14 weeks, exhibited the reduction in the total aortic plaque area （48.8%±6.6%vs. 74.6%±8.0%,P19±0.003.） mm2.s.（0.03.0}0.0062. mm2. P16.4%±3.7%vs. 3..7%±2.0%, P1）, while the increase in the thickness of the fibrous cap (（2..6±2.1）μm vs.（14.6±1.5）μm, P1). Transcriptome sequencing of the aortic arch in the mice revealed the involvement of the PPARα and the fatty acid metabolic signaling pathways in dapagliflozin’s mechanism of ameliorating cellular aging and plaque progression. In vitro, dapagliflozin inhibited the expression of PPARα and its downstream signal FABP4, by which the accumulation of senescent cells in human aortic smooth muscle cells （HASMCs） was reduced under high-fat conditions. This effect was accompanied by a reduction in the intracellular lipid content and alleviation of oxidative stress. However, these beneficial effects of dapagliflozin could be reversed by the PPARα *** analysis and molecular docking simulations revealed that dapagliflozin might exert its effects by directly interacting with the RXRA protein, thereby influencing the expression of the PPARα signaling pathway. In conclusion, the cellular senescence of aortic smooth muscle cells is potentially altered by dapagliflozin through the suppression of the RXRA-PPARα-FABP4 s

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Discovery of first-in-class DOT1L inhibitors against the R2.1Q gain-of-function mutation in the catalytic domain with therapeutic potential of lung cancer

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3605-3623页

作者： Zehui tan Ning Guo Zhi cao Shuyu Liu Jiayu Zhang Deyi Ma Jiahao Zhang Wencai Lv Nan Jiang Linghe Zang Lihui Wang Xin Zhai Key Laboratory of Structure-Based Drug Design and Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China department of Pharmacology Shenyang Pharmaceutical UniversityShenyang 110016China

Recent research certified that DOT1L and its mutations represented by R2.1Q were potential targets for the treatment of lung ***,a series of adenosine-containing derivatives were identified with DOT1LR2.1Q inhibition through antiproliferation assay and Western blot analysis in the H460R2.1Q *** most promising compound 3. significantly reduced DOT1LR2.1Q mediated H3.79 methylation and effectively inhibited the proliferation,self-renewal,migration,and invasion of lung cancer cell lines at low micromolar *** cell permeability and cellular target engagement of 3. were verified by both CETSA and DARTS *** the H460R2.1Q OE cell-derived xenograft(CDX)model,3. displayed pronounced tumor growth inhibition after intraperitoneal administration at 2. mg/kg dose for 3.weeks(TGI=54.3.%),without obvious toxicities.A pharmacokinetic study revealed that 3. possessed tolerable properties(t_(1/2.=1.93.0.91 h,F=97.2.)after intraperitoneal administration in *** study confirmed that 3. suppressed malignant phenotypes of lung cancer carrying R2.1Q gain-of-function mutation via the MAPK/ERK signaling ***,analysis of the binding modes between molecules and DOT1LWT/R2.1Q proteins put forward the“Induced-fit”allosteric model in favor to the discovery of potent DOT1L candidates.

关键词： DOT1L R2.1Q mutation Lung cancer Adenosine-containing inhibitors Epigenetics

Adsorption limitation investigation on olefins for Cu–BTC

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Friction 2024年第4期12卷 606-617页

作者： Xiao YANG Yunbo WANG Weihua cao Ruizheng JIANG Guoxin XIE Yuying cao Xiaowen QI School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China Key Laboratory of Self-Lubricating Spherical Plain Bearing Technology of Hebei Province Yanshan UniversityQinhuangdao 066004China State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Aviation Key Laboratory of Science and Technology on Generic Technology of Self-Lubricating Spherical Plain Bearing Yanshan UniversityQinhuangdao 066004China

To utilize Cu-benzene-1,3.5-tricarboxylate(Cu-BTC)adsorbed lubricant oils in the self-lubricating field,the adsorption properties of Cu-BTC on different 1-olefins must be *** this work,1-hexene,1-octene,1-nonene,1-decene,1-undecene,and 1-dodecene were studied by the Monte Carlo method and *** adsorption limit of Cu-BTC for n-olefins was determined as 1-undecene by the adsorption *** suggested a limit for even straight-chain molecules to the adsorption of *** maximum ratio of the olefin length of the largest pore diameter(L/D)of Cu-BTC was approximately ***,theoretical calculations(radial distribution function(RDF))and experiments(infrared(IR)spectra)confirmed the interaction of n-olefin adsorbates and the Cu-BTC framework occurred between the-CH=of olefins and the Cu and O atoms of the Cu-BTC *** work adds to the understanding and investigation of the adsorption of liquid lubricants using Cu-BTC as a metal-organic framework(MOF).

关键词： metal-organic framework(MOF) Cu-benzene-1,3.5-tricarboxylate(Cu-BTC) Monte Carlo method adsorption properties 1-olefins