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Highly Improved Creep Resistance in Polypropylene Through Thermally Reduced Graphene Oxide and Its Creep Lifetime Prediction

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Chinese Journal of Polymer Science 2024年第2期42卷 256-266,I0010页

作者： can-can Zhang jun-Long Yang Ya-Jiang Huang Guang-Xian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu610065China

Polypropylene(PP) exhibits suboptimal creep resistance due to the presence of methyl groups on its main chain, leading to irregular chain segment distribution, diminished inter-chain interaction, and crystallinity. This structural feature causes chain slippage in PP under stress,significantly constraining its service lifetime. In this study, thermally reduced graphene oxide(TrGO) nanosheets were incorporated into the PP matrix, yielding a nanocomposite with exceptional creep resistance performance. Results demonstrated that at a stress of 25 MPa, a 2.0 wt% TrGO content could enhance the creep failure lifetime of PP by 21.5 times compared to neat PP. Rheology, transmission electron microscopy(TEM),and scanning electron microscopy(SEM) characterization techniques were employed to analyze the mechanism of TrGO's influence on PP's creep behavior. It was observed that when TrGO content exceeded 1.0 wt%, an effective particle network structure formed within the PP matrix. This homogeneously dispersed TrGO-formed particle network structure restricted the migration and rearrangement of PP molecular chains, enabling prolonged stress resistance without structural failure. By combining the time-strain superposition method with the critical failure strain as a criterion, generalized creep compliance curves for PP and its composites were established, facilitating the prediction of material creep failure lifetimes, with a strong agreement between experimental and predicted lifetime values. This research proposes a novel strategy aimed at developing polypropylene materials and products with enhanced long-term stability and durability, thus extending service life, reducing failure risk, and broadening their potential across various application domains.

关键词： Thermally reduced graphene oxide Polypropylene Creep failure and lifetime prediction

Stereochemical editing:Catalytic racemization of secondary alcohols and amines

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Chinese Chemical Letters 2024年第5期35卷 17-31页

作者： jun Zhang Zhiyao Zheng can Zhu Department of Chemistry Fudan UniversityShanghai 200438China Department of Organic Chemistry Arrhenius LaboratoryStockholm UniversityStockholm 10691Sweden

Chiral alcohols and amines are important structural units widely existing in pharmaceuticals,agrochemicals,and food *** kinetic resolution(DKR)is an efficient strategy to deliver optically active alcohols and amines from their *** the development of DKR method,racemization catalyst plays as a crucial element with the requirement of compatibility with the kinetic resolution(KR)*** this paper,recent advance in the catalytic racemization of secondary alcohols and amines is summarized based on different types of racemizing intermediates,which are redox racemization via ketone/imine intermediates,racemization via radical intermediates,and racemization via carbocation *** racemization of secondary alcohols and amines is also enclosed.

关键词： Racemization Secondary alcohols Amines Kinetic resolution Dynamic kinetic resolution

Highly Hydrolysis-Resistant Polyimide Fibers Prepared by Thermal Crosslinking with Inherent Carboxyl Groups

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Chinese Journal of Polymer Science 2024年第2期42卷 247-255,I0010页

Easy hydrolysis in alkaline environments limits the use of polyimide fibers in environmental protection. The hydrolysis resistance levels of polyimide fibers can be improved by crosslinking of the macromolecular chains. In this work, crosslinked polyimide fibers(CPI fibers) were produced by intrinsic carboxyl decarboxylation for the first time. The thermal stability of the polyimide fibers containing the intrinsic carboxyl groups(PIC fibers) was studied, and the temperature of the decarboxylation-crosslinking reaction was determined to be 450 ℃. The PIC fibers were hotdrawn to initiate thermal crosslinking of the carboxyl groups and molecular chain orientation at high temperature. The CPI fibers had high tensile strengths(0.72-1.46 GPa) and compressive strengths(401-604 MPa). The oriented macromolecules and chemically crosslinked structure improved the tightness of the molecular chains and endowed the CPI fibers with excellent hydrolytic resistance. The CPI-50 fiber did not dissolve in a 0.5 wt% NaOH solution during heating at 90 ℃ for 10 h, and the tensile strength retention reached 87% when treated in 0.5 wt% NaOH solutions at 90 ℃ for 1 h, providing a guarantee for its application in alkaline corrosive environments.

关键词： Polyimide Carboxyl group Crosslinking Hydrolysis-resistance

An international guideline with six personalised titration schedules for preventing myocarditis and pneumonia associated with clozapine

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General Psychiatry 2022年第3期35卷 157-162页

作者： Jose de Leon can-jun ruan Georgios Schoretsanitis Christopher Rohde Elif Anıl Yağcıoğlu Trino Baptista Oleg O Kirilochev Carlos De las Cuevas Christoph U Correll Mental Health Research Center Eastern State HospitalLexingtonKentuckyUSA 2 Biomedical Research Centre in Mental Health Net(CIBERSAM)Hospital Santiago ApóstolVitoria-GasteizSpain 3 Laboratory of Clinical PsychopharmacologyBeijing An Ding HospitalBeijingChina 4 The National Clinical Research Centre for Mental Disorders&Beijing Key Lab of Mental DisordersBeijing An Ding HospitalBeijingChina 5 PsychiatryUniversity of ZürichZurichSwitzerland 6 Psychiatry ResearchZucker Hillside HospitalGlen OaksNew YorkUSA 7 Affective DisordersAarhus University HospitalAarhusDenmark 8 Clinical MedicineAarhus UniversitetAarhusDenmark 9 PsychiatryHacettepe UniversitesiAnkaraTurkey 10PhysiologyLos Andes University Medical SchoolMeridaBolivarian Republic of Venezuela 11Clinical PharmacologyAstrakhan State Medical UniversityAstrakhanAstrahanskaâRussian Federation 12Department of Internal MedicineDermatology and Psychiatry and Instituto Universitario de Neurociencia(IUNE)Universidad de La LagunaLa LagunaSpain 13Child and Adolescent PsychiatryCharitéUniversitätsmedizin BerlinBerlinGermany

White blood cell(WBC)monitoring has reduced clozapinetreated patient deaths associated with agranulocytosis to a ***,clozapine protocols and package inserts worldwide provide no instructions for preventing myocarditis or pneumonia during clozapine *** worldwide are largely unaware of ***,as they worry about agranulocytosis,their clozapine-treated patients are at risk of dying from pneumonia or ***,an international guideline with 104 authors from 50 countries/regions was recently published to provide personalised clozapine titration schedules for adult *** forum article reviews pneumonia and myocarditis occurring during clozapine titration,as well as the three most innovative aspects of this new guideline:(1)personalised titration,(2)C reactive protein(CRP)measures,and(3)dose predictions based on blood *** metabolism is influenced by 3 levels of complexity:(1)ancestry groups,(2)sex-smoking subgroups,and(3)presence/absence of poor metabolizer *** 3 groups of variables should determine the maintenance dose and speed of clozapine titration;they are summarised in a table in the *** international clozapine titration guideline recommends measuring CRP levels simultaneously with WBC,at baseline and weekly at least for the first 4 weeks of titration,the highest risk period for clozapine-induced myocarditis.

关键词： titration subgroups absence

Paeoniflorin,the Main Monomer Component of Paeonia lactiflora,Exhibits Anti-inflammatory Properties in Osteoarthritis Synovial Inflammation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 433-442页

作者： CHEN Pu ZHOU jun ruan An-min MA Yu-feng WANG Qing-fu Department of Orthopaedic Surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Department of Orthopaedic Surgery Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Orthopaedic Surgery Beijing Longfu HospitalBeijing 100010China

Objective:To explore the mechanism of paeoniflorin(PF)on osteoarthritis(OA)synovial inflammation from network pharmacology to experimental ***:Targets of OA were constructed by detecting the database of network database platforms(Therapeutic Target database,Drug Bank and Gene Cards),and the targets of PF were constructed by Pub Chem and Herbal Ingredients'Targets *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of these co-targeted genes were conducted via Database for Annotation,Visualization,and Integrated Discovery(DAVID)database,and protein-protein interaction(PPI)networks were conducted via the search tool for the retrieval of interacting genes(STRING)*** counting kit-8(CCK-8)assay was performed to assess the potential toxicity of PF on human OA fibroblast-like synoviocytes(FLS),quantitative real-time polymerase chain reaction(q PCR),enzyme-linked immunosorbent assay(ELISA)and Western blot were used to verify the potential mechanism of PF in synovial ***:Twenty-six co-targeted genes were *** enrichment results showed that these co-targeted genes were most likely localized in the cytoplasm,and the biological processes mainly involved'cellular response to hypoxia''lipopolysaccharide(LPS)-mediated signaling pathway'and'positive regulation of gene expression'.KEGG pathway analysis indicated that these co-targeted genes may function through pathways associated with'hypoxia-inducible factor-1(HIF-1)signaling pathway'and'tumornecrosis factor(TNF)signaling pathway'.The PPI network showed that the top 3 hub genes were TP53,TNF,and *** docking results showed that PF was well docking with ***-8 showed no potential toxicity of 10,20 and 50μmol/L PF on human OA *** PF significantly decreased the expression levels of interleukin-1β,interleukin-6,TNF-αmatrix metalloproteinase 13(MMP13),and a disintegrin and metalloproteinase with thrombospondin motifs 5(ADAMTS5)and TNF

关键词： paeoniflorin osteoarthritis synovial inflammation tumor necrosis factor-α network pharmacology Paeonia lactiflora

Alkyl chain modulation of asymmetric hexacyclic fused acceptor synergistically with wide bandgap third component for high efficiency ternary organic solar cells

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1713-1719页

作者： Shufang Li Huilan Guan can Zhu Chaoyuan Sun Qingya Wei jun Yuan Yingping Zou College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Institute of Carbon Neutrality and New Energy School of Electronics and InformationHangzhou Dianzi UniversityHangzhou 310018China

Herein,two asymmetric hexacyclic fused small molecule acceptors(SMAs),namely BP4F-HU and BP4F-UU,were *** elongated outside chains in the BP4F-UU molecule played a crucial role in optimizing the morphology of blend film,thereby improving charge mobility and reducing energy loss within the corresponding ***,the PM6:BP4F-UU device exhibited a higher open-circuit voltage(V_(oc))of 0.878 V compared to the PM6:BP4F-HU device with a V_(oc)of 0.863 ***,a new wide bandgap SMA named BTP-TA was designed and synthesized as the third component to the PM6:BP4F-UU host binary devices,which showed an ideal complementary absorption spectrum in PM6:BP4F-UU *** addition,BTP-TA can achieve efficient intermolecular energy transfer to BP4F-UU by fluorescence resonance energy transfer(FRET)pathway,due to the good overlap between the photoluminescence(PL)spectrum of BTP-TA and the absorption region of ***,ternary devices with 15wt%BTP-TA exhibits broader photon utilization,optimal blend morphology,and reduced charge recombination compared to the corresponding binary ***,PM6:BP4F-UU:BTP-TA ternary device achieved an optimal power conversion efficiency(PCE)of 17.83%with simultaneously increased V_(oc)of 0.905 V,short-circuit current density(J_(sc))of 26.14 mA/cm^(2),and fill factor(FF)of 75.38%.

关键词： asymmetric hexacyclic acceptor outside chain wide bandgap acceptor ternary organic solar cells

Development of a new strategy for the analysis of chemical medications in serum with HPLC using protein precipitation,on-line SPE and column switching

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Development of a new strategy for the analysis of chemical m...

Short-term effects of cupping and scraping therapy for chronic nonspecific low-back pain:A prospective,multicenter randomized trial

中国药理学会第三届全国治疗药物监测学术年会

作者： Wen-biao LI Jing HE Wei GUO Zuo-li SUN can-jun ruan Laboratory of Clinical Psychopharmacology Beijing Key Lab of Mental DisordersBeijing Anding HospitalCapital Medical University

Analysis of drug concentration in serum/plasma with high performance liquid chromatography (HPLC) is widely used in both overall drug development process and therapeutic drug monitoring (TDM).Commonly used HPLC is ordinarily a single channel system consists of one pump and one column with auto-sampler,detector and working *** samples must be pre treated before injection into the *** sample preparation techniques include liquid-liquid extraction(LLE),solid-phase extrction(SPE) and protein precipitation(PP).The former two techniques are always labour intensive,low detection through-put and error prone processes with multi-step manual *** is a simple and easy handling technique,but the supernatant is always impure with large volumn. Dual chanel HPLC with two pumps,two columns and one switching valve has been developed in the last decades to do on-line SPE with direct injection of serum or plasma into the *** types of on-line SPE columns are commercially available:the different kinds of reverse-phase(RP) columns,restricted access material(RAM) columns and turbulent flow chromatography(TFC) *** columns are easily to be contaminated and clogged,and need to be changed *** and TFC columns function as a pre-column,in combination with an analytical column and column switching,to remove proteinaceous materials prior to analytical chromatographic *** on-line SPE methods have been reported for the determination of different kinds of medications/metabolites in serum or *** these mehtods have not been widely used,because of short on-line SPE column life-time,low drug recovery and high costs. We have developed a new strategy by combining PP,on-line SPE and column switching together. The protein precipitation reagent we used has a very high protein removal efficiency(>99.4%), high drug extraction efficiency(>70%) and low organic solvent usage(less than the sample volumn).After centrifugation,the s

关键词： Protein Precipitation On-line SPE Column Switching High Performance Liquid Chromatography

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Journal of Integrative Medicine 2024年第1期22卷 39-45页

作者： jun-yan He Xiao-yu Tu Zi-fei Yin Hui Mu Ming-jun Luo Xing-yu Chen Wei-bin Cai Xue Zhao can Peng Fan-fu Fang can Lü Bai Li School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Rehabilitation Medicine and Physiotherapy the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Rehabilitation Medicine and Training PLA 458 HospitalGuangzhou 510602Guangdong ProvinceChina No.3 Ward of Acupuncture Rehabilitation Department Guangdong Second Traditional Chinese Medicine HospitalGuangzhou 510095Guangdong ProvinceChina

Background As one of the most common musculoskeletal ailments,chronic nonspecific low-back pain(CNLBP)causes persistent disability and substantial medical *** evidence shows that the incidence rate of CNLBP in young and middle-aged people who are demanded rapidly recovery and social contribution is *** guidelines indicate a reduced role for medicines in the management of *** The present study investigates the short-term effects of cupping and scraping therapy using a medicated balm,compared to nonsteroidal anti-inflammatory drug(NSAID)with a capsaicin plaster,in the treatment of ***,setting,participants and interventions We designed a prospective multicenter randomized clinical trial enrolling patients from January 1,2022 to December 31,2022.A total of 156 patients with CNLBP were randomized into two parallel *** sodium-sustained release tablets were administered orally to participants in the control group for one week while a capsaicin plaster was applied *** in the test group were treated with cupping and scraping using a medical device and medicated *** outcome measures Primary outcome was pain recorded using the visual analogue scale(VAS).Two secondary outcomes were recorded using the Japanese Orthopedic Association low-back pain scale(JOA)and the traditional Chinese medicine(TCM)syndrome integral scale(TCMS)as assessment *** Between baseline and postintervention,all changes in outcome metric scales were statistically significant(Pcantly greater treatment effect in all outcome variables,as indicated by lower VAS and TCMS scores and higher JOA scores,after the one-week intervention period(P<0.001).Further,according to the findings of multivariate linear regression analysis,the participants’pain(VAS score)was related to their marital status,age,smoking habits and body mass *** adverse r

关键词： Chronic nonspecific low-back pain Traditional Chinese medicine Cupping and scraping therapy

Cholecystokinin and cholecystokinin-A receptor: An attractive treatment strategy for biliary dyskinesia?

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World Journal of Gastroenterology 2024年第3期30卷 283-285页

作者： jun Chang Yan Liu Ting-can Jiang Lan Zhao Jian-Wei Liu Tianjin Institute of Acupuncture and Moxibustion The First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Department of Gastroenterology Tianjin Hospital of Integrated Traditional Chinese and Western Medicine Nankai HospitalTianjin 300100China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Biliary dyskinesia is a relatively common gastrointestinal disease that is increas-ing in incidence as living standards ***,its underlying pathogenesis remains unclear,hindering the development of therapeutic ***,“Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct”demonstrated that cholecystokinin(CCK)regulates the contractile function of the common bile duct through interaction with the CCK-A receptor in interstitial Cajal-like cells,contributing to improving the academic understanding of biliary tract dynamics and providing emerging directions for the pathogenesis and clinical management of biliary *** letter provides a brief overview of the role of CCK and CCK-A receptors in biliary dyskinesia from the perspective of animal experiments and clinical studies,and discusses prospects and challenges for the clinical application of CCK and CCK-A receptors as potential therapeutic targets.

关键词： Cholecystokinin Cholecystokinin-A receptor Biliary dyskinesia Interstitial Cajal-like cell Therapeutic target