Clozapine is strongly associated with the risk of pneumonia and inflammation
作者机构：University of Kentucky Mental Health Research CenterEastern State HospitalLexingtonKentuckyUSA Beijing Key Laboratory of Mental DisordersBeijing Anding HospitalBeijingChina InsermBordeaux Population Health Research CenterUniversity of Bordeaux Faculty of Medical SciencesBordeauxAquitaineFrance
出 版 物：《General Psychiatry》 (综合精神医学（英文）)
年 卷 期：2020年第33卷第2期
页 面：66-72页
核心收录：
学科分类：0402[教育学-心理学(可授教育学、理学学位）] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 1009[医学-特种医学] 10[医学]
基 金：National Alliance for Research on Schizophrenia and Depression NARSAD
主 题：inflammation pneumonia mortality
摘 要：Clinicians need to remember that(1)systemic inflammations can increase clozapine level;(2)clozapine,by itself,can cause inflammation,particularly during titration that is too rapid for that patient;(3)clozapine may increase the risk of infection;and(4)more specifically,clozapine may be particularly strongly associated with the risk of *** appears to be associated with high mortality in clozapine patients around the *** who are alert to the risk of pneumonia in clozapine patients may significantly decrease mortality in clozapine *** is no data on COVID-19 infections in clozapine patients,but based on what we know about clozapine pharmacology,we can hypothesise that clozapine,possibly by impairing immunological mechanisms,may increase the risk of pneumonia in infected *** importantly,once fever and/or pneumonia develops,the clozapine dose should be cut in half to decrease the risk of clozapine *** there is any doubt that in spite of halving the dose there are still signs of clozapine intoxication,completely stopping clozapine may be *** the signs of inflammation and fever have disappeared,the clozapine dose can be increased to the prior dosage level.
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