Clozapine is strongly associated with the risk of pneumonia and inflammation
作者机构:University of Kentucky Mental Health Research CenterEastern State HospitalLexingtonKentuckyUSA Beijing Key Laboratory of Mental DisordersBeijing Anding HospitalBeijingChina InsermBordeaux Population Health Research CenterUniversity of Bordeaux Faculty of Medical SciencesBordeauxAquitaineFrance
出 版 物:《General Psychiatry》 (综合精神医学(英文))
年 卷 期:2020年第33卷第2期
页 面:66-72页
核心收录:
学科分类:0402[教育学-心理学(可授教育学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 1009[医学-特种医学] 10[医学]
基 金:National Alliance for Research on Schizophrenia and Depression NARSAD
主 题:inflammation pneumonia mortality
摘 要:Clinicians need to remember that(1)systemic inflammations can increase clozapine level;(2)clozapine,by itself,can cause inflammation,particularly during titration that is too rapid for that patient;(3)clozapine may increase the risk of infection;and(4)more specifically,clozapine may be particularly strongly associated with the risk of *** appears to be associated with high mortality in clozapine patients around the *** who are alert to the risk of pneumonia in clozapine patients may significantly decrease mortality in clozapine *** is no data on COVID-19 infections in clozapine patients,but based on what we know about clozapine pharmacology,we can hypothesise that clozapine,possibly by impairing immunological mechanisms,may increase the risk of pneumonia in infected *** importantly,once fever and/or pneumonia develops,the clozapine dose should be cut in half to decrease the risk of clozapine *** there is any doubt that in spite of halving the dose there are still signs of clozapine intoxication,completely stopping clozapine may be *** the signs of inflammation and fever have disappeared,the clozapine dose can be increased to the prior dosage level.