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Past,present and future of preserving and restoring function in the visual system:removing galectin-3 as a promising treatment

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Neural Regeneration Research 2017年第1期12卷 58-59页

作者： Silmara de Lima Henrique Rocha Mendonca camila oliveira goulart Ana M.Blanco Martinez Laboratories for Neuroscience Research in Neurosurgery and F.M.Kirby Neurobiology Center Children's Hospital BostonDepartmentsof Surgery and Ophthalmology and Program in NeuroscienceHarvard Medical SchoolBostonMAUSA Laboratorio de Neurodegeneracao e Reparo-Departamento de Patologia-Faculdade de Medicina-HUCFF-UFRJ-Rio de Janeiro-RJ Brazil Polo Universitairio Macae UFRJMacaeRJBrazil

Great advances in retinal ganglion cells survival（RGCs）,optic nerve preservation and regeneration have been made in the past ***,we know that RGCs are capable of regenerating the full length of the optic nerve,cross... 详细信息

关键词： RGCs preserving regeneration preservation galectin removing optic capable ganglion microglia

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Comparison of morphological and functional outcomes of mouse sciatic nerve repair with three biodegradable polymer conduits containing poly (lactic acid)

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Neural Regeneration Research 2018年第10期13卷 1811-1819页

作者： Fernanda Marques Pestana Rui C.C.Domingues Júlia Teixeira oliveira Daniela F.P.A.Durco camila oliveira goulart Henrique Rocha Mendonca Anne Caroline Rodrigues dos Santos Natália Tavares de Campos Beatriz Theodoro da Silva Cristina Cardoso Pereira Cristiano Piacsek Borges Ana Maria Blanco Martinez Pós Graduacao em Ciências Morfológicas Instituto de Ciências Biomédicas-UFRJRio de Janeiro RJ Brazil Anatomia Patológica-Faculdade de Medicina-HUCFF-UFRJ Rio de Janeiro RJ Brazil Laboratório de Neurodegeneracao e Reparo-Faculdade de Medicina-HUCFF-UFRJ Rio de Janeiro RJ Brazil Programa de Eng. Química COPPE-UFRJRio de Janeiro Brazil Polo Universitário de Macaé Laboratório Integrado de Produtos Bioativos e BiociênciasMacaê UFRJ Brazil

Poly（lactic acid）（PLA）-containing nerve guidance conduits（NGCs） are currently being investigated for nerve repair as an alternative to autograft, which leads to permanent functional impairment in the territory innervated by the removed nerve. Combination of polymers modifies the physical properties of the conduits, altering their nerve-guidance properties. Conduits made from PLA-only or combined with other polymers have been used successfully for nerve repair, but their efficiency has not been compared. We compared the morphological and functional outcomes of peripheral nerve repair by using NGCs made of poly（lactic acid） and combined or not with polycaprolactone（PLA/PCL） or polyvinylpyrrolidone（PLA/PVP）. To assess the functional recovery, we employed a mechanical hyperalgesia analysis, sciatic functional index（SFI）, and electroneuromyography. The mechanical hyperalgesia analysis showed that the PLA group improved more rapidly than the PLA/PVP and PLA/PCL groups; similarly, in the electroneuromyography assay, the PLA group exhibited higher amplitude than the PLA/PCL and PLA/PVP groups. However, the SFI improvement rates did not differ among the groups. Morphologically, the PLA group showed more vascularization, while the nerve fiber regeneration did not differ among the groups. In conclusion, the PLA-only conduits were superior to the other NGCs tested for nerve repair.

关键词： sciatic nerve tubulization biodegradable conduit poly(lactic acid) regeneration

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WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Neurotrauma and mesenchymal stem cells treatment:From experimental studies to clinical trials

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World Journal of Stem Cells 2014年第2期6卷 179-194页

作者： Ana Maria Blanco Martinez camila de oliveira goulart Bruna dos Santos Ramalho Júlia Teixeira oliveira Fernanda Martins Almeida Laboratory of Neurodegeneration and Repair Institute of Biomedical SciencesHealth Science Center Pathology Department Faculty of MedicineFederal University of Rio de Janeiro Federal University of Rio de Janeiro Campus Macaé

Mesenchymal stem cell(MSC)therapy has attracted the attention of scientists and clinicians around the *** and pre-clinical experimental studies have highlighted the positive effects of MSC treatment after spinal cord and peripheral nerve *** effects are believed to be due to their ability to differentiate into other cell lineages,modulate inflammatory and immunomodulatory responses,reduce cell apoptosis,secrete several neurotrophic factors and respond to tissue injury,among *** are many pre-clinical studies on MSC treatment for spinal cord injury(SCI)and peripheral nerve ***,the same is not true for clinical trials,particularly those concerned with nerve trauma,indicating the necessity of more well-constructed studies showing the benefits that cell therapy can provide for individuals suffering the consequences of nerve *** for clinical trials for SCI treatment the results obtained so far are not as beneficial as those described in experimental *** these reasons basic and pre-clinical studies dealing with MSC therapy should emphasize the standardization of protocols that could be translated to the clinical set with consistent and positive *** review is based on pre-clinical studies and clinical trials available in the literature from 2010 until *** the time of writing this article there were 43 and 36 pre-clinical and 19 and 1 clinical trials on injured spinal cord and peripheral nerves,respectively.

关键词： Neurotrauma Stem cell therapy Mesenchymal stem cells Pre-clinical studies Clinical trials

Modeling uncertainties of reservoir flushing simulations

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International Journal of Sediment Research 2023年第5期38卷 698-710页

作者： camila Bergmann goulart Tobias Bleninger Hugo de oliveira Fagundes Fernando Mainardi Fan Department of Environmental Engineering Federal University of Parana Institute of Hydraulic Research Federal University of Rio Grande do Sul

Every dam or barrage construction affects the watercourse and the retention of sediment that previously was carried by the river, which can lead to siltation of the reservoir and obstruction of water intakes over time, reducing their capacities. However, the information available regarding the effect of sediment and drawdown parameters, sediment management at reservoirs, as well as different equational approaches,is scarce. The current research aims to evaluate the effect of parameters associated with numerical modeling of sediment management in reservoirs considering scenarios with different drawdowns,transport equations, sediment size distributions, and thickness of the initial sediment layer. The case study of the Aimore s Hydropower Plant(HPP) is used, applying the Delft3D-FLOW model for twodimensional modeling. All parameters influenced the volume of mobilized sediment, among which the initial layer thickness was the parameter that resulted in the greatest changes in simulated results. In general, the results show that the uncertainties in the input parameters outweigh the uncertainties between the techniques, which found large variations in results when evaluating the use of different transport equations. These results indicate the importance of proper estimation of model parameters for predicting effects with accuracy and the need for such studies before planning and management operations are evaluated to avoid environmental harm and energy waste.

关键词： Reservoir sedimentation Sediment transport modeling Flushing Sediment management

Extraintestinal manifestations of inflammatory bowel disease, nitroxidative stress and dysbiosis: What is the link between them?

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BIOCELL 2021年第3期45卷 461-481页

作者： AMYLLY SANUELLY DA PAZ MARTINS SAMARA BOMFIM GOMES CAMPOS MARÍLIA oliveira FONSECA goulart FABIANA ANDRÉA MOURA Programa de Pós-Graduação da Rede Nordeste de Biotecnologia(RENORBIO) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Programa de Pós-Graduação em Ciências da Saúde(PPGCS) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Programa de Pós-Graduação em Química e Biotecnologia(PPGQB/UFAL) Campus A.C.SimõesAvenida Lourival Melo Motas/nTabuleiro dos MartinsMaceióAL 57072-970Brazil Programa de Pós-Graduação em Nutrição(PPGNU/UFAL) Programa de Pós-Graduação em Ciências Médicas(PPGCM/UFAL)Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil

Inflammatory bowel disease(IBD),which includes Crohn’s disease and ulcerative colitis,has a not yet completely defined aetiology and is characterized by a progressive chronic inflammation that involves nitroxidative stress and *** manifestations can occur and affect several organs,including the liver and bile ducts,joints,skin,eyes,and less frequently,the heart,brain,and kidneys,increasing the risk of morbidity and *** repercussions may be associated with the activity or severity of *** present review proposes to report and analyse the participation of dysbiosis and nitroxidative stress in the genesis of extraintestinal manifestations,aiming to contribute to a better understanding of the disease and to focus on the development of individualized preventive and therapeutic strategies.

关键词： Oxidative stress Microbiota Bacterial translocation Ulcerative colitis Crohn disease

Efficacy of oral consumption of curcumin/Curcuma longa for symptom improvement in inflammatory bowel disease:A systematic review of animal models and a meta-analysis of randomized clinical trials

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BIOCELL 2022年第9期46卷 2015-2047页

作者： MARLA DE CERQUEIRA ALVES MONISE oliveira SANTOS NASSIB BEZERRA BUENO ORLANDO ROBERTO PIMENTEL DE ARAúJO MARíLIA oliveira FONSECA goulart FABIANA ANDRéA MOURA Programa de Pós-Graduacao em Nutricao(PPGNUT) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Instituto de Química e Biotecnologia(IQB) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Programa de Pós-Gradua玢o em Ciências da Saúde(PPGCS) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Programa de Pós-Gradua玢o da Rede Nordeste de Biotecnologia(RENORBIO) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Programa de Pós-Gradua玢o em Ciências Médicas(PPGCM) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil

The roots of the vegetal Curcuma due to its high content of polyphenols,has been used successfully in several clinical *** review assessed the effect of curcumin/Curcuma longa on symptoms and metabolic changes in inflammatory bowel disease(IBD).A systematic review of animal models and randomized clinical trials(RCTs)was conducted by searching the following electronic databases:PubMed,CENTRAL,LILACS,Science Direct,and *** 997 found records,62 were *** than 90%of the animal studies reported an improvement in macroscopic,histologic and/or functional activity;80%identified decreased oxidative and/or inflammatory biomarkers in animals treated with *** the RCTs,intention-to-treat analysis showed that oral curcumin was effective in inducing clinical remission(n=281,RR:3.15 CI 95%[1.22–8.10]p=0.0017;i2=72.2%,p=0.006)and clinical response(n=259,RR:1.60 CI 95%[1.09–2.35]p=0.0017;i2=59.7%,p=0.042)but not endoscopic remission(n=161,RR:2.91 CI 95%[0.58–14.58]p=0.195;i2=72.7%,p=0.026).These results confirm that oral supplementation with curcumin/Curcuma longa has beneficial actions in animal colitis and,when associated with drug therapy,is effective in the treatment of patients with IBD.

关键词： Ulcerative colitis Crohn’s disease Oxidative stress Curcuma Turmeric

Disseminated cutaneous leishmaniasis due to Leishmania(Leishmania) amazonensis in human immunodeficiency virus(HIV)-infected patients: A report of two cases

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Asian Pacific Journal of Tropical Medicine 2021年第6期14卷 281-284页

作者： camila F Araújo Iara B N oliveira Murilo B Silveira Fátima Ribeiro-Dias Hospital de Doenças Tropicais Doutor Anuar Auad GoiâniaGoiásBrazil Laboratório de Imunidade Natural(LIN) Instituto de Patologia Tropical e Saúde PúblicaUniversidade Federal de GoiásGoiâniaGoiásBrazil

Rationale: Co-infection of human immunodeficiency virus(HIV) and Leishmania spp. has impact on clinical and therapeutic outcomes of leishmaniases. Most studies do not present the identification of Leishmania species causing American tegumentary leishmaniasis in co-infections. In the Americas, Leishmania(L.) Viannia(V.) braziliensis and L.(V.) guyanensis have been identified. Patient concerns: In this study, two cases of American tegumentary leishmaniasis in patients infected with HIV are described. Patients presented several lesions with rapid dissemination and mucosal involvement. Diagnosis: Disseminated cutaneous leishmaniasis caused by L. amazonensis was identified by molecular test. Interventions: The patients were treated with conventional therapies for HIV infection and American tegumentary leishmaniasis. Outcomes: In co-infection, the clinical manifestations are atypical and the treatment response can be impaired. Lessons: These cases show that HIV infection impacts L. amazonensis infection and point to the relevance of identifying Leishmania species, which can lead to a better patient management.

关键词： Leishmania amazonensis HIV Disseminated cutaneous leishmaniasis Case report

Curcumin in inflammatory bowel diseases:Cellular targets and molecular mechanisms

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BIOCELL 2023年第11期47卷 2547-2566页

作者： AMYLLY SANUELLY DA PAZ MARTINS MARLA DE CERQUEIRA ALVES ORLANDO ROBERTO PIMENTEL DE ARAÚJO FABIANA oliveira DOS SANTOS CAMATARI MARÍLIA oliveira FONSECA goulart FABIANA ANDRÉA MOURA Rede Nordeste de Biotecnologia(RENORBIO) Instituto de química e BiotecnologiaUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil Programa de Pós-graduação em Nutrição(PPGNUT) Faculdade de Nutrição(FANUT)Universidade Federal de Alagoas(UFAL)Maceió57072-900Brasil Programa de Pós-Graduação em Química e Biotecnologia(PPGQB) Instituto de química e BiotecnologiaUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil Colegiado de Nutrição Universidade de Pernambuco(UPE)Campus PetrolinaPernambuco56328-900Brasil Programa de Pós-Graduação em Ciências da Saúde(PPGCS) Instituto de Ciências da SaúdeUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil Programa de Pós-graduação em Ciências Médicas(PPGCM) Faculdade de MedicinaUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil

Curcumin,a natural product,has exhibited promising effects in both animal models and clinical trials,interacting with a multitude of factors linked to Inflammatory Bowel Disease(IBD).These factors encompass cytokines,oxidative stress-associated enzymes,and modulation of the intestinal ***,curcumin has demonstrated therapeutic potential in animal models of colitis,wherein it exerts a negative regulatory influence on pivotal signaling pathways such as PI3/Akt,JAK/STAT,andβ-***,it inhibits the expression of proinflammatory enzymes and co-stimulatory molecules(including RANKL,ICAM-1,CD205,CD256,TLR4,among others),while curbing immune cell chemotaxis,thereby attenuating the characteristic neutrophil infiltration observed in *** facet of curcumin’s action involves its modulation of the intestinal ***,the microbiota itself contributes to beneficial biotrans formations of curcumin,thereby enhancing its effectiveness in IBD *** a clinical front,curcumin has demonstrated the ability to induce clinical and/or endoscopic remission without any reported toxic ***,curcumin warrants consideration as an adjunctive therapy in IBD *** clinical investigations should concentrate on meticulously evaluating curcumin’s impact on these precise therapeutic targets.

关键词： Curcuminoids Polyphenols CDAI scores Ulcerative colitis Antioxidant

A combined computational pipeline to detect circular RNAs in human cancer cells under hypoxic stress

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Journal of Molecular Cell Biology 2019年第10期11卷 829-844页

作者： Antonella Di Liddo camila de oliveira Freitas Machado Sandra Fischer Stefanie Ebersberger Andreas WHeumliller Julia EWeigand Michaela Muller-McNicoll Kathi Zarnack Buchmann Institute for Molecular Life Sciences Goethe University FrankfurtFrankfurt am MainGermany Institute of Cell Biology and Neuroscience Goethe University FrankfurtFrankfurt am MainGermany Institute for Cardiovascular Regeneration Goethe University FrankfurtFrankfurt am MainGermany Department of Biology Technical University DarmstadtGermany Institute of Molecular Biology(IMB) MainzGermany

Hypoxia is associated with several diseases,including *** that are deprived of adequate oxygen supply trigger tran-scriptional and post-transcriptional responses,which control cellular pathways such as angiogenesis,proliferation,and metabolic *** RNAs(circRNAs)are a novel class of mainly non-coding RNAs,which have been implicated in multiple cancers and attract increasing attention as potential ***,we characterize the circRNA signatures of three different cancer cell lines from cervical(HeLa),breast(MCF-7),and lung(A549)cancer under *** order to reliably detect circRNAs,we integrate available tools with custom approaches for quantification and statistical analysis?Using this consolidated computational pipeline,we identify?12000 circRNAs in the three cancer *** molecular characteristics point to an involvement of complementary RNA sequences as well as trans-acting factors in circRNA biogenesis,such as the RNA-binding protein HNRNPC-Notably,we detect a number of circRNAs that are more abundant than their linear *** addition,64 circRNAs significantly change in abundance upon hypoxia,in most cases in a cell type-specific *** summary,we present a comparative circRNA profiling in human cancer cell lines,which promises novel insights into the biogenesis and function of circRNAs under hypoxic stress.

关键词： circular RNA computational pipeline differential expression cancer cells hypoxia RNA-Seq