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SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients

Journal of molecular Cell Biology 2022年第4期14卷 51-64页

作者： marjorie C.Pontelli italo A.Castro Ronaldo B.martins Leonardo La Serra Flavio P.Veras Daniele C.Nascimento camila m.silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais m.Lima Juliano P.Souza Brenda C.Vitti Diego B.Caetite mikhael H.F.de Lima Spencer D.Stumpf Cassandra E.Thompson Louis-marie Bloyet Juliana E Toller-Kawahisa marcela C.Giannini Leticia P.Bonjorno marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira maira N.Benatti Lorena L.F.Pontes Rodrigo C.Santana Fernando C.Vilar maria Auxiliadora-martins Pei-Yong Shi Thiago m.Cunha Rodrigo T.Calado JoséC.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda Virology Research Center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil Center of Research in Inflammatory Diseases Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Celland molecular Biology Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional Blood Centerof Ribeirao Preto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Biochemistry&molecular Biology the University of Texas Medical BranchGalvestonTX7755USA Divisions of Clinical lmmunology Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Pathology Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of molecular microbiology.Washington University in St.Louis Saint LouisMO 63110USA

The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity *** cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral *** found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell *** addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)*** rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung *** results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host.

关键词： SARS-CoV-2 CoVID-19 lymphocytopenia peripheral blood mononuclear cell(PBmC) lymphocytes monocytes apoptosis

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Progress of Pb-Sn mixed Perovskites for Photovoltaics: A Review

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Energy & Environmental materials 2022年第2期5卷 370-400页

作者： Rajapakshe mudiyanselage Indrachapa Bandara Shashini m.silva Cameron C.L.Underwood K.D.G.Imalka Jayawardena Radu A.Sporea S.Ravi P.silva Advanced Technology Institute Faculty of Engineering and Physical SciencesUniversity of SurreyGuildford Surrey GU27XHUnited Kingdom

Pb-Sn mixed perovskites are becoming increasingly popular as narrowbandgap(1.2–1.3 eV)light absorbers in single-junction perovskite solar cells(PSCs)and as bottom cells for all-perovskite tandem solar cells,for highefficiency,low-cost,lightweight,roll-to-roll printable photovoltaic(PV)*** the first report of planar Pb:Sn mixed PSCs in 2014,the power conversion efficiencies(PCE)have increased from 10%to 21%by the end of 2020 with an exponential growth in research conducted in this *** much effort,the performance and stability of Pb-Sn mixed PSCs are still limited,which constrains their long-term use in all-perovskite tandem *** review highlights the avenues explored in improving different aspects of Pb-Sn mixed PSCs and provides a comprehensive discussion of the interdependent factors affecting the device *** includes compositional engineering of the perovskite crystal,absorber layer fabrication and crystallization methods,bandgap tuning,Sn4+reduction,and surface passivation of the absorber layer,as well as the selection of interlayers and electrodes of the final PSC.

关键词： inorganic-organic hybrids lead-tin mixed perovskites perovskites photovoltaics solution-processed

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Understanding the corrosion of mg alloys in in vitro urinary tract conditions: A step forward towards a biodegradable metallic ureteral stent

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Journal of magnesium and Alloys 2023年第11期11卷 4301-4324页

作者： margarida Pacheco Ivo m.Aroso Joana m.silva Sviatlana V.Lamaka Jan Bohlen maria Nienaber Dietmar Letzig Estêvão Lima Alexandre A.Barros Rui L.Reis 3B’s Research Group-Research Institute on Biomaterials Biodegradables and BiomimeticsUniversity of MinhoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Institute of Surface Science Helmholtz-Zentrum hereon GmbHGermany Institute of material and Process Design Helmholtz-Zentrum hereon GmbHGermany School of Health Sciences Life and Health Sciences Research Institute(ICVS)University of MinhoBragaPortugal

Ureteral stents play a fundamental role in modern time urology. However, following the deployment, stent-related symptoms are frequent and affect patient health and quality of life. Using biodegradable metals as ureteral stent materials have emerged as a promising strategy, mainly due to the improved radial force and slower degradation rate expected. Therefore, this study aimed to characterize different biodegradable metals in urinary tract environment to understand their propensity for future utilization as base materials for ureteral stents. The corrosion of 5 mg alloys - AZ31, mg-1Zn, mg-1Y, pure mg, and mg-4Ag - under simulated urinary tract conditions was accessed. The corrosion layer of the different alloys presented common elements, such as mg(OH)_(2), mgO, and phosphate-containing products, but slight variations in their chemical compositions were detected. The corrosion rate of the different metals varied, which was expected given the differences in the corrosion layers. On top of this, the findings of this study highlighted the significant differences in the samples' corrosion and corrosion layers when in stagnant and flowing conditions. With the results of this study, we concluded that mg-1Zn and mg-4Ag presented a higher propensity for localized corrosion, probably due to a less protective corrosion layer;mg-4Ag corroded faster than all the other four alloys,and mg-1Y stood out due to its distinct corrosion pattern, that showed to be more homogeneous than all the other four samples, making this one more attractive for the future studies on biodegradable metals.

关键词： Biodegradable metals magnesium alloys Localized corrosion Biodegradable metallic ureteral stent

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An unsettling explanation for the failure of skatole-baited ovitraps to capture Culex mosquitoes

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Insect Science 2019年第5期26卷 873-880页

作者： marcelo H.S.Paiva Rosangela m.R.Barbosa Suzane A.Santos Norma m.silva marcia B.Paula Constancia F.J.Ayres Walter S.Leal Depariamento de Entomologia Instituto Aggeu MagalhaesFundagao Oswaldo CruzAv. Professor Moraes RegoRecifePEBrazil CentroAcademicodoAgreste Universidade Federalde Pernambuco CaruaruPEBrazil Departamentode Biologia Celular Embriologia e GeneticaCentro de Ciencias Biologicas Universidade Federal de Santa CatarinaFlorianopolisSC.Brazil Faculdade de Saude PCiblica Departamento de Epidemiologia Universidade de Sao PauloSao PauloSPBrazil Department of molecular and Cellular Biology University of California-DavisDavisCaliforniaUSA

Culex mosquitoes are primarily found in temperate and tropical regions worldwide where they play a crucial role as main vectors of filarial worms and arboviruses. In Recife, a northeast city in Brazil, high densities of Culex quinquefasciatus are often found in association with human populated areas. In marked contrast to another part of the city, field tests conducted in the neighborhood of Sitio dos Pintos showed that trapping of mosquitoes in skatole-baited ovitraps did not differ significantly from captures in control (water) traps. Thus, classical and molecular taxonomic approaches were used to analyze the Culex species circulating in Sitio dos Pintos. Results obtained from both approaches agreed on the cocirculation of Culex quinquefasciatus and Culex nigripalpus in three different areas of this neighborhood. What was initially considered as an unexpected failure of this lure turned out to be a more unsettling problem, that is, the first report in Recife of Culex nigripalpus, a vector of Venezuelan equine encephalitis virus and West Nile virus. Unplanned urbanization processes close to remnants of the Atlantic forest, such as observed in Sitio dos Pintos, may have contributed to the introduction of Cx. nigripalpus in urban areas.

关键词： Culex quinquefasciatus Culex nigripalpus dengue oviposition attractant skatole West Nile virus Zika

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Compounds from Stevia rebaudiana Bertoni leaves: An overview of non-conventional extraction methods and challenges

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Food Bioscience 2022年第2期46卷 108-121页

作者： Dj´essica Tatiane Raspe camila da silva Silvio Cl´audio da Costa ograma de P´os-Graduaç˜ao em Ciˆencia de Alimentos Universidade Estadual de Maring´aAv.Colombo579087020-900Maring´aPRBrazil Departamento de Tecnologia Universidade Estadual de Maring´aAv.ˆAngelo Moreira da Fonseca180087506-370UmuaramaPRBrazil Departamento de Bioquímica Universidade Estadual de Maring´aAv.Colombo579087020-900Maring´aPRBrazil

To overcome the inconveniences related to its conventional obtainment of natural sweeteners and active compounds from Stevia rebaudiana Bertoni,methods involving application of technology,such as ultrasound assisted extraction,microwave assisted extraction,extraction under pressurized conditions by means of pressurized liquid extraction,subcritical water extraction and supercritical fluid extraction have been *** this review,these emerging techniques were analyzed and discussed,the process variables and operational strategies,their impacts on the extraction and their comparison against the conventional techniques were *** and the possibility of operational automation,the use of less energy and solvents,in addition to the reduced complexity of the subsequent purification steps,make up viable alternatives suitable for a possible industrial *** processes leverage the concept of green chemistry,but still suffer limitations related to acquisition and maintenance costs,in addition to the effects of the action of some of these technologies remaining unexplored.

关键词： Active compounds Natural sweeteners Steviol glycosides Technology application

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Complexed amino acid minerals ***-glycinate chelated minerals:Impact on the performance of old laying hens

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Animal Nutrition 2024年第1期16卷 395-408页

作者： marcos J.B.Santos maria C.m.m.Ludke Leandro m.silva Carlos B.V.Rabello mércia R.Barros Fabiano S.Costa Clariana S.Santos Jamille S.S.Wanderley Department of Animal Science Rural Federal University of PernambucoRecifePEBrazil Department of Veterinary Science Rural Federal University of PernambucoRecifePEBrazil

The present study was to evaluate the effect of trace minerals(Zn,mn,and Cu)from complexed amino acid minerals(ZmCAA)and bis-glycinate chelated minerals(ZmCGly)in laying hen diets on performance,internal and external egg quality,yolk mineral deposition,intestinal morphometry,and bone *** 78 to 98 weeks of age,400 White LSL-Lite strain laying hens were distributed in a randomized design with 4 treatments with 10 replicates per *** were distributed in a 2×2 factorial arrangement using either Zn,mn,and Cu of ZmCAA or ZmCGly source at 2 levels:low(20,20,and 3.5 mg/kg of Zn,mn,and Cu,respectively)or high(40,40,and 7 mg/kg of Zn,mn,and Cu,respectively).The analysis of variance was performed,and in cases where differences were observed,the means were compared using Tukey?s test(Pmineral supplementation had a significant impact on the performance of laying *** fed ZmCAA had higher egg production(P=0.01),egg weight(P=0.02),egg mass(P=0.01),and lower feed conversion ratio(P=0.05)compared to those fed *** ZmCAA supplementation showed higher albumen height(P=0.01),albumen weight(P=0.01),and eggshell thickness(Pmn(Pmetry(PmCAA *** the small intestine,ZmCAA resulted in longer villi(P=0.02)and shorter crypt depth(P=0.01)in the *** and ileum measurements were influenced by the level and source of trace minerals(PmCAA exhibited superior performance,egg quality,deposition of trace minerals in the egg yolk,and bone density compared to hens fed *** this study,older laying hens supplemented with ZmCAA at lower levels demonstrated adequate levels of supplementation.

关键词： Bis-glycinates metal-amino acids Radiodensity Trace minerals

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Cytokines,cytokine gene polymorphisms and Helicobacter pylori infection:Friend or foe?

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World Journal of Gastroenterology 2014年第18期20卷 5235-5243页

作者： camila A Figueiredo Cintia Rodrigues marques Ryan dos Santos Costa Hugo Bernardino F da silva Neuza m Alcantara-Neves Instituto de Ciências da Saúde Universidade Federal da BahiaSalvadorBahia 41110-100Brazil

Helicobacter pylori(***)is a flagellated,spiralshaped,microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50%of the human *** is a risk factor for gastritis,ulcer disease and stomach *** against *** is mainly related to Th1/Th17 skewing,and the activation of regulatory T cells is the main strategy used to limit inflammatory responses,which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases,including ***,host genetic factors that affect cytokines may determine differences in the susceptibility to many *** this review,we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to *** and discuss how such polymorphisms may influence infection/disease outcomes.

关键词： Helicobacter pylori Stomach cancer Immunity Cytokines Polymorphisms

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Combining neural progenitor cell transplant and rehabilitation for enhanced recovery after cervical spinal cord injury

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Neural Regeneration Research 2024年第7期19卷 1433-1434页

作者： camila m.Freria Paul Lu Department of Neurosciences University of CaliforniaSan DiegoLa JollaCAUSA Veterans Administration San Diego Healthcare System San DiegoCAUSA

Efforts to promote recovery of function after human spinal cord injury(SCI) will likely require interventions to rgeting the corticospinal tract(CST) motor system:the most important pathway for voluntary motor control in *** system has historically been the most refractory to regenerative efforts after *** "nonregeneration" of the CST changed when robust regeneration of the CST into spared tissue was demonstrated by the inactivation of phosphatase and tensin homolog and delivery of inosine.

关键词： cervical progenitor injury

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Effect of solvent mixtures on the ultrasound-assisted extraction of compounds from pineapple by-product

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Food Bioscience 2022年第6期50卷 1217-1224页

作者： Gabriella Giovana Zampar Isabella Carolina Zampar Sandra Beserra da silva de Souza camila da silva Beatriz Cervejeira Bolanho Barros Department of Agricultural Science Maringá State UniversityUmuarama87500-000Brazil Department of Technology Maringá State UniversityUmuarama87506-370Brazil

Extraction of compounds from pineapple by-products can be affected by operational conditions and *** study aimed to(i)carry out the ultrasound-assisted extraction of phenolic compounds from pineapple peels using different types of solvents and operating conditions and(ii)characterize the extracts *** solvents with the highest efficiency in extracting total phenolic compounds(TPC),namely water,ethanol,and acid solution(1 mol L−1 HCl),were tested in different proportions using a simplex-centroid mixture *** effects of time(5–45 min),temperature(30–60°C),and ultrasonic power(0–100 W)were also *** were assessed for antioxidant potential,phenolic profile,and sugar *** contents ranged from 219.75 to 405.06 mg GAE 100 g−1,with the highest value obtained in the mixture of ethanol(0.50)and acid solution(0.50).The extract with the highest TPC content and antioxidant activity was obtained at 60°C,50 W of ultrasonic power and 30 *** extract obtained under these conditions contained fructose(7.17 g 100 g−1)and glucose(8.29 g 100 g−1)as major soluble sugars and caffeic acid(217.65 mg 100 g−1)as the major phenolic ***,the extraction of compounds under the conditions studied is an alternative to the valorization of pineapple waste.

关键词： Ananas comosus Fruit waste Phenolic compounds Soluble sugars Solid–liquid extraction

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N-acetylcysteine modulates angiogenesis and vasodilation in stomach such as DNA damage in blood of portal hypertensive rats

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World Journal of Gastroenterology 2015年第43期21卷 12351-12360页

作者： Francielli Licks Renata minuzzo Hartmann camila marques Elizangela Schemitt Josieli Raskopf Colares mariana do Couto Soares Juliana Reys camila Fisher Juliana da silva Norma Possa marroni Universidade Federal do Rio Grande do Sul Instituto de Tecnologia do Paraná Universidade Luterana do Brasil

AIm: To evaluate the antioxidant effect of N-acetylcysteine(NAC) on the stomach of rats with portal ***: Twenty-four male Wistar rats weighing ± 250 g were divided into four experimental groups(n =6 each): Sham-operated(SO),SO + NAC,partial portal vein ligation(PPVL),and PPVL + NAC. Treatment with NAC in a dose of 10 mg/kg(i.p.) diluted in 0.6 m L of saline solution was administered daily for 7 d starting 8 d after the surgery. Animals from the PPVL and SO group received saline solution(0.6 m L) for the same period of time as the PPVL + NAC and SO + NAC group. On the 15 th day the animals were anesthetized and we evaluated portal pressure by cannulating mesenteric artery. After,we removed the stomach for further analysis. We performed immunohistochemical analysis for endothelial nitric oxide synthase(e NOS),vascular endothelial growth factor(VEGF),and nitrotirosine(NTT) proteins in stomach. We also evaluated e NOS and VEGF by Western blot analysis and assessed DNA damage in blood samples by the comet ***: The portal hypertension group exhibited increases in portal pressure when compared to SO group(29.8 ± 1.8 vs 12.0 ± 0.3 mm Hg)(P me was observed when we compared the e NOS(56.8 ± 3.7 vs 13.46 ± 2.8 pixels)(P mmunohistochemistry of the PPVL animals with the SO group. The expression of e NOS(0.39 ± 0.03 vs 0.25 ± 0.03 a.μ)(P mals. We also evaluated the DNA damage by comet assay,and observed an increase on damage index and damage frequency on those animals. NAC decreased portal pressure values in PPVL + NAC animals(16.46 ± 2 vs 29.8 ± 1.8 mm Hg)(P mpared to PPVL. The expression of e NOS(14.60 ± 4.1 vs 56.8 ± 3.7 pixels)(P < 0.001

关键词： N-Acetylcysteine Portal hypertension Gastropathy Oxidative stress Antioxidant

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