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Histone deacetylase enzymes and selective histone deacetylase inhibitors for antitumor effects and enhancement of antitumor immunity in glioblastoma

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Neuroimmunology and Neuroinflammation 2018年第11期5卷 1-18页

作者： caleb J.Yelton Swapan K.Ray Department of Pathology Microbiologyand ImmunologyUniversity of South Carolina School of MedicineColumbiaSC 29209USA

Glioblastoma multiforme (GBM), which is the most common primary central nervous system malignancy in adults, has long presented a formidable challenge to researchers and clinicians alike. Dismal 5-year survival rates of the patients with these tumors and the ability of the recurrent tumors to evade primary treatment strategies have prompted a need for alternative therapies in the treatment of GBM. Histone deacetylase (HDAC) inhibitors are currently a potential epigenetic therapy modality under investigation for use in GBM with mixed results. While these agents show promise through a variety of proposed mechanisms in the pre-clinical realm, only several of these agents have shown this same promise when translated into the clinical arena, either as monotherapy or for use in combination regimens. This review will examine the current state of use of HDAC inhibitors in GBM, the mechanistic rationale for use of HDAC inhibitors in GBM, and then examine an exciting new mechanistic revelation of certain HDAC inhibitors that promote antitumor immunity in GBM. The details of this antitumor immunity will be discussed with an emphasis on application of this antitumor immunity towards developing alternative therapies for treatment of GBM. The final section of this article will provide an overview of the current state of immunotherapy targeted specifically to GBM.

关键词： Glioblastoma histone deacetylase inhibitors antitumor effects antitumor immunity

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外星人尚未到来?

环球科学 2020年第3期 28-35页

作者：凯莱布·沙夫(caleb Scharf) 谢懿(翻译) 哥伦比亚天体生物学中心不详

到目前为止,人类尚未在地球,上找到外星人留下的痕迹,但在一些科学家看来,这并不代表外星人不存在--就算外星人遍布银河系,我们也不必为地球至今未被造访过而感到惊讶。

关键词：外星人银河系地球

Thermal Annealing of Gold Thin Films on the Structure and Surface Morphology Using RF Magnetron Sputtering

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材料科学与工程（中英文B版） 2018年第2期8卷 66-76页

作者： Moniruzzaman Syed caleb Glaser Cameron Hynes Muhtadyuzzaman Syed Division of Natural and Mathematical Sciences Lemoyne-Owen CollegeMemphisTN 38126USA Sandia National Laboratories AlbuquerqueNM 87185USA Department of Electrical and Computer Engineering Purdue UniversityWest LafayetteIN 47907USA

Gold(Au)thin films were deposited on SiO2 substrate under argon(Ar)gas environment using RF(radio frequency)magnetron sputtering at room temperature for various deposition *** samples have been annealed at the temperature range of 250-450°*** change of the structural and surface morphological properties of both as-deposited and annealed films has been studied using an AFM(atomic force microscope),XRD(X-ray diffraction)and Raman *** improvement of crystallinity was observed at the annealing temperature of 350°C and degradation was found *** agreement with XRD and Raman measurements,both crystallite size and crystalline volume fraction were found to be increased having maximum at 350°C and decreased *** result can be explained by simple kinetic theory where sticking probabilities,Au structures agglomerated on SiO2 surfaces and surface coverage of Au atoms must be ***,it can also be explained by the occurrence of two competing phenomena like roughening induced grain growth and smoothing induced inhibition of grain growth with increasing annealing *** mechanisms are also discussed.

关键词： Gold annealing and magnetron sputtering

Current Status and Future Challenges of Weather Radar Polarimetry: Bridging the Gap between Radar Meteorology/Hydrology/Engineering and Numerical Weather Prediction

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Advances in Atmospheric Sciences 2019年第6期36卷 571-588页

作者： Guifu ZHANG Vivek N.MAHALE Bryan J.PUTNAM Youcun QI Qing CAO ANDrew D.BYRD Petar BUKOVCIC Dusan S.ZRNIC Jidong GAO Ming XUE Youngsun JUNG Heather D.REEVES Pamela L.HEINSELMAN AlexANDer RYZHKOV Robert D.PALMER Pengfei ZHANG Mark WEBER Greg M.MCFARQUHAR Berrien MOORE III Yan ZHANG Jian ZHANG J.VIVEKANANDAN Yasser AL-RASHID Richard L.ICE Daniel S.BERKOWITZ Chong-chi TONG caleb FULTON Richard J.DOVIAK University of Oklahoma NOAA/National Weather Service Enterprise Electronics Corporation NOAA/National Severe Storms Laboratory National Center for Atmospheric Research Raytheon Company Radar Operations Center

After decades of research and development, the WSR-88 D(NEXRAD) network in the United States was upgraded with dual-polarization capability, providing polarimetric radar data(PRD) that have the potential to improve weather observations,quantification, forecasting, and warnings. The weather radar networks in China and other countries are also being upgraded with dual-polarization capability. Now, with radar polarimetry technology having matured, and PRD available both nationally and globally, it is important to understand the current status and future challenges and opportunities. The potential impact of PRD has been limited by their oftentimes subjective and empirical use. More importantly, the community has not begun to regularly derive from PRD the state parameters, such as water mixing ratios and number concentrations, used in numerical weather prediction(NWP) *** this review, we summarize the current status of weather radar polarimetry, discuss the issues and limitations of PRD usage, and explore potential approaches to more efficiently use PRD for quantitative precipitation estimation and forecasting based on statistical retrieval with physical constraints where prior information is used and observation error is included. This approach aligns the observation-based retrievals favored by the radar meteorology community with the model-based analysis of the NWP community. We also examine the challenges and opportunities of polarimetric phased array radar research and development for future weather observation.

关键词： weather radar polarimetry radar meteorology numerical weather prediction data assimilation microphysics parameterization forward operator

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Energy modeling and data structure framework for Sustainable Human-Building Ecosystems （SHBE）- a review

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Frontiers in Energy 2018年第2期12卷 314-332页

作者： Suraj TALELE caleb TRAYLOR Laura ARPAN Cali CURLEY Chien-Fei CHEN Julia DAY Richard FEIOCK Mirsad HADZIKADIC William J. TOLONE Stan INGMAN Dale YEATTS Omer T. KARAGUZEL Khee Poh LAM Carol MENASSA Svetlana PEVNITSKAYA Thomas SPIEGELHALTER Wei YAN Yimin ZHU Yong X. TAO Department of Mechanical and Energy Engineering University of North Texas Denton Texas 76203 USA College of Communication & Information Florida State University Tallahassee FL 32306 USA School of Public and Environmental Affairs Indiana University-Purdue University Indianapolis Indianapolis 1N 46202 USA Department of Sociology University of Tennessee Knoxville Knoxville TN 37996 USA Human Ecology Department of Construction Management Washington State University Pullman WA 99164 USA Reubin O'D. Askew School of Public Administration and Policy Florida State University Tallahassee FL 32306 USA College of Computing and Informatics University of North Carolina Charlotte Charlotte NC 28223 USA Department of Gerontology University of North Texas Denton TX 76203 USA Department of Gerontology and Department of Sociology University of North Texas Denton TX 76203 USA CMU School of Architecture Carnegie Mellon University Pittsburgh PA 15213 USA School of Design & Environment National University of Singapore Singapore 117566 Singapore Department of Civil and Environmental Engineering University of Michigan Ann Arbor MI 48109 USA Department of Economics Florida State University Tallahassee FL 32306 USA Department of Architecture Florida Intemational University Miami FL 33199 USA College of Architecture Texas A & M University College Station TX 77843 USA Bert S. Turner Department of Construction Management Louisiana State University Baton Rogue LA 70803 USA College of Engineering and Computing Nova Southeastern University Davie FL 33314 USA

This paper contributes an inclusive review of scientific studies in the field of sustainable human building ecosystems （SHBEs）. Reducing energy consumption by making buildings more energy efficient has been touted as an easily attainable approach to promoting carbon-neutral energy societies. Yet, despite significant progress in research and technology development, for new buildings, as energy codes are getting more stringent, more and more technologies, e.g., LED lighting, VRF systems, smart plugs, occupancy-based controls, are used. Nevertheless, the adoption of energy efficient measures in buildings is still limited in the larger context of the developing countries and middle income/low-income population. The objective of Sustainable Human Building Ecosystem Research Coordination Network （SHBE-RCN） is to expand synergistic investigative podium in order to subdue barriers in engineering, architectural design, social and economic perspectives that hinder wider application, adoption and subsequent performance of sustainable building solutions by recognizing the essential role of human behaviors within building-scale ecosystems. Expected long-term outcomes of SHBE-RCN are collaborative ideas for transformative technologies, designs and methods of adoption for future design, construction and operation of sustainable buildings.

关键词： sustainability building energy modeling(BEM) occupant behaviors (OB) sustainable ecosystems System for the Observation of Populous Heterogeneous Information (SOPHI)

Contribution of Ambulatory Blood Pressure Monitoring to the Management of Arterial Hypertension at Blaise CompaoréUniversity Hospital

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World Journal of Cardiovascular Diseases 2017年第12期7卷 442-450页

作者： Yibar Kambiré Georges Kinda Georges R.C. Milllogo Lassina Konaté Issa Diallo K. Jonas Kologo Jean-Baptiste Tougouma Germain D. Mandi R. Aristide Yaméogo Salifou Yaogo caleb Tindano André K. Samadoulougou Patrice Zabsonré Department of Medicine and Medical Specialties Blaise COMPAORE University Hospital Ouagadougou Burkina Faso Department of Health Sciences University of Ouagadougou Ouagadougou Burkina Faso Cardiology Department Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Cardiology Department Souro Sanou University Hospital Bobo-Dioulasso Burkina Faso

Background: Hypertension is a major public health concern in Burkina Faso. Its management relies on in-office medical setting blood pressure monitoring which is known to be an imperfect diagnosis tool. Objective: This study aims to assess the contribution of ambulatory blood pressure monitoring in the management of hypertension at Blaise Compaoré University Hospital. Methods: A monocentric descriptive retrospective study was conducted in the cardiology outpatient unit of Blaise Compaoré University Hospital. Patients aged at least 18 years who underwent ambulatory blood pressure monitoring between March 2013 and June 2015 were enrolled. Hypertension was defined as follows: average blood pressure over 24 hours > 130/80 mmHg, or diurnal blood pressure > 135/85 mmHg, or nocturnal blood pressure >120/70 mmHg. Data were analyzed using the SPSS 20.0 software. The threshold for significance was set at 5% for a validity interval at 95%. Chi square test was used for?the statistical analysis. Results: A total of 122 patients were enrolled. The main reasons for ambulatory monitoring were the evaluation of hypertensive therapy (51.6%) and the diagnosis confirmation (39.3%). The results of the ambulatory monitoring found 61.4% of the patients with hypertension and 37.7% with normal blood pressure. A treatment adjustment was made for 36.1% of the patients;an initiation of antihypertensive therapy was undertaken for 24.6%, an abstention from drug therapy was recommended?for 23.8%,?and the pursuit of previous treatment for 13.1% of the patients. Conclusion: Ambulatory blood pressure monitoring should be used more often in order to optimize the management of hypertension in our current practice.

关键词： Hypertension Diagnosis Treatment Ambulatory Monitoring Africa

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顾盛与北美汉籍收藏

图书馆论坛 2022年第1期42卷 130-136页

作者：杨海峥北京大学中文系北京大学中国古文献研究中心

北美汉籍收藏的起步,与1844年中美《望厦条约》的签订有着直接的关系。签订中美《望厦条约》的美方代表凯莱布·顾盛于1845年运往美国的一批237种2,547卷藏书,不仅是美国历史上第一批成规模的中文藏书,也是美国国会图书馆汉籍收藏的发端... 详细信息

北美汉籍收藏的起步,与1844年中美《望厦条约》的签订有着直接的关系。签订中美《望厦条约》的美方代表凯莱布·顾盛于1845年运往美国的一批237种2,547卷藏书,不仅是美国历史上第一批成规模的中文藏书,也是美国国会图书馆汉籍收藏的发端,在北美汉籍收藏史上具有重要的意义。

关键词：顾盛望厦条约北美汉籍

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血府逐瘀汤加减治疗PCI术后稳定性心绞痛气滞血瘀型临床观察

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云南中医中药杂志 2022年第2期43卷 29-32页

作者：徐迦勒姜钧文辽宁中医药大学辽宁沈阳110032 辽宁中医药大学附属医院辽宁沈阳110034

目的观察血府逐瘀汤加减治疗冠心病PCI术后稳定性心绞痛气滞血瘀型患者的临床疗效。方法80例患者按照随机对照原则分为对照组和治疗组各40例,对照组予西药规范化治疗,治疗组予常规西药治疗基础上联合血府逐瘀汤加减治疗,治疗2周后,观察... 详细信息

目的观察血府逐瘀汤加减治疗冠心病PCI术后稳定性心绞痛气滞血瘀型患者的临床疗效。方法80例患者按照随机对照原则分为对照组和治疗组各40例,对照组予西药规范化治疗,治疗组予常规西药治疗基础上联合血府逐瘀汤加减治疗,治疗2周后,观察2组西雅图心绞痛量表积分(SAQ)、中医证候疗效、心电图疗效。结果2组西雅图心绞痛量表积分(SAQ)较前改善(P0.05)。结论应用西药基础上,联合血府逐瘀汤加减治疗气滞血瘀型冠心病PCI术后稳定性心绞痛能明显改善患者临床症状。

关键词： PCI术后心绞痛气滞血瘀证血府逐瘀汤

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自私的数据组

世界科学 2019年第1期 58-59页

作者：韩真卡莱布·沙夫纽约哥伦比亚大学天体生物学中心 ***

我们产生的数据是用来服务于我们还是我们为之所用?人类基因组大概有两张CD的数据,人类整体每秒能够产生20 000张CD的数据你一定听说过这样的说法,'基因是进化中永恒的贵族,当肉体的宿主来来去去时,它们会照顾自己'。这个说法来自于理... 详细信息

我们产生的数据是用来服务于我们还是我们为之所用?人类基因组大概有两张CD的数据,人类整体每秒能够产生20 000张CD的数据你一定听说过这样的说法,'基因是进化中永恒的贵族,当肉体的宿主来来去去时,它们会照顾自己'。这个说法来自于理查德·道金斯的《自私的基因》,该书2017年被评为史上最具影响力的科学书籍。而人类实际生产的可操作信息已经超过了所有我们遗传物质的编码信息,人类携带大多数可操作信息进入未来。我们将

关键词：数据组微生物组莎士比亚