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The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions:insights from a single-arm,phase II trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2202-2214页

作者： Bo Cheng caichen li Jianfu li Longlong Gong Peng liang Ying Chen Shuting Zhan Shan Xiong Ran Zhong Hengrui liang Yi Feng Runchen Wang Haixuan Wang Hongbo Zheng Jun liu Chengzhi Zhou Wenlong Shao Yuan Qiu Jiancong Sun Zhanhong Xie Zhu liang Chenglin Yang Xiuyu Cai Chunxia Su Wei Wang Jianxing He Wenhua liang Department of Thoracic Surgery and Oncology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouChina Medical Department Genecast Biotechnology Co.LtdWuxiChina Department of Radiation Oncology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Respiratory Medicine the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouChina Department of Cardiothoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiangChina Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenChina Department of VIP Inpatient Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaSun Yat-sen UniversityGuangzhouChina Department of Medical Oncology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina

Immune checkpoint inhibitors targeting the programmed cell death-1(PD-1)protein significantly improve survival in patients with advanced non-small-cell lung cancer(NSCLC),but its impact on early-stage ground-glass opacity(GGO)lesions remains *** is a single-arm,phase II trial(NCT04026841)using Simon’s optimal two-stage design,of which 4 doses of sintilimab(200 mg per 3 weeks)were administrated in 36 enrolled multiple primary lung cancer(MPLC)patients with persistent high-risk(Lung-RADS category 4 or had progressed within 6 months)*** primary endpoint was objective response rate(ORR).T/B/NK-cell subpopulations,TCR-seq,cytokines,exosomal RNA,and multiplexed immunohistochemistry(mIHC)were monitored and compared between responders and ***,two intent-to-treat(ITT)lesions(pure-GGO or GGO-predominant)showed responses(ORR:5.6%,2/36),and no patients had progressive disease(PD).No grade 3-5 TRAEs *** total response rate considering two ITT lesions and three non-intent-to-treat(NITT)lesions(pure-solid or solid-predominant)was 13.9%(5/36).The proportion of CD8^(+)T cells,the ratio of CD8^(+)/CD4^(+),and the TCR clonality value were significantly higher in the peripheral blood of responders before treatment and decreased over ***,the mIHC analysis showed more CD8^(+)T cells infiltrated in ***,responders’cytokine concentrations of EGF and CTLA-4 increased during *** exosomal expression of fatty acid metabolism and oxidative phosphorylation gene signatures were down-regulated among ***,PD-1 inhibitor showed certain activity on high-risk pulmonary GGO lesions without safety *** effects were associated with specific T-cell re-distribution,EGF/CTLA-4 cytokine compensation,and regulation of metabolism pathways.

关键词： lesions metabolism doses

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广州女性低剂量CT肺癌筛查结果及高危因素探索

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中国肺癌杂志 2024年第5期27卷 345-358页

作者：卢炫庄邱秋霞杨春玉黎才琛李坚福熊珊程博周楚静杜小芹张屹何建行梁文华钟南山广州医科大学附属第一医院广州510120 广州呼吸健康研究院广州510120 广州医科大学南山学院广州511436 广州市卫生健康委员会广州510080 南方医科大学广州510515

背景与目的肺癌高居中国恶性肿瘤发病率和死亡率之首。既往肺癌筛查试验大多为针对吸烟者等高危人群的选择性筛查,然而亚洲肺癌病例非吸烟女性占相当比例。本研究旨在评估广州市社区女性的肺癌患病率并探究肺癌高危因素。方法采用胸部... 详细信息

背景与目的肺癌高居中国恶性肿瘤发病率和死亡率之首。既往肺癌筛查试验大多为针对吸烟者等高危人群的选择性筛查,然而亚洲肺癌病例非吸烟女性占相当比例。本研究旨在评估广州市社区女性的肺癌患病率并探究肺癌高危因素。方法采用胸部低剂量计算机断层扫描(low-dose computed tomography,LDCT)对广州市40-74岁女性居民行肺癌筛查,并根据2018版《中国肺癌低剂量螺旋CT筛查指南》对肺结节进行分类管理及计算阳性结节和肺癌检出率。筛查对象在行检查前均须完成“肺癌危险因素调研问卷”,后对问卷危险因素进行最小绝对收缩和选择算子惩罚Logistic回归分析。结果分析共纳入6256名女性,发现阳性结节1228例(19.63%),确诊肺癌117例(1.87%),其中原位癌6例,I期103例(占肺癌比例88.03%)。根据问卷变量行最小绝对收缩和选择算子(Least absolute shrinkage and selection operator,LASSO)惩罚Logistic回归分析发现,年龄≥50岁(OR=1.07,95%CI:1.06-1.07)、个人恶性肿瘤史(OR=3.29,95%CI:3.22-3.37)、纺织职业(OR=1.10,95%CI:1.08-1.13)、小时候使用煤为燃料(OR=1.14,95%CI:1.13-1.16)以及食物过敏史(OR=1.10,95%CI:1.07-1.13)是该地区女性肺癌的高危因素。结论胸部LDCT可以发现大量早期肺癌,可用于女性肺癌筛查。年龄≥50岁、个人恶性肿瘤史、纺织职业、小时候使用煤为燃料和食物过敏史是该地区女性人群肺癌的高危因素,需提高该群体对肺癌早筛的重视程度。

关键词：肺肿瘤低剂量CT 早期筛查高危因素

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The impact of postoperative EGFR-TKIs treatment on residual GGO lesions after resection for lung cancer

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Signal Transduction and Targeted Therapy 2021年第3期6卷 599-601页

作者： Bo Cheng caichen li Yi Zhao Jianfu li Shan Xiong Hengrui liang Zhichao liu Wenchuang Zeng Wenhua liang Jianxing He Department of Thoracic Surgery and Oncology the First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhou 510120China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiChina

Dear Editor,In recent years,the incidence of multifocal lung cancer is increasing,called multiple primary lung cancer(MPLC).Synchronous MPLC(sMPLC)is defined by multiple malignant lesions occurring at the same time.1 In clinical practice,it was always extremely difficult to remove all lesions simultaneously for sMPLC ***,unresected GGO lesions after primary surgery frequently caught the risk of progression.

关键词： lesions lung cancer

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Advances in lung cancer screening and early detection

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Cancer Biology & Medicine 2022年第5期19卷 591-608页

作者： caichen li Huiting Wang Yu Jiang Wenhai Fu Xiwen liu Ran Zhong Bo Cheng Feng Zhu Yang Xiang Jianxing He Wenhua liang Department of Thoracic Oncology and Surgery the First Affiliated Hospital of Guangzhou Medical UniversityChina National Center for Respiratory MedicineChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhou 510120China Dongguan Affiliated Hospital of Southern Medical University Dongguan People HospitalDongguan 523059China Department of Internal Medicine Detroit Medical Center Sinai-Grace HospitalDetroitMichigan 48235USA Department of Thoracic Surgery Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China Department of Oncology the First People’s Hospital of ZhaoqingZhaoqing 526020China

Lung cancer is associated with a heavy cancer-related burden in terms of patients’physical and mental health *** randomized controlled trials,the US-National Lung Screening Trial(NLST)and Nederlands-Leuvens Longkanker Screenings Onderzoek(NELSON),indicated that low-dose CT(LDCT)screening results in a statistically significant decrease in mortality in patients with lung cancer,LDCT has become the standard approach for lung cancer ***,many issues in lung cancer screening remain unresolved,such as the screening criteria,high false-positive rate,and radiation *** review first summarizes recent studies on lung cancer screening from the US,Europe,and Asia,and discusses risk-based selection for screening and the related ***,an overview of novel techniques for the differential diagnosis of pulmonary nodules,including artificial intelligence and molecular biomarker-based screening,is ***,current explorations of strategies for suspected malignancy are ***,this review aims to help clinicians understand recent progress in lung cancer screening and alleviate the burden of lung cancer.

关键词： Lung cancer screening low-dose CT early detection strategies biomarkers

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后金融危机时代的政府预算管理变革——基于OECD国家的考察

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经济与管理研究 2016年第6期37卷 105-113页

作者：马蔡琛李宛姝南开大学经济学院/中国财税发展研究中心南开大学经济学院

2008年爆发的全球金融危机,促使许多国家采用新的或调整已有的政府预算管理模式,包括拓展预算资源分配视野的中期预算框架和组建独立于行政机构与立法机构之外的财政委员会。OECD国家的经济普遍较为发达,也一直走在预算管理改革的前列,... 详细信息

2008年爆发的全球金融危机,促使许多国家采用新的或调整已有的政府预算管理模式,包括拓展预算资源分配视野的中期预算框架和组建独立于行政机构与立法机构之外的财政委员会。OECD国家的经济普遍较为发达,也一直走在预算管理改革的前列,在经济新常态的背景下,借鉴后金融危机时代这些国家的改革方法和经验,将有助于推进中国预算管理现代化的进程。

关键词：政府预算中期财政规划中期预算后金融危机时代

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中国政府会计准则体系的框架设计与路径选择——基于会计准则诸要素的国际比较视角

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会计与经济研究 2016年第5期30卷 36-48页

作者：马蔡琛李宛姝南开大学经济学院天津300071

2015年发布的《政府会计准则——基本准则》是我国政府会计改革的里程碑事件,而一个完善的政府会计体系需要具体准则体系的支撑。在对发达经济体政府会计的核算基础和政府间差异进行整体比较的基础上,对中国与美国的政府会计体系分别从... 详细信息

2015年发布的《政府会计准则——基本准则》是我国政府会计改革的里程碑事件,而一个完善的政府会计体系需要具体准则体系的支撑。在对发达经济体政府会计的核算基础和政府间差异进行整体比较的基础上,对中国与美国的政府会计体系分别从政府财务资源的分类、财务资源披露的完整性与绩效信息披露三个方面进行系统比较分析,以期为制定中国政府会计具体准则体系提供一个较具启示性的参照系。研究认为,改革过程要注意对预算会计体系的改进、重视对专项财政资金的财务披露以及促进与绩效预算改革的支撑互补。

关键词：政府会计预算会计政府预算绩效管理

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Predilection site and risk factor of second primary cancer:A pancancer analysis based on the SEER database

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Chinese Medical Journal 2023年第12期136卷 1500-1502页

作者： Shan Xiong Hengrui liang Peng liang Xiuyu Cai caichen li Ran Zhong Jianfu li Bo Cheng Feng Zhu limin Ou Zisheng Chen Yi Zhao Hongsheng Deng Zhuxing Chen Zhichao liu Zhanhong Xie Feng li Jianxing He Wenhua liang Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouGuangdong 510120China Department of General Internal Medicine Sun Yat-sen University Cancer CentreState Key Laboratory of Oncology in South ChinaCollaborative Innovation Centre for Cancer MedicineGuangzhouGuangdong 510160China Department of General Internal Medicine Detroit Médica Center Sinai-Grace HospitalDetroit MI 48235USA Department of Oncology The First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510660China Department of Respiratory Medicine The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuanGuangdong 511518China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China

To the Editor:Over the past few years,the number of cancer survivors has continued to increase,primarily driven by the growing and aging population and the improvements in cancer detection and *** than 16.9 million Americans with prior cancers were alive on January 1,2019,and the number of cancer survivors was estimated to reach>22.1 million by January 1,2030.[1]The lifetime risk of individual second primary cancer(SPC)has been confirmed when confronted with such a large amount of cancer survivors.[2]Definition of specific site is shown in supplementary material,http://***/CM9/B616.

关键词： lifetime continued primarily

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肺癌早筛早诊的精准化探索

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中国肿瘤临床 2021年第10期48卷 506-510页

作者：梁文华黎才琛何建行国家呼吸医学中心广州医科大学附属第一医院广州呼吸健康研究院国家呼吸系统疾病国家临床研究中心呼吸疾病国家重点实验室广州市510030 肇庆市第一人民医院肿瘤科南方医科大学南方医院胸外科

目前,肺癌仍是全世界范围内癌症相关死亡的主要原因。早期肺癌可以实现治愈,而晚期肺癌患者的5年生存率极低,因此早诊早治是提高生存率的关键。既往研究已经证实了运用低剂量CT对肺癌高危人群进行筛查可降低肺癌相关死亡率,但肺癌早期... 详细信息

目前,肺癌仍是全世界范围内癌症相关死亡的主要原因。早期肺癌可以实现治愈,而晚期肺癌患者的5年生存率极低,因此早诊早治是提高生存率的关键。既往研究已经证实了运用低剂量CT对肺癌高危人群进行筛查可降低肺癌相关死亡率,但肺癌早期诊治策略仍有许多问题亟需解决,如高危人群的选择和肺结节良恶性的鉴别判断尚欠精准。本研究总结近年来本课题组在肺癌早筛早诊方面的有关工作,并对相关研究进展进行综述,包括利用数据挖掘及队列孟德尔随机分析等手段探索新的肺癌高危因素,研发人工智能及血浆游离DNA检测等工具辅助高危结节的鉴别诊断和处理,以及开发药物治疗极早期肺癌的新手段等,希望为肺癌早筛早诊的临床实践及科研方向提供思路。

关键词：肺癌肺结节高危人群早期筛查早期诊断

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Asian,regional,and national burdens of respiratory tract cancers and associated risk factors from 1990 to 2019:A systematic analysis for the global burden of disease study 2019

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2023年第4期1卷 249-258页

作者： Ran Zhong Xiuyu Cai Jianfu li Peiling Chen Runchen Wang Xinting li Feng li Shan Xiong caichen li Huiting Wang Yang Xiang Shuting Zhan Ziwen Yu Haixuan Wang Chunyan li lixuan lin Wenhai Fu Xin Zheng Shen Zhao Kang Zhang Jianxing He Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhouGuangdong 510000China Guangzhou Medical University GuangzhouGuangdong 510000China Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510050China The First People Hospital of Zhaoqing ZhaoqingGuangdong 526000China Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao 999078China

Background:Respiratory cancer is the leading cause of cancer-related deaths worldwide,but its statistics vary between the East and *** study aimed to estimate the burdens of tracheal,bronchus,and lung(TBL)cancer and larynx cancer and their attributable risks from 1990 to 2019 in Asia,and at regional and national ***:This research evaluated the incidence,mortality,years lived with disability,years of life lost,and disability-adjusted life years(DALYs)for respiratory tract cancers using the Global Burden of Diseases,Injuries,and Risk Factors Study(GBD)2019 ***-standardized rates were calculated for TBL cancer from 1990 to 2019,adjusted for smoking and socio-demographic index(SDI).Deaths from TBL cancer and larynx cancer attributable to each risk factor were estimated for 33 Asian ***:The age-standardized incidence and death rates for TBL cancer in Asia declined from 2010 to 2019,while the incidence rate of larynx cancer *** was the leading specific risk factor for deaths from both TBL and larynx *** burden of TBL cancer in Asian countries was influenced by SDI and smoking,particularly among males in Central ***,DALYs,and incidences of larynx cancer in East Asia had not changed significantly over the past 30 years,but showed slight downward trends in males and both sexes combined,and an upward trend in females in recent ***:The past decade saw increases in numbers of incident cases and deaths from TBL cancer and larynx cancer in *** and smoking were the main factors influencing the disease burden of TBL cancer in Asian *** study highlights the need for tailored cancer control programs to address the burden of respiratory tract cancers in different Asian countries.

关键词： Tracheal,bronchus,and lung(TBL)cancer Larynx cancer Smoking Socio-demographic index Global burden of diseases,injuries,and risk factors study(GBD) Asia

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沙棘提取物促进大鼠肛周脓肿术后创面愈合效果及对p38/MK2通路的影响

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安徽医药 2024年第1期28卷 26-30,I0003页

作者：童偲辰北京市和平里医院普外科北京100000

目的探讨沙棘提取物对大鼠肛周脓肿术后创面愈合及p38/丝裂原活化蛋白激酶2(MK2)通路的影响。方法2021年6—12月,选取SD大鼠60只,采用随机数表法分成假手术组、模型组、阳性对照组(左氧氟沙星,63 mg/kg)、沙棘提取物低(5 g/kg)、中(10 g... 详细信息

目的探讨沙棘提取物对大鼠肛周脓肿术后创面愈合及p38/丝裂原活化蛋白激酶2(MK2)通路的影响。方法2021年6—12月,选取SD大鼠60只,采用随机数表法分成假手术组、模型组、阳性对照组(左氧氟沙星,63 mg/kg)、沙棘提取物低(5 g/kg)、中(10 g/kg)、高(20 g/kg)剂量组,每组10只。构建肛周脓肿术后大鼠模型,测量大鼠术后0 d和观察期(7 d和14 d)的创面大小,计算创面愈合率;采用EliSA法检测大鼠血清中肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β和IL-6水平;观察大鼠创面组织病理改变;应用实时荧光定量PCR(RT-qPCR)法检测大鼠创面组织p38、MK2mRNA,蛋白质印迹法检测大鼠创面组织p38、MK2蛋白。结果模型组大鼠创面组织表皮厚度最薄,细胞边界模糊,细胞排列紊乱,阳性对照组和沙棘提取物各剂量组表皮厚度明显增加,且随着沙棘提取物剂量的增加表皮厚度逐渐增厚。与假手术组比较,创面组织p38、MK2 mRNA(1.00±0.02比1.82±0.12,1.00±0.03比1.70±0.14)和创面组织p38、MK2蛋白(0.61±0.07比0.89±0.08,0.63±0.07比0.92±0.10)表达水平显著升高(P<0.05)。与模型组比较,阳性对照组和沙棘提取物各剂量组大鼠创面愈合率显著升高,血清TNF-α、IL-1β和IL-6水平、创面组织p38、MK2 mRNA(1.82±0.12比0.69±0.07、1.35±0.10、0.96±0.09、0.75±0.09,1.70±0.14比0.61±0.08、1.30±0.11、0.98±0.06、0.66±0.07)以及创面组织p38、MK2蛋白(0.89±0.08比0.29±0.03、0.75±0.09、0.56±0.08、0.32±0.04,0.92±0.10比0.33±0.04、0.80±0.09、0.59±0.07、0.36±0.06)表达水平显著降低(P<0.05)。结论沙棘提取物可有效提高大鼠肛周脓肿术后创面的愈合效果,其机制可能与降低大鼠血清炎性因子,并抑制p38/MK2通路相关蛋白表达有关。

关键词：肛周脓肿沙棘提取物 p38/丝裂原活化蛋白激酶2通路大鼠,Sprague-Dawley

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