Advances in lung cancer screening and early detection

作     者：Caichen Li Huiting Wang Yu Jiang Wenhai Fu Xiwen Liu Ran Zhong Bo Cheng Feng Zhu Yang Xiang Jianxing He Wenhua Liang Caichen Li;Huiting Wang;Yu Jiang;Wenhai Fu;Xiwen Liu;Ran Zhong;Bo Cheng;Feng Zhu;Yang Xiang;Jianxing He;Wenhua Liang

作者机构：Department of Thoracic Oncology and Surgerythe First Affiliated Hospital of Guangzhou Medical UniversityChina National Center for Respiratory MedicineChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhou 510120China Dongguan Affiliated Hospital of Southern Medical UniversityDongguan People HospitalDongguan 523059China Department of Internal MedicineDetroit Medical Center Sinai-Grace HospitalDetroitMichigan 48235USA Department of Thoracic SurgeryNanfang Hospital of Southern Medical UniversityGuangzhou 510515China Department of Oncologythe First People’s Hospital of ZhaoqingZhaoqing 526020China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2022年第19卷第5期

页      面：591-608页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by the China National Science Foundation(Grant Nos.82022048 and 81871893) the Key Project of Guangzhou Scientific Research Project(Grant No.201804020030) 

主　　题：Lung cancer screening low-dose CT early detection strategies biomarkers 

摘      要：Lung cancer is associated with a heavy cancer-related burden in terms of patients’physical and mental health *** randomized controlled trials,the US-National Lung Screening Trial(NLST)and Nederlands-Leuvens Longkanker Screenings Onderzoek(NELSON),indicated that low-dose CT(LDCT)screening results in a statistically significant decrease in mortality in patients with lung cancer,LDCT has become the standard approach for lung cancer ***,many issues in lung cancer screening remain unresolved,such as the screening criteria,high false-positive rate,and radiation *** review first summarizes recent studies on lung cancer screening from the US,Europe,and Asia,and discusses risk-based selection for screening and the related ***,an overview of novel techniques for the differential diagnosis of pulmonary nodules,including artificial intelligence and molecular biomarker-based screening,is ***,current explorations of strategies for suspected malignancy are ***,this review aims to help clinicians understand recent progress in lung cancer screening and alleviate the burden of lung cancer.