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Effects of Maxingloushi decoction on immune inflammation and programmed death markers in mice with chronic obstructive pulmonary disease

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World Journal of Emergency Medicine 2022年第1期13卷 40-45页

作者： Li Li jun Yan Lin-qin Ma Wei Bi cai-jun wu Emergency Department Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Institute of Sepsis Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND: To investigate effects of Maxingloushi decoction on lung inflammation and programmed death markers(programmed death-1 [PD-1], programmed death-ligand 1 [PD-L1]) in the lung tissue, peripheral blood, and bronchoalveolar lavage fl uid(BLF) in a mouse model of chronic obstructive pulmonary disease(COPD).METHODS: Thirty-six mature male BALB/C mice were randomly divided into normal group(group A, n=6), COPD model group(group B, n=10), Maxingloushi decoction + COPD group(group C, n=10), and PD-1 inhibitor + COPD group(group D, n=10). The COPD model was established by smoke inhalation combined with lipopolysaccharide(LPS). Levels of PD-1 and PD-L1 in plasma and BLF were measured by enzyme-linked immunosorbent assay(ELISA). Histopathological techniques were used to semi-quantitatively analyze the immuno-fluorescence optical density(IOD) value of the lung tissue. RESULTS: In plasma and BLF, the expression of PD-1 in the group B was higher than that in the group A, and the expression of PD-L1 was lower than that in the group A. The expression of PD-1 and PD-L1 in the lung tissue was normalized in the group C in comparison with the group B(P<0.05) and the group D(P<0.05), and infl ammatory cell infiltration in the lung tissue was also ***: These findings reveal that COPD causes an immune imbalance in the peripheral blood and lung tissue, and that both Maxingloushi decoction and PD-1 inhibitor treatment can mitigate lung inflammation in COPD by reducing PD-1 expression and increasing PD-L1 expression. The treatment effect of Maxingloushi decoction may be superior to that of PD-1 inhibitor.

关键词： Chronic obstructive pulmonary disease Programmed death-1 Programmed death-ligand 1 Mice Immune Maxingloushi decoction

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Clinical characteristics of patients with Haff disease after eating crayfish

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World Journal of Emergency Medicine 2019年第3期10卷 156-159页

作者： cai-jun wu Hai-jiang Zhou Wei Gu Department of Emergency Medicine Dongzhimen Hospital Institute of Sepsis Beijing University of Chinese Medicine Beijing 100700 China Department of Emergency Medicine Beijing Chao-yang Hospital Capital Medical University Beijing China Emergency Medicine Center Chuiyangliu Hospital Affi liated to Tsinghua University Beijing China

BACKGROUND: The study aimed to explore the clinical presentations, laboratory findings, treatments and prognosis of patients with Haff disease after eating crayfi sh. METHODS: Sixteen patients with Haff disease after eating crayfish were admitted to the Emergency Department of Beijing Chao-yang Hospital between june 2013 and August 2017. Clinical data was retrospectively analyzed. RESULTS: Alcohol consumption and exercise were found to be most commonly associated with the onset of rhabdomyolysis after consuming crayfi sh. Most patients were young adults and the symptoms mostly occurred within 24 hours of consumption of crayfi sh. Clinical symptoms included myalgia (100%), fatigue (87.5%), nausea (43.8%), dizziness (62.5%), chest distress (37.5%) and fever (18.8%). Also found after laboratory testing was elevations in the levels of creatine kinase (11,376±5,535 U/L), myoglobin (350±158 ng/mL), lactate dehydrogenase (6,539±3,180 U/L), alanine transaminase (174±71 U/L) and aspartate aminase (348±100 U/L). The incidence of renal dysfunction was low (6.25%), and all 16 patients had a good prognosis. CONCLUSION: Patients with Haff disease exhibited typical symptoms after consuming crayfish, and laboratory findings gave highly accurate diagnostic results. The development of rhabdomyolysis was considered to be associated with alcohol consumption and exercise, but further studies are needed to demonstrate its relationship with crayfi sh consumption. Compared with other causes of rhabdomyolysis, rhabdomyolysis after crayfi sh consumption has fewer complications and better prognosis.

关键词： Haff disease Rhabdomyolysis Crayfish

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A Novel Magnetic Separation Oxygen-enriched Method and the Influence of Temperature and Magnetic Field on Enrichment

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Journal of Thermal Science 2007年第1期16卷 79-83页

作者： Li WANG jun cai Ping wu Lige TONG Shufeng SUN School of Mechanical Engineering University of Science and Technology Beijing Beijing 100083 China

A novel oxygen-enriched method is presented. Using two opposite magnetic poles of two magnets with certain distance forms a magnetic space having a field intensity gradient near its borders. When air injected into the magnetic space outflows from the magnetic space via its borders, oxygen molecules in air will experience the interception effect of the gradient magnetic field, but nitrogen molecules will outflow without hindrance. Thereby the continuous oxygen enrichment is realized. The results show that the maximum increment of oxygen concentration reaches 0.49% at 298 K when the maximum product of magnetic flux density and field intensity gradient is 563T^2/m. The enrichment level is significantly influenced by the gas temperature and the magnetic field. The maximum increment of oxygen concentration drops to 0.16% when the gas temperature rises to 343 K, and drops to 0.09% when the maximum product of magnetic flux density and gradient is reduced to 101 T^2/m from 563 T^2/m.

关键词： magnetic separation oxygen enrichment oxygen separation gradient magnetic field magnetizing force

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Predictive role of interleukin-6 and CAT score in mechanical ventilation in patients with chronic obstructive pulmonary disease at the acute exacerbation stage in the emergency department

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World Journal of Emergency Medicine 2020年第2期11卷 93-96页

作者： Wei Bi Yan Sun Lin-qin Ma cai-jun wu Department of Emergency Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Institute of Sepsis Beijing University of Chinese MedicineBeijing 100700China Department of Emergency Sanhedongshan HospitalHebei 065200China

BACKGROUND:The study aimed to evaluate the predictive role of interleukin-6(IL-6)and chronic obstructive pulmonary disease(COPD)assessment test(CAT)score in mechanical ventilation(MV)in COPD patients at the acute exacerbation stage in the emergency department(ED).METHODS:For a one-year period,among adult patients in the ED who met the criteria of acute exacerbation of COPD,158 who received MV within 48 hours after admission were compared to 294 who didn't require MV within the same period after ***-6 level and CAT score were compared between the two *** predicted value of IL-6 and CAT score was assessed by logistic regression analysis and a receiver operating characteristic(ROC)***:The IL-6 and CAT scores in the 158 MV patients were much higher than those ***-6 and CAT scores were independent predictors of MV within 48 hours using logistic regression analysis(IL-6:odds ratio[OR]1.053,95%confidence interval[CI]1.039–1.067,P<0.001;CAT score:OR 1.122,95%CI 1.086–1.159,P<0.001).The combination of IL-6 and CAT scores(area under ROC curve[AUC]0.826,95%CI 0.786–0.866,P<0.001)improved the accuracy of predicting MV within 48 hours when compared with IL-6(AUC 0.752,95%CI 0.703–0.800,P<0.001)and CAT scores alone(AUC 0.739,95%CI 0.692–0.786,P<0.001).The sensitivity and specificity were 69.6%,74.1%,75.32%and 63.6%,***:The combined of IL-6 and CAT scores is useful for evaluating the risk of COPD patients at acute exacerbation in ED,and can provide a predictive value for MV or not within 48 hours.

关键词： Interleukin-6 Chronic obstructive pulmonary disease(COPD) COPD assessment test Risk stratifi cation Receive operating characteristic curve

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Effects of arbuscular mycorrhizal fungi on zinc uptake,translocation and accumulation in winter wheat during whole plant growth stages

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Pedosphere 2024年第2期34卷 374-384页

作者： Jing YANG Chuangye ZHANG Yifan LIU Yuanzhe MA Xiangyao wu jun cai Fuyong wu College of Natural Resources and Environment Northwest A&F UniversityYangling 712100China Key Laboratory of Plant Nutrition and Agricultural Environment of Northwest of Ministry of Agriculture Yangling 712100China

Although arbuscular mycorrhizal fungi(AMF)could play important roles in zinc(Zn)uptake in host plants,the effects of AMF on Zn uptake and transport in winter wheat during the whole growth stages remain unclear.A pot experiment was conducted to investigate the effects of Funneliformis mosseae(Fm)and Claroideoglomus etunicatum(Ce)on Zn absorption,transport,and accumulation in winter wheat growing in soils spiked with different Zn levels(0,2.5,and 25 mg kg^(-1)).The results showed that there was a significant correlation between mycorrhizal colonization rate and Zn absorption efficiency in winter wheat roots during the post-anthesis period,but there was no significant correlation during the pre-anthesis *** mycorrhizal fungi significantly increased Zn concentrations(0.56–1.58 times)in wheat grains under 0 mg kg^(-1)Zn level,but decreased Zn concentrations in wheat grains under 25 mg kg^(-1)Zn ***,at the filling and maturity stages,AMF increased Zn absorption rate and the contribution of root Zn uptake to grain Zn by 3–14 and 0.36–0.64 times,respectively,under 0 mg kg^(-1)Zn level and 0.21–1.02 and 0.27–0.37 times,respectively,under 2.5 mg kg^(-1)Zn ***,AMF decreased root Zn absorption rate(0.32–0.61 times)and increased the contribution of Zn remobilization in vegetative tissues to grain Zn(1.69–2.01 times)under 25 mg kg^(-1)Zn *** study would complement the mechanisms and effects of AMF on Zn absorption and transport in winter wheat and provide a potential method for the application of AMF to enrich wheat grain Zn.

关键词： grain Zn source mycorrhizal response post-anthesis period Zn absorption rate Zn remobilization

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Straw return decreases polycyclic aromatic hydrocarbon (PAH) accumulation in winter wheat and human health risk by enhancing PAH dissipation in rhizosphere soil

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Pedosphere 2024年第4期34卷 699-708页

作者： jun cai He ZHANG Xiangyao wu Yifan LIU Yunmei wu Jinfeng WANG Chuangye ZHANG Benhua SUN Fuyong wu College of Natural Resources and Environment Northwest A&F UniversityYangling 712100China Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China Ministry of AgricultureYangling 712100China

Straw return in situ,a common agronomic measure in China,has been widely used not only to increase crop yields and improve soil nutrients but also to remove polycyclic aromatic hydrocarbons(PAHs)from agricultural ***,the safety risks of food crops(i.e.,human health risk of wheat grains)grown in PAHs-contaminated agricultural soils amended with crop straw remain uncertain.A pot experiment was conducted in a PAHs-contaminated agricultural soil cultivated with winter wheat under different ratios of corn straw addition(0%(control,CK),1%,2.5%,and 5%,weight/weight).Results showed that corn straw addition significantly(P<0.05)decreased PAH concentrations in rhizosphere soil,roots,straws,and grains by 48.32%–50.01%,11.85%–42.67%,9.78%–28.03%,and 14.16%–31.67%,respectively,compared with CK,whereas the transfer factors of PAHs from roots to straws were significantly(P<0.05)increased.A correlation heatmap showed that PAH concentrations in roots,straws,and grains were positively(P<0.01)correlated with those in rhizosphere *** indicated that corn straw decreased PAH accumulation in winter wheat due to the increase of PAH dissipation in the rhizosphere soil,although it enhanced PAH transfer in winter *** incremental lifetime cancer risk(ILCR)model indicated that corn straw significantly(P<0.05)decreased the human health risk of winter wheat grains by 29.73%–45.05%.Overall,corn straw apparently reduced PAH accumulation in winter wheat,ecological risk,and human health risk via enhancing PAH dissipation in the rhizosphere *** findings provide an important scientific basis and theoretical guidance for agricultural safety production.

关键词： corn straw addition ecological risk food crops incremental lifetime cancer risk transfer factor

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Risk Factor Analyses for the Return of Spontaneous Circulation in the Asphyxiation Cardiac Arrest Porcine Model

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Chinese Medical Journal 2015年第8期128卷 1096-1101页

作者： cai-jun wu Zhi-jun Guo Chun-Sheng Li Yi Zhang jun Yang Department of Emergency Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China

Background： Animal models of asphyxiation cardiac arrest （ACA） are frequently used in basic research to mirror the clinical course of cardiac arrest （CA）. The rates of the return of spontaneous circulation （ROSC） inACA animal models are lower than those from studies that have utilized ventricular fibrillation （VF） animal models. The purpose of this study was to characterize the factors associated with the ROSC in the ACA porcine model. Methods： Forty-eight healthy miniature pigs underwent endotracheal tube clamping to induce CA. Once induced, CA was maintained untreated for a period of 8 min. Two minutes following the initiation of cardiopulmonary resuscitation （CPR）, defibrillation was attempted until ROSC was achieved or the animal died. To assess the factors associated with ROSC in this CA model, logistic regression analyses were performed to analyze gender, the time of preparation, the amplitude spectrum area （AMSA） from the beginning of CPR and the pH at the beginning of CPR. A receiver-operating characteristic （ROC） curve was used to evaluate the predictive value ofAMSA for ROSC. Results： ROSC was only 52.1% successful in this ACA porcine model. The multivariate logistic regression analyses revealed that ROSC significantly depended on the time of preparation, AMSA at the beginning of CPR and pH at the beginning of CPR. The area under the ROC curve in for AMSA at the beginning of CPR was 0.878 successful in predicting ROSC （95% confidence intervals： 0.773-0.983）, and the optimum cut-offvalue was 15.62 （specificity 95.7% and sensitivity 80.0%）. Conclusions： The time of preparation, AMSA and the pH at the beginning of CPR were associated with ROSC in this ACA porcine model. AMSA also predicted the likelihood of ROSC in this ACA animal model.

关键词： Asphyxia Cardiac Arrest Cardiopulmonary Resuscitation Logistic Regression Analyses Return of Spontaneous Circulation

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Optimization of resource allocation in FDD massive MIMO systems

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Digital Communications and Networks 2024年第1期10卷 117-125页

作者： jun cai Chuan Yin Youwei Ding School of Artificial Intelligence and Information Technology Nanjing University of Chinese MedicineNanjing 210046China School of Electronic and Information Hangzhou Dianzi UniversityHangzhou 310018ZhejiangChina

The performance of massive MIMO systems relies heavily on the availability of Channel State Information at the Transmitter(CSIT).A large amount of work has been devoted to reducing the CSIT acquisition overhead at the pilot training and/or CsI feedback *** fact,the downlink communication generally includes three stages,i.e.,pilot training,CsI feedback,and data *** three stages are mutually related and jointly determine the overall system ***,there exist few studies on the reduction of csIT acquisition overhead from the global point of *** this paper,we integrate the Minimum Mean Square Error(MMSE)channel estimation,Random Vector Quantization(RVQ)based limited feedback and Maximal Ratio Combining(MRC)precoding into a unified framework for investigating the resource allocation *** particular,we first approximate the covariance matrix of the quantization error with a simple expression and derive an analytical expression of the received Signal-to-Noise Ratio(SNR)based on the deterministic equivalence *** the three performance metrics(the spectral efficiency,energy efficiency,and total energy consumption)oriented problems are formulated *** practical system requirements,these three metrics can be collaboratively ***,we propose an optimization solver to derive the optimal partition of channel coherence *** results verify the benefits of the proposed resource allocation schemes under three different scenarios and illustrate the tradeoff of resource allocation between three stages.

关键词： Massive MIMO FDD CSIT Resource allocation

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Geochemical identification of a source rock affected by migrated hydrocarbons and its geological significance:Fengcheng Formation,southern Mahu Sag,junggar Basin,NW China

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Petroleum Science 2024年第1期21卷 100-114页

作者： Wen-Long Dang Gang Gao Xin-cai You Ke-Ting Fan jun wu De-Wen Lei Wen-jun He Yong Tang State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum(Beijing)Beijing102249China School of GeoSciences China University of Petroleum(Beijing)Beijing102249China Exploration&Development Institute Xinjiang Oil Field CompanyKaramay834000XinjiangChina

The Fengcheng Formation is a crucial source rock and the primary reservoir for oil accumulation in the Mahu *** oils are distributed throughout the Fengcheng Formation,ranging from the edge to the interior of the sag in the southern Mahu *** crude oils originate from in-situ source rocks in shallowly buried areas and the inner deep *** migration,the crude oil from the inner deep sag affects the source rocks close to carrier beds,leading to changes in the organic geochemical characteristics of the source *** changes might alter source rock evaluations and oil-source *** on data such as total organic carbon(TOC),Rock-Eval pyrolysis of source rocks,and gas chromatography-mass spectrometry(GC-MS)of the saturated fraction,and considering the geological characteristics of the study area,we define the identification characteristics of source rock affected by migrated hydrocarbons and establish the various patterns of influence that migrated hydrocarbons have on the source rock of the Fengcheng Formation in the southern Mahu *** source rocks of the Fengcheng Formation are mostly fair to good,containing mainly Type II organic matter and being thermally mature enough to generate *** rocks affected by migrated hydrocarbons exhibit relatively high hydrocarbon contents(S1/TOC>110 mg HC/g TOC,Extract/TOC>30%,HC:hydrocarbon),relatively low Rock-Eval Tmax values,and relatively high tricyclic terpane contents with a descending and mountain-shaped ***,biomarker composition parameters indicate a higher thermal maturity than in-situ source *** a comparison of the extract biomarker fingerprints of adjacent reservoirs and mudstones in different boreholes,three types of influence patterns of migrated hydrocarbons are identified:the edge-influence of thin sandstone-thick mudstone,the mixed-influence of sandstone-mudstone interbedded,and the full-influence of thick sandstone-thin *** finding reminds

关键词： Organic geochemistry Source rock Influence of migrated hydrocarbons Fengcheng Formation Southern Mahu Sag

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Mirizzi syndrome:Problems and strategies

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 234-240页

作者： jun wu Shuang-Yong cai Xu-Liang Chen Zhi-Tao Chen Shao-Hua Shi Department of Hepatobiliary and Pancreatic Surgery People’s Hospital of Jiulongpo DistrictChongqing 400050China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310003China

Mirizzi syndrome is a serious complication of gallstone *** is caused by the impacted stones in the gallbladder neck or cystic *** of the features of Mirizzi syndrome is severe inflammation or dense fibrosis at the Calot’s *** our clinical practice,bile duct,branches of right hepatic artery and right portal vein clinging to gallbladder infundibulum are often observed due to gallbladder infundibulum adhered to right hepatic *** intraoperative damage of branches of right hepatic artery occurs more easily than that of bile duct,all of which are hidden pitfalls for *** resonance cholangiopancreatography(MRCP)and endoscopic retrograde cholangiopancreatography(ERCP)are the preferable tools for the diagnosis of Mirizzi *** cholecystectomy in Mirizzi syndrome is easy to damage branches of right hepatic artery and bile duct due to gallbladder infundibulum adhered to right hepatic *** cholecystectomy is an easy,safe and definitive approach to Mirizzi *** combined with the application of ERCP,a laparoscopic management of Mirizzi syndrome by well-trained surgeons is feasible and *** objective of this review was to highlight its existing problems:(1)low preoperative diagnostic rate,(2)easy to damage bile duct and branches of right hepatic artery,and(3)high concomitant gallbladder ***,the review aimed to discuss the possible therapeutic strategies:(1)to enhance its preoperative recognition by imaging findings,and(2)to avoid potential pitfalls during surgery.

关键词： Mirizzi syndrome Bile duct injury Artery injury Surgical treatment Subtotal cholecystectomy

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