Predictive role of interleukin-6 and CAT score in mechanical ventilation in patients with chronic obstructive pulmonary disease at the acute exacerbation stage in the emergency department

作     者：Wei Bi Yan Sun Lin-qin Ma Cai-jun Wu Wei Bi;Yan Sun;Lin-qin Ma;Cai-jun Wu

作者机构：Department of EmergencyBeijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Institute of SepsisBeijing University of Chinese MedicineBeijing 100700China Department of EmergencySanhedongshan HospitalHebei 065200China 

出 版 物：《World Journal of Emergency Medicine》 (世界急诊医学杂志（英文）)

年 卷 期：2020年第11卷第2期

页      面：93-96页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from Dongzhimen Hospital Fund of Special Talent(2018RC01) Beijing University of Chinese Medicine Fund of Project(2019-JYB-XJSJJ-025) 

主　　题：Interleukin-6 Chronic obstructive pulmonary disease(COPD) COPD assessment test Risk stratifi cation Receive operating characteristic curve 

摘      要：BACKGROUND:The study aimed to evaluate the predictive role of interleukin-6(IL-6)and chronic obstructive pulmonary disease(COPD)assessment test(CAT)score in mechanical ventilation(MV)in COPD patients at the acute exacerbation stage in the emergency department(ED).METHODS:For a one-year period,among adult patients in the ED who met the criteria of acute exacerbation of COPD,158 who received MV within 48 hours after admission were compared to 294 who didn t require MV within the same period after ***-6 level and CAT score were compared between the two *** predicted value of IL-6 and CAT score was assessed by logistic regression analysis and a receiver operating characteristic(ROC)***:The IL-6 and CAT scores in the 158 MV patients were much higher than those ***-6 and CAT scores were independent predictors of MV within 48 hours using logistic regression analysis(IL-6:odds ratio[OR]1.053,95%confidence interval[CI]1.039–1.067,P0.001;CAT score:OR 1.122,95%CI 1.086–1.159,P0.001).The combination of IL-6 and CAT scores(area under ROC curve[AUC]0.826,95%CI 0.786–0.866,P0.001)improved the accuracy of predicting MV within 48 hours when compared with IL-6(AUC 0.752,95%CI 0.703–0.800,P0.001)and CAT scores alone(AUC 0.739,95%CI 0.692–0.786,P0.001).The sensitivity and specificity were 69.6%,74.1%,75.32%and 63.6%,***:The combined of IL-6 and CAT scores is useful for evaluating the risk of COPD patients at acute exacerbation in ED,and can provide a predictive value for MV or not within 48 hours.