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中央财政科技计划项目管理专业机构高质量发展途径研究

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农业科技管理 2024年第1期43卷 1-5页

作者：张凯蔡彦虹张慧李岩农业农村部科技发展中心北京100176

农业农村部科技发展中心自2015年成为中央财政科技计划项目管理专业机构,先后承接了“化学肥料和农药减施增效综合技术研发”“北方干旱半干旱与南方红黄壤等中低产田能力提升科技创新”等10个重点专项及“转基因生物新品种培育”1个重... 详细信息

农业农村部科技发展中心自2015年成为中央财政科技计划项目管理专业机构,先后承接了“化学肥料和农药减施增效综合技术研发”“北方干旱半干旱与南方红黄壤等中低产田能力提升科技创新”等10个重点专项及“转基因生物新品种培育”1个重大专项的具体管理任务。成为专业机构以来,中心聚焦服务产业发展关键任务目标,不断理顺关系、创新方式、苦练内功、优化服务,扎实推进一流专业机构建设,切实体现了“接得住、管得好”的改革精神,探索出项目管理专业机构管理中央财政科技计划项目的有效路径。文章综述了中心专业机构建设过程中,在理顺关系、创新方式、苦练内功、面向产业、党建引领等方面的有效探索,梳理了对农业系统相关司局、事业单位重点工作的科技支撑案例,并对下一步专业机构建设进行了展望,以期为农业科技管理提供借鉴。

关键词：国家重点研发计划实施成效支撑案例粮食安全绿色发展耕地保护精准扶贫

Induced pluripotent stem cells(iPSCs):molecular mechanisms of induction and applications

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2065-2090页

作者： Jonas Cerneckis Hongxia cai yanhong Shi Department of Neurodegenerative Diseases Beckman Research Institute of City of HopeDuarteCA 91010USA Irell&Manella Graduate School of Biological Sciences Beckman Research Institute of City of HopeDuarteCA 91010USA

The induced pluripotent stem cell(iPSC)technology has transformed in vitro research and holds great promise to advance regenerative *** have the capacity for an almost unlimited expansion,are amenable to genetic engineering,and can be differentiated into most somatic cell *** have been widely applied to model human development and diseases,perform drug screening,and develop cell *** this review,we outline key developments in the iPSC field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic *** begin by discussing the pivotal discoveries that revealed the potential of a somatic cell nucleus for reprogramming and led to successful generation of *** consider the molecular mechanisms and dynamics of somatic cell reprogramming as well as the numerous methods available to induce ***,we discuss various iPSC-based cellular models,from mono-cultures of a single cell type to complex three-dimensional organoids,and how these models can be applied to elucidate the mechanisms of human development and *** use examples of neurological disorders,coronavirus disease 2019(COVID-19),and cancer to highlight the diversity of disease-specific phenotypes that can be modeled using iPSC-derived *** also consider how iPSC-derived cellular models can be used in high-throughput drug screening and drug toxicity ***,we discuss the process of developing autologous and allogeneic iPSC-based cell therapies and their potential to alleviate human diseases.

关键词： mechanisms programming holds

Identification of coastal water quality by multivariate statistical techniques in two typical bays of northern Zhejiang Province,East China Sea

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Acta Oceanologica Sinica 2017年第2期36卷 1-10页

作者： YE Ran LIU Lian WANG Qiong YE Xiansen CAO Wei HE Qinyan cai yanhong Marine Environmental Monitoring Centre of Ningbo State Oceanic Administration (SOA) School of Marine Sciences Ningbo University

The Hangzhou Bay（HZB） and Xiangshan Bay（XSB）, in northern Zhejiang Province and connect to the East China Sea（ECS） were considerably affected by the consequence of water quality degradation. In this study, we analyzed physical and biogeochemical properties of water quality via multivariate statistical techniques. Hierarchical cluster analysis（HCA） grouped HZB and XSB into two subareas of different pollution sources based on similar physical and biogeochemical properties. Principal component analysis（PCA） identified three latent pollution sources in HZB and XSB respectively and emphasized the importance of terrestrial inputs, coastal industries as well as natural processes in determining the water quality of the two bays. Therefore, proper measurement for the protection of aquatic ecoenvironment in HZB and XSB were of great urgency.

关键词： coastal water quality Hangzhou Bay Xiangshan Bay hierarchical cluster analysis principal component analysis latent pollution sources

Phytoplanktonic biogeography in the subtropical coastal waters,East China Sea along intensive anthropogenic stresses: roles of environmental versus spatial factors

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Acta Oceanologica Sinica 2023年第4期42卷 103-113页

作者： Ran Ye Haibo Zhang Yige Yu Qing Xu Dandi Shen Min Ren Lian Liu yanhong cai Marine Environmental Monitoring Centre of Ningbo Ningbo 315012China

Understanding the relative roles of local environmental effects and spatial effects on phytoplankton community is of essential importance to study the biogeography of them at regional scale. However, the determinants that driving the biogeography of phytoplankton communities in the coastal area of northern Zhejiang still remained unclear. We surveyed phytoplankton community compositions in water columns associated with environmental and spatial influences across five subzones that geographically covering this region over four seasons. Diatoms and dinoflagellates were recorded as the main dominant groups and Coscinodiscus oculs-iridis, Coscinodiscus jonesianus, and Skeletonema costatum, were identified as the major abundant species existing in all *** structured environmental conditions, rather than pure spatial or environmental factors, substantially shaped the biogeography of phytoplankton community, with the former mainly comprised of water temperature,dissolved oxygen, phosphate, pH, and salinity, and the latter referring to a non-negligible factor. This study was the first integrated research that combining environmental filtering with spatial factors in structuring phytoplankton communities at a complete tempo-spatial scale. Our results may facilitate to the further study of harmful algal blooms early-warning in this region.

关键词： biogeography of phytoplankton community environmental factors spatial factors coastal area of northern Zhejiang

Ecological thresholds of phytoplankton community across environmental gradients in the harmful algal blooms-frequently-occurring,subtropical coastal waters,East China Sea

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Acta Oceanologica Sinica 2021年第6期40卷 100-110页

作者： Ran Ye Chunying Ge Qiong Wang Qing Xu Guofeng Xu Yongkang Yan Mingli Qin yanhong cai Yuejun Fei Marine Environmental Monitoring Centre of Ningbo Ningbo 315012China

Phytoplankton communities can response immediately and directly to environmental changes,and thus have been applied as reliable biotic indicators in aquatic *** study provided insights into the relationships concerning ecological thresholds of phytoplankton communities and individual taxon in response to environmental changes in coastal waters of northern Zhejiang Province,East China *** demonstrated that there existed seasonal variations of phytoplankton community ecological thresholds of which spring being higher than those in *** for individual species,Prorocentrum donghaiense and Noctiluca scintillans were identified as the most tolerant and sensitive indicator species in spring and summer,*** exhibited strong indications in response to environmental *** findings highlighted that phytoplankton community structure in this region was stable when environmental gradients were below the thresholds of sensitive species,whereas potential harmful algal blooms may occur when environmental gradients exceeded the thresholds of tolerant species.

关键词： ecological thresholds phytoplankton community environmental gradients indicator species coastal waters of northern Zhejiang Province

The biogeographical distribution of tree species-abundance and its relation to climatic factors in mass islands

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Acta Oceanologica Sinica 2017年第9期36卷 87-90页

作者： LI Xiaoming WU Chengzhen GU Wu YE Ran ZHANG Haibo QI Ping WANG Shengqiang ZHOU Siying WEI Yongjie cai yanhong State Oceanic Administration Beijing 100860 China Wuyi University Wuyishan 354300 China Marine Environmental Monitoring Center of Ningbo Ningbo 315012 China Marine Environmental Monitoring Center of Tianjin Tianjin 300450 China

Tree species-abundance in forests is a function of geographical area and climate, although it is not clear whether such relationships apply to mass islands. We examined the spatial pattern of tree species in mass islands along the coast of Zhejiang, East China Sea using the Preston model, to identify the relationships between tree communities and climatic conditions. The results show that：（1） the biogeographical distribution of tree species-abundance conformes to Preston＇s log-normal pattern, and is in accordance with the findings in both tropical rainforests and estuarine forests;（2） the climatic factors related to tree communities in mass islands are similar to that of the subtropical zone, including the major species of evergreen needle-leaf, broad-leaf and deciduous broad-leaf forests. We conclude that the Preston model can be applied to the trees of mass islands and thus facilitate the systematic ecological researches of vegetation species＇ composition in subtropical zone.

关键词： mass islands species-abundance spatial pattern log-normal model

FLOWERING LOCUS T(FT)in Photosensitive Type Chrysanthemum Accelerates Flowering in Arabidopsis

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 819-830页

作者： Fenglan Wang Zhenyuan cai Zhimei Li Shilong Zhang Honghui Luo Qing Wu Hanhan Xia yanhong Guo College of Horticulture and Landscape Architecture Zhongkai University of Agriculture and EngineeringGuangzhou510225China

FLOWERING LOCUS T(FT)is an important factor for integrating flowering signals through the photoperiod pathway,which significantly promotes *** chrysanthemum varieties are short-day plants,sensitive to the photoperiod,which limits their ornamental and annual production *** this study,we aim to analyze the nutrients and flowering-related genes of chrysanthemums with different photoperiod types and to clone and verify the function of the flowering-related gene *** found that the formation of floral buds requires the accumulation of starch while consuming soluble sugars and the expression patterns of flowering-related genes GIGANTEA(GI),CONSTANS(CO),and FT in ***‘Zilian’and ***‘Zihongtuogui’had a certain synchronization during floral buds differentiation according to our quantitative validation,and the expression levels of CmGI,CmCO and CmFT in ***‘Zihongtuogui’were higher than those in ***.‘Zilian’in the later stage of *** was cloned from photosensitive ***‘Zihongtuogui’and polypeptide alignment and phylogenetic analysis showed that CmFT was clustered in FT-like *** further functional verification,we obtained two Arabidopsis transgenic *** results showed that CmFT transgenic ft mutant lines can significantly accelerate flowering in ***,we can initially confirm that CmFT plays an important role in promoting flowering,which may be the key reason for the photosensitivity of ***‘Zihongtuogui’.Overall,the results of this study are of great importance in revealing the flowering mechanism of different photoperiod types of chrysanthemums.

关键词： Chrysanthemum morifolium flowering-related genes CmFT photoperiod pathway heterologous expression

剪切载荷作用下胶接材料界面动应力强度因子的研究

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机械强度 2008年第3期30卷 450-454页

作者：蔡艳红陈浩然大连理工大学工业装备结构分析国家重点实验室大连116024

主要研究剪切载荷作用下,胶接材料中弹性和粘弹性界面间Griffith裂纹尖端动态应力强度因子的时间响应。采用积分变换方法,得到Laplace域内弹性和粘弹性材料的应力和位移的含未知系数的表达式;引入位错密度函数,并通过边界条件和界面连... 详细信息

主要研究剪切载荷作用下,胶接材料中弹性和粘弹性界面间Griffith裂纹尖端动态应力强度因子的时间响应。采用积分变换方法,得到Laplace域内弹性和粘弹性材料的应力和位移的含未知系数的表达式;引入位错密度函数,并通过边界条件和界面连接条件,导出反映裂纹尖端奇异性的奇异积分方程组,采用Gauss积分,并运用Gauss-Jacobi求积公式化奇异积分方程组为代数方程组,利用配点法进行求解;最后经过Laplace逆变换,求得动态应力强度因子的时间响应。得到Ⅱ型动应力强度因子随着粘弹性材料的剪切松弛参量的增加而增大,膨胀松弛参量的增加而减小;随着弹性材料的剪切模量和泊松比的增加而增大。

关键词：胶接材料界面裂纹动态应力强度因子积分变换奇异积分方程

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竞争条件下的P2P网贷平台定价策略研究

清华大学学报（自然科学版） 2015年第4期55卷 470-474页

作者：张春霞蔡炎宏刘淳北京大学经济学院北京100871 中国农业银行北京100005 清华大学经济管理学院北京100084

互联网金融正在中国经济体制下迅猛发展,对整个金融生态产生积极影响,P2P网贷平台是其中最有活力和代表性的业务模式,而定价策略是其成功的核心要素。该文借鉴传统双边市场定价理论,建立竞争条件下P2P平台的定价模型,并就模型均衡状态... 详细信息

互联网金融正在中国经济体制下迅猛发展,对整个金融生态产生积极影响,P2P网贷平台是其中最有活力和代表性的业务模式,而定价策略是其成功的核心要素。该文借鉴传统双边市场定价理论,建立竞争条件下P2P平台的定价模型,并就模型均衡状态的经济意义进行探讨。建模分析结果表明:均衡状态下,平台对投资人的定价低于平台对借款人的定价;平台的利润与平台的差异化程度正相关;平台低于竞争对手定价时,将赢得更多的市场份额。相关理论结果可很好地解释现存P2P平台的不对称定价、产品差异化和价格战等实践。

关键词：互联网金融 P2P网贷平台双边市场定价策略