检索结果-南通市图书馆

Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1

引用

World Journal of Gastrointestinal Oncology 2024年第3期16卷 1006-1018页

作者： Jun-Jun Lin Ye-cai lu Department of Gastrointestinal Surgery Chaohu Hospital of Anhui Medical UniversityChaohu 238000Anhui ProvinceChina

BACKGROUND Colorectal cancer(CRC)is one very usual tumor together with higher death ***-specific protease 21(USP21)has been confirmed to take part into the regulation of CRC progression through serving as a ***,the promotive function of USP21 has also discovered in the progression of ***1 has illustrated to be modulated by USP7,USP22 and USP51 in ***,the regulatory functions of USP21 on ZEB1 in CRC progression need more *** To investigate the relationship between USP21 and ZEB1 in CRC *** The mRNA and protein expressions were assessed through RT-qPCR,western blot and IHC *** interaction between USP21 and ZEB1 was evaluated through Co-IP and GST pull down *** cell proliferation was detected through colony formation *** cell migration and invasion abilities were determined through Transwell *** stemness was tested through sphere formation *** tumor growth was evaluated through in vivo mice *** In this work,USP21 and ZEB1 exhibited higher expression in CRC,and resulted into poor ***,the interaction between USP21 and ZEB1 was further *** was demonstrated that USP21 contributed to the stability of ZEB1 through modulating ubiquitination *** addition,USP21 streng-thened cell proliferation,migration and stemness through regulating *** last,through in vivo assays,it was illustrated that USP21/ZEB1 axis aggravated tumor *** For the first time,these above findings manifested that USP21 promoted tumorigenicity and stemness of CRC by deubiquitinating and stabilizing *** discovery suggested that USP21/ZEB1 axis may provide novel sights for the treatment of CRC.

关键词： Ubiquitin-specific protease 21 ZEB1 Stemness Colorectal cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Anticancer Potential of Quassinoids-A Mini-Review

引用

Engineering 2024年第7期38卷 27-38页

作者： cai lu Si-Nan lu Di Di Wei-Wei Tao lu Fan Jin-Ao Duan Ming Zhao Chun-Tao Che Jiangsu Collaborative Innovation Center of Chinese Medicinal Resource Industrialization Nanjing University of Chinese MedicineNanjing 210023China National and Local Collaborative Engineering Center of Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine Nanjing University of Chinese MedicineNanjing 210023China School of Chinese Medicine&School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China Department of Pharmaceutical Sciences College of PharmacyUniversity of Illinois ChicagoChicagoIL 60612USA

The anticancer potential of quassinoids has attracted a great deal of attention for decades,and scientific data revealing their possible applications in cancer management are continuously increasing in the *** from the potent cytotoxic and antitumor properties of these degraded triterpenes,several quassinoids have exhibited synergistic effects with anticancer *** article provides an overview of the potential anticancer properties of quassinoids,including their cytotoxic and antitumor activities,mechanisms of action,safety evaluation,and potential benefits in combination with anticancer drugs.

关键词： Quassinoid Anticancer potential Antiproliferative mechanism Safety evaluation Synergistical combination with anticancer drugs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Glucagon-like-peptide-1 receptor agonists and the management of type 2 diabetes-backwards and forwards

引用

World Journal of Diabetes 2024年第3期15卷 326-330页

作者： Michael Horowitz lu cai Md Shahidul Islam Department of Medicine University of AdelaideAdelaide 5005Australia Pediatric Research Institute University of LouisvilleLouisvilleKY 40202United States Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa

This editorial is stimulated by the article by Alqifari et al published in the World Journal of Diabetes(2024).Alqifari et al focus on practical advice for the clinical use of glucagon-like-peptide-1(GLP-1)receptor agonists(GLP-1RAs)in the management of type 2 diabetes and this editorial provides complementary *** initially give a brief historical perspective of the development of GLP-1RAs stimulated by recognition of the‘incretin effect’,the substantially greater insulin increase to enteral when compared to euglycaemic intravenous glucose,and the identification of the incretin hormones,GIP and *** addition to stimulating insulin,GLP-1 reduces postprandial glucose levels by slowing gastric ***-1RAs were developed because native GLP-1 has a very short plasma *** majority of current GLP-1RAs are administered by subcutaneous injection once a *** are potent in glucose lowering without leading to hypoglycaemia,stimulate weight loss in obese individuals and lead to cardiovascular and renal *** landscape in relation to GLP-1RAs is broadening rapidly,with different formulations and their combination with other peptides to facilitate both glucose lowering and weight *** is a need for more information relating to the effects of GLP-1RAs to induce gastrointestinal symptoms and slow gastric emptying which is likely to allow their use to become more effective and personalised.

关键词： Glucagon-like-peptide-1 Glucose-dependent insulinotropic peptide Gastric emptying Type 2 diabetes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Alzheimer's disease and low-dose radiation therapy:A new hope

引用

Radiation Medicine and Protection 2024年第1期5卷 1-6页

作者： Neal E.Dunlap Robert P.Friedland lu cai Department of Radiation Oncology University of Louisville School of MedicineLouisvilleKY40202USA Department of Neurology The University of Louisville School of MedicineLouisvilleKY40202USA Pediatric Research Institute Departments of PediatricsPharmacology and ToxicologyUniversity of Louisville School of MedicineLouisvilleKY40202USA

The concept of low-dose radiation(LDR)-induced hormetic responses was initially observed approximately 70 years ago and systematically reviewed along with the discovery of LDR-induced adaptive responses in a cytogenetic in vitro study in *** the end of the 1990s,discussions regarding the potential applications of LDRinduced hormesis and adaptive responses for preventing or treating chronic diseases,such as Alzheimer’s disease(AD)had taken *** 2016,reports on radiotherapy for the subjects with AD and for genetic AD model mice were ***,several preclinical studies with animal models of AD and clinical studies in AD subjects were conducted.A significant milestone was achieved with the online availability of a new Systematic Review based on qualified publications from these preclinical and clinical *** mini-review provides a concise historical introduction to LDR-induced hormesis and adaptive responses with discussion of AD radiotherapy with either LDR or relatively high dose *** of this Systematic Review cover promising outcomes,challenges,and new questions,followed by discussion of potential mechanisms.

关键词： Alzheimer’s disease Low-dose radiation Radiation adaptive response Radiation hormesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese version of the Perth Alexithymia Questionnaire:psychometric properties and clinical applications

引用

General Psychiatry 2024年第2期37卷 274-283页

作者： Xin-lu cai Qingying Ye Ke Ni Lin Zhu Qian Zhang Minmin Yin Zhe Zhang Wei Wei David A.Preece Bao-Ming Li Institute of Brain Science and Department of Physiology School of Basic Medical SciencesHangzhou Normal UniversityHangzhouZhejiangChina Zhejiang Philosophy and Social Science Laboratory for Research in Early Development and Childcare Hangzhou Normal UniversityHangzhouZhejiangChina Qiqihar Mental Health Center QiqiharChina Department of Special Education Faculty of EducationHangzhou Normal UniversityHangzhouZhejiangChina Department of Neurobiology Affiliated Mental Health Center&Hangzhou Seventh People's Hospital Zhejiang University School of MedicineHangzhouZhejiangChina Liangzhu Laboratory MOE Frontier Science Center for Brain Science and Brain-machine IntegrationState Key Laboratory of Brain-machine IntelligenceZhejiang UniversityHangzhouZhejiangChina NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang UniversityHangzhouChina School of Population Health and Curtin enAble Institute Curtin UniversityPerthWestern AustraliaAustralia School of Psychological ScienceThe University of Western AustraliaPerthWestern AustraliaAustralia

Background The alexithymia trait is of high clinical *** Perth Alexithymia Questionnaire(PAQ)was recently developed to enable detailed facet-level and valence-specific assessments of *** In this paper,we introduce the first Chinese version of the PAQ and examine its psychometric properties and clinical *** In Study 1,the PAQ was administered to 990 Chinese *** examined its factor structure,internal consistency,test-retest reliability,as well as convergent,concurrent and discriminant *** Study 2,four groups,including a major depressive disorder(MDD)group(n=50),a matched healthy control group for MDD(n=50),a subclinical depression group(n=50)and a matched healthy control group for subclinical depression(n=50),were *** comparisons were conducted to assess the clinical relevance of the *** In Study 1,the intended five-factor structure of the PAQ was found to fit the data *** PAQ showed good internal consistency and test-retest reliability,as well as good convergent,concurrent and discriminant *** Study 2,the PAQ was able to successfully distinguish the MDD group and the subclinical depression group from their matched healthy *** The Chinese version of the PAQ is a valid and reliable instrument for comprehensively assessing alexithymia in the general population and adults with clinical/subclinical depression.

关键词： clinical instrument matched

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Leech Poecilobdella manillensis protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites

引用

World Journal of Gastroenterology 2024年第29期30卷 3488-3510页

作者： Xia Liu Xing-Qiu Liang Tian-cai lu Zhe Feng Min Zhang Nan-Qing Liao Feng-Lian Zhang Bo Wang Li-Sheng Wang Medical College Guangxi UniversityNanning 530004Guangxi Zhuang Autonomous RegionChina Department of Traditional Chinese Medicine HIV/AIDS Clinical Treatment Center of Guangxi(Nanning)The Fourth People’s Hospital of NanningNanning 530023Guangxi Zhuang Autonomous RegionChina Department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina General Manager’s Office Guangxi Fuxinyi Biological Technology Co.Ltd.Pingnan 537300Guangxi Zhuang Autonomous RegionChina Department of Joint and Sports Medicine Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Department of Gerontology Nanning Social Welfare HospitalNanning 530004Guangxi Zhuang Autonomous RegionChina

BACKGROUND Hyperuricemia(HUA)is a public health concern that needs to be solved *** lyophilized powder of Poecilobdella manillensis has been shown to significantly alleviate HUA;however,its underlying metabolic regulation remains *** To explore the underlying mechanisms of Poecilobdella manillensis in HUA based on modulation of the gut microbiota and host *** A mouse model of rapid HUA was established using a high-purine diet and potassium oxonate *** mice received oral drugs or ***,16S rRNA sequencing and ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry-based untargeted metabolomics were performed to identify changes in the microbiome and host metabolome,*** levels of uric acid transporters and epithelial tight junction proteins in the renal and intestinal tissues were analyzed using an enzyme-linked immunosorbent *** The protein extract of Poecilobdella manillensis lyophilized powder(49 mg/kg)showed an enhanced anti-trioxypurine ability than that of allopurinol(5 mg/kg)(Pluded the genera of Prevotella,Delftia,Dialister,Akkermansia,Lactococcus,Escherichia_Shigella,Enterococcus,and ***,22 metabolites in the serum were found to be closely related to the anti-trioxypurine activity of Poecilobdella manillensis powder,which correlated to the Kyoto Encyclopedia of Genes and Genomes pathways of cysteine and methionine metabolism,sphingolipid metabolism,galactose metabolism,and phenylalanine,tyrosine,and tryptophan *** analysis found that changes in the gut microbiota were significantly related to these *** The proteins in Poecilobdella manillensis powder were effective for ***,they are associated with improvements in g

关键词： Gut microbiota Metabolism Multi-omics Poecilobdella manillensis Sphingolipid metabolism pathway Galactose metabolism pathway Hyperuricemia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

服务业对外开放与制造业企业出口产品质量

引用

当代财经 2024年第6期 124-138页

作者：李超蔡露露云南大学经济学院云南昆明650500 中国人民大学经济学院北京100872

中国制造业企业如何从依托出口产品数量向质量转变,服务业对外开放从非实物要素投入的角度提供了新的视角。将产品质量引入消费者偏好和制造业企业的生产出口决策,通过构建一个包含消费者和服务、制造两类生产企业的局部均衡模型来阐释... 详细信息

中国制造业企业如何从依托出口产品数量向质量转变,服务业对外开放从非实物要素投入的角度提供了新的视角。将产品质量引入消费者偏好和制造业企业的生产出口决策,通过构建一个包含消费者和服务、制造两类生产企业的局部均衡模型来阐释服务业对外开放水平提高对制造业企业出口产品质量的影响。基于政策文本构建服务业开放影响指数,就服务业对外开放与制造业企业出口产品质量的实证研究发现,服务业对外开放主要通过削减制造业企业生产成本和提高企业生产率来改善产品质量,改善作用与开放的服务业类型有关,与制造业企业本身的地域特征、所有制属性以及企业所在行业的服务要素依赖程度无关。理论和经验证据表明,中国应该进一步消除服务行业的外商投资障碍以扩大服务业对外开放水平,在对外开放过程中需要有侧重地引导外资和先进的生产技术流向生产性服务行业,但无须过分注重制造业企业的地理布局、生产技术与所有制差异。

关键词：服务业对外开放出口产品质量制造业企业成本制造业企业生产率

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Diabetic cardiomyopathy:Importance of direct evidence to support the roles of NOD-like receptor protein 3 inflammasome and pyroptosis

引用

World Journal of Diabetes 2024年第8期15卷 1659-1662页

作者： lu cai Yi Tan Md Shahidul Islam Michael Horowitz Kupper A Wintergerst Pediatric Research Institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyUniversity of LouisvilleWendy Novak Diabetes InstituteNorton Children’s HospitalLouisvilleKY 40202United States Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Department of Medicine University of AdelaideAdelaide 5005Australia Pediatric Research Institute Division of EndocrinologyDepartment of PediatricsWendy Novak Diabetes InstituteNorton Children’s HospitalUniversity of LouisvilleLouisvilleKY 40202United States

Recently,the roles of pyroptosis,a form of cell death induced by activated NODlike receptor protein 3(NLRP3)inflammasome,in the pathogenesis of diabetic cardiomyopathy(DCM)have been extensively ***,most studies have focused mainly on whether diabetes increases the NLRP3 inflammasome and associated pyroptosis in the heart of type 1 or type 2 diabetic rodent models,and whether various medications and natural products prevent the development of DCM,associated with decreased levels of cardiac NLRP3 inflammasome and *** direct link of NLRP3 inflammasome and associated pyroptosis to the pathogenesis of DCM remains unclear based on the limited evidence derived from the available studies,with the approaches of NLRP3 gene silencing or pharmaceutical application of NLRP3 specific *** thus emphasize the requirement for more systematic studies that are designed to provide direct evidence to support the link,given that several studies have provided both direct and indirect evidence under specific *** editorial emphasizes that the current investigation should be circumspect in its conclusion,i.e.,not overemphasizing its role in the pathogenesis of DCM with the fact of only significantly increased expression or activation of NLRP3 inflammasome and pyroptosis in the heart of diabetic rodent *** clear-cut evidence-based causative roles of NLRP3 inflammasome and pyroptosis in the pathogenesis of DCM can help to develop effective and safe medications for the clinical management of DCM,targeting these biomarkers.

关键词： Diabetic cardiomyopathy Nucleotide oligomerization domain NOD-like receptor protein 3 inflammasome Cardiac cell death Pyroptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

回溯、思考、践行:人与自然和谐共生的现代化

引用

重庆社会科学 2024年第2期 28-40页

作者：朱锦秀蔡璐重庆师范大学继续教育学院重庆400047 重庆师范大学马克思主义学院重庆401331

人与自然和谐共生的现代化是新时代关于人与自然关系的高度凝练,深刻领悟这一新论断,深入贯彻习近平生态文明思想,需要从历史逻辑、理论逻辑和实践逻辑进行把握。通过梳理坚持和发展马克思主义生态文明思想、弘扬中华优秀传统文化、反... 详细信息

人与自然和谐共生的现代化是新时代关于人与自然关系的高度凝练,深刻领悟这一新论断,深入贯彻习近平生态文明思想,需要从历史逻辑、理论逻辑和实践逻辑进行把握。通过梳理坚持和发展马克思主义生态文明思想、弘扬中华优秀传统文化、反拨资本主义生态僭越逻辑的发展进程,有助于把握新时代人与自然关系的发展趋势;统筹“生命共同体”“两山论”“两个重大”关于人与自然关系的科学理念,深刻认识其内涵意蕴对于践行人与自然和谐共生的现代化具有现实意义;立足系统治理、数字引领、助力全球的总体规划,彰显了以习近平同志为核心的党中央的思想智慧,为全球环境治理提供了中国智慧和中国方案,展现了我们党坚定不移地推动和实现中国式现代化的信心与决心。

关键词：人与自然和谐共生中国式现代化绿色发展

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于双光子聚合3D打印的光纤法珀微波导腔制备及传感特性研究

引用

光学学报 2024年第2期44卷 120-126页

作者：陈茂庆刘思源蔡露刘强赵勇东北大学信息科学与工程学院辽宁沈阳110819 东北大学流程工业综合自动化国家重点实验室辽宁沈阳110819 河北省微纳精密光学传感与检测技术重点实验室河北秦皇岛066004

将光纤法布里-珀罗(法珀)微腔与微波导相结合,提出一种光纤法珀微波导腔高灵敏度折射率传感器。光纤法珀微腔可以将光场限制在微米量级的区域内,并对腔内的微波导结构起支撑保护作用;微波导在保证结构良好导光能力的同时,基于其强倏逝... 详细信息

将光纤法布里-珀罗(法珀)微腔与微波导相结合,提出一种光纤法珀微波导腔高灵敏度折射率传感器。光纤法珀微腔可以将光场限制在微米量级的区域内,并对腔内的微波导结构起支撑保护作用;微波导在保证结构良好导光能力的同时,基于其强倏逝场特性,进一步提升整体结构的折射率灵敏度。此外,基于飞秒激光双光子聚合高精度3D打印技术,可实现波导直径仅为2μm的光纤法珀微波导腔,并保证良好的制备重复性。实验结果表明:随着光纤法珀微波导腔传感器腔内液体折射率的增加,传感器的干涉光谱发生蓝移,在1.3346~1.3764折射率范围内灵敏度可达525.81 nm/RIU,与仿真获得折射率灵敏度(555.14 nm/RIU)结果接近;该传感器还展现了优良的线性响应特性,线性拟合系数可达0.9948;相比于传统无微波导的光纤法珀微腔结构,干涉光谱峰值提升了8.2 dB,折射率灵敏度提升了近4倍。

关键词：光纤传感器光纤法珀微波导腔微波导双光子聚合3D打印折射率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：