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Primary Non-HFE Hemochromatosis:A Review

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Journal of clinical and Translational Hepatology 2023年第4期11卷 925-931页

作者： Alla Turshudzhyan David c.wu George Y.wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Iron homeostasis is a complex process in which iron uptake and use are tightly *** Type 1 or HFE hemochromatosis results from homozygous mutations in the gene that encodes human homeostatic iron regulator(known as human factors engineering,HFE)protein,a regulator of hepcidin,and makes up approximately 90%of all hemochromatosis ***,four types of hemochromatosis do not involve the HFE *** are non-HFE hemochromatosis type 2A(HFE2,encoding HJV),type 2B(HAMP,encoding hepcidin),type 3(TFR2,encoding transferring receptor-2),and types 4A and B(SLc40A1,encoding *** hemochromatosis is extremely *** allele frequencies have been estimated to be 74/100,000 for type 2A,20/100,000 for type 2B,30/100,000 for type 3,and 90/100,000 for type 4 *** guidelines recommend that the diagnosis be made by ruling out HFE mutations,history,physical examination,laboratory values(ferritin and transferrin saturation),magnetic resonance or other imaging,and liver biopsy if *** less common,non-HFE hemochromatosis can cause iron overload as severe as the HFE *** most cases,treatment involves phlebotomy and is successful if started before irreversible damage *** diagnosis and treatment are important because it prevents chronic liver *** review updates the mutations and their pathogenetic consequences,the clinical picture,diagnostic guidelines,and treatment of hemochromatosis.

关键词： Non-HFE Hemochromatosis cirrhosis Iron homeostasis

Diagnostic and Therapeutic Strategies for Peritoneal Tuberculosis: A Review

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Journal of clinical and Translational Hepatology 2019年第2期7卷 140-148页

作者： David c.wu Leon D.Averbukh George Y.wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Peritoneal tuberculosis(PTB),although rarer than its pulmonary counterpart,is a serious health concern in regions of the world with high tuberculosis *** with baseline immunocompromise condition,whether acquired or medically induced,are at greatest risk for experiencing *** medical treatment of the condition is similar to that of the pulmonary disease,the generally immunocompromised state of those infected with PTB,along with a lack of highly sensitive and specific testing methods make early diagnosis *** review discusses the risks factors,clinical features,diagnostic methods,and treatment options for PTB.

关键词： Peritoneal tuberculosis Tuberculosis Liver disease Human immunodeficiency virus

Statin-induced Liver Injury Patterns: A clinical Review

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Journal of clinical and Translational Hepatology 2022年第3期10卷 543-552页

作者： Leon D.Averbukh Alla Turshudzhyan David c.wu George Y.wu Department of Medicine Division of Gastroenterology-HepatologyAllegheny Health NetworkPittsburghPAUSA Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Since their introduction in 1987,hydroxymethyl glutaryl coenzyme A reductase(HMG-coA)inhibitors,more commonly known as statins,have become some of the most widely prescribed medications in the *** generally considered to be safe and well tolerated,statins have been associated with several side effects including mild liver dysfunction manifested by increases in ***,statins have been noted to induce more serious hepatic injury,including liver injury with autoimmune *** literature supports statin induced liver injury presenting in either hepatocellular or cholestatic patterns,though with the former being the prevailing pattern of ***,severe liver injury is uncommon with statin use and is generally reversible without any intervention other than offending statin *** evaluating cases of suspected statininduced liver injury,a complete medical history,laboratory tests including a complete metabolic panel,autoimmune markers,and viral panel,as well as hepatic imaging,are crucial for a complete causality analysis with validated tools such as Roussel Uclaf causality Assessment *** aim of this review is to review the current evidence for statininduced liver injury and cholestasis.

关键词： Drug-induced liver injury Statin cholestatic liver injury Hepatocellular liver injury cholestasis Autoimmune hepatitis

Biliary Mucinous cystadenoma: A Review of the Literature

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Journal of clinical and Translational Hepatology 2019年第2期7卷 149-153页

作者： Leon D.Averbukh David c.wu Woo cheal cho George Y.wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Department of Pathology Hartford HospitalHartfordCTUSA

Biliary mucinous cystadenomas are cystic neoplasms commonly mistaken for simple *** are rare and generally benign tumors,often incidentally found on imaging and during unrelated surgical *** tend to be slow growing though may reach symptomatic *** of biliary mucinous cystadenomas may have serious consequences secondary to their potential for malignant transformation into biliary mucinous ***,we review the epidemiology,etiology,pathology,diagnostic modalities,histology,and available treatment methods for mucinous cystadenomas reported in current literature.

关键词： Biliarymucinous cystadenoma Biliary mucinous cystadenocarcinoma cystic neoplasm

Accurate nanoelectrode recording of human pluripotent stem cell-derived cardiomyocytes for assaying drugs and modeling disease

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Microsystems & Nanoengineering 2017年第1期3卷 382-388页

作者： Ziliang carter Lin Allister F.McGuire Paul W.Burridge Elena Matsa Hsin-Ya Lou Joseph c.wu Bianxiao cui Department of Applied Physics Stanford UniversityStanfordCA 94305USA Department of chemistry Stanford UniversityStanfordCA 94305USA Stanford cardiovascular Institute Stanford UniversityStanfordCA 94305USA Department of Pharmacology and center for Pharmacogenomics Northwestern UniversityChicagoIL 60611USA

The measurement of the electrophysiology of human pluripotent stem cell-derived cardiomyocytes is critical for their biomedical applications,from disease modeling to drug ***,a method that enables the high-throughput intracellular electrophysiology measurement of single cardiomyocytes in adherent culture is not *** address this area,we have fabricated vertical nanopillar electrodes that can record intracellular action potentials from up to 60 single beating *** access is achieved by highly localized electroporation,which allows for low impedance electrical access to the intracellular ***,we demonstrate that this method provides the accurate measurement of the shape and duration of intracellular action potentials,validated by patch clamp,and can facilitate cellular drug screening and disease modeling using human pluripotent stem *** study validates the use of nanopillar electrodes for myriad further applications of human pluripotent stem cell-derived cardiomyocytes such as cardiomyocyte maturation monitoring and electrophysiology-contractile force correlation.

关键词： cardiomyocytes drug screening electrophysiology human pluripotent stem cells multielectrode array

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心肌再生的分子影像评价

中华心血管病杂志 2008年第11期36卷 1045-1047页

作者：曹丰司瑞 Joseph c.wu 王海昌第四军医大学西京医院心血管内科西安710032 美国斯坦福大学放射科

近来的研究显示，将骨骼肌成肌细胞（skeletal myoblasts，SKMs）、内皮祖细胞（endothelial progenitor cells，EPcs）、骨髓干细胞（bone marrow stem cells，BMcs）和胚胎干细胞H0（embryonic stem cells，EScs）移植入梗死心肌可改善心室重构和心脏功能。再生过程的可能机制包括：干细胞分化为心肌细胞；细胞因子的旁分泌或募集外周干细胞到缺血区域。

关键词：影像评价心肌再生骨骼肌成肌细胞骨髓干细胞分子内皮祖细胞胚胎干细胞

A cRITERION FOR TWO KINDS OF PEIERLS TRANSITIONS

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chinese Physics Letters 1985年第3期2卷 141-144页

作者： Z.Wang c.wu X.Sun Department of Physics Fudan UniversityShanghai

Two different kinds of Peierls transitions can exist depending on the anisotropic ratio y of intrachain and interchain coupling.γhas a critical valueγo;if_(γ>γo),the Peierls transition will exhibit a cDW accompanied by a metal-semiconductor transition(kind I);if_(γcγo),only cDW and superlattice occur at Peierls transition(kind II).Some experimental evidences are discussed.

关键词： coupling. transition transitions

catalytic performances of cobalt-based catalysts for hydrogen generation with sodium borohydride solution

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Catalytic performances of cobalt-based catalysts for hydroge...

Effects of long-term preservation on amphibian body conditions:implications for historical morphological research

第九届全国氢能学术会议

作者： c.wu,F.wu,Y.Bai Beijing Institute of Technology,china

Hydrogen supply is one of the most important issues for wide practice of proton exchange membrane fuel cell(PEMFc).There are many ways to get *** instance,mass hydrogen production can be gained with chemical methods,from electrolysis of water,or by biologic ***,it is found that hydrogen generation from catalysis of sodium borohydride(NaBH) is flexible and controllable,and may be a promising way for on-site

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Effects of long-term preservation on amphibian body conditio...