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MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class c) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAURABH R.KIRAN D.SINGH R.vAISH v.S.cHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the c0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Simple and Efficient Method for Deprotection of Tetrahydropyranyl Ethers by Using Silica Supported Sodium Hydrogen Sulphate

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chinese Journal of chemistry 2012年第5期30卷 1189-1191页

作者： Kumar K. Ravi satyanarayana P. v. v. Reddy B. Srinivasa RA chem Pharma Limited Research and Development Division Prasanth Nagar Hyderabad 500072 AP India Department of chemistry Aeharya Nagarjuna University Nagarjuna Nagar Guntur 522510 AP India

Tetrahydropyranyl （THP） ethers have been efficiently and simply deprotected by using Silica supported sodium hydrogen sulphate （NaHSO4-SiO2） in methanol at room temperature to regenerate the parent alcohols in hig... 详细信息

关键词： THP ethers deprotection NaHSO4-SiO2 methanol reusable catalyst

Synthesis, characterization and Antimicrobial Activity of Oxovanadium（Iv） complexes of Schiff Base Hydrazones containing Quinoxaline Moiety

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chinese Journal of chemistry 2012年第4期30卷 935-940页

作者： Lakshmi, P. v. Anantha satyanarayana, T. Reddy, P. Saritha Department of chemistry University College for Women Osmania University HyderabadIndia OUPG college Osmania University Mirzapur India

The oxovanadium（Iv） complexes of the Schiff base hydrazones, synthesized from 3-hydrazinoquinoxaline-2- one （HQO） with salicylaldehyde （HSHQO）, o-hydroxyacetophenone （HHAHQO）, dehydroacetic acid （HDHAHQO） and o-nitrobenzaldehyde （NBHQO） were synthesized and characterized on the basis of analytical, conductance, magnetic moment, infrared, NMR, ESR and electronic spectral data. The ligands HSHQO, HDHAHQO behaved as monobasic tridentate ONN donors through phenolic oxygen, azomethine nitrogens. The ligand HAHQO acted as a monobasic bidentate ON donor through the phenolic oxygen, azomethine （free） nitrogen and the ligand NBHQO acted as neutral bidentate ON donor through oxygen of the nitro group and azomethine （free） nitrogen.

关键词： oxovanadium(Iv) hydrazones ONN donor ON donor

catalytic applications of nano β-PbO in Paal-Knorr reaction

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chinese chemical Letters 2011年第8期22卷 891-894页

作者： Sk.Khadeer Pasha v.S.v.satyanarayana A.Sivakumar K.chidambaram L.John Kennedy Physics Division School of Advanced SciencesVIT UniversityVellore 632014India chemistry Division School of Advanced SciencesVIT UniversityVellore 632014India

Several 2,5-dimethyl-N-substituted pyrroles were prepared by the condensation of different substituted anilines with 2,5- hexanedione using nano lead oxide as an efficient and recyclable *** the synthesized compounds are confirmed through IR, ~1H NMR,^（13）c NMR and mass spectral *** lead oxide β-PbO（P85） was prepared by dissolving lead acetate dihydrate in 1- propanol at a pH 9.0 under stirring at 85℃.The structural study and surface morphology of the lead oxide（PbO） were characterized using X-ray diffraction（XRD）,Scanning electron microscopy（SEM） and the functional groups of the PbO sample were investigated using infrared spectrophotometer.

关键词： 2 5-Dimethyl-N-substituted pyrroles Nano β-PbO Spectral data catalyst characterization

Effect of sintering temperature on the chemical bonding,electronic structure and electrical transport properties of β-Ga_(1.9)Fe_(0.1)O_(3) compounds

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Journal of Materials Science & Technology 2021年第8期67卷 135-144页

作者： Swadipta Roy c.v.Ramana center for Advanced Materials Research(cMR) University of Texas at El PasoEl Paso500 W University AveEl PasoTX79968United States

A model system,which is based on iron(Fe)doped gallium oxide(Ga_(2)O_(3))(Ga_(1.9)Fe_(0.1)O_(3)),has been considered to elucidate the combined effect of transition-metal ion doping and processing temperature on the chemistry,local structure and chemical bonding,and electrical transport properties of a wide band gap oxide(Ga_(2)O_(3)).The Ga_(1.9)Fe_(0.1)O_(3) compounds were synthesized using standard high-temperature solid state reaction *** effect of processing conditions in terms of different calcination and sintering environments on the structural and electrical properties of Ga_(1.9)Fe_(0.1)O_(3) compounds is studied in *** characterization by Raman spectroscopy revealed that Ga_(1.9)Fe_(0.1)O_(3) compounds exhibit monoclinic crystal symmetry,which is quite similar to the intrinsic parental crystal structure,though Fedoping induces lattice *** temperature(T_(sint))which was varied in the range of 900-1200℃,has significant impact on the structure,chemical bonding,and electrical properties of Ga_(1.9)Fe_(0.1)O_(3) *** spectroscopic measurements indicate the proper densification of the Ga_(1.9)Fe_(0.1)O_(3) compounds achieved through complete Fe diffusion into the parent Ga_(2)O_(3) lattice which is evident at the highest sintering *** X-ray photoelectron spectroscopy validates the chemical states of the constituent elements in Ga_(1.9)Fe_(0.1)O_(3) *** electrical properties of Ga_(1.9)Fe_(0.1)O_(3) fully controlled by T_(sint),which governed the grain size and microstructural *** temperature and frequency dependent electrical measurements demonstrated the salient features of the Fe doped Ga_(2)O_(3) *** activation energy determined from Arrhenius equation is 0.5 e *** results demonstrate that control over structure,morphology,chemistry and electrical properties of the Ga_(1.9)Fe_(0.1)O_(3) compounds can be achieved by optimizing T_(sint).

关键词： Ga_(2)O_(3)compounds Fe-doping Raman spectroscopy chemical bonding Electrical properties

Size Effects of the critical Temperature in Ferroelectric Thin Films

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communications in Theoretical Physics 2007年第7期48卷 183-188页

作者： v.c.Lo Institute of Physics and center for condensed Matter Physics Chinese Academy of SciencesBeijing 100080China

The size effects of the critical behaviors for the systems of interacting spins are discussed extensively *** this paper,the finite-size dependence of the critical temperature and susceptibility of the ferroelectric thinfilm are investigated numerically based on the four-state Potts model with the nearest-neighbor interactions between thedipole *** four orientations of the domains exist in the ferroelectric film and the movement of the domainwalls determines the polarization switching process besides the boundary conditions of the *** critical exponentsare obtained and our investigations show that the boundary conditions play the important roles for the ferroelectricproperties of the thin films and the critical behavior of the thin films strongly depends on the feature of the surface.

关键词： ferroelectric thin film critical temperature size effects

Multifunctional A356 alloy/PKSAnp composites:Microstructure and mechanical properties

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Defence Technology（防务技术） 2020年第3期16卷 731-736页

作者： v.S.Aigbodion I.c.Ezema Department of Metallurgical and Materials Engineering University of NigeriaNsukkaNigeria

Mechanical properties and microstructure of multifunctional composites produced with palm kernel shell ash nano particle(PKSAnp)-A356 alloy composites was *** composites were produced using Double layer feeding stir casting method(DLF-ScM) by adding 1 wt%-4 wt.% *** microstructure,density,electrical and mechanical properties were *** results shows that there was a uniform distribution of the PKSAnp in A356 *** mismatch at the interface between the PKSAnp and A356 alloy was 4.26%.Improvement of 30.47%,41.91%,49.52%,40.90% and 65.09% were obtained for hardness values,tensile,yield strength,%elongation and impact energy at 4 wt% *** work has established that the developed composites can be used for multifunctional applications where combination of toughness and strength is vital.

关键词： PKSAnp A356 alloy Microstructure Electrical and mechanical properties