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comparison of sperm retrieval and reproductive outcome in azoospermic men with testicular failure and obstructive azoospermia treated for infertility

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Asian Journal of Andrology 2014年第4期16卷 602-606页

作者： Sandro c Esteves christina Prudencio Bill Seol Sidney Verza jr c.ristopher knoedler Ashok Agarwal ANDROFERT Center for Male Reproduction Campinas Brazil center for Reproductive Medicine The Cleveland Clinic Foundation Cleveland USA.

We assessed the rates of sperm retrieval and intracytoplasmic sperm injection outcomes, including the neonatal profile of infants conceived, in men with testicular failure. Three-hundred and sixty-five men with testicular failure who underwent micro-dissection testicular sperm extraction were included in this study. We compared their outcomes with 40 men with testicular failure who used donor sperm for injections due to failed retrieval, and 146 men with obstructive azoospermia who underwent percutaneous sperm retrieval. The retrieval rate in testicular failure was 41.4%, and the results were lower than the obstructed azoospermia （100%; adjusted odds ratio： 0.033; 95% ch 0.007-0.164; P 〈 0.001）. Live birth rates after sperm injections were lower in men with testicular failure （19.9%） compared with donor sperm （37.5%; adjusted OR： 0.377 （95% ch 0.233-0.609, P 〈 0.001）） and obstructive azoospermia （34.2%; adjusted OR： 0.403 （95% cI： 0.241-0.676, P= 0.001）. Newborn parameters of infants conceived were not significantly different among the groups. We concluded that the chances of obtaining sperm on retrieval and achieving a live birth after intracytoplasmic sperm injection （IcSI） are reduced in men with testicular failure. The profile of infants conceived after sperm injection does not seem to be negatively affected by testicular failure.

关键词： infant intracytoplasmic sperm injection obstructive azoospermia pregnancy outcome sperm retrieval testicular failure

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Bone Research 2024年第3期12卷 502-516页

作者： Bobin Mi Yuan Xiong Samuel knoedler Michael Alfertshofer Adriana c.Panayi Haixing Wang Sien Lin Gang Li Guohui Liu Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and Technology1277 Jiefang AvenueWuhan 430022China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022China Division of Plastic Surgery Department of SurgeryBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Institute of Regenerative Biology and Medicine Helmholtz Zentrum MünchenMunichGermany Division of Hand Plastic and Aesthetic SurgeryLudwig-Maximilian University MunichMunichGermany Department of Hand- Plastic and Reconstructive SurgeryMicrosurgeryBurn Trauma CenterBG Trauma Center LudwigshafenUniversity of HeidelbergLudwigshafenGermany Department of Orthopaedics&Traumatology Stem Cells and Regenerative Medicine LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalShatinHong KongSAR 999077P.R.China

Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues,including the skeletal and immune *** studies have elucidated the intricate bidirection... 详细信息

关键词： skeleton insight irreversible

Immunomodulatory Nanosystems:Advanced Delivery Tools for Treating chronic Wounds

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Research 2023年第4期6卷 55-77页

作者： Xiangyu chu Yuan Xiong Samuel knoedler Li Lu Adriana cPanayi Michael Alfertshofe Dongsheng Jiang Yuval Rinkevich Ze Lin Zhiming Zhao Guandong Daia Bobin Mi Guohui Liu Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022China Division of Plastic Surgery Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02152USA institute of Regenerative Biology and Medicine Helmholtz Zentrum MunchenMax-Lebsche-Platz 3181377 MunichGermany Department of Hand Plastic and Reconstructive SurgeryMicrosurgeryBurn CenterBG Trauma Center LudwigshafenUniversity of HeidelbergLudwig-Guttmann-Strasse 1367071 Ludwigshafen/Rhine Germany.Division of HandPlastic and Aesthetic SurgeryLudwig-Maximilian University MunichMunichGermany Department of Orthopedics Suizhou HospitalHubei University of MedicineSuizhou 441300China Pingshan District People'sHospitalof Shenzhen Pingshan General Hospital of Southern Medical UniversityShenzhenGuangdong 518118China

The increasingly aging society led to a rise in the prevalence of chronic wounds(cWs),posing a significant burden to public health on a global *** of the key features of cWs is the presence of a maladjusted immune microenvironment characterized by persistent and excessive(hyper)inflammation.A variety of immunomodulatory therapies have been proposed to address this ***,to date,current delivery systems for immunomodulatory therapy remain inadequate and lack *** highlights the need for new therapeutic delivery systems,such as nanosystems,to manage the pathological inflammatory imbalance and,ultimately,improve the treatment outcomes of *** a plethora of immunomodulatory nanosystems modifying the immune microenvironment of cWs have shown promising therapeutic effects,the literature on the intersection of immunomodulatory nanosystems and cWs remains relatively ***,this review aims to provide a comprehensive overview of the pathogenesis and characteristics of the immune microenvironment in cWs,discuss important advancements in our understanding of cW healing,and delineate the versatility and applicability of immunomodulatory nanosystems-based therapies in the therapeutic management of *** addition,we herein also shed light on the main challenges and future perspectives in this rapidly evolving research field.

关键词： Tools healing herein

Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-cGGGAGc prevent valproic acid-induced bone loss

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Signal Transduction and Targeted Therapy 2024年第2期9卷 751-765页

作者： Xudong Xie Peng cheng Liangcong Hu Wu Zhou Detai Zhang Samuel knoedler Guodong Liu Yuan Xiong Hang Xue Yiqiang Hu Barbara Kern Doha Obed Adriana cPanayi Lang chen chenchen Yan Ze Lin Guandong Dai Bobin Mi Yingze Zhang Guohui Liu Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022China Department of clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022P.R.China Division of Plastic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02152USA Department of Plastic Surgery and Hand Surgery Klinikum Rechts der IsarTechnical University of MunichMunichGermany Medical center of Trauma and War Injuries Daping HospitalArmy Medical UniversityChonqing 400042China Department of Plastic Surgery Campus CharitéMitte|Campus Virchow-KlinikumCharité-Universitätsmedizin Berlincorporate member of Freie Universität BerlinHumboldt-Universität zu Berlin and Berlin Institute of HealthBerlinGermany Berlin Institute of Health Charité-Universitätsmedizin BerlinBerlinGermany Department of Plastic AestheticHand and Reconstructive SurgeryHannover Medical SchoolHannoverGermany Department of Hand Plastic and Reconstructive SurgeryMicrosurgeryBurn CenterBG Trauma Center LudwigshafenUniversity of HeidelbergLudwig-Guttmann-Strasse 1367071 Ludwigshafen/RhineGermany Pingshan District People’s Hospital of Shenzhen Pingshan General Hospital of Southern Medical UniversityShenzhenGuangdong 518118China Department of Orthopaedic Surgery The Third Hospital of Hebei Medical UniversityNO.139 Ziqiang RoadShijiazhuang 050051China

The clinical role and underlying mechanisms of valproic acid(VPA)on bone homeostasis remain ***,we confirmed that VPA treatment was associated with decreased bone mass and bone mineral density(BMD)in both patients and *** effect was attributed to VPA-induced elevation in osteoclast formation and *** RNA-sequencing,we observed a significant rise in precursor miR-6359 expression in VPA-treated osteoclast precursors in vitro,and further,a marked upregulation of mature miR-6359(miR-6359)in vivo was demonstrated using quantitative real-time PcR(qRT-PcR)and miR-6359 fluorescent in situ hybridization(miR-6359-FISH).Specifically,the miR-6359 was predominantly increased in osteoclast precursors and macrophages but not in neutrophils,T lymphocytes,monocytes and bone marrow-derived mesenchymal stem cells(BMScs)following VPA stimulation,which influenced osteoclast differentiation and bone-resorptive ***,VPA-induced miR-6359 enrichment in osteoclast precursors enhanced reactive oxygen species(ROS)production by silencing the SIRT3 protein expression,followed by activation of the MAPK signaling pathway,which enhanced osteoclast formation and activity,thereby accelerating bone ***,there are no medications that can effectively treat VPA-induced bone ***,we constructed engineered small extracellular vesicles(E-sEVs)targeting osteoclast precursors in bone and naturally carrying anti-miR-6359 by introducing of EXOmotif(cGGGAGc)in the 3’-end of the anti-miR-6359 *** confirmed that the E-sEVs exhibited decent bone/osteoclast precursor targeting and exerted protective therapeutic effects on VPA-induced bone loss,but not on ovariectomy(OVX)and glucocorticoid-induced osteoporotic models,deepening our understanding of the underlying mechanism and treatment strategies for VPA-induced bone loss.

关键词： miR protective stimulation