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Genomic landscape of pancreatic neuroendocrine tumors

World Journal of Gastroenterology 2014年第46期20卷 17498-17506页

作者： Niklas Gebauer christian Schmidt-Werthern Veronica Bernard Alfred c Feller Tobias Keck Nehara Begum Dirk Rades Hendrik Lehnert Georg Brabant c.ristoph thorns Department of Pathology University Hospital of Schleswig-Holstein23538 LuebeckGermany Department of Surgery University Hospital of Schleswig-Holstein23538 LuebeckGermany Department of Radiation Oncology University Hospital of Schleswig-Holstein 23538 LuebeckGermany Department of Internal Medicine I University Hospital of Schleswig-Holstein23538 LuebeckGermany

AIM: To investigate the prognostic role of genomic stability and copy number alterations (cNAs) pancreatic neuroendocrine tumors (PanNETs).

关键词： Array comparative genomic hybridization copy number alterations chromosomal aberrations Pancreatic neuroendocrine tumors Prognosis

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Environmental siblings of black agents of human chromoblastomycosis

引用

Fungal Diversity 2014年第2期65卷 47-63页

作者： V.A.Vicente M.J.Najafzadeh Jiufeng Sun R.R.Gomes D.Robl S.G.Marques c.M.P.S.Azevedo G.S.de Hoog cBS-KNAW Fungal Biodiversity centre P.O.Box 851673508AD UtrechtThe Netherlands Microbiology Parasitology and Pathology Post-graduation ProgramDepartment of Basic PathologyFederal University of ParanáCuritibaPRBrazil Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Peking University Health Science center Research Center for Medical MycologyBeijingChina Sun-Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhouChina Second Medical Military University ShanghaiChina King Abdulassiz University Jeddah JeddahSaudi Arabia Department of Parasitology and Mycology and Cancer Molecular Pathology Research CenterGhaem HospitalSchool of MedicineMashhad University of Medical SciencesMashhadIran Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhouChina Federal University of Maranhão University Hospital of the Federal University of MaranhãoSão LuísBrazil cedro Laboratory and University Hospital of the Federal University of Maranhão São LuísBrazil Institute of Biomedical Sciences University of São Paulo(USP)CEP 05508-900 São PauloBrazil

Agents of human chromoblastomycosis,a skin disease almost exclusively caused by members of the order chaetothyriales,are assumed to be traumatically inoculated into the skin with sharp environmental materials such as plant thorns or wooden splinters carrying the respective *** the supposition that such fungi should have their main habitat in the environment,we investigated the occurrence of black fungi in living areas of patients with *** South America Fonsecaea agents are prevalent as agents of the disease,while also related cladophialophora species,known from other types of skin infections,are known from the *** environmental isolates were preliminarily selected as possible agents of chromoblastomycosis,based on *** from ITS sequence data isolates were attributed to the genera cladophialophora,cyphellophora,Exophiala,Fonsecaea,Phialophora,and Veronaea.A total of 45 fungi morphologically identified as Fonsecaea or cladophialophora isolated from debris and thorns of living prickly plants in Brazil were processed for taxonomic *** analysis revealed that the isolates indeed belonged to the chaetothyriales,but only rarely an agent of chromoblastomycosis was concerned;only two strains of *** and one *** were isolated from debris *** remaining isolates belonged to hitherto unknown molecular siblings of *** novel taxa are introduced.

关键词： Black yeasts Environmental isolation chromoblastomycosis Opportunistic fungi Virulence Infection route

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