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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes c.Heinzel Antal nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGcs). However, the use of tnGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGcs and compared the various features of these improved silk^(+) tnGcs with the tubes without holes(silk^(–) tnGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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Microstructural Evolution during Forming of Metals

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Journal of Materials Science & Technology 2001年第4期17卷 409-412页

作者： n.Hansen Materials Research Department, risφ national Laboratory,DK-4000 Roskilde, Denmark riso natl Lab Mat Res Dept DK-4000 Roskilde Denmark

The microstructural evolution during plastic deformation is described as grain subdivision on a finer and finer scale with increasing strain. Key structural features are dislocation boundaries and high angle boundaries. These boundaries have characteristic parameters which are used in a comparison of deformation microstructures produced under different conditions.

关键词： Microstructural Evolution during Forming of Metals EcAE

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5DGWO-GAn:A novel Five-Dimensional Gray Wolf Optimizer for Generative Adversarial network-Enabled Intrusion Detection in IoT Systems

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computers, Materials & continua 2025年第1期82卷 881-911页

作者： Sarvenaz Sadat Khatami Mehrdad Shoeibi Anita Ershadi Oskouei Diego Martín Maral Keramat Dashliboroun Department of Data Science Engineering University of HoustonHoustonTX 77204USA The WPI Business School Worcester Polytechnic InstituteWorcesterMA 01609USA School of Systems and Enterprises Stevens Institute of TechnologyHobokenNJ 07030USA Department of computer Science Escuela de Ingeniería Informática de SegoviaUniversidad de ValladolidSegovia40005Spain Ernest G.Welch School of Art&Design Georgia State UniversityAtlantaGA 30303USA

The Internet of Things(IoT)is integral to modern infrastructure,enabling connectivity among a wide range of devices from home automation to industrial control *** the exponential increase in data generated by these interconnected devices,robust anomaly detection mechanisms are *** detection in this dynamic environment necessitates methods that can accurately distinguish between normal and anomalous behavior by learning intricate *** paper presents a novel approach utilizing generative adversarial networks(GAns)for anomaly detection in IoT ***,optimizing GAns involves tuning hyper-parameters such as learning rate,batch size,and optimization algorithms,which can be challenging due to the non-convex nature of GAn loss *** address this,we propose a five-dimensional Gray wolf optimizer(5DGWO)to optimize GAn *** 5DGWO introduces two new types of wolves:gamma(γ)for improved exploitation and convergence,and theta(θ)for enhanced exploration and escaping local *** proposed system framework comprises four key stages:1)preprocessing,2)generative model training,3)autoencoder(AE)training,and 4)predictive model *** generative models are utilized to assist the AE training,and the final predictive models(including convolutional neural network(cnn),deep belief network(DBn),recurrent neural network(Rnn),random forest(RF),and extreme gradient boosting(XGBoost))are trained using the generated data and AE-encoded *** evaluated the system on three benchmark datasets:nSL-KDD,UnSW-nB15,and *** conducted on diverse IoT datasets show that our method outperforms existing anomaly detection strategies and significantly reduces false *** 5DGWO-GAn-cnnAE exhibits superior performance in various metrics,including accuracy,recall,precision,root mean square error(RMSE),and convergence *** proposed 5DGWO-GAn-cnnAE achieved the lowest RMSE values across the nSL-KDD,UnSW-nB15,and

关键词： Internet of things intrusion detection generative adversarial networks five-dimensional binary gray wolf optimizer deep learning

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A generic procedure for determining atomic LS spectral terms and their LS eigenfunctions

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chinese Physics B 2009年第2期18卷 542-548页

作者：熊庄 Bacalis n c AMS Research center Southeast University Theoretical and Physical chemistry Institute National Hellenic Research Foundation

This paper develops a Fortran code which is capable to construct the simplest LS eigenfunctions for desired symmetry and determine all permitted atomic LS spectral terms under a given orbital occupancy by implementing and extending the Schaefer and Harris method. Examples （in some cases the most complete set to date） of multiple spectroscopic terms of LS coupling of atomic states for both non-equivalent and equivalent electronic configurations are given. It also corrects a few observed errors from the recent literature.

关键词： LS coupling multiples spectroscopic term

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numerical analysis of a magnetohydrodynamic duct flow with flow channel insert under a non-uniform magnetic field

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Journal of Hydrodynamics 2018年第6期30卷 1134-1142页

作者： c.n.Kim Department of Mechanical Engineering College of Engineering Kyung Hee University

This study performs a numerical analysis of three-dimensional liquid metal(LM) magnetohydrodynamic(MHD) flows in a square duct with an FcI in a non-uniform magnetic field. The current study predicts detailed information on flow velocity, Lorentz force, pressure, current and electric potential of MHD duct flows for different Hartmann numbers. Also, the effect of the electric conductivity of FcI on the pressure drop along the main flow direction in a non-uniform magnetic field is examined. The present study investigates the features of LM MHD flows in consideration of the interdependency among the flow variables.

关键词： non-uniform magnetic field liquid metal blanket magnetohydrodynamic(MHD) duct flow flow channel insert

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Lateral lymph node dissection for low rectal cancer: Is it necessary?

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World Journal of Gastroenterology 2019年第31期25卷 4294-4299页

作者： niki christou Jeremy Meyer christian Toso Frédéric ris nicolas christian Buchs Service de chirurgie Digestive Endocrinienne et GénéraleCHU de LimogesLimoges Cedex 87042France Division of Digestive Surgery University Hospitals of GenevaGenève 1211Switzerland Unit of Surgical Research University of GenevaGenève 1206Switzerland

Rectal cancer constitutes a major public health *** mesorectal excision has remained the gold standard treatment for mid and low rectal tumors since its introduction in the late *** of all lymph nodes located in the mesorectum has indeed improved pathological and oncological ***,when cancer spreads to the lateral lymph nodes(located along the iliac and obturator arteries)Western and Japanese practices *** the Western guidelines consider this condition as an advanced form of the disease and use neoadjuvant radiochemotherapy liberally,the Japanese guidelines define it as a local disease and proceed to lateral lymph node dissection with or without neoadjuvant ***,we review the current literature regarding both therapeutic strategies,with the aim of contributing to potential improvements in treatment and outcome for patients with low and mid rectal cancer.

关键词： Total mesorectum excision Mesorectal resection Lateral node metastasis Extended lymphadenectomy

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OH and O radicals production in atmospheric pressure air/Ar/H_2O gliding arc discharge plasma jet

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Plasma Science and Technology 2017年第12期19卷 71-80页

作者： n c ROY M R TALUKDER A n cHOWDHURY Plasma Science and Technology Laboratory Department of Applied Physics and Electronic EngineeringUniversity of RajshahiRajshahi 6205Bangladesh Bangladesh council of Scientific and Industrial Research Laboratory Rajshahi Rajshahi 6206Bangladesh

Atmospheric pressure air/Ar/H_2O gliding arc discharge plasma is produced by a pulsed dc power supply. An optical emission spectroscopic（OES） diagnostic technique is used for the characterization of plasmas and for identifications of OH and O radicals along with other species in the plasmas. The OES diagnostic technique reveals the excitation Tx？≈？5550–9000 K, rotational Tr？≈？1350–2700 K and gas Tg？≈？850–1600 K temperatures, and electron density n？（1.1-1.9） ′101 4 cm^（-3） e under different experimental conditions. The production and destruction of OH and O radicals are investigated as functions of applied voltage and air flow rate. Relative intensities of OH and O radicals indicate that their production rates are increased with increasing Ar content in the gas mixture and applied voltage. nereveals that the higher densities of OH and O radicals are produced in the discharge due to more effective electron impact dissociation of H_2O and O_2 molecules caused by higher kinetic energies as gained by electrons from the enhanced electric field as well as by enhanced n *** productions of OH and O are decreasing with increasing air flow rate due to removal of Joule heat from the discharge region but enhanced air flow rate significantly modifies discharge maintenance properties. Besides, Tgsignificantly reduces with the enhanced air flow rate. This investigation reveals that Ar plays a significant role in the production of OH and O radicals.

关键词： reactive oxygen species(ROS) optical emission spectroscopy(OES) gliding arc discharge plasma kinetics broadening mechanism

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Shape of the geometrically active atomic states of carbon

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chinese Physics B 2010年第2期19卷 219-224页

作者：熊庄 Bacalis n.c. AMS Research center Southeast University Theoretical and Physical chemistry Institute National Hellenic Research FoundationVasileos Constantinou 48AthensGreece 11635

We have developed a computer code for {／em ab initio} the variational configuration interaction calculation of the electronic structure of atoms via variationally optimized Lagurre type orbitals, treating the orbital effective charges as variational parameters. Excited states of the same symmetry, in order to avoid the inherent restrictions of the standard method of Hylleraas--Unheim and MacDonald, are computed variationally by minimizing the recently developed minimization functionals for excited states. By computing, at the minimum, the one-electron density and the probability distribution of the two-electron angle, and the most probable two-electron angle, we investigate the atomic states of the carbon atom. We show that, without resorting to the （admittedly unproven） concept of hybridization, as an intrinsic property of the atomic wave function, the most probable value of the two-electron angle is around the known angles of carbon bonding, i.e. either 109^／circ or 120^／circ or 180^／circ, depending on each low-lying state of the bare carbon atom.

关键词： carbon hybridization excited states variational principle

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Stellar energy loss rates associated with photoneutrino processes in the minimal extension of the standard model

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chinese Physics c 2023年第4期47卷 74-80页

作者： c.Aydın Department of Physics Karadeniz Technical University61080TrabzonTurkey

Using the minimal extension of the standard model and considering the charge radius and the anapole moments of a neutrino,we derive analytical expressions for the stellar energy loss rates associated with the production of a neutrino pair e+γ→ve+ve νein hot plasma under three limiting regimes(nondegenerate,intermediate,and degenerate electrons)of the temperature,electron chemical potential,and plasma *** obtained results reveal the presence of an extra contribution of approximately 10%based on the considered calculations.

关键词： neutrinos pair production stellar energy-loss rates form factors electron-positron plasmas

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