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区结核病规程下化学治疗后涂片阳性肺结核病人的评价

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国际结核病与肺部疾病杂志 1995年第1期 16-22页

作者： Manjula Datta M.P.Radhamani R.Selvaraj c.n.paramasivan B.n.Gopalan c.R.Sudeendra R.Prabhakar 屠德华 Tuberculois Research centre ICMRchetputMadrasIndia

这是1986年4月—1899年3月间北Arcot区开始抗结核化学治疗的3357名涂片阳性病人回顾性队列分析的情况报告。1988年11月至1989年6月(治疗开始后6到36个月)间对这些病人做一次家庭访问并获得其中76％病人情况(包括死亡)的资料。治疗方案... 详细信息

这是1986年4月—1899年3月间北Arcot区开始抗结核化学治疗的3357名涂片阳性病人回顾性队列分析的情况报告。1988年11月至1989年6月(治疗开始后6到36个月)间对这些病人做一次家庭访问并获得其中76％病人情况(包括死亡)的资料。治疗方案是由病人选择的。2306(69％)病人接受短程方案(Scc),1051(31％)病人接受标准化学治疗(非Scc),在Scc和非Scc方案中分别有43％和35％病人完成了他们80％以上的治疗。总死亡率为28％,其余病人中,31％有活动性疾病并排菌,其中培养阳性的65％耐鼻烟肼,12％耐利福平。4％耐鼻烟肼和利福平,19％耐异烟肼和链霉素。一个重要的发现是,即使用药量不足他们应治疗的50％病人中,56％为结核菌阴性。然而,不充分或不规则化学治疗的病人比充分化学治疗的病人死亡率在4倍以上,涂片阳性率约2倍。短程方案病人与标准方案病人之间没有比较。因为是病人选择他们的治疗而且各组是不可比的。

关键词：化学治疗标准方案规程总死亡率细菌学治疗方案病人死亡痰标本阳性率回顾性

印度既往接受过抗结核治疗患者的一线和二线抗结核药耐药谱

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国际结核病与肺部疾病杂志 2010年第3期5卷 116-119页

作者： c.n.paramasivan F.Rehman F.Wares n.Sundar Mohan S.Sundar S.Devi P.R.narayanan 赵津王雪静 Foundation for Innovative new Diagnostics GenevaSwitzerland Tuberculosis Research centre Indian Council of Medical ResearchChennal Office of the World Health Organization Representative to India New DelhiIndia Tuberculosis Research centre Indian Council of Medical ResearchChennai

本文对2001-2004年间,全印度2816例复治失败结核病患者的痰培养和药物敏感试验结果,在chennai的结核病研究中心进行了回顾性分析。其中1498例(53%)被确诊为患有耐多药结核病(MDR-TB),671例(44.8%)至少耐一种二线抗结核药,分别为:490例(3... 详细信息

本文对2001-2004年间,全印度2816例复治失败结核病患者的痰培养和药物敏感试验结果,在chennai的结核病研究中心进行了回顾性分析。其中1498例(53%)被确诊为患有耐多药结核病(MDR-TB),671例(44.8%)至少耐一种二线抗结核药,分别为:490例(32.7%)耐乙硫异烟胺,245例(16.4%)耐氧氟沙星,169例(11.3%)耐卡那霉素;69例(4.6%)为广泛耐药结核病(XDR-TB)。尽管本结果是从高度选择的、不具代表性的患者人群中获得,但耐多药结核病患者中的二线抗结核药耐药率(包括XDR率)如此之高仍值得关注。因此,以高质量的DOTS服务来预防M/XDR-TB的产生,仍是目前的首要任务。此外,也需要尽快扩展在修改后的国家结核病控制规划(RnTcP)下的高质量的规划管理,以及更加规范规划之外对二线抗结核药的使用。

关键词：耐药既往治疗过的结核病印度

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes c.Heinzel Antal nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGcs). However, the use of tnGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGcs and compared the various features of these improved silk^(+) tnGcs with the tubes without holes(silk^(–) tnGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Distributed Healthcare Framework Using MMSM-SVM and P-SVM classification

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computers, Materials & continua 2022年第1期70卷 1557-1572页

作者： R.Sujitha B.paramasivan Department of Information Technology National Engineering College(Autonomous)Kovilpatti628503TamilnaduIndia

With the modernization of machine learning techniques in healthcare,different innovations including support vector machine(SVM)have predominantly played a major role in classifying lung cancer,predicting coronavirus disease 2019,and other *** particular,our algorithm focuses on integrated datasets as compared with other existing *** this study,parallel-based SVM(P-SVM)andmulticlass-basedmultiple submodels(MMSM-SVM)were used to analyze the optimal classification of lung *** analysis aimed to find the optimal classification of lung diseases with id and stages,such as key-value pairs in MapReduce combined with P-SVM and MMSVM for binary and multiclasses,*** nonlinear classification,kernel clustering-based SVM embedded with multiple submodels was *** algorithms were developed using Apache spark environment,and data for the analysis were retrieved from microscope lab,UcI,Kaggle,and General Thoracic surgery database along with some electronic health records related to various lung diseases to increase the dataset size to 5 *** measures were conducted using a 5 GB dataset with five *** size was finally increased,and task analysis and cPU utilization were measured.

关键词： Lung cancer cOVID-19 machine learning deep learning parallel based support vector machine multiclass-based multiple submodel

nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte non-aqueous electrolyte

Biochar amendments and its impact on soil biota for sustainable agriculture

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Biochar 2020年第3期2卷 287-305页

作者： Abhijeet Pathy Jyotiprakash Ray Balasubramanian paramasivan Agricultural and Environmental Biotechnology Group Department of Biotechnology and Medical EngineeringNational Institute of Technology RourkelaOdisha 769008India

Beneficial microbes in soil biota are known to enhance plant growth by stimulating the nutrient supply and by devising certain mechanisms to cope up with the biotic(diseases)or abiotic(salinity,drought,and pollution)*** to their effectiveness and sustainability concerns,the application of microbes in the agricultural sector has seen a positive surge *** has been commended as an exemplary carrier material for beneficial microbes in the soil *** is generally produced from the waste biomasses,which not only resolve the management crisis of agricultural wastes but also render many benefits such as enhancement of soil properties,alteration of nutritional dynamics,removal of pollutants,and in the stimulation of beneficial microbial diversity in *** strategic application of biochar in agricultural land could help provide agronomic,economic,and environmental *** certain risks are associated with the application of biochar,attention needs to be paid while preferring for soil *** present review focused on highlighting the role of microbes in plant *** influence of biochar on soil biota along with its detailed mechanisms was discussed further to delineate the scope of biochar in soil ***,the risks associated with the biochar amendments and the future perspectives in this research arena were highlighted.

关键词： Biochar Sustainable agriculture Soil biota Microbes Plant growth Microbial interaction

Energy Based Random Repeat Trust computation in Delay Tolerant network

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computer Systems Science & Engineering 2023年第9期46卷 2845-2859页

作者： S.Dheenathayalan B.paramasivan national Engineering college Kovilpatti628503India

As the use of mobile devices continues to rise,trust administration will significantly improve security in routing the guaranteed quality of service(QoS)supply in Mobile Ad Hoc networks(MAnET)due to the mobility of the *** is no continuance of network communication between nodes in a delay-tolerant network(DTn).DTn is designed to complete recurring connections between *** approach proposes a dynamic source routing protocol(DSR)based on a feed-forward neural network(FFnn)and energybased random repetition trust calculation in *** another node is looking for a node that swerved off of its path in this situation,routing will fail since it won’t recognize ***,in the suggested strategy,nodes do not stray from their pathways for *** is only likely that the message will reach the destination node if the nodes encounter their destination or an appropriate transitional node on their default mobility route,based on their pattern of *** EBRRTc-DTn algorithm(Energy based random repeat trust computation)is based on the time that has passed since nodes last encountered the destination *** to other existing techniques,simulation results show that this process makes the best decision and expertly determines the best and most appropriate route to send messages to the destination node,which improves routing performance,increases the number of delivered messages,and decreases delivery ***,the suggested method is better at providing better QoS(Quality of Service)and increasing network lifetime,tolerating network system latency.

关键词： MAnETs energy competent dynamic source routing protocol delay tolerant network energy-based random repeat trust computation quality of service network lifetime routing

Green ionic metal-organic frameworks as nanocatalysts for cO_(2)fixation

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nano Research 2025年第1期18卷 260-269页

作者： nuria Martín Miguel Maireles-Porcar Julián Sánchez Velandia Belén Altava Francisco G.cirujano Eduardo García-Verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

co,ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(nMR),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free cO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TOns of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis cO_(2)conversion